Search results
- 1.0567614 - ÚOCHB 2024 RIV GB eng J - Journal Article
Lubos, Marta - Pícha, Jan - Selicharová, Irena - Žák, Jiří - Buděšínský, Miloš - Mitrová, Katarína - Žáková, Lenka - Jiráček, Jiří
Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications.
Journal of Peptide Science. Roč. 29, č. 7 (2023), č. článku e3478. ISSN 1075-2617. E-ISSN 1099-1387
R&D Projects: GA MŠMT(CZ) LX22NPO5104; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : antagonism * dicarba * disulfide mimetics * insulin mimetic peptide * insulin receptor * staple * triazole
OECD category: Biochemistry and molecular biology
Impact factor: 2.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/psc.3478
Permanent Link: https://hdl.handle.net/11104/0338851File Download Size Commentary Version Access 10.1002psc.3478.pdf 2 1.1 MB Publisher’s postprint open-access - 2.0554206 - BC 2022 RIV DE eng J - Journal Article
Kozelková, Tereza - Doležel, David - Grunclová, Lenka - Kučera, Matěj - Perner, Jan - Kopáček, Petr
Functional characterization of the insulin signaling pathway in the hard tick Ixodes ricinus.
Ticks and Tick-borne Diseases. Roč. 12, č. 4 (2021), č. článku 101694. ISSN 1877-959X. E-ISSN 1877-9603
R&D Projects: GA ČR(CZ) GA18-01832S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : rhipicephalus boophilus microplus * blood * synganglion * receptors * localization * metabolism * expression * proteins * insights * target * Tick * Ixodes ricinus * Insulin receptor * akt * tor * RNA interference
OECD category: Parasitology
Impact factor: 3.817, year: 2021
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1877959X21000479?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0328824 - 3.0543107 - ÚOCHB 2022 RIV DE eng J - Journal Article
Asai, Seiya - Žáková, Lenka - Selicharová, Irena - Marek, Aleš - Jiráček, Jiří
A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin.
Analytical and Bioanalytical Chemistry. Roč. 413, č. 17 (2021), s. 4531-4543. ISSN 1618-2642. E-ISSN 1618-2650
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : binding assay * insulin receptor * insulin secretion * radioligand * secretagogue * β Cells
OECD category: Biochemistry and molecular biology
Impact factor: 4.478, year: 2021
Method of publishing: Limited access
https://doi.org/10.1007/s00216-021-03423-3
Permanent Link: http://hdl.handle.net/11104/0320393 - 4.0539200 - ÚOCHB 2022 RIV US eng J - Journal Article
Hajduch, Jan - Fabre, Benjamin - Klopp, Benjamin - Pohl, Radek - Buděšínský, Miloš - Šolínová, Veronika - Kašička, Václav - Köprülüoglu, Cemal - Eyrilmez, Saltuk M. - Lepšík, Martin - Hobza, Pavel - Mitrová, Katarína - Lubos, Marta - Garre Hernández, María Soledad - Jiráček, Jiří
Multipodal insulin mimetics built on adamantane or proline scaffolds.
Bioorganic Chemistry. Roč. 107, Feb (2021), č. článku 104548. ISSN 0045-2068. E-ISSN 1090-2120
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : insulin receptor * peptidomimetics * scaffold * solid-phase peptide synthesis * hormone binding * molecular dynamics
OECD category: Organic chemistry
Impact factor: 5.307, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.bioorg.2020.104548
Permanent Link: http://hdl.handle.net/11104/0317235 - 5.0531656 - ÚOCHB 2021 RIV cze P - Patent Document
Jiráček, Jiří - Žáková, Lenka - Vaněk, Václav - Veverka, Václav - Brzozowski, A. M.
Derivát inzulinu s cyklickou strukturou v C-konci B-řetězce.
[An insulin derivative with a cyclic structure at the C-terminus of the B-chain.]
2020. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - The University of York. Date of the patent acceptance: 04.06.2020. Patent Number: 308383
Institutional support: RVO:61388963
Keywords : insulin receptor * agonism * diabetes * insulin analogue
OECD category: Biochemistry and molecular biology
https://isdv.upv.cz/doc/FullFiles/Patents/FullDocuments/308/308383.pdf
Permanent Link: http://hdl.handle.net/11104/0310278 - 6.0523844 - FGÚ 2021 RIV US eng J - Journal Article
Zouhar, Petr - Rakipovski, G. - Bokhari, M. H. - Busby, O. - Paulsson, J. F. - Conde-Frieboes, K. W. - Fels, J. J. - Raun, K. - Andersen, B. - Cannon, B. - Nedergaard, J.
