Search results
- 1.0574383 - ÚOCHB 2024 RIV NL eng J - Journal Article
Dejmek, Milan - Brázdová, Andrea - Otava, Tomáš - Pimková Polidarová, Markéta - Klíma, Martin - Smola, Miroslav - Vavřina, Zdeněk - Buděšínský, Miloš - Dračínský, Martin - Liboska, Radek - Bouřa, Evžen - Birkuš, Gabriel - Nencka, Radim
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
European Journal of Medicinal Chemistry. Roč. 259, November (2023), č. článku 115685. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61388963
Keywords : cyclic dinucleotides * STING * cancer * intratumoral administration * immunotherapy
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115685
Permanent Link: https://hdl.handle.net/11104/0344716File Download Size Commentary Version Access 10.1016j.ejmech.2023.115685.pdf 0 5.2 MB Publisher’s postprint open-access
Research data: PDB - 2.0574079 - FGÚ 2024 RIV CH eng J - Journal Article
Plecitá-Hlavatá, Lydie - Brázdová, Andrea - Křivonosková, Monika - Hu, Ch.-J. - Phang, T. - Tauber, Jan - Li, M. - Zhang, H. - Hoetzenecker, K. - Crnkovic, S. - Kwapiszewska, G. - Stenmark, K. R.
Microenvironmental regulation of T-cells in pulmonary hypertension.
Frontiers in Immunology. Roč. 14, Jul 11 (2023), č. článku 1223122. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA MŠMT(CZ) LTAUSA18107
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : pulmonary fibroblasts * HDAC inhibitors * pulmonary hypertension * T-cells * γδ T-cells * Tregs
OECD category: Immunology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fimmu.2023.1223122
Permanent Link: https://hdl.handle.net/11104/0344444 - 3.0570640 - ÚOCHB 2024 RIV CZ eng J - Journal Article
Vaneková, Lenka - Pimková Polidarová, Markéta - Charvát, Vilém - Vavřina, Zdeněk - Veverka, Václav - Birkuš, Gabriel - Brázdová, Andrea
Development and Characterization of a Chronic Hepatitis B Murine Model With a Mutation in the START Codon of an HBV Polymerase.
Physiological Research. Roč. 72, č. 1 (2023), s. 37-47. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : chronic hepatitis B murine model * HBsAg * HBcAg * pAAV system * minicircle HBV
OECD category: Medicinal chemistry
Impact factor: 2.1, year: 2022
Method of publishing: Open access
https://doi.org/10.33549/physiolres.934979
Permanent Link: https://hdl.handle.net/11104/0341954 - 4.0565954 - ÚOCHB 2024 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Vaneková, Lenka - Břehová, Petra - Dejmek, Milan - Vavřina, Zdeněk - Birkuš, Gabriel - Brázdová, Andrea
Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells.
ACS Infectious Diseases. Roč. 9, č. 1 (2023), s. 23-32. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : chronic hepatitis B * STING * nonparenchymal liver cells * antiviral immunity * cytokine * HBV-persistent mouse model
OECD category: Biochemistry and molecular biology
Impact factor: 5.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acsinfecdis.2c00424
Permanent Link: https://hdl.handle.net/11104/0337421 - 5.0563508 - ÚOCHB 2023 RIV CH eng J - Journal Article
Vaneková, Lenka - Pimková Polidarová, Markéta - Veverka, Václav - Birkuš, Gabriel - Brázdová, Andrea
Multiparametric Flow Cytometry-Based Immunophenotyping of Mouse Liver Immune Cells.
