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- 1.0476344 - ÚEB 2018 RIV FR eng J - Journal Article
Řezníčková, Eva - Tenora, L. - Pospíšilová, Pavlína - Galeta, J. - Jorda, Radek - Berka, K. - Majer, Pavel - Potáček, M. - Kryštof, Vladimír
ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles.
European Journal of Medicinal Chemistry. Roč. 127, FEB 15 (2017), s. 632-642. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LO1204; GA ČR(CZ) GA15-15264S; GA MŠMT(CZ) LM2015047
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : i-receptor kinase * beta signaling pathway * small-molecule inhibitor * tgf-beta * domain inhibitors * growth * fibrosis * cancer * potent * series * Transforming growth factor beta receptor I * Protein kinase * Inhibitor * Substituted pyrrolo[1,2-b]pyrazoles
OECD category: Pharmacology and pharmacy; Pharmacology and pharmacy (UOCHB-X)
Impact factor: 4.816, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272863File Download Size Commentary Version Access 2017_Reznickova_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_632.pdf 4 1.3 MB Other open-access - 2.0468499 - ÚEB 2017 RIV US eng J - Journal Article
Tenora, L. - Galeta, J. - Řezníčková, Eva - Kryštof, Vladimír - Potáček, M.
Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethy1-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase.
Journal of Organic Chemistry. Roč. 81, č. 23 (2016), s. 11841-11856. ISSN 0022-3263. E-ISSN 1520-6904
R&D Projects: GA ČR(CZ) GA15-15264S
Institutional support: RVO:61389030
Keywords : c-h functionalization * pyridine n-oxides * receptor-type-i * direct arylation * tgf-beta * galunisertib ly2157299 * domain inhibitors * bond activation * growth * withasomnine
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 4.849, year: 2016
Permanent Link: http://hdl.handle.net/11104/0266335File Download Size Commentary Version Access 2016_Tenora_JOURNAL OF ORGANIC CHEMISTRY_11841.pdf 0 2.4 MB Other open-access