Search results

  1. 1.
    0542896 - MBÚ 2022 RIV NL eng J - Journal Article
    Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Dvořáková, Barbora - Šírová, Milada - Říhová, Blanka - Randárová, Eva - Kraus, Michal - Tomala, Jakub - Studenovský, Martin - Vondráčková, Michaela - Sedláček, Radislav - Makovický, Peter - Fučíková, J. - Vošahlíková, Š. - Spíšek, R. - Kostka, Libor - Etrych, Tomáš - Kovář, Marek
    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.
    Journal of Controlled Release. Roč. 332, APR 10 2021 (2021), s. 563-580. ISSN 0168-3659. E-ISSN 1873-4995
    R&D Projects: GA ČR(CZ) GA19-05649S; GA MŠk(CZ) LM2015040; GA MŠk(CZ) ED1.1.00/02.0109
    Research Infrastructure: CCP - 90040
    Institutional support: RVO:61388971 ; RVO:61389013 ; RVO:68378050
    Keywords : Ritonavir derivate * Polymer carrier * pH-controlled release * Antitumor activity * Proteasome inhibition * STAT3 signaling inhibition
    OECD category: Microbiology; Polymer science (UMCH-V)
    Impact factor: 9.776, year: 2020
    Method of publishing: Limited access
    https://www.sciencedirect.com/science/article/pii/S0168365921001267
    Permanent Link: http://hdl.handle.net/11104/0320232
     
     
  2. 2.
    0541383 - BTÚ 2021 RIV US eng J - Journal Article
    Noonepalle, S. - Shen, S. - Ptáček, Jakub - Tavares, M. T. - Zhang, G. - Stránský, Jan - Pavlíček, Jiří - Ferreira, G. M. - Hadley, M. - Pelaez, G. - Bařinka, Cyril - Kozikowski, A. P. - Villagra, A.
    Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models.
    Journal of Medicinal Chemistry. Roč. 63, č. 18 (2020), s. 10246-10262. ISSN 0022-2623. E-ISSN 1520-4804
    R&D Projects: GA MŠk(CZ) LM2018127; GA ČR GA15-19640S; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : antitumor-activity * force-field * hdac6 * acetylation * gromacs * charmm * implementation * metabolism * discovery * maps
    OECD category: Medicinal chemistry
    Impact factor: 7.446, year: 2020
    Method of publishing: Open access
    https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c00567
    Permanent Link: http://hdl.handle.net/11104/0318945
     
     
  3. 3.
    0509279 - ÚEB 2020 RIV CH eng J - Journal Article
    Bildziukevich, Uladzimir - Özdemir, Zülal - Wimmer, Zdeněk
    Recent achievements in medicinal and supramolecular chemistry of betulinic acid and its derivatives.
    Molecules. Roč. 24, č. 19 (2019), č. článku 3546. E-ISSN 1420-3049
    R&D Projects: GA MPO(CZ) FV10599; GA MPO(CZ) FV30300
    Institutional support: RVO:61389030
    Keywords : ADME parameters * Antitumor activity * Antiviral activity * Betulinic acid * Cytotoxicity * Physicochemical parameters * Structural modification * Supramolecular self-assembly
    OECD category: Chemical engineering (plants, products)
    Impact factor: 3.267, year: 2019
    Method of publishing: Open access
    http://dx.doi.org/10.3390/molecules24193546
    Permanent Link: http://hdl.handle.net/11104/0300033
    FileDownloadSizeCommentaryVersionAccess
    2019_Bildziukevich_MOLECULES_3546.pdf6646.6 KBOtheropen-access
     
     
  4. 4.
    0506413 - BFÚ 2020 RIV US eng J - Journal Article
    Zajac, Juraj - Kostrhunová, Hana - Novohradský, Vojtěch - Vrána, Oldřich - Raveendran, R. - Gibson, D. - Kašpárková, J. - Brabec, Viktor
    Potentiation of mitochondrial dysfunction in tumor cells by conjugates of metabolic modulator dichloroacetate with a Pt(IV) derivative of oxaliplatin.
    Journal of Inorganic Biochemistry. Roč. 156, MAR 2016 (2016), s. 89-97. ISSN 0162-0134. E-ISSN 1873-3344
    R&D Projects: GA ČR(CZ) GA14-21053S; GA MŠk(CZ) LH14317; GA MŠk(CZ) LD14019
    Institutional support: RVO:68081707
    Keywords : in-vitro cytotoxicity * platinum(iv) complexes * antitumor-activity * increases sensitivity
    OECD category: Biochemistry and molecular biology
    Impact factor: 3.348, year: 2016
    Method of publishing: Limited access
    https://www.sciencedirect.com/science/article/pii/S0162013415301331?via%3Dihub
    Permanent Link: http://hdl.handle.net/11104/0297657
     
