Search results
- 1.0574366 - ÚOCHB 2024 RIV US eng J - Journal Article
Břehová, Petra - Řezníčková, E. - Škach, Kryštof - Jorda, R. - Dejmek, