Search results
- 1.0582851 - ÚOCHB 2025 RIV CH eng J - Journal Article
Matoušková, Zuzana - Orsághová, Katarína - Srb, Pavel - Pytelková, Jana - Kukačka, Zdeněk - Buša, Michal - Hajdušek, Ondřej - Šíma, Radek - Fábry, Milan - Novák, Petr - Horn, Martin - Kopáček, Petr - Mareš, Michael
An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans.
International Journal of Molecular Sciences. Roč. 25, č. 4 (2024), č. článku 2240. ISSN 1661-6596
R&D Projects: GA ČR(CZ) GA21-08826S; GA ČR(CZ) GA22-27695S; GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA22-30920S; GA MŠMT(CZ) LUC23037
Institutional support: RVO:61388963 ; RVO:61388971 ; RVO:60077344
Keywords : cathepsin * cysteine protease * tick * parasite * saliva * thyropin * protease inhibitor * protein structure
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms25042240
Permanent Link: https://hdl.handle.net/11104/0350903 - 2.0570585 - ÚOCHB 2024 RIV US eng J - Journal Article
Buša, Michal - Matoušková, Zuzana - Bartošová-Sojková, Pavla - Pachl, Petr - Řezáčová, Pavlína - Eichenberger, R. M. - Deplazes, P. - Horn, Martin - Štefanić, S. - Mareš, Michael
An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.
Journal of Biological Chemistry. Roč. 299, č. 3 (2023), č. článku 102970. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA19-17269S; GA ČR(CZ) GA21-16565S; GA MŠMT(CZ) LTAUSA19109
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : cystatin * stefin * protease inhibitor * cysteine cathepsin * protein structure * protein evolution * helminth parasite
OECD category: Biochemistry and molecular biology
Impact factor: 4.8, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.jbc.2023.102970
Permanent Link: https://hdl.handle.net/11104/0341888
Research data: RCSB PDB - 3.0558626 - BC 2023 RIV CH eng J - Journal Article
Abbas, M. - Chlastáková, Adéla - Jmel, Mohamed Amine - Iliaki-Giannakoudaki, E. - Chmelař, J. - Kotsyfakis, Michalis
Serpins in Tick Physiology and Tick-Host Interaction.
Frontiers in Cellular and Infection Microbiology. Roč. 12, MAY 19 2022 (2022), č. článku 892770. ISSN 2235-2988. E-ISSN 2235-2988
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GM22-18424M
Institutional support: RVO:60077344
Keywords : serine proteinase-inhibitors * cross-class inhibitor * t-cell subsets * haemaphysalis-longicornis * boophilus-microplus * ixodes-scapularis * platelet-aggregation * complement-system * salivary protein * cathepsin-g * tick saliva * serpins * immunomodulation * therapeutic effects * anti-tick vaccine * tick host interaction
OECD category: Biochemistry and molecular biology
Impact factor: 5.7, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fcimb.2022.892770/full
Permanent Link: https://hdl.handle.net/11104/0338403 - 4.0553871 - ÚOCHB 2023 RIV GB eng J - Journal Article
Benýšek, Jakub - Buša, Michal - Rubešová, Petra - Fanfrlík, Jindřich - Lepšík, Martin - Brynda, Jiří - Matoušková, Zuzana - Bartz, U. - Horn, Martin - Gütschow, M. - Mareš, Michael
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 37, č. 1 (2022), s. 515-526. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : Cathepsin K * protease inhibitor * cyanohydrazide warhead * azadipeptide nitrile * crystal structure
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1080/14756366.2021.2024527
Permanent Link: http://hdl.handle.net/11104/0328551 - 5.0550906 - BC 2022 RIV CH eng J - Journal Article
Kotál, Jan - Buša, Michal - Urbanová, Veronika - Řezáčová, Pavlína - Chmelař, J. - Langhansová, H. - Sojka, Daniel - Mareš, Michael - Kotsyfakis, Michalis
Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion.
