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- 1.0578510 - ÚOCHB 2024 RIV US eng J - Journal Article
Novotná, Kateřina - Tenora, Lukáš - Prchalová, E. - Paule, J. - Alt, J. - Veeravalli, V. - Lam, J. - Wu, Y. - Šnajdr, Ivan - Gori, S. - Mettu, V. S. - Tsukamoto, T. - Majer, Pavel - Slusher, B. S. - Rais, R.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Journal of Medicinal Chemistry. Roč. 66, č. 22 (2023), s. 15493-15510. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18166; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : phase-I * 6-diazo-5-oxo-l-norleucine DON * clinical pharmacology
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01681
Permanent Link: https://hdl.handle.net/11104/0347498File Download Size Commentary Version Access 10.1021acs.jmedchem.3c01681.pdf 0 2.8 MB Publisher’s postprint open-access - 2.0565069 - ÚOCHB 2023 RIV US eng J - Journal Article
Rais, R. - Lemberg, K. M. - Tenora, Lukáš - Arwood, M. L. - Pal, A. - Alt, J. - Wu, Y. - Lam, J. - Aguilar, J. M. H. - Zhao, L. - Peters, D. E. - Tallon, C. - Pandey, R. - Thomas, A. G. - Dash, R. P. - Seiwert, T. - Majer, Pavel - Leone, R. D. - Powell, J. D. - Slusher, B. S.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Science Advances. Roč. 8, č. 46 (2022), č. článku eabq5925. ISSN 2375-2548. E-ISSN 2375-2548
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : 6-diazo-5-oxo-l-norleucine DON * phase II * glutamine metabolism
OECD category: Organic chemistry
Impact factor: 13.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1126/sciadv.abq5925
Permanent Link: https://hdl.handle.net/11104/0336617 - 3.0547369 - ÚOCHB 2022 RIV AE eng J - Journal Article
Alt, J. - Gori, S. S. - Lemberg, K. M. - Pal, A. - Veeravalli, V. - Wu, Y. - Aguilar, J. M. H. - Dash, R. P. - Tenora, Lukáš - Majer, Pavel - Sun, Q. - Slusher, B. S. - Rais, R.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
Current Drug Metabolism. Roč. 22, č. 9 (2021), s. 735-745. ISSN 1389-2002. E-ISSN 1875-5453
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : Glutamine antagonist * purine synthesis * formylglycinamide ribonucleotide * formylglycinamidine ribonucleotide * biomarker * cancer * LC-MS
OECD category: Organic chemistry
Impact factor: 3.408, year: 2021
Method of publishing: Limited access
https://doi.org/10.2174/1389200222666210831125041
Permanent Link: http://hdl.handle.net/11104/0323608 - 4.0522291 - ÚOCHB 2021 RIV US eng J - Journal Article
Lemberg, K. M. - Zhao, L. - Wu, Y. - Veeravalli, V. - Alt, J. - Aguilar, J. M. H. - Dash, R. P. - Lam, J. - Tenora, Lukáš - Rodriguez, C. - Nedelcovych, M. T. - Brayton, C. - Majer, Pavel - Blakeley, J. O. - Rais, R. - Slusher, B. S.
The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
Molecular Cancer Therapeutics. Roč. 19, č. 2 (2020), s. 397-408. ISSN 1535-7163. E-ISSN 1538-8514
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : 6-diazo-5-oxo-L-norleucine DON * cancer * metabolism
OECD category: Organic chemistry
Impact factor: 6.261, year: 2020
Method of publishing: Limited access
https://mct.aacrjournals.org/content/19/2/397
Permanent Link: http://hdl.handle.net/11104/0306808 - 5.0504477 - ÚOCHB 2020 RIV US eng J - Journal Article
Tenora, Lukáš - Alt, J. - Dash, R. P. - Gadiano, A. J. - Novotná, Kateřina - Veeravalli, V. - Lam, J. - Kirkpatrick, Q. R. - Lemberg, K. M. - Majer, Pavel - Rais, R. - Slusher, B. S.
Tumor-Targeted Delivery of 6-Diazo-5-oxo-L-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs.
Journal of Medicinal Chemistry. Roč. 62, č. 7 (2019), s. 3524-3538. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : phase II * doxorubicin prodrugs * cathepsin B
OECD category: Organic chemistry
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b02009
Permanent Link: http://hdl.handle.net/11104/0296099