Search results
- 1.0576613 - BTÚ 2024 RIV GB eng J - Journal Article
Bielcikova, Z. - Werner, Lukáš - Štursa, Jan - Černý, V. - Křížová, L. - Špaček, J. - Hlousek, S. - Vočka, M. - Bartosova, O. - Pesta, M. - Kološtová, K. - Klezl, P. - Bobek, V. - Truksa, Jaroslav - Štemberková-Hubáčková, Soňa - Petruzelka, L. - Michálek, P. - Neužil, Jiří
Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial.
Therapeutic Advances in Medical Oncology. Roč. 15, March 28 (2023), č. článku 17588359231197957. ISSN 1758-8340. E-ISSN 1758-8359
R&D Projects: GA MZd(CZ) NU21-03-00545
Keywords : case series * efficacy * mechanism of action * mitocans * mitochondria
OECD category: Oncology
Impact factor: 4.9, year: 2022
Method of publishing: Open access
https://journals.sagepub.com/doi/10.1177/17588359231197957
Permanent Link: https://hdl.handle.net/11104/0347246 - 2.0572870 - BTÚ 2024 RIV NL eng J - Journal Article
Bielcikova, Z. - Štursa, Jan - Křížová, L. - Dong, L. - Špaček, J. - Hlousek, S. - Vocka, M. - Rohlenová, Kateřina - Bartosova, O. - Černý, V. - Padrta, T. - Pesta, M. - Michálek, P. - Hubáčková, Soňa - Kološtová, K. - Pospíšilová, E. - Bobek, V. - Klezl, P. - Zobalová, Renata - Endaya, Berwini - Rohlena, Jakub - Petruzelka, L. - Werner, Lukáš - Neužil, Jiří
Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trial.
ECLINICALMEDICINE. Roč. 57, MAR 2023 (2023), č. článku 101873. E-ISSN 2589-5370
Institutional support: RVO:86652036
Keywords : Phase I * Ib clinical trial * Cancer * Mitochondrially targeted tamoxifen * Renal cell carcinoma
OECD category: General and internal medicine
Impact factor: 15.1, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S2589537023000500?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0343476 - 3.0569955 - BTÚ 2023 RIV US eng J - Journal Article
Arbon, D. - Zeniskova, K. - Subrtova, K. - Mach, J. - Štursa, Jan - Machado, M. - Zahedifard, F. - Leštinová, T. - Hierro Yap, Carolina - Neužil, Jiří - Volf, P. - Ganter, M. - Zoltner, M. - Zíková, Alena - Werner, Lukáš - Suták, R.
Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens.
Antimicrobial Agents and Chemotherapy. Roč. 66, č. 8 (2022). ISSN 0066-4804. E-ISSN 1098-6596
R&D Projects: GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA20-14409S; GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF18_046/0016045; GA ČR(CZ) GA20-14409S
Institutional support: RVO:86652036 ; RVO:60077344
Keywords : Candida * Cryptococcus * drug * Leishmania
OECD category: Pharmacology and pharmacy; Cell biology (BC-A)
Impact factor: 4.9, year: 2022
Method of publishing: Open access
https://journals.asm.org/doi/10.1128/aac.00727-22
Permanent Link: https://hdl.handle.net/11104/0341283 - 4.0569654 - BTÚ 2024 RIV US eng J - Journal Article
Zeniskova, K. - Mach, J. - Arbon, D. - Štursa, Jan - Werner, Lukáš - Zoltner, M. - Suták, R.
The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis.
Antimicrobial Agents and Chemotherapy. Roč. 67, č. 2 (2023). ISSN 0066-4804. E-ISSN 1098-6596
Institutional support: RVO:86652036
Keywords : Naegleria fowleri * primary amoebic meningoencephalitis * antiparasitic * oxaborole * amoeba
OECD category: Microbiology
Impact factor: 4.9, year: 2022
Method of publishing: Limited access
https://journals.asm.org/doi/10.1128/aac.01506-22
Permanent Link: https://hdl.handle.net/11104/0342635 - 5.0556801 - BTÚ 2023 RIV GB eng J - Journal Article
Vačurová, Eliška - Trnovská, J. - Svoboda, P. - Skop, V. - Novosadová, Vendula - Reguera, David Pajuelo - Petrezselyova, Silvia - Piavaux, Benoit - Endaya, Berwini - Špoutil, František - Zudová, Dagmar - Štursa, Jan - Melčová, M. - Bielcikova, Z. - Werner, Lukáš - Procházka, Jan - Sedláček, Radislav - Hüttl, M. - Štemberková-Hubáčková, Soňa - Haluzík, M. - Neužil, Jiří
Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice.
Nature Communications. Roč. 13, č. 1 (2022), č. článku 1866. E-ISSN 2041-1723
R&D Projects: GA ČR(CZ) GA18-02550S; GA ČR(CZ) GA18-10832S; GA ČR(CZ) GA20-05942S; GA ČR(CZ) GX21-04607X; GA MZd(CZ) NV17-30138A; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) EF16_013/0001775
Research Infrastructure: Czech-BioImaging - 90062
Institutional support: RVO:86652036 ; RVO:68378050
Keywords : mitotic clonal expansion * body-composition changes * adipose-tissue * cellular senescence * insulin-resistance
OECD category: Endocrinology and metabolism (including diabetes, hormones)
Impact factor: 16.6, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41467-022-29486-z
Permanent Link: http://hdl.handle.net/11104/0331426 - 6.0556526 - BTÚ 2023 RIV GB eng J - Journal Article
Štemberková-Hubáčková, Soňa - Zobalová, Renata - Dubišová, Maria - Šmigová, J. - Dvořáková, Šárka - Kořínková, Klára - Ezrová, Zuzana - Endaya, Berwini - Blažková, Kristýna - Vlčák, Erik - Brisudová, Petra - Le, Dan-Diem Thi - Juhás, Štefan - Rosel, D. - Kelemen, Daniela Cristina - Sovilj, Dana - Vačurová, Eliška - Čajka, Tomáš - Filimonenko, Vlada - Dong, L. - Anděra, Ladislav - Hozák, Pavel - Brabek, J. - Bielcikova, Z. - Štursa, Jan - Werner, Lukáš - Neužil, Jiří
Simultaneous targeting of mitochondrial metabolism and immune checkpoints as a new strategy for renal cancer therapy.
Clinical and Translational Medicine. Roč. 12, č. 3 (2022), č. článku e645. ISSN 2001-1326. E-ISSN 2001-1326
R&D Projects: GA ČR(CZ) GA20-05942S; GA ČR(CZ) GX21-04607X; GA ČR(CZ) GA18-02550S; GA ČR(CZ) GA19-08772S; GA MZd NU21-03-00195; GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT LTC19048; GA MŠMT(CZ) LO1609; GA MŠMT(CZ) EF16_013/0001775
Grant - others:AV ČR(CZ) StrategieAV21/18
Program: StrategieAV
Institutional support: RVO:86652036 ; RVO:68378050 ; RVO:67985904 ; RVO:67985823
Keywords : Mitochondrially targeted tamoxifen * Renal cancer * Immunotherapy
OECD category: Pathology
Impact factor: 10.6, year: 2022
Method of publishing: Open access
https://onlinelibrary.wiley.com/doi/10.1002/ctm2.645
Permanent Link: http://hdl.handle.net/11104/0331774 - 7.0548987 - BTÚ 2022 RIV US eng J - Journal Article
Sandoval-Acuna, Cristian - Torrealba, Natalia - Tomkova, Veronika - Jadhav, Sukanya B. - Blažková, Kristýna - Merta, L. - Lettlová, Sandra - Adamcová, Miroslava Kari - Rosel, D. - Brabek, J. - Neužil, Jiří - Štursa, Jan - Werner, Lukáš - Truksa, Jaroslav
Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy.
