Search results
- 1.0546864 - FGÚ 2022 RIV US eng J - Journal Article
Dolejší, Eva - Chetverikov, Nikolai - Szánti-Pintér, Eszter - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - El-Fakahany, E. E. - Kudová, Eva - Jakubík, Jan
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors.
Biochemical Pharmacology. Roč. 192, Oct (2021), č. článku 114699. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 6.100, year: 2021 ; AIS: 1.082, rok: 2021
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.bcp.2021.114699DOI: https://doi.org/10.1016/j.bcp.2021.114699
Permanent Link: http://hdl.handle.net/11104/0323241File Download Size Commentary Version Access 21_0129_0546864.pdf 0 3.5 MB Publisher’s postprint open-access - 2.0546861 - FGÚ 2022 RIV NL eng J - Journal Article
Dolejší, Eva - Szánti-Pintér, Eszter - Chetverikov, Nikolai - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - Kudová, Eva - Jakubík, Jan
Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptor.
Neuropharmacology. Roč. 199, Nov 1 (2021), č. článku 108798. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neurosteroid * steroid hormone * allosteric modulation * muscarinic receptor
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 5.273, year: 2021 ; AIS: 1.157, rok: 2021
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.neuropharm.2021.108798DOI: https://doi.org/10.1016/j.neuropharm.2021.108798
Permanent Link: http://hdl.handle.net/11104/0323238File Download Size Commentary Version Access 21_0128_0546861.pdf 0 6.6 MB Publisher’s postprint open-access - 3.0544565 - FGÚ 2022 RIV US eng J - Journal Article
Staszewski, M. - Nelic, Dominik - Jończyk, J. - Dubiel, M. - Frank, A. - Stark, H. - Bajda, M. - Jakubík, Jan - Walczyński, K.
Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists.
ACS Chemical Neuroscience. Roč. 12, č. 13 (2021), s. 2503-2519. ISSN 1948-7193. E-ISSN 1948-7193
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : antagonists * histamine H3 receptor * muscarinic M2 receptor * muscarinic M4 receptor * structure−activity relationships * guanidine
OECD category: Physiology (including cytology)
Impact factor: 5.780, year: 2021 ; AIS: 1.113, rok: 2021
Method of publishing: Open access
Result website:
https://pubs.acs.org/doi/10.1021/acschemneuro.1c00237DOI: https://doi.org/10.1021/acschemneuro.1c00237
Permanent Link: http://hdl.handle.net/11104/0321411 - 4.0541423 - FGÚ 2022 RIV CH eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E.
Allosteric Modulation of GPCRs of Class A by Cholesterol.
International Journal of Molecular Sciences. Roč. 22, č. 4 (2021), č. článku 1953. ISSN 1661-6596. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : GPCRs * cholesterol * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 6.208, year: 2021 ; AIS: 1.064, rok: 2021
Method of publishing: Open access
Result website:
https://www.mdpi.com/1422-0067/22/4/1953DOI: https://doi.org/10.3390/ijms22041953
Permanent Link: http://hdl.handle.net/11104/0318982 - 5.0538466 - FGÚ 2021 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Chetverikov, Nikolai - El-Fakahany, E. E. - Doležal, Vladimír
The operational model of allosteric modulation of pharmacological agonism.
Scientific Reports. Roč. 10, č. 1 (2020), č. článku 14421. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : receptor theory * operational model * allosteric modulation
OECD category: Pharmacology and pharmacy
Impact factor: 4.380, year: 2020 ; AIS: 1.285, rok: 2020
Method of publishing: Open access
Result website:
https://www.nature.com/articles/s41598-020-71228-yDOI: https://doi.org/10.1038/s41598-020-71228-y
Permanent Link: http://hdl.handle.net/11104/0316262 - 6.0523829 - FGÚ 2021 RIV CH eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E.
Current Advances in Allosteric Modulation of Muscarinic Receptors.
Biomolecules. Roč. 10, č. 2 (2020), č. článku 325. ISSN 2218-273X. E-ISSN 2218-273X
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : acetylcholine * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 4.879, year: 2020 ; AIS: 1.041, rok: 2020
Method of publishing: Open access
Result website:
https://doi.org/10.3390/biom10020325DOI: https://doi.org/10.3390/biom10020325
Permanent Link: http://hdl.handle.net/11104/0308111 - 7.0504451 - FGÚ 2020 RIV US eng J - Journal Article
Jakubík, Jan - Randáková, Alena - El-Fakahany, E. E. - Doležal, Vladimír
Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators.
PLoS ONE. Roč. 14, č. 3 (2019), č. článku e0214255. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : binding experiments * equlibrium * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 2.740, year: 2019 ; AIS: 0.926, rok: 2019
Method of publishing: Open access
Result website:
https://doi.org/10.1371/journal.pone.0214255DOI: https://doi.org/10.1371/journal.pone.0214255
Permanent Link: http://hdl.handle.net/11104/0296079