Search results
- 1.0577921 - ÚOCHB 2024 RIV GB eng J - Journal Article
Kraina, Pavel - Česnek, Michal - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Fulton, C. J. - Davidson, E. K. - Smith, B. P. - Watts, V. J. - Janeba, Zlatko
Discovery of a potent and selective human AC2 inhibitor based on 7-deazapurine analogues of adefovir.
Bioorganic & Medicinal Chemistry. Roč. 95, November (2023), č. článku 117508. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adefovir * 7-deazapurine * prodrugs * adenylate cyclase
OECD category: Organic chemistry
Impact factor: 3.5, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.bmc.2023.117508
Permanent Link: https://hdl.handle.net/11104/0346999 - 2.0573369 - ÚOCHB 2024 RIV US eng J - Journal Article
Vaňková, Karolína - Keough, D. T. - Hocková, Dana - Guddat, L. W. - Janeba, Zlatko
N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
ChemMedChem. Roč. 18, č. 15 (2023), č. článku e202300211. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA ČR(CZ) GA19-07707S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * inhibitors * hypoxanthine-guanine-(xanthine) phosphoribosyltransferase * malaria * Plasmodium falciparum
OECD category: Organic chemistry
Impact factor: 3.4, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/cmdc.202300211
Permanent Link: https://hdl.handle.net/11104/0343833 - 3.0559133 - ÚOCHB 2023 RIV FR eng J - Journal Article
Vaňková, Karolína - Doleželová, Eva - Tloušťová, Eva - Hocková, Dana - Zíková, Alena - Janeba, Zlatko
Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase.
European Journal of Medicinal Chemistry. Roč. 239, September (2022), č. článku 114559. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-07707S; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : acyclic nucleoside phosphonates * nucleotides * Suzuki reaction * Trypanosoma * tubercidin
OECD category: Organic chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2022.114559
Permanent Link: https://hdl.handle.net/11104/0332552 - 4.0558031 - ÚOCHB 2023 RIV CH eng J - Journal Article
Krečmerová, Marcela - Majer, Pavel - Rais, R. - Slusher, B. S.
Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects.
Frontiers in Chemistry. Roč. 10, May (2022), č. článku 889737. ISSN 2296-2646. E-ISSN 2296-2646
R&D Projects: GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * antivirals * prodrugs * protides * GCPII * prostate-specific membrane antigen * FOLH1 * 2-PMPA
OECD category: Organic chemistry
Impact factor: 5.5, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fchem.2022.889737
Permanent Link: http://hdl.handle.net/11104/0331849 - 5.0556926 - ÚOCHB 2023 RIV CH eng J - Journal Article
Andrei, G. - Fiten, P. - Krečmerová, Marcela - Opdenakker, G. - Topalis, D. - Snoeck, R.
Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance.
Biomedicines. Roč. 10, č. 3 (2022), č. článku 580. E-ISSN 2227-9059
R&D Projects: GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : vaccinia virus * DNA polymerase * drug resistance * nucleotide analogues * cidofovir * acyclic nucleoside phosphonates * phosphonoacetic acid
OECD category: Biochemistry and molecular biology
Impact factor: 4.7, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/biomedicines10030580
Permanent Link: http://hdl.handle.net/11104/0331038 - 6.0551643 - ÚOCHB 2023 RIV DE eng J - Journal Article
Česnek, Michal - Šafránek, Michal - Dračínský, Martin - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Hayes, M. P. - Watts, V. J. - Janeba, Zlatko
Halogen-Dance-Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2-Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases.
ChemMedChem. Roč. 17, č. 1 (2022), č. článku e202100568. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adenylate cyclase * Bordetella pertussis * inhibitors * prodrugs
OECD category: Organic chemistry
Impact factor: 3.4, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/cmdc.202100568
Permanent Link: http://hdl.handle.net/11104/0326883 - 7.0543267 - ÚOCHB 2022 RIV FR eng J - Journal Article
Břehová, Petra - Chaloupecká, Ema - Česnek, Michal - Skácel, Jan - Dračínský, Martin - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Soto-Velasquez, M. P. - Watts, V. J. - Janeba, Zlatko
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
European Journal of Medicinal Chemistry. Roč. 222, Oct 15 (2021), č. článku 113581. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adefovir * adenylate cyclase * Bacillus anthracis * Bordetella pertussis * inhibitors * prodrugs
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113581
Permanent Link: http://hdl.handle.net/11104/0320504 - 8.0538783 - ÚOCHB 2022 RIV GB eng J - Journal Article
Pomeislová, Alice - Otmar, Miroslav - Rubešová, Petra - Benýšek, Jakub - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Pohl, Radek - Poštová Slavětínská, Lenka - Pomeisl, Karel - Krečmerová, Marcela
1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β.
Bioorganic & Medicinal Chemistry. Roč. 32, Feb 15 (2021), č. článku 115998. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) LM2018133; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61389013 ; RVO:68378271
Keywords : thiadiazoles * 5-amino-1,2,4-thiadiazol-3-(2H)-one * acyclic nucleoside phosphonates * epigenetic * cathepsin K * glycogen synthase kinase 3β
OECD category: Biochemistry and molecular biology; Polymer science (UMCH-V); Organic chemistry (FZU-D)
Impact factor: 3.461, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.bmc.2021.115998
Permanent Link: http://hdl.handle.net/11104/0316958 - 9.0518224 - ÚOCHB 2020 PT eng A - Abstract
Janeba, Zlatko
Adenylate cyclase inhibitors based on acyclic nucleoside phosphonates.
IC3TC 2019. 3rd International Caparica Christmas Conference on Translational Chemistry. Caparica: Bioscope, 2019. s. 143.
[IC3TC 2019. International Caparica Christmas Conference on Translational Chemistry /3./. 02.12.2019-05.12.2019, Caparica]
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : adenylate cyclase * acyclic nucleoside phosphonates * PMEA
OECD category: Organic chemistry
Permanent Link: http://hdl.handle.net/11104/0303427 - 10.0511182 - FZÚ 2020 RIV GB eng J - Journal Article
Pomeisl, Karel - Krečmerová, M. - Pohl, R. - Snoeck, R. - Andrei, G.
Synthesis of fluorinated acyclic nucleoside phosphonates with 5-azacytosine base moiety.
Tetrahedron. Roč. 75, č. 39 (2019), s. 1-13, č. článku 130529. ISSN 0040-4020. E-ISSN 1464-5416
Institutional support: RVO:68378271
Keywords : acyclic nucleoside phosphonates * 5-Azacytosine * fluorinated nucleotides * prodrugs * phosphonates
OECD category: Organic chemistry
Impact factor: 2.233, year: 2019
Method of publishing: Limited access
https://doi.org/10.1016/j.tet.2019.130529
Permanent Link: http://hdl.handle.net/11104/0301517