Search results
- 1.0585825 - ÚOCHB 2025 RIV US eng J - Journal Article
Keough, D. T. - Petrová, Magdalena - King, G. - Kratochvil, Michal - Pohl, Radek - Doležalová, E. - Ziková, A. - Guddat, L. W. - Rejman, Dominik
Development of Prolinol Containing Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: Rational Structure-Based Drug Design.
Journal of Medicinal Chemistry. Roč. 67 (2024), s. 7158-7175. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.4c00021
Permanent Link: https://hdl.handle.net/11104/0353500File Download Size Commentary Version Access 10.1021acs.jmedchem.4c00021.pdf 0 12.2 MB Publisher’s postprint open-access - 2.0583634 - BFÚ 2024 RIV US eng J - Journal Article
Kostrhunová, Hana - McGhie, B. S. - Marková, Lenka - Nováková, Olga - Kašpárková, Jana - Aldrich-Wright, J.R. - Brabec, Viktor
Platinum(IV) Derivatives of [Pt(1iS/i,2iS/i-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells.
Journal of Medicinal Chemistry. Roč. 66, č. 12 (2023), s. 7894-7908. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA21-27514S
Institutional support: RVO:68081707
Keywords : cyclooxygenase inhibitors * anticancer activity * in-vitro * death * complexes * mechanism * cisplatin * mitochondrial * cytotoxicity
OECD category: Inorganic and nuclear chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00269
Permanent Link: https://hdl.handle.net/11104/0351654 - 3.0582097 - BFÚ 2024 RIV US eng J - Journal Article
Kašpárková, Jana - Hernandez-Garcia, A. - Kostrhunová, Hana - Goicuria, M. - Novohradský, Vojtěch - Bautista, D. - Marková, Lenka - Santana, M.D. - Brabec, Viktor - Ruiz, J.
Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis.
Journal of Medicinal Chemistry. Roč. 67, č. 1 (2023), s. 691-708. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA23-06316S
Institutional support: RVO:68081707
Keywords : photodynamic anticancer * carbene complexes * apoptosis * therapy * necrosis
OECD category: Pharmacology and pharmacy
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01978
Permanent Link: https://hdl.handle.net/11104/0350372 - 4.0579804 - ÚMG 2024 RIV US eng J - Journal Article
Mejdrova, I. - Dušek, J. - Škach, K. - Štefela, A. - Škoda, J. - Chalupský, Karel - Dohnalová, Klára - Pávková, I. - Kronenberger, T. - Rashidian, A. - Smutná, L. - Duchoslav, V. - Smutný, T. - Pávek, P. - Nencka, R.
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
Journal of Medicinal Chemistry. Roč. 66, č. 4 (2023), s. 2422-2456. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LM2015040; GA ČR GA22-05167S; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:68378050
Keywords : pregnane-x-receptor * car * activation * pxr * ligand * derivatives * identification * artemisinin * metabolites * expression
OECD category: Cell biology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01140
Permanent Link: https://hdl.handle.net/11104/0348603 - 5.0579081 - ÚMG 2024 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Peřina, M. - Vojáčková, V. - Pospíšil, T. - Djukic, S. - Škerlová, Jana - Grúz, J. - Renešová, N. - Klener, P. - Řezáčová, P. - Strnad, M. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-id/i]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry. Roč. 65, č. 13 (2022), s. 8881-8896. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : roscovitine * expression * cell line
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02184
Permanent Link: https://hdl.handle.net/11104/0347953 - 6.0578510 - ÚOCHB 2024 RIV US eng J - Journal Article
Novotná, Kateřina - Tenora, Lukáš - Prchalová, E. - Paule, J. - Alt, J. - Veeravalli, V. - Lam, J. - Wu, Y. - Šnajdr, Ivan - Gori, S. - Mettu, V. S. - Tsukamoto, T. - Majer, Pavel - Slusher, B. S. - Rais, R.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Journal of Medicinal Chemistry. Roč. 66, č. 22 (2023), s. 15493-15510. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18166; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : phase-I * 6-diazo-5-oxo-l-norleucine DON * clinical pharmacology
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01681
Permanent Link: https://hdl.handle.net/11104/0347498File Download Size Commentary Version Access 10.1021acs.jmedchem.3c01681.pdf 0 2.8 MB Publisher’s postprint open-access - 7.0578119 - MBÚ 2024 RIV US eng J - Journal Article
Bendová, K. - Raclavský, V. - Novotný, R. - Luptáková, Dominika - Popper, M. - Nový, Z. - Hajduch, M. - Petřík, M.
