Search results
- 1.0585591 - MBÚ 2025 RIV GB eng J - Journal Article
Dostál, Z. - Zholobenko, A. V. - Přichystalová, H. - Gottschalk, B. - Valentová, Kateřina - Malli, R. - Modrianský, M.
Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular CaSUP2+/SUP elevations and mitochondrial depolarisation.
Biochemical Pharmacology. Roč. 222, April 2024 (2024), č. článku 116094. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA23-04654S
Institutional support: RVO:61388971
Keywords : calcium * 2,3-dehydrosilybin * polyphenols * flavonoids * silymarin * apoptosis * injury * Hypertonic stress * Quercetin * 2,3-dehydrosilybin * H9c2 cells * Calcium
OECD category: Pharmacology and pharmacy
Impact factor: 5.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0006295224000777?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0353287 - 2.0578183 - MBÚ 2024 RIV cze P - Patent Document
Viktorová, J. - Křen, Vladimír - Holasová, K. - Macek, T. - Valentová, Kateřina - Biedermann, David - Dobiasová, S.
Farmaceutický přípravek pro léčbu lékově rezistentních bakteriálních infekcí.
[A pharmaceutical preparation for the treatment of drug-resistant bacterial infections.]
2023. Owner: Vysoká škola chemicko-technologická v Praze, Mikrobiologický ústav AV ČR, v. v. i. Date of the patent acceptance: 27.09.2023. Patent Number: 309821. Territorial Protection: národní patent v členském státě EU .
R&D Projects: GA MŠMT(CZ) LUC23061; GA ČR GA21-00551S; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388971
Keywords : 2,3-dehydrosilybin * silymarin * drug-resistant * infection * antibiotic
OECD category: Pharmacology and pharmacy
https://isdv.upv.cz/doc/FullFiles/Patents/FullDocuments/309/309821.pdf
Permanent Link: https://hdl.handle.net/11104/0347227File Download Size Commentary Version Access Patent 309821 2023.pdf 4 590.4 KB Other open-access - 3.0558662 - MBÚ 2023 RIV GB eng J - Journal Article
Křen, Vladimír - Valentová, Kateřina
Silybin and its congeners: from traditional medicine to molecular effects.
Natural Product Reports. Roč. 39, č. 6 (2022), s. 1264-1281. ISSN 0265-0568. E-ISSN 1460-4752
R&D Projects: GA ČR GA21-00551S; GA MŠMT(CZ) LTC20070
EU Projects: European Commission(CZ) CA17104 - STRATAGEM
Institutional support: RVO:61388971
Keywords : milk thistle * silymarin flavonolignans * in-vitro * silibinin * silychristin * isosilybin * 2,3-dehydrosilybin * diastereoisomers * identification * derivatives
OECD category: Medicinal chemistry
Impact factor: 11.9, year: 2022
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2022/NP/D2NP00013J
Permanent Link: https://hdl.handle.net/11104/0332537 - 4.0550096 - MBÚ 2022 RIV CH eng J - Journal Article
Tvrdý, V. - Hrubša, M. - Jirkovský, E. - Biedermann, David - Kutý, M. - Valentová, Kateřina - Křen, Vladimír - Mladěnka, P.
Silymarin dehydroflavonolignans chelate zinc and partially inhibit alcohol dehydrogenase.
Nutrients. Roč. 13, č. 12 (2021), č. článku 4238. E-ISSN 2072-6643
R&D Projects: GA ČR(CZ) GA18-00121S
Institutional support: RVO:61388971
Keywords : Alcohol dehydrogenase * Chelation * Dehydrosilybin * Docking * Flavonolignans * Glutamate dehydrogenase * Silybin * Zinc
OECD category: Biochemistry and molecular biology
Impact factor: 6.706, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2072-6643/13/12/4238
Permanent Link: http://hdl.handle.net/11104/0325947 - 5.0547158 - MBÚ 2022 RIV CH eng J - Journal Article
Vrba, J. - Papoušková, B. - Lněničková, K. - Kosina, P. - Křen, Vladimír - Ulrichová, J.
Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases.
Antioxidants. Roč. 10, č. 6 (2021), č. článku 954. E-ISSN 2076-3921
R&D Projects: GA ČR GA21-00551S
Institutional support: RVO:61388971
Keywords : dehydrosilybin * silybin * metabolism * glucuronidation * sulfation * UDP-glucuronosyltransferase * sulfotransferase
OECD category: Biochemistry and molecular biology
Impact factor: 7.675, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2076-3921/10/6/954
Permanent Link: http://hdl.handle.net/11104/0323480 - 6.0543091 - MBÚ 2022 RIV CH eng J - Journal Article
Lomozová, Z. - Tvrdý, V. - Hrubša, M. - Catapano, M.C. - Macáková, K. - Biedermann, David - Kučera, R. - Křen, Vladimír - Mladěnka, P. - Valentová, Kateřina
Dehydroflavonolignans from Silymarin Potentiate Transition Metal Toxicity In Vitro but Are Protective for Isolated Erythrocytes Ex Vivo.