UCP1-independent glucose-lowering effect of leptin in type 1 diabetes: only in conditions of hypoleptinemia.
American Journal of Physiology - Endocrinology And Metabolism. Roč. 318, č. 1 (2020), E72-E76. ISSN 0193-1849. E-ISSN 1522-1555
Institutional support: RVO:67985823
Keywords : glucagon * insulin receptor antagonist * thermoneutrality * leptin * type 1 diabetes * uncoupling protein 1
OECD category: Endocrinology and metabolism (including diabetes, hormones)
Impact factor: 4.310, year: 2020
Method of publishing: Open access
https://doi.org/10.1152/ajpendo.00253.2019
Permanent Link: http://hdl.handle.net/11104/0308122 - 7.0523500 - BC 2021 RIV GB eng J - Journal Article
Smýkal, Vlastimil - Pivarči, Martin - Provazník, Jan - Bazalová, Olga - Jedlička, Pavel - Lukšan, Ondřej - Horák, Aleš - Vaněčková, Hana - Beneš, V. - Fiala, Ivan - Hanus, Robert - Doležel, David
Complex evolution of insect insulin receptors and homologous decoy receptors, and functional significance of their multiplicity.
Molecular Biology and Evolution. Roč. 37, č. 6 (2020), s. 1775-1789. ISSN 0737-4038. E-ISSN 1537-1719
R&D Projects: GA ČR(CZ) GA18-21200S; GA ČR GA17-01003S; GA ČR GA15-23681S
EU Projects: European Commission(XE) 726049 - InPhoTime
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : insulin signaling * insulin receptor * decoy of insulin receptor
OECD category: Biochemistry and molecular biology; Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology (UOCHB-X)
Impact factor: 16.240, year: 2020
Method of publishing: Open access
https://academic.oup.com/mbe/article-pdf/doi/10.1093/molbev/msaa048/32984781/msaa048.pdf
Permanent Link: http://hdl.handle.net/11104/0308743 - 8.0501554 - ÚOCHB 2020 RIV GB eng J - Journal Article
Jiráček, Jiří - Žáková, Lenka
Insulin Receptor Binding: From venom peptides to a potential diabetes treatment.
eLife. Roč. 8, Feb 12 (2019), č. článku e44829. ISSN 2050-084X. E-ISSN 2050-084X
Institutional support: RVO:61388963
Keywords : insulin receptor * binding * mimetics
OECD category: Biochemistry and molecular biology
Impact factor: 7.080, year: 2019
Method of publishing: Open access
https://elifesciences.org/articles/44829
Permanent Link: http://hdl.handle.net/11104/0296333 - 9.0499715 - ÚOCHB 2019 RIV eng P - Patent Document
Jiráček, Jiří - Žáková, Lenka - Vaněk, Václav - Veverka, Václav - Brzozowski, A. M.
Insulin derivative with cyclic structure in the C-terminus of the B-chain.
2018. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - The University of York. Date of the patent acceptance: 27.06.2018. Patent Number: EP3160993
Institutional support: RVO:61388963
Keywords : insulin receptor * agonism * diabetes * insulin analogue
OECD category: Biochemistry and molecular biology
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=EP&NR=3160993B1&KC=B1&FT=D&ND=4&date=20180627&DB=&locale=en_EP#
Permanent Link: http://hdl.handle.net/11104/0291926File Download Size Commentary Version Access 0499715.pdf 3 901.4 KB Other open-access - 10.0498264 - ÚOCHB 2019 RIV US eng J - Journal Article
Chrudinová, Martina - Žáková, Lenka - Marek, Aleš - Socha, Ondřej - Buděšínský, Miloš - Hubálek, Martin - Pícha, Jan - Macháčková, Kateřina - Jiráček, Jiří - Selicharová, Irena
A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.
Journal of Biological Chemistry. Roč. 293, č. 43 (2018), s. 16818-16829. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : insulin * insulin-like growth factor (IGF) * structure-function * insulin receptor * protein design * kinetics * binding * Site 1
OECD category: Biochemistry and molecular biology
Impact factor: 4.106, year: 2018
http://www.jbc.org/content/293/43/16818.full
Permanent Link: http://hdl.handle.net/11104/0291126File Download Size Commentary Version Access 0498264.pdf 2 2.3 MB Publisher’s postprint open-access