Search results
- 1.0547996 - ÚEB 2022 RIV GB eng J - Journal Article
Kiss, M. A. - Peřina, M. - Bazgier, Václav - May, N. V. - Baji, Á. - Jorda, R. - Frank, É.
Synthesis of dihydrotestosterone derivatives modified in the A-ring with (hetero)arylidene, pyrazolo[1,5-a]pyrimidine and triazolo[1,5-a]pyrimidine moieties and their targeting of the androgen receptor in prostate cancer.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 211, JUL (2021), č. článku 105904. ISSN 0960-0760
R&D Projects: GA ČR GA20-15621S; GA MŠMT(CZ) LM2018131
Institutional support: RVO:61389030
Keywords : 2-arylidene-dihydrotestosterone * Androgen receptor * Azolo[1,5-a]pyrimidines * Crystal structures * Flexible docking * Heterocyclization * Transcriptional activity
OECD category: Biochemistry and molecular biology
Impact factor: 5.011, year: 2021
Method of publishing: Open access
http://doi.org/10.1016/j.jsbmb.2021.105904
Permanent Link: http://hdl.handle.net/11104/0324132File Download Size Commentary Version Access 2021_Kiss_JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY_105904.pdf 1 4.1 MB Other open-access - 2.0540075 - ÚEB 2021 RIV CH eng J - Journal Article
Tammam, M. A. - Rárová, Lucie - Kvasnicová, Marie - Gonzalez, Gabriel - Emam, A. M. - Mahdy, A. - Strnad, Miroslav - Ioannou, E. - Roussis, V.
Bioactive Steroids from the Red Sea Soft Coral Sinularia polydactyla.
Marine Drugs. Roč. 18, č. 12 (2020), č. článku 632. E-ISSN 1660-3397
R&D Projects: GA ČR(CZ) GA19-01383S; GA ČR GA20-15621S
Institutional support: RVO:61389030
Keywords : androgen receptor * anti-inflammatory * cytotoxic * neuroprotective * Sinularia polydactyla * soft coral * steroids
OECD category: Organic chemistry
Impact factor: 5.118, year: 2020
Method of publishing: Open access
http://doi.org/10.3390/md18120632
Permanent Link: http://hdl.handle.net/11104/0317741File Download Size Commentary Version Access 2020_Tammam_MARINE DRUGS_632.pdf 1 9.2 MB Other open-access - 3.0510440 - ÚMG 2020 RIV GB eng J - Journal Article
Pavlickova, V. - Jurásek, M. - Rimpelová, S. - Záruba, K. - Sedlák, David - Šimková, M. - Kodr, D. - Staňková, E. - Fahnrich, J. - Rottnerová, Z. - Bartůněk, Petr - Lapčík, O. - Drasar, P. - Ruml, T.
Oxime-based 19-nortestosterone-pheophorbide a conjugate: bimodal controlled release concept for PDT.
Journal of Materials Chemistry B. Roč. 7, č. 36 (2019), s. 5465-5477. ISSN 2050-750X. E-ISSN 2050-7518
R&D Projects: GA MŠMT LO1220; GA MŠMT LM2015063; GA MŠMT(CZ) LO1304
Institutional support: RVO:68378050
Keywords : human breast-cancer * mediated photodynamic therapy * androgen-receptor * prostate-cancer * in-vitro * biological evaluation * pyropheophorbide-a * cellular uptake * pheophorbide * photosensitizers
OECD category: Cell biology
Impact factor: 5.344, year: 2019
Method of publishing: Limited access
https://pubs.rsc.org/en/content/articlelanding/2019/TB/C9TB01301F#!divAbstract
Permanent Link: http://hdl.handle.net/11104/0306733 - 4.0496501 - ÚEB 2019 RIV US eng J - Journal Article
Jorda, Radek - Hendrychová, Denisa - Voller, Jiří - Řezníčková, Eva - Gucký, Tomáš - Kryštof, Vladimír
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
Journal of Medicinal Chemistry. Roč. 61, č. 20 (2018), s. 9105-9120. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LO1204; GA ČR GA17-14007S
Institutional support: RVO:61389030
Keywords : small-molecule inhibitors * metastatic breast-cancer * 1st global approval * thermal shift assay * dna-damage response * in-vitro * androgen receptor * cdk inhibitors * highly potent * 2,6,9-trisubstituted purines
OECD category: Oncology
Impact factor: 6.054, year: 2018
Permanent Link: http://hdl.handle.net/11104/0289264File Download Size Commentary Version Access 2018_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_9105.pdf 5 7.3 MB Other open-access - 5.0488706 - ÚEB 2019 RIV NL eng J - Journal Article
Jorda, Radek - Bučková, Zuzana - Řezníčková, Eva - Bouchal, J. - Kryštof, Vladimír
Selective inhibition reveals cyclin-dependent kinase 2 as another kinase that phosphorylates the androgen receptor at serine 81.
Biochimica Et Biophysica Acta-Molecular Cell Research. Roč. 1865, č. 2 (2018), s. 354-363. ISSN 0167-4889. E-ISSN 1879-2596
R&D Projects: GA MŠMT(CZ) LO1204; GA MŠMT(CZ) LO1304
Institutional support: RVO:61389030
Keywords : Androgen receptor * Cyclin-dependent kinase * Inhibitor * Phosphorylation * Serine 81
OECD category: Biochemistry and molecular biology
Impact factor: 4.739, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283248File Download Size Commentary Version Access 2018_Jorda_BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH_354.pdf 2 2.4 MB Other open-access