Search results
- 1.0574366 - ÚOCHB 2024 RIV US eng J - Journal Article
Břehová, Petra - Řezníčková, E. - Škach, Kryštof - Jorda, R. - Dejmek, Milan - Vojáčková, V. - Šála, Michal - Kovalová, M. - Dračínský, Martin - Dolníková, A. - Strmeň, Timotej - Kinnertová, M. - Chalupský, Karel - Dvořáková, Alexandra - Gucký, T. - Mertlíková-Kaiserová, Helena - Klener, P. - Nencka, Radim - Kryštof, V.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Journal of Medicinal Chemistry. Roč. 66, č. 16 (2023), s. 11133-11157. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : gene expression * highly potent
OECD category: Oncology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.3c00575
Permanent Link: https://hdl.handle.net/11104/0344703File Download Size Commentary Version Access 10.1021acs.jmedchem.3c00575.pdf 0 7.8 MB Publisher’s postprint open-access - 2.0573990 - ÚMG 2024 RIV US eng J - Journal Article
Straiker, A. - Dvorakova, M. - Bosquez-Berger, T. - Blahoš, Jaroslav - Mackie, K.
A collection of cannabinoid-related negative findings from autaptic hippocampal neurons.
Scientific Reports. Roč. 13, č. 1 (2023), č. článku 9610. ISSN 2045-2322. E-ISSN 2045-2322
Institutional support: RVO:68378050
Keywords : CB1 RECEPTOR * 2-ARACHIDONOYL GLYCEROL * PRESYNAPTIC INHIBITION * PROTEIN DESENSITIZATION * DESENSITIZATION * TRANSMISSION * ANDAMIDE * POTENT
OECD category: Biochemistry and molecular biology
Impact factor: 4.6, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41598-023-36710-3
Permanent Link: https://hdl.handle.net/11104/0344366 - 3.0571539 - BTÚ 2024 RIV US eng J - Journal Article
Temml, V. - Kollar, J. - Schoenleitner, T. - Hoell, A. - Schuster, D. - Kutil, Zsofia
Combination of In Silico and In Vitro Screening to Identify Novel Glutamate II Inhibitors.
Journal of Chemical Information and Modeling. Roč. 63, č. 4 (2023), s. 1249-1259. ISSN 1549-9596. E-ISSN 1549-960X
R&D Projects: GA ČR(CZ) GJ19-22269Y
Institutional support: RVO:86652036
Keywords : CARBOXYPEPTIDASE-II * PHARMACOPHORE MODELS * POTENT INHIBITORS
OECD category: Analytical chemistry
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jcim.2c01269
Permanent Link: https://hdl.handle.net/11104/0343285 - 4.0560992 - ÚOCHB 2023 RIV US eng J - Journal Article
Santos, L. H. - Kronenberger, T. - Almeida, R. G. - Silva, E. B. - Rocha, R. E. O. - Oliveira, J. C. - Barreto, L. V. - Skinner, D. - Fajtová, Pavla - Giardini, M. A. - Woodworth, B. - Bardine, C. - Lourenço, A. L. - Craik, C. S. - Poso, A. - Podust, L. M. - McKerrow, J. H. - Siqueira-Neto, J. L. - O'Donoghue, A. J. - Da Silva Júnior, E. N. - Ferreira, R. S.
Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2.
Journal of Chemical Information and Modeling. Roč. 62, č. 24 (2022), s. 6553-6573. ISSN 1549-9596. E-ISSN 1549-960X
Institutional support: RVO:61388963
Keywords : nor-β-lapachone * Trypanosoma cruzi activity * potent antitumor activity
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jcim.2c00693
Permanent Link: https://hdl.handle.net/11104/0333755 - 5.0555482 - ÚMG 2022 RIV US eng J - Journal Article
Sedlák, David - Wilson, T.A. - Tjarks, W. - Radomska, H.S. - Wang, H. - Kolla, Jayaprakash Narayana - Lesnikowski, Z. J. - Spicakova, A. - Ali, T. - Ishita, K. - Rakotondraibe, L.H. - Vibhute, S. - Wang, D. - Anzenbacher, P. - Bennett, C. - Bartůněk, Petr - Coss, C.C.
