Search results
- 1.0572189 - ÚEM 2024 RIV CH eng J - Journal Article
Svobodová, B. - Pulkrabová, L. - Pánek, D. - Misiachna, Anna - Kolcheva, Marharyta - Andrýs, R. - Handl, J. - Čapek, J. - Nývltová, P. - Roušar, T. - Prchal, L. - Hepnarová, V. - Hrabinová, M. - Mucková, L. - Tosnerová, D. - Karabanovich, G. - Finger, V. - Soukup, O. - Horák, Martin - Korabecný, J.
Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease.
International Journal of Molecular Sciences. Roč. 24, č. 11 (2023), č. článku 9124. ISSN 1661-6596
R&D Projects: GA ČR(CZ) GA22-24384S; GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:68378041
Keywords : Alzheimer’s disease * acetylcholinesterase * enzyme inhibition * N-methyl-d-aspartate receptor * multi-target directed ligands * monoamine oxidase A/B
OECD category: Pharmacology and pharmacy
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms24119124
Permanent Link: https://hdl.handle.net/11104/0342960File Download Size Commentary Version Access Svobodová 2023.pdf 2 3.8 MB Publisher’s postprint open-access - 2.0541833 - ÚEM 2022 RIV CH eng J - Journal Article
Konečný, J. - Misiachna, Anna - Hrabinová, M. - Pulkrábková, L. - Benková, M. - Prchal, L. - Kučera, T. - Kobrlová, T. - Finger, V. - Kolcheva, Marharyta - Kortus, Štěpán - Jun, D. - Valko, M. - Horák, Martin - Soukup, O. - Korábečný, J.
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.
Biomolecules. Roč. 11, č. 1 (2021), č. článku 3. E-ISSN 2218-273X
R&D Projects: GA MZd(CZ) NU20-08-00296
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:68378041
Keywords : acetylcholinesterase * Alzheimer´s disease * butyrylcholinesterase * fluorene * in vitro * in silico * multi-target directed ligands * N-methyl-d-aspartate receptor
OECD category: Pharmacology and pharmacy
Impact factor: 6.064, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2218-273X/11/1/3
Permanent Link: http://hdl.handle.net/11104/0319349 - 3.0541685 - FGÚ 2022 RIV CH eng J - Journal Article
Konečný, J. - Misiachna, Anna - Hrabinová, M. - Pulkrábková, L. - Benková, M. - Prchal, L. - Kučera, T. - Kobrlová, T. - Finger, V. - Kolcheva, Marharyta - Kortus, Štěpán - Jun, D. - Valko, M. - Horák, Martin - Soukup, O. - Korábečný, J.
Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists.
Biomolecules. Roč. 11, č. 1 (2021), č. článku 3. E-ISSN 2218-273X
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:67985823
Keywords : acetylcholinesterase * Alzheimer´s disease * butyrylcholinesterase * fluorene * in vitro * in silico * multi-target directed ligands * N-methyl-d-aspartate receptor
OECD category: Pharmacology and pharmacy
Impact factor: 6.064, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2218-273X/11/1/3
Permanent Link: http://hdl.handle.net/11104/0319216 - 4.0541524 - FGÚ 2022 RIV NL eng J - Journal Article
Sládek, Martin - Liška, Karolína - Houdek, Pavel - Sumová, Alena
Modulation of single cell circadian response to NMDA by diacylglycerol lipase inhibition reveals a role of endocannabinoids in light entrainment of the suprachiasmatic nucleus.
Neuropharmacology. Roč. 185, Mar 1 (2021), č. článku 108455. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA17-14704S
Institutional support: RVO:67985823
Keywords : circadian * suprachiasmatic nucleus * N-Methyl-D-aspartate * endocannabinoids * PER2::LUC * phase response curve
OECD category: Physiology (including cytology)
Impact factor: 5.273, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.neuropharm.2021.108455
Permanent Link: http://hdl.handle.net/11104/0319091 - 5.0490287 - FGÚ 2019 RIV US eng J - Journal Article
Krausová, Barbora - Slavíková, Barbora - Nekardová, Michaela - Hubálková, Pavla - Vyklický, Vojtěch - Chodounská, Hana - Vyklický ml., Ladislav - Kudová, Eva
Positive Modulators of the N-Methyl-D-aspartate Receptor: Structure-Activity Relationship Study of Steroidal 3-Hemiesters.