Antioxidants. Roč. 10, č. 5 (2021), č. článku 679. E-ISSN 2076-3921
R&D Projects: GA ČR(CZ) GA18-00121S
Institutional support: RVO:61388971
Keywords : flavonolignans * silymarin * milk thistle * dehydroflavonolignans * dehydrosilybin * dehydrosilychristin * hydroxyl radical * iron * copper * prooxidation
OECD category: Microbiology
Impact factor: 7.675, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2076-3921/10/5/679
Permanent Link: http://hdl.handle.net/11104/0320379 - 7.0532776 - MBÚ 2021 RIV CH eng J - Journal Article
Dobiasová, S. - Řehořová, K. - Kučerová, D. - Biedermann, David - Káňová, Kristýna - Petrásková, Lucie - Koucká, K. - Václavíková, R. - Valentová, Kateřina - Ruml, T. - Macek, T. - Křen, Vladimír - Viktorová, J.
Multidrug Resistance Modulation Activity of Silybin Derivatives and Their Anti-Inflammatory Potential.
Antioxidants. Roč. 9, č. 5 (2020), č. článku 455. E-ISSN 2076-3921
R&D Projects: GA ČR(CZ) GA18-00150S
Institutional support: RVO:61388971
Keywords : silybin * dehydrosilybin * immunomodulation * P-glycoprotein * doxorubicin resistance,
OECD category: Medicinal chemistry
Impact factor: 6.313, year: 2020
Method of publishing: Open access
https://www.mdpi.com/2076-3921/9/5/455
Permanent Link: http://hdl.handle.net/11104/0311240 - 8.0497949 - MBÚ 2019 RIV CH eng J - Journal Article
Hrčková, G. - Kubašková Mačák, T. - Benada, Oldřich - Kofroňová, Olga - Tůmová, L. - Biedermann, David
Differential effects of the flavonolignans silybin, silychristin and 2,3-dehydrosilybin on mesocestoides vogae larvae (cestoda) under hypoxic and aerobic in vitro conditions.
Molecules. Roč. 23, č. 11 (2018), s. 2999. E-ISSN 1420-3049
R&D Projects: GA MŠMT(CZ) LTC18071; GA MŠMT(CZ) LO1509; GA ČR(CZ) GA18-00150S
Institutional support: RVO:61388971
Keywords : 2,3-dehydrosilybin * Aerobic and hypoxic cultivation * Mesocestoides vogae larvae
OECD category: Parasitology
Impact factor: 3.060, year: 2018
Permanent Link: http://hdl.handle.net/11104/0290399 - 9.0497478 - MBÚ 2019 RIV US eng J - Journal Article
Tvrdý, V. - Catapano, M.C. - Rawlik, T. - Karlíčková, J. - Biedermann, David - Křen, Vladimír - Mladěnka, P. - Valentová, Kateřina
Interaction of isolated silymarin flavonolignans with iron and copper.
Journal of Inorganic Biochemistry. Roč. 189, DEC 2018 (2018), s. 115-123. ISSN 0162-0134. E-ISSN 1873-3344
R&D Projects: GA ČR(CZ) GA18-00121S
Institutional support: RVO:61388971
Keywords : Silybin * Silychristin * Dehydrosilybin
OECD category: Medicinal chemistry
Impact factor: 3.224, year: 2018
Permanent Link: http://hdl.handle.net/11104/0290043 - 10.0473521 - MBÚ 2018 RIV US eng J - Journal Article
Filippopoulou, K. - Papaevgeniou, N. - Lefakia, M. - Paraskevopoulou, A. - Biedermann, David - Křen, Vladimír - Chondrogianni, N.
2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.
Free Radical Biology and Medicine. Roč. 103, FEB 2017 (2017), s. 256-267. ISSN 0891-5849. E-ISSN 1873-4596
R&D Projects: GA MŠMT(CZ) LD15081
Institutional support: RVO:61388971
Keywords : 2,3-dehydrosilybin A/B * Anti-aging * Anti-aggregation
OECD category: Biochemistry and molecular biology
Impact factor: 6.020, year: 2017
Permanent Link: http://hdl.handle.net/11104/0270644