Structure-Activity Relationship of para-Carborane Selective Estrogen Receptor beta Agonists.
Journal of Medicinal Chemistry. Roč. 64, č. 13 (2021), s. 9330-9353. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LM2015063; GA MŠMT(CZ) LM2018130
Research Infrastructure: CZ-OPENSCREEN II - 90063
Institutional support: RVO:68378050
Keywords : neutron-capture therapy * boron clusters * g-protein * ligands * design * alpha * prostate * bearing * potent * disruption
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00555
Permanent Link: http://hdl.handle.net/11104/0329993 - 6.0555025 - BC 2022 RIV CH eng J - Journal Article
Sojka, Daniel - Šnebergerová, Pavla - Robbertse, Luise
Protease Inhibition-An Established Strategy to Combat Infectious Diseases.
International Journal of Molecular Sciences. Roč. 22, č. 11 (2021), č. článku 5762. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA20-05736S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : plasmodium-falciparum * plasmepsin-v * malaria parasites * drug discovery * potent * validation * proteins * invasion * egress * target * protease * parasites * inhibition * therapy * infectious diseases
OECD category: Immunology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/11/5762
Permanent Link: http://hdl.handle.net/11104/0329643 - 7.0545805 - ÚOCHB 2022 RIV US eng J - Journal Article
Lemke, C. - Benýšek, Jakub - Brajtenbach, D. - Breuer, C. - Jílková, Adéla - Horn, Martin - Buša, Michal - Ulrychová, Lenka - Illies, A. - Kubatzky, K. F. - Bartz, U. - Mareš, Michael - Gütschow, M.
An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
Journal of Medicinal Chemistry. Roč. 64, č. 18 (2021), s. 13793-13806. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : highly potent * vinyl sulfone * inhibitors
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01178
Permanent Link: http://hdl.handle.net/11104/0322454 - 8.0541528 - ÚMG 2021 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Šturc, A. - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, M. - Peřina, M. - Pospíšil, T. - Šiiroká, J. - Urbánek, L. - Pachl, P. - Řezáčová, Pavlína - Strnad, M. - Klener, P. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : biological evaluation * cell-cycle * roscovitine * potent * apoptosis * subgroups * purines * abt-199
OECD category: Biochemistry and molecular biology
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0319083 - 9.0537297 - BC 2021 RIV GB eng J - Journal Article
Corrigan, T.S. - Diaz, L.M.L. - Border, S.E. - Ratigan, S.C. - Kasper, K.Q. - Sojka, Daniel - Fajtova, P. - Caffrey, C.R. - Salvesen, G. S. - McElroy, C.A. - Hadad, C.M. - Ekici, O.D.
Design, synthesis, andin vitroevaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1387-1402. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : asparaginyl endopeptidase * schistosoma-mansoni * michael acceptors * caspase family * key mediators * legumain * expression * potent * generation * epoxides * Proteasome inhibitor * caspase and legumain inhibitors * aza-peptide carbonyls * anticancer * antiparasitic
OECD category: Microbiology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/pdf/10.1080/14756366.2020.1781107?needAcces
Permanent Link: http://hdl.handle.net/11104/0315029 - 10.0509895 - BFÚ 2020 RIV US eng J - Journal Article
Kostrhunová, Hana - Zajac, Juraj - Novohradský, Vojtěch - Kašpárková, Jana - Malina, Jaroslav - Aldrich-Wright, J.R. - Petruzzella, V. - Sirota, R. - Gibson, D. - Brabec, Viktor
A Subset of New Platinum Antitumor Agents Kills Cells by a Multimodal Mechanism of Action Also Involving Changes in the Organization of the Microtubule Cytoskeleton.
Journal of Medicinal Chemistry. Roč. 62, č. 10 (2019), s. 5176-5190. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA18-09502S
Institutional support: RVO:68081707
Keywords : potent cytotoxic agents * deacetylase inhibitor * anticancer activity * pt(iv) derivatives * in-vitro
OECD category: Medicinal chemistry
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00489
Permanent Link: http://hdl.handle.net/11104/0300487