International Journal of Molecular Sciences. Roč. 22, č. 10 (2021), č. článku 5371. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-07247S; GA ČR(CZ) GA21-08826S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : rhipicephalus boophilus microplus * hard tick * functional-characterization * ornithodoros-moubata * protease inhibitors * proteolytic-enzymes * salivary cystatin * egg-white * expression * gut * cathepsin * crystal structure * cysteine protease * digestion * Ixodes ricinus * midgut * parasite
OECD category: Microbiology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/10/5371
Permanent Link: http://hdl.handle.net/11104/0326208 - 6.0548469 - ÚOCHB 2022 CZ eng A - Abstract
Hadzima, Martin - Houštecká, Radka - Pallová, Lenka - Hánová, Iva - Fanfrlík, Jindřich - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Horn, Martin - Mareš, Michael - Majer, Pavel
Design, Synthesis and Activity of Biomimetic Macrocyclic Inhibitors of Human Cathepsin D.
Liblice 2021. 55th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2021. s. 112.
[Liblice 2021. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /55./. 03.11.2021-06.11.2021, Špindlerův Mlýn]
Institutional support: RVO:61388963
Keywords : inhibitor * cathepsin * macrocycles * peptides * statine * synthesis
OECD category: Medicinal chemistry
Permanent Link: http://hdl.handle.net/11104/0324491 - 7.0547816 - BC 2023 RIV GB eng J - Journal Article
Dvoryakova, E. A. - Vinokurov, Konstantin - Tereshchenkova, V. F. - Dunaevsky, Y. E. - Belozersky, M. A. - Oppert, B. - Filippova, I. Y. - Elpidina, E. N.
Primary digestive cathepsins L of Tribolium castaneum larvae: Proteomic identification, properties, comparison with human lysosomal cathepsin L.
Insect Biochemistry and Molecular Biology. Roč. 140, JAN 01 (2022), č. článku 103679. ISSN 0965-1748. E-ISSN 1879-0240
Institutional support: RVO:60077344
Keywords : cysteine cathepsins * digestive enzymes * digestive cathepsin L
OECD category: Biochemistry and molecular biology
Impact factor: 3.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0965174821001624?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0338954 - 8.0540888 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Rubešová, Petra - Fanfrlík, Jindřich - Fajtová, Pavla - Řezáčová, Pavlína - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Emal, C. D. - Renslo, A. R. - Roush, W. R. - Horn, Martin - Caffrey, C. R. - Mareš, Michael
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
ACS Infectious Diseases. Roč. 7, č. 5 (2021), s. 1077-1088. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LH15040; GA MŠMT LO1302; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine peptidase * drug target * parasite * Schistosoma mansoni * vinyl sulfone inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00501
Permanent Link: http://hdl.handle.net/11104/0318491 - 9.0538783 - ÚOCHB 2022 RIV GB eng J - Journal Article
Pomeislová, Alice - Otmar, Miroslav - Rubešová, Petra - Benýšek, Jakub - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Pohl, Radek - Poštová Slavětínská, Lenka - Pomeisl, Karel - Krečmerová, Marcela
1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β.
Bioorganic & Medicinal Chemistry. Roč. 32, Feb 15 (2021), č. článku 115998. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) LM2018133; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61389013 ; RVO:68378271
Keywords : thiadiazoles * 5-amino-1,2,4-thiadiazol-3-(2H)-one * acyclic nucleoside phosphonates * epigenetic * cathepsin K * glycogen synthase kinase 3β
OECD category: Biochemistry and molecular biology; Polymer science (UMCH-V); Organic chemistry (FZU-D)
Impact factor: 3.461, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.bmc.2021.115998
Permanent Link: http://hdl.handle.net/11104/0316958 - 10.0537480 - BC 2021 RIV US eng J - Journal Article
Hartigan, Ashlie - Kosakyan, Anush - Pecková, Hana - Eszterbauer, E. - Holzer, Astrid S.
Transcriptome ofSphaerospora molnari(Cnidaria, Myxosporea) blood stages provides proteolytic arsenal as potential therapeutic targets against sphaerosporosis in common carp.
BMC Genomics. Roč. 21, č. 1 (2020), č. článku 404. ISSN 1471-2164. E-ISSN 1471-2164
R&D Projects: GA ČR(CZ) GX19-28399X
EU Projects: European Commission(XE) 634429 - ParaFishControl
Institutional support: RVO:60077344
Keywords : signal peptide peptidase * matrix metalloproteinases * cysteine protease * malaria parasite * gene-expression * drug target * cathepsin-l * sp-nov * identification * myxozoa * Myxozoa * In silico screening * Proteases * Aquaculture * Parasite * Drug targets
OECD category: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Impact factor: 3.969, year: 2020
Method of publishing: Open access
https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-020-6705-y
Permanent Link: http://hdl.handle.net/11104/0315288