Search results
- 1.0566162 - FGÚ 2023 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena
Insights into the operational model of agonism of receptor dimers.
Expert Opinion on Drug Discovery. Roč. 17, č. 11 (2022), s. 1181-1191. ISSN 1746-0441. E-ISSN 1746-045X
R&D Projects: GA ČR(CZ) GJ19-06106Y
Institutional support: RVO:67985823
Keywords : operational model of agonism * operational efficacy * allosteric modulation * receptor dimers * GPCRs * receptor channels
OECD category: Pharmacology and pharmacy
Impact factor: 6.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1080/17460441.2023.2147502
Permanent Link: https://hdl.handle.net/11104/0337590 - 2.0564844 - ÚOCHB 2023 RIV CH eng J - Journal Article
Szczurowska, Ewa - Szánti-Pintér, Eszter - Randáková, Alena - Jakubík, Jan - Kudová, Eva
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids.
International Journal of Molecular Sciences. Roč. 23, č. 21 (2022), č. článku 13075. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Biochemistry and molecular biology; Physiology (including cytology) (FGU-C)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms232113075
Permanent Link: https://hdl.handle.net/11104/0336401File Download Size Commentary Version Access 10.3390ijms232113075.pdf 3 4.3 MB Publisher’s postprint open-access - 3.0546864 - FGÚ 2022 RIV US eng J - Journal Article
Dolejší, Eva - Chetverikov, Nikolai - Szánti-Pintér, Eszter - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - El-Fakahany, E. E. - Kudová, Eva - Jakubík, Jan
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors.
Biochemical Pharmacology. Roč. 192, Oct (2021), č. článku 114699. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 6.100, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.bcp.2021.114699
Permanent Link: http://hdl.handle.net/11104/0323241 - 4.0546861 - FGÚ 2022 RIV NL eng J - Journal Article
Dolejší, Eva - Szánti-Pintér, Eszter - Chetverikov, Nikolai - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - Kudová, Eva - Jakubík, Jan
Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptor.
Neuropharmacology. Roč. 199, Nov 1 (2021), č. článku 108798. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neurosteroid * steroid hormone * allosteric modulation * muscarinic receptor
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 5.273, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.neuropharm.2021.108798
Permanent Link: http://hdl.handle.net/11104/0323238 - 5.0541423 - FGÚ 2022 RIV CH eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E.
Allosteric Modulation of GPCRs of Class A by Cholesterol.
International Journal of Molecular Sciences. Roč. 22, č. 4 (2021), č. článku 1953. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : GPCRs * cholesterol * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/4/1953
Permanent Link: http://hdl.handle.net/11104/0318982 - 6.0538466 - FGÚ 2021 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Chetverikov, Nikolai - El-Fakahany, E. E. - Doležal, Vladimír
The operational model of allosteric modulation of pharmacological agonism.
Scientific Reports. Roč. 10, č. 1 (2020), č. článku 14421. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : receptor theory * operational model * allosteric modulation
OECD category: Pharmacology and pharmacy
Impact factor: 4.380, year: 2020
Method of publishing: Open access
https://www.nature.com/articles/s41598-020-71228-y
Permanent Link: http://hdl.handle.net/11104/0316262 - 7.0532987 - FGÚ 2021 RIV GB eng J - Journal Article
Sivčev, Sonja - Slavíková, Barbora - Ivetic, Milorad - Knězů, Michal - Kudová, Eva - Zemková, Hana
Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel gating.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 202, Sep (2020), č. článku 105725. ISSN 0960-0760
R&D Projects: GA ČR(CZ) GA18-05413S; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : ATP * purinergic P2X receptors * bile acids * lithocholic acid * ivermectin * allosteric modulation
OECD category: Neurosciences (including psychophysiology; Neurosciences (including psychophysiology (UOCHB-X)
Impact factor: 4.294, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.jsbmb.2020.105725
Permanent Link: http://hdl.handle.net/11104/0311490 - 8.0523829 - FGÚ 2021 RIV CH eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E.
Current Advances in Allosteric Modulation of Muscarinic Receptors.
Biomolecules. Roč. 10, č. 2 (2020), č. článku 325. E-ISSN 2218-273X
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : acetylcholine * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 4.879, year: 2020
Method of publishing: Open access
https://doi.org/10.3390/biom10020325
Permanent Link: http://hdl.handle.net/11104/0308111 - 9.0507827 - FGÚ 2020 RIV US eng J - Journal Article
Sivčev, Sonja - Slavíková, Barbora - Rupert, Marian - Ivetic, Milorad - Nekardová, Michaela - Kudová, Eva - Zemková, Hana
Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating.
Journal of Neurochemistry. Roč. 150, č. 1 (2019), s. 28-43. ISSN 0022-3042. E-ISSN 1471-4159
R&D Projects: GA ČR(CZ) GA16-12695S; GA ČR(CZ) GA18-05413S; GA ČR(CZ) GBP208/12/G016; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : allosteric modulation * ATP * P2XR * testosterone derivatives * purinergic receptors * ivermectin
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.066, year: 2019
Method of publishing: Open access with time embargo
https://doi.org/10.1111/jnc.14718
Permanent Link: http://hdl.handle.net/11104/0298791 - 10.0504451 - FGÚ 2020 RIV US eng J - Journal Article
Jakubík, Jan - Randáková, Alena - El-Fakahany, E. E. - Doležal, Vladimír
Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators.
PLoS ONE. Roč. 14, č. 3 (2019), č. článku e0214255. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : binding experiments * equlibrium * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 2.740, year: 2019
Method of publishing: Open access
https://doi.org/10.1371/journal.pone.0214255
Permanent Link: http://hdl.handle.net/11104/0296079