Search results
- 1.0567543 - ÚOCHB 2024 RIV CH eng J - Journal Article
Szczurowska, Ewa - Szánti-Pintér, Eszter - Chetverikov, Nikolai - Randáková, Alena - Kudová, Eva - Jakubík, Jan
Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids.
International Journal of Molecular Sciences. Roč. 24, č. 1 (2023), č. článku 507. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * Alzheimer's disease * Parkinson's disease * schizophrenia * substance abuse * depression
OECD category: Neurosciences (including psychophysiology; Physiology (including cytology) (FGU-C)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms24010507
Permanent Link: https://hdl.handle.net/11104/0338789File Download Size Commentary Version Access 23_0567543.pdf 1 3.4 MB Publisher’s postprint open-access - 2.0564844 - ÚOCHB 2023 RIV CH eng J - Journal Article
Szczurowska, Ewa - Szánti-Pintér, Eszter - Randáková, Alena - Jakubík, Jan - Kudová, Eva
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids.
International Journal of Molecular Sciences. Roč. 23, č. 21 (2022), č. článku 13075. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Biochemistry and molecular biology; Physiology (including cytology) (FGU-C)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms232113075
Permanent Link: https://hdl.handle.net/11104/0336401File Download Size Commentary Version Access 10.3390ijms232113075.pdf 3 4.3 MB Publisher’s postprint open-access - 3.0546864 - FGÚ 2022 RIV US eng J - Journal Article
Dolejší, Eva - Chetverikov, Nikolai - Szánti-Pintér, Eszter - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - El-Fakahany, E. E. - Kudová, Eva - Jakubík, Jan
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors.
Biochemical Pharmacology. Roč. 192, Oct (2021), č. článku 114699. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 6.100, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.bcp.2021.114699
Permanent Link: http://hdl.handle.net/11104/0323241 - 4.0546460 - FGÚ 2022 RIV CH eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Hochmalová, Martina - Zimčík, Pavel - Mulenga, Mutale Jane - Boulos, J. - Jakubík, Jan
Fusion with Promiscuous G alpha(16) Subunit Reveals Signaling Bias at Muscarinic Receptors.
International Journal of Molecular Sciences. Roč. 22, č. 18 (2021), č. článku 10089. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GJ19-06106Y
Institutional support: RVO:67985823
Keywords : muscarinic receptors * signaling bias * fusion proteins * non-canonical signaling
OECD category: Pharmacology and pharmacy
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/18/10089
Permanent Link: http://hdl.handle.net/11104/0322964 - 5.0542922 - FGÚ 2022 RIV GB eng J - Journal Article
Randáková, Alena - Jakubík, Jan
Functionally selective and biased agonists of muscarinic receptors.
Pharmacological Research. Roč. 169, July (2021), č. článku 105641. ISSN 1043-6618. E-ISSN 1096-1186
R&D Projects: GA ČR(CZ) GJ19-06106Y
Institutional support: RVO:67985823
Keywords : muscarinic receptors * signalling bias * functional selectivity * G-proteins * beta-arrestins
OECD category: Pharmacology and pharmacy
Impact factor: 10.334, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.phrs.2021.105641
Permanent Link: http://hdl.handle.net/11104/0320252 - 6.0524902 - FGÚ 2021 RIV US eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Doležal, Vladimír - El-Fakahany, E. E. - Boulos, J. - Jakubík, Jan
Agonist-Specific Conformations of the M-2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics.
Journal of Chemical Information and Modeling. Roč. 60, č. 4 (2020), s. 2325-2338. ISSN 1549-9596. E-ISSN 1549-960X
R&D Projects: GA ČR(CZ) GA17-16182S; GA ČR(CZ) GJ19-06106Y
Research Infrastructure: CESNET II - 90042
Institutional support: RVO:67985823
Keywords : muscarinic receptors * agonist-specific conformations * signalling bias * accelerated molecular dynamics
OECD category: Pharmacology and pharmacy
Impact factor: 4.956, year: 2020
Method of publishing: Limited access
https://doi.org/10.1021/acs.jcim.0c00041
Permanent Link: http://hdl.handle.net/11104/0309133 - 7.0523829 - FGÚ 2021 RIV CH eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E.
Current Advances in Allosteric Modulation of Muscarinic Receptors.
Biomolecules. Roč. 10, č. 2 (2020), č. článku 325. E-ISSN 2218-273X
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : acetylcholine * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 4.879, year: 2020
Method of publishing: Open access
https://doi.org/10.3390/biom10020325
Permanent Link: http://hdl.handle.net/11104/0308111 - 8.0491286 - FGÚ 2019 RIV US eng J - Journal Article
Popelíková, Anna - Bahník, Š. - Lobellová, Veronika - Svoboda, Jan - Stuchlík, Aleš
Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat.
Psychopharmacology. Roč. 235, č. 7 (2018), s. 2013-2025. ISSN 0033-3158. E-ISSN 1432-2072
R&D Projects: GA ČR(CZ) GA17-04047S
Institutional support: RVO:67985823
Keywords : anticholinergics * muscarinic receptors * learning * memory * Morris water maze * rat
OECD category: Neurosciences (including psychophysiology
Impact factor: 3.424, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285296 - 9.0490596 - ÚFCH JH 2019 GR eng A - Abstract
Langmaier, Jan - Záliš, Stanislav - Samec, Zdeněk
Lipophilicity of acetylcholine and some related agonists and antagonists of its muscarinic receptors examined by ion transfer voltammetry.
17th ESEAC 2018. International Conference on Electroanalysis. Book of Abstracts. Athens: University of Athens, 2018. s. 130-130.
[ESEAC 2018. International Conference on Electroanalysis /17./. 03.06.2018-07.06.2018, Rhodes]
R&D Projects: GA ČR(CZ) GA17-05387S
Institutional support: RVO:61388955
Keywords : voltammetry * acetylcholine * muscarinic receptors
OECD category: Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Permanent Link: http://hdl.handle.net/11104/0284769File Download Size Commentary Version Access 0490596.pdf 1 453.2 KB Publisher’s postprint require - 10.0458562 - FGÚ 2017 RIV US eng M - Monography Chapter
Jakubík, Jan - El-Fakahany, E. E.
Allosteric Modulation of Muscarinic Receptors.
Muscarinic Receptor: From Structure to Animal Models. New York: Springer, 2016 - (Mysliveček, J.; Jakubík, J.), s. 95-130. Neuromethods, 107. ISBN 978-1-4939-2857-6
R&D Projects: GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:67985823
Keywords : muscarinic receptors * allosteric modulation * radioligand binding functional response
Subject RIV: ED - Physiology
Permanent Link: http://hdl.handle.net/11104/0258820