[68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography.
Journal of Medicinal Chemistry. Roč. 66, č. 11 (2023), s. 7584-7593. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MŠMT(CZ) LM2018133; GA TA ČR(CZ) TN02000109
Institutional support: RVO:61388971
Keywords : cystic-fibrosis * siderophore * cenocepacia * pseudomonas * ornibactin * ga-68-siderophores * aeruginosa * epidemiology * pet
OECD category: Analytical chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00469LX
Permanent Link: https://hdl.handle.net/11104/0347152File Download Size Commentary Version Access bendova-et-al-2023-68ga-ga-ornibactin-for-burkholderia-cepacia-complex-infection-imaging-using-positron-emission (1).pdf 1 4.5 MB Publisher’s postprint open-access - 8.0576497 - BC 2024 RIV US eng J - Journal Article
Chai, J. - Wu, J. - Li, J. - Liao, H. - Lu, W. - Guo, R. - Shao, Z. - Jmel, Mohamed Amine - Martins, Larissa Almeida - Hackeng, T. - Ippel, H. - Dijkgraaf, I. - Kotsyfakis, Michalis - Xu, X.
Novel Amphibian Bowman-Birk-Like Inhibitor with Antioxidant and Anticoagulant Effects Ameliorates Pancreatitis Symptoms in Mice.
Journal of Medicinal Chemistry. Roč. 66, č. 17 (2023), s. 11869-11880. ISSN 0022-2623. E-ISSN 1520-4804
Grant - others:AV ČR(CZ) NSFC-19-15
Program: Bilaterální spolupráce
Institutional support: RVO:60077344
Keywords : PEPTIDE LEUCINE ARGININE * TRYPSIN-INHIBITOR * SKIN SECRETIONS
OECD category: Pharmacology and pharmacy
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00475
Permanent Link: https://hdl.handle.net/11104/0346051 - 9.0574516 - BFÚ 2024 RIV US eng J - Journal Article
Novohradský, Vojtěch - Marco, A. - Marková, Lenka - Cutillas, N. - Ruiz, J. - Brabec, Viktor
Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells.
Journal of Medicinal Chemistry. Roč. 66, č. 14 (2023), s. 9766-9783. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR(CZ) GA23-06307S
Institutional support: RVO:68081707
Keywords : EPITHELIAL-MESENCHYMAL TRANSITION * IRIDIUM(III) COMPLEXES * CHEMOTHERAPY
OECD category: Inorganic and nuclear chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00586
Permanent Link: https://hdl.handle.net/11104/0350069 - 10.0574366 - ÚOCHB 2024 RIV US eng J - Journal Article
Břehová, Petra - Řezníčková, E. - Škach, Kryštof - Jorda, R. - Dejmek, Milan - Vojáčková, V. - Šála, Michal - Kovalová, M. - Dračínský, Martin - Dolníková, A. - Strmeň, Timotej - Kinnertová, M. - Chalupský, Karel - Dvořáková, Alexandra - Gucký, T. - Mertlíková-Kaiserová, Helena - Klener, P. - Nencka, Radim - Kryštof, V.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Journal of Medicinal Chemistry. Roč. 66, č. 16 (2023), s. 11133-11157. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : gene expression * highly potent
OECD category: Oncology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.3c00575
Permanent Link: https://hdl.handle.net/11104/0344703File Download Size Commentary Version Access 10.1021acs.jmedchem.3c00575.pdf 0 7.8 MB Publisher’s postprint open-access