Search results
- 1.0360763 - ÚOCHB 2012 RIV CA eng J - Journal Article
Sedláček, Ondřej - Břehová, Petra - Pohl, Radek - Holý, Antonín - Janeba, Zlatko
The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions.
Canadian Journal of Chemistry. Roč. 89, č. 4 (2011), s. 488-489. ISSN 0008-4042. E-ISSN 1480-3291
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * PMEDAP * cross-coupling * antiviral * antitumor
Subject RIV: CC - Organic Chemistry
Impact factor: 1.242, year: 2011
Permanent Link: http://hdl.handle.net/11104/0198236 - 2.0360711 - ÚOCHB 2012 RIV US eng J - Journal Article
Mertlíková-Kaiserová, Helena - Rumlová, Michaela - Tloušťová, Eva - Procházková, Eliška - Holý, Antonín - Votruba, Ivan
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
Biochemical Pharmacology. Roč. 82, č. 2 (2011), s. 131-138. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : resistance * acyclic nucleoside phosphonates * PMEG * PMEDAP
Subject RIV: CE - Biochemistry
Impact factor: 4.705, year: 2011
Permanent Link: http://hdl.handle.net/11104/0198197 - 3.0346304 - ÚOCHB 2011 RIV NL eng J - Journal Article
Hájek, Miroslav - Cvilink, Viktor - Votruba, Ivan - Holý, Antonín - Mertlíková-Kaiserová, Helena
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
European Journal of Pharmacology. Roč. 643, č. 1 (2010), s. 6-12. ISSN 0014-2999. E-ISSN 1879-0712
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * PMEG * PMEDAP * telomere length * telomerase inhibition
Subject RIV: CC - Organic Chemistry
Impact factor: 2.737, year: 2010
Permanent Link: http://hdl.handle.net/11104/0187372 - 4.0326327 - ÚOCHB 2010 RIV GR eng J - Journal Article
Otová, B. - Hrdý, J. - Votruba, Ivan - Holý, Antonín
In Vivo Modulation of Angiogenic Genes Expression by Acyclic Nucleoside Phosphonates PMEDAP and PMEG.
Anticancer Research. Roč. 29, č. 4 (2009), s. 1295-1302. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : PMEDAP * PMEG * proangiogenic genes
Subject RIV: CC - Organic Chemistry
Impact factor: 1.428, year: 2009
Permanent Link: http://hdl.handle.net/11104/0173462 - 5.0195090 - UOCHB-X 20030422 RIV GR eng J - Journal Article
Valeriánová, M. - Otová, B. - Bílá, V. - Hanzalová, J. - Votruba, Ivan - Holý, Antonín - Eckschlager, T. - Krejčí, O. - Trka, J.
PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis .I.in vitro./I. conditions.
Anticancer Research. Roč. 23, - (2003), s. 4933-4940. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA AV ČR IBS4055109
Institutional research plan: CEZ:AV0Z4055905
Keywords : N 6 -substituted derivatives of PMEDAP * genotoxicity * apoptosis
Subject RIV: CC - Organic Chemistry
Impact factor: 1.347, year: 2003
Permanent Link: http://hdl.handle.net/11104/0090757 - 6.0194333 - UOCHB-X 20010178 RIV GR eng J - Journal Article
Bobková, K. - Gut, I. - Mandys, V. - Holý, Antonín - Votruba, Ivan - Otová, B.
Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/Cub rat strain bearing T-cell lymphoma.
Anticancer Research. Roč. 21, - (2001), s. 2725-2731. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA ČR GV203/96/K001; GA MZd NL5423
Institutional research plan: CEZ:AV0Z4055905
Keywords : spontaneous lymphoma * PMEDAP
Subject RIV: CC - Organic Chemistry
Impact factor: 1.416, year: 2001
Permanent Link: http://hdl.handle.net/11104/0090011 - 7.0194329 - UOCHB-X 20010174 RIV GR eng J - Journal Article
Valeriánová, M. - Votruba, Ivan - Holý, Antonín - Mandys, Václav - Otová, B.
Antitumour activity of N 6 -substituted PMEDAP derivatives against T-cell lymphoma.
Anticancer Research. Roč. 21, - (2001), s. 2057-2064. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA ČR GV203/96/K128; GA MZd NL5423
Institutional research plan: CEZ:AV0Z4055905
Keywords : PMEDAP derivatives
Subject RIV: CC - Organic Chemistry
Impact factor: 1.416, year: 2001
Permanent Link: http://hdl.handle.net/11104/0090007 - 8.0101563 - UOCHB-X 20043129 GR eng A - Abstract
Zápotocký, M. - Starková, J. - Votruba, Ivan - Holý, Antonín - Stříteský, J. - Trka, J. - Otová, B.
Antineoplastic effect of acyclic nucleotide 9-[(2-phosphonomethoxy)ethyl]-2,6-diaminopurine - induction of apoptosis.
12th Euroconference on Apoptosis. Chania: Institute of Chania, 2004. s. P122.
[Euroconference on Apoptosis /12./. 17.09.2004-20.09.2004, Chania]
Keywords : PMEDAP * antineoplastic effect
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0008985 - 9.0092831 - ÚOCHB 2008 RIV CZ eng J - Journal Article
Zápotocký, M. - Hanzalová, J. - Starková, J. - Votruba, Ivan - Holý, Antonín - Otová, B.
Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): Origin of resistence.
[Experimentální terapie s 9-[2-(fosfonomethoxy)ethyl]-2,6-diaminopurinem (PMEDAP): původ resistence.]
Folia Biologica. Roč. 53, č. 3 (2007), s. 79-84. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : MRP4 * MRP5 * PMEDAP resistance
Subject RIV: CC - Organic Chemistry
Impact factor: 0.596, year: 2007
Permanent Link: http://hdl.handle.net/11104/0153048 - 10.0044422 - ÚOCHB 2007 RIV US eng J - Journal Article
Schinkmanová, Markéta - Votruba, Ivan - Holý, Antonín
N6-Methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.
[N6-Methyl-AMP aminohydrolasa aktivuje N6-substituované purinové acyklické nukleosidfosfonáty.]
Biochemical Pharmacology. Roč. 71, č. 9 (2006), s. 1370-1376. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA AV ČR(CZ) 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : N6-methyl-AMP aminohydrolase * me-AMP * cypr-PMEDAP * PMEG
Subject RIV: CC - Organic Chemistry
Impact factor: 3.581, year: 2006
Permanent Link: http://hdl.handle.net/11104/0137201