Cancer Research. Roč. 81, č. 9 (2021), s. 2289-2303. ISSN 0008-5472. E-ISSN 1538-7445
R&D Projects: GA ČR(CZ) GA16-12816S; GA ČR(CZ) GA18-13103S; GA ČR(CZ) GC17-01192J; GA ČR(CZ) GA18-10832S
Institutional support: RVO:86652036 ; RVO:68378050
Keywords : sulfur cluster * cancer * biogenesis * breast * cells
OECD category: Oncology; Oncology (UMG-J)
Impact factor: 13.312, year: 2021
Method of publishing: Limited access
https://cancerres.aacrjournals.org/content/81/9/2289
Permanent Link: http://hdl.handle.net/11104/0325023 - 8.0542237 - BTÚ 2022 RIV GB eng J - Journal Article
Ezrová, Zuzana - Nahácka, Zuzana - Štursa, Jan - Werner, Lukáš - Vlčák, Erik - Králová Viziová, Petra - Berridge, M.V. - Sedláček, Radislav - Zobalová, Renata - Rohlena, Jakub - Boukalová, Štěpána - Neužil, Jiří
SMAD4 loss limits the vulnerability of pancreatic cancer cells to complex I inhibition via promotion of mitophagy.
Oncogene. Roč. 40, č. 14 (2021), s. 2539-2552. ISSN 0950-9232. E-ISSN 1476-5594
R&D Projects: GA MZd(CZ) NV16-31604A; GA ČR GA19-20553S; GA ČR(CZ) GA20-18513S; GA ČR(CZ) GJ20-11724Y; GA ČR(CZ) GA18-02550S; GA MŠMT(CZ) EF16_027/0008353; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT LO1220; GA MŠMT(CZ) LM2015062; GA MŠMT(CZ) EF16_013/0001775; GA MŠMT(CZ) LM2018126; GA MŠMT EF16_013/0001789; GA MŠMT EF18_046/0015861; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:86652036 ; RVO:68378050
Keywords : biguanide derivative * reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) * Smad4 protein
OECD category: Genetics and heredity (medical genetics to be 3); Genetics and heredity (medical genetics to be 3) (UMG-J)
Impact factor: 8.756, year: 2021
Method of publishing: Limited access
https://www.nature.com/articles/s41388-021-01726-4?elqTrackId=c7cc7e8c0df94ff7a61453bf09cfb167
Permanent Link: http://hdl.handle.net/11104/0319702 - 9.0520704 - BTÚ 2020 RIV US eng J - Journal Article
Hubáčková, Soňa - Davidová, Eliška - Rohlenová, Kateřina - Štursa, Jan - Werner, Lukáš - Anděra, Ladislav - Dong, L. - Terp, M. G. - Hodný, Zdeněk - Ditzel, H. J. - Rohlena, Jakub - Neužil, Jiří
Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2.
Cell Death and Differentiation. Roč. 26, č. 2 (2019), s. 276-290. ISSN 1350-9047. E-ISSN 1476-5403
R&D Projects: GA ČR(CZ) GA18-02550S; GA ČR(CZ) GA17-07635S; GA ČR GA15-02203S; GA ČR GA16-22823S; GA ČR GA17-20904S; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LM2015062
Institutional support: RVO:86652036 ; RVO:68378050
Keywords : oncogene-induced senescence * cellular senescence * oxidative stress * dna-damage
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UMG-J)
Impact factor: 10.717, year: 2019
Method of publishing: Open access
https://www.nature.com/articles/s41418-018-0118-3
Permanent Link: http://hdl.handle.net/11104/0305395 - 10.0492834 - BTÚ 2019 RIV GB eng J - Journal Article
Cuyas, E. - Fernandez-Arroyo, S. - Verdura, S. - Garcia, R.A-F. - Štursa, Jan - Werner, Lukáš - Blanco-Gonzalez, E. - Montes-Bayon, M. - Joven, J. - Viollet, B. - Neužil, Jiří - Menendez, J. A.
Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.
Oncogene. Roč. 37, č. 7 (2018), s. 963-970. ISSN 0950-9232. E-ISSN 1476-5594
R&D Projects: GA ČR(CZ) GA16-12816S; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:86652036
Keywords : HUMAN CELL-LINE * MESENCHYMAL TRANSITION * CANCER-CELLS
OECD category: Biochemistry and molecular biology
Impact factor: 6.634, year: 2018
Permanent Link: http://hdl.handle.net/11104/0286267