Journal of Medicinal Chemistry. Roč. 61, č. 10 (2018), s. 4505-4516. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA17-02300S; GA ČR(CZ) GBP208/12/G016; GA TA ČR(CZ) TE01020028; GA MZd(CZ) NV15-29370A; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:AV ČR(CZ) MSM200111601
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neurosteroids * N-Methyl-D-aspartate receptor * positive modulators
OECD category: Neurosciences (including psychophysiology
Impact factor: 6.054, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284547 - 6.0475164 - ÚOCHB 2018 RIV IE eng J - Journal Article
Riedlová, Kamila - Nekardová, Michaela - Kačer, P. - Syslová, K. - Vazdar, M. - Jungwirth, Pavel - Kudová, Eva - Cwiklik, Lukasz
Distributions of therapeutically promising neurosteroids in cellular membranes.
Chemistry and Physics of Lipids. Roč. 203, Mar (2017), s. 78-86. ISSN 0009-3084. E-ISSN 1873-2941
R&D Projects: GA TA ČR(CZ) TE01020028; GA ČR(CZ) GAP303/12/1464; GA ČR GA15-14292S; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963 ; RVO:61388955
Keywords : steroids * N-methyl-D-aspartate receptors * membranes * molecular dynamics * chromatography
OECD category: Physical chemistry; Physical chemistry (UFCH-W)
Impact factor: 2.766, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272677 - 7.0474014 - FGÚ 2018 RIV NL eng J - Journal Article
Gažová, Z. - Soukup, O. - Šepsová, V. - Šipošová, K. - Drtinová, L. - Jošt, P. - Spilovská, K. - Korábečný, J. - Nepovímová, E. - Fedunová, D. - Horák, Martin - Kaniaková, Martina - Wang, Z. J. - Hamouda, A. K. - Kuča, K.
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment.
Biochimica Et Biophysica Acta-Molecular Basis of Disease. Roč. 1863, č. 2 (2017), s. 607-619. ISSN 0925-4439. E-ISSN 1879-260X
R&D Projects: GA ČR(CZ) GA16-08554S
Institutional support: RVO:67985823
Keywords : amyloid * aggregation * muscarinic/nicotinic acetylcholine receptor antagonist * N-Methyl-d-aspartate receptor antagonist * Alzheimer's disease * A beta peptide * beta-secretase inhibitor
OECD category: Neurosciences (including psychophysiology
Impact factor: 5.108, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271109 - 8.0384731 - ÚOCHB 2013 JP eng A - Abstract
Kudová, Eva - Chodounská, Hana - Slavíková, Barbora - Kapras, Vojtěch - Vyklický, Vojtěch - Borovská, Jiřina - Krausová, Barbora - Vyklický ml., Ladislav
Structure-Activity Relationship of 3-Substituted Pregnanolones Acting on the N-Methyl-D-Aspartate Receptors.
15th International Congress on Hormonal Steroids and Hormones and Cancer. Kanazawa: -, 2012.
[International Congress on Hormonal Steroids and Hormones and Cancer /15./. 15.11.2012-17.11.2012, Kanazawa]
R&D Projects: GA ČR(CZ) GAP303/12/1464; GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : N-methyl-D-aspartate receptors * NMDA
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0214277 - 9.0142561 - FGU-C 20030178 RIV CZ eng J - Journal Article
Hliňák, Zdeněk - Krejčí, I.
N-methyl-D-aspartate prevented memory deficits induced by MK-801 in mice.
Physiological Research. Roč. 52, č. 6 (2003), s. 809-812. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA ČR GA309/00/1644
Institutional research plan: CEZ:AV0Z5011922
Keywords : N-methyl-D-aspartate * MK-801 * spatial memory
Subject RIV: FH - Neurology
Impact factor: 0.939, year: 2003
Permanent Link: http://hdl.handle.net/11104/0040262 - 10.0142436 - FGU-C 20030033 RIV GB eng J - Journal Article
Malomouzh, A. I. - Mukhtarov, M. R. - Nikolsky, E. E. - Vyskočil, František - Lieberman, E. M. - Urazaev, A. K.
Glutamate regulation of non-quantal release of acetylcholine in the rat neuromuscular junction.
Journal of Neurochemistry. Roč. 85, č. 1 (2003), s. 206-213. ISSN 0022-3042. E-ISSN 1471-4159
R&D Projects: GA AV ČR IAA7011902; GA ČR GA305/02/1333; GA ČR GA202/02/1213
Institutional research plan: CEZ:AV0Z5011922; CEZ:MSM 113100003
Keywords : muscle endplate * nitric oxide * N-methyl-D-aspartate receptor
Subject RIV: CG - Electrochemistry
Impact factor: 4.825, year: 2003
Permanent Link: http://hdl.handle.net/11104/0040139