     
  5. 5.
    0451455 - ÚFCH JH 2017 RIV IE eng J - Journal Article
    Pruchnik, H. - Kral, Teresa - Poradowski, D. - Drynda, A. - Obmińska-Mrukowicz, B. - Hof, Martin
    New cytotoxic butyltin complexes with 2-sulfobenzoic acid: Molecular interaction with lipid bilayers and DNA as well as in vitro anticancer activity.
    Chemico-Biological Interactions. Roč. 243, JAN 2016 (2016), s. 107-118. ISSN 0009-2797. E-ISSN 1872-7786
    R&D Projects: GA ČR GBP208/12/G016
    Institutional support: RVO:61388955
    Keywords : Butyltin 2-sulfobenzoates * Antitumor activity * Lipid bilayer
    Subject RIV: CF - Physical ; Theoretical Chemistry
    Impact factor: 3.143, year: 2016
    Permanent Link: http://hdl.handle.net/11104/0252631
    FileDownloadSizeCommentaryVersionAccess
    0451455.pdf02.7 MBPublisher’s postprintrequire
     
     
  6. 6.
    0435173 - BFÚ 2015 RIV GB eng J - Journal Article
    Kašpárková, Jana - Thibault, T. - Kostrhunová, Hana - Štěpánková, Jana - Vojtíšková, Marie - Muchová, T. - Midoux, P. - Malinge, J.M. - Brabec, Viktor
    Different affinity of nuclear factor-kappa B proteins to DNA modified by antitumor cisplatin and its clinically ineffective trans isomer.
    FEBS Journal. Roč. 281, č. 5 (2014), s. 1393-1408. ISSN 1742-464X. E-ISSN 1742-4658
    R&D Projects: GA ČR(CZ) GAP301/10/0598
    Institutional support: RVO:68081707
    Keywords : antitumor activity * cisplatin * DNA
    Subject RIV: BO - Biophysics
    Impact factor: 4.001, year: 2014
    Permanent Link: http://hdl.handle.net/11104/0239098
     
     
  7. 7.
    0429932 - ÚEB 2015 RIV GB eng J - Journal Article
    Cmoch, P. - Korda, A. - Rárová, Lucie - Oklešťková, Jana - Strnad, Miroslav - Luboradzki, R. - Pakulski, Z.
    Synthesis and structure-activity relationship study of cytotoxic lupane-type 3 beta-O-monodesmosidic saponins with an extended C-28 side chain.
    Tetrahedron. Roč. 70, č. 17 (2014), s. 2717-2730. ISSN 0040-4020. E-ISSN 1464-5416
    R&D Projects: GA MŠk(CZ) LO1204
    Institutional support: RVO:61389030
    Keywords : BETULIN DERIVATIVES * SECONDARY ALCOHOLS * ANTITUMOR-ACTIVITY
    Subject RIV: EB - Genetics ; Molecular Biology
    Impact factor: 2.641, year: 2014
    Permanent Link: http://hdl.handle.net/11104/0234895
    FileDownloadSizeCommentaryVersionAccess
    2014_Cmoch_TETRAHEDRON_2717.pdf1982.1 KBOtheropen-access
     
     
  8. 8.
    0194800 - UOCHB-X 20030106 RIV CZ eng J - Journal Article
    Čapek, Petr - Otmar, Miroslav - Masojídková, Milena - Votruba, Ivan - Holý, Antonín
    A facile synthesis of 9-deaza analogue of olomoucine.
    Collection of Czechoslovak Chemical Communications. Roč. 68, č. 4 (2003), s. 779-791. ISSN 0010-0765
    R&D Projects: GA MŠk OC D13.20
    Institutional research plan: CEZ:AV0Z4055905
    Keywords : purines * antitumor activity * cytostatics
    Subject RIV: CC - Organic Chemistry
    Impact factor: 1.041, year: 2003
    Permanent Link: http://hdl.handle.net/11104/0090471
     
     
  9. 9.
    0173431 - UEM-P 20010027 RIV GR eng J - Journal Article
    Viale, M. - Vánnozzi, M. O. - Mandys, Václav - Esposito, M.
    Time-dependent Influence of Procaine Hydrochloride on Cisplatin Antitumor Activity in P388 Tumor Bearing Mice.
    Anticancer Research. Roč. 21, - (2001), s. 485-488. ISSN 0250-7005. E-ISSN 1791-7530
    Institutional research plan: CEZ:AV0Z5039906
    Keywords : cisplatin * procaine * antitumor activity
    Subject RIV: EA - Cell Biology
    Impact factor: 1.416, year: 2001
    Permanent Link: http://hdl.handle.net/11104/0070464
     
     
  10. 10.
    0126618 - BFU-R 20013179 RIV ES eng C - Conference Paper (international conference)
    Neplechová, Kamila - Kašpárková, Jana - Prokop, Radim - Farrell, N. - Brabec, Viktor
    Antitumor efficient platinum complexes with trans-geometry and their reactions with DNA.
    Book of Abstracts. Barcelona, 2001, s. 399.
    [FIGIPS MEETING IN INORGANIC CHEMISTRY /6./. Barcelona (ES), 15.07.2001-20.07.2001]
    Institutional research plan: CEZ:AV0Z5004920
    Keywords : DNA modification * platinum complexes * antitumor activity
    Subject RIV: BO - Biophysics
    Permanent Link: http://hdl.handle.net/11104/0024846