Methods and Protocols. Roč. 5, č. 5 (2022), č. článku 70. E-ISSN 2409-9279
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : flow cytometry * immunophenotyping * mouse liver * PBS-based liver perfusion * non-parenchymal cells
OECD category: Biochemistry and molecular biology
Impact factor: 2.4, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/mps5050070
Permanent Link: https://hdl.handle.net/11104/0335459 - 6.0559980 - ÚOCHB 2023 RIV GB eng J - Journal Article
Dejmek, Milan - Šála, Michal - Brázdová, Andrea - Vaneková, Lenka - Smola, Miroslav - Klíma, Martin - Břehová, Petra - Buděšínský, Miloš - Dračínský, Martin - Procházková, Eliška - Zavřel, Martin - Šimák, Ondřej - Páv, Ondřej - Bouřa, Evžen - Birkuš, Gabriel - Nencka, Radim
Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Structure. Roč. 30, č. 8 (2022), s. 1146-1156. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : cyclic dinucleotides * prodrugs * STING agonists * isonucleosides * cytokines * cancer
OECD category: Organic chemistry
Impact factor: 5.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.str.2022.05.012
Permanent Link: https://hdl.handle.net/11104/0333087 - 7.0556976 - ÚOCHB 2023 RIV CH eng J - Journal Article
Gérard, C. - Thébault, M. - Lamarthee, B. - Genet, C. - Cattin, F. - Brázdová, Andrea - Janikashvili, N. - Cladière, C. - Ciudad, M. - Ouandji, S. - Ghesquière, T. - Greigert, H. - Tinel, C. - Adotevi, O. - Saas, P. - Samson, M. - Audia, S. - Bonnotte, B.
Human Monocyte-Derived Suppressor Cell Supernatant Induces Immunoregulatory Effects and Mitigates xenoGvHD.
Frontiers in Immunology. Roč. 13, March (2022), č. článku 827712. ISSN 1664-3224. E-ISSN 1664-3224
Institutional support: RVO:61388963
Keywords : myeloid-derived suppressor cell * xeno GVHD * supernatant characteristics * GMP-good manufacturing practice * immunoregualtion
OECD category: Immunology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fimmu.2022.827712
Permanent Link: http://hdl.handle.net/11104/0331101 - 8.0556396 - ÚOCHB 2023 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Břehová, Petra - Dejmek, Milan - Birkuš, Gabriel - Brázdová, Andrea
STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis.
ACS Infectious Diseases. Roč. 8, č. 3 (2022), s. 463-471. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : STING * cGAS-STING pathway * apoptosis * monocytes * proinflammatory cytokines * interferons
OECD category: Biochemistry and molecular biology
Impact factor: 5.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acsinfecdis.1c00554
Permanent Link: http://hdl.handle.net/11104/0330938 - 9.0543611 - ÚOCHB 2022 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Břehová, Petra - Kaiser, Martin Maxmilian - Smola, Miroslav - Dračínský, Martin - Smith, Joshua - Marek, Aleš - Dejmek, Milan - Šála, Michal - Gutten, Ondrej - Rulíšek, Lubomír - Novotná, Barbora - Brázdová, Andrea - Janeba, Zlatko - Nencka, Radim - Bouřa, Evžen - Páv, Ondřej - Birkuš, Gabriel
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP).
Journal of Medicinal Chemistry. Roč. 64, č. 11 (2021), s. 7596-7616. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-08772S
Institutional support: RVO:61388963
Keywords : DNA sensor * interferon genes * cyclic GMP-AMP
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c00301
Permanent Link: http://hdl.handle.net/11104/0320799 - 10.0540798 - ÚOCHB 2022 RIV US eng J - Journal Article
Janikashvili, N. - Gérard, C. - Thébault, M. - Brázdová, Andrea - Boibessot, C. - Cladière, C. - Ciudad, M. - Greigert, H. - Ouandji, S. - Ghesquière, T. - Samson, M. - Audia, S. - Saas, P. - Bonnotte, B.
Efficiency of human monocyte-derived suppressor cell-based treatment in graft-versus-host disease prevention while preserving graft-versus-leukemia effect.
OncoImmunology. Roč. 10, č. 1 (2021), č. článku 1880046. ISSN 2162-4011
Institutional support: RVO:61388963
Keywords : graft-versus-host disease * graft-versus-leukemia effect * human monocyte-derived suppressor cells * immunosuppressive drugs * inflammation * regulatory T cells
OECD category: Immunology
Impact factor: 8.110, year: 2020
Method of publishing: Open access
https://doi.org/10.1080/2162402X.2021.1880046
Permanent Link: http://hdl.handle.net/11104/0318397