Search results
- 1.0559889 - ÚOCHB 2023 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2022. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 10.05.2022. Patent Number: US11325931
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/055264571/publication/US11325931B2?q=US11325931B2
Permanent Link: https://hdl.handle.net/11104/0333018 - 2.0559886 - ÚOCHB 2023 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2022. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 12.01.2022. Patent Number: EP3177632
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/patent/search/family/055264571/publication/EP3177632B1?q=EP3177632B1
Permanent Link: https://hdl.handle.net/11104/0333015 - 3.0558031 - ÚOCHB 2023 RIV CH eng J - Journal Article
Krečmerová, Marcela - Majer, Pavel - Rais, R. - Slusher, B. S.
Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects.
Frontiers in Chemistry. Roč. 10, May (2022), č. článku 889737. ISSN 2296-2646. E-ISSN 2296-2646
R&D Projects: GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * antivirals * prodrugs * protides * GCPII * prostate-specific membrane antigen * FOLH1 * 2-PMPA
OECD category: Organic chemistry
Impact factor: 5.5, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fchem.2022.889737
Permanent Link: http://hdl.handle.net/11104/0331849 - 4.0531699 - ÚOCHB 2021 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2020. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 28.01.2020. Patent Number: US10544176
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=10544176B2&KC=B2&FT=D&ND=4&date=20200128&DB=&locale=en_EP
Permanent Link: http://hdl.handle.net/11104/0310314 - 5.0510193 - ÚOCHB 2020 RIV US eng J - Journal Article
Dash, R. P. - Tichý, Tomáš - Veeravalli, V. - Lam, J. - Alt, J. - Wu, Y. - Tenora, Lukáš - Majer, Pavel - Slusher, B. S. - Rais, R.
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
Molecular Pharmaceutics. Roč. 16, č. 10 (2019), s. 4292-4301. ISSN 1543-8384. E-ISSN 1543-8392
Institutional support: RVO:61388963
Keywords : 2-PMPA * glutamate carboxypeptidase II * oral bioavailability * pharmacokinetics * prodrugs
OECD category: Organic chemistry
Impact factor: 4.321, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00637
Permanent Link: http://hdl.handle.net/11104/0300720 - 6.0501191 - ÚOCHB 2019 RIV eng P - Patent Document
Slusher, B. - Rais, R. - Krečmerová, Marcela - Tichý, Tomáš - Majer, Pavel - Jančařík, Andrej
Prodrugs of prostate specific membrane antigen (PSMA) inhibitor.
2018. Owner: The Johns Hopkins University - Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 05.06.2018. Patent Number: US9988407
Institutional support: RVO:61388963
Keywords : 2-Phosphonomethylpentanedioic acid (2-PMPA) * glutamate carboxypeptidase II * GCPII * PSMA * pivaloyloxymethyl * isopropyloxycarbonyloxymethyl * POM * POC * prodrug
OECD category: Organic chemistry
https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=US&NR=9988407B2&KC=B2&FT=D&ND=4&date=20180605&DB=&locale=en_EP#
Permanent Link: http://hdl.handle.net/11104/0293187File Download Size Commentary Version Access 0501191.pdf 7 5.3 MB Other open-access - 7.0480357 - ÚOCHB 2018 RIV US eng J - Journal Article
Nedelcovych, M. - Dash, R. P. - Tenora, Lukáš - Zimmermann, S. C. - Gadiano, A. J. - Garrett, C. - Alt, J. - Hollinger, K. R. - Pommier, E. - Jančařík, Andrej - Rojas, C. - Thomas, A. G. - Wu, Y. - Wozniak, K. - Majer, Pavel - Slusher, B. S. - Rais, R.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its gamma-Substituted Ester Prodrugs.
Molecular Pharmaceutics. Roč. 14, č. 10 (2017), s. 3248-3257. ISSN 1543-8384. E-ISSN 1543-8392
Institutional support: RVO:61388963
Keywords : 2-PMPA * glutamate carboxypeptidase II * neurological disease * intranasal * pharmacokinetics * prodrugs
OECD category: Organic chemistry
Impact factor: 4.556, year: 2017
Permanent Link: http://hdl.handle.net/11104/0276143 - 8.0459240 - ÚOCHB 2017 RIV US eng J - Journal Article
Majer, Pavel - Jančařík, Andrej - Krečmerová, Marcela - Tichý, Tomáš - Tenora, Lukáš - Wozniak, K. - Wu, Y. - Pommier, E. - Ferraris, D. - Rais, R. - Slusher, B. S.
Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA).
Journal of Medicinal Chemistry. Roč. 59, č. 6 (2016), s. 2810-2819. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:61388963
Keywords : glutamate carboxypeptidase II * glutamate * 2-PMPA * prodrug
Subject RIV: CC - Organic Chemistry
Impact factor: 6.259, year: 2016
Permanent Link: http://hdl.handle.net/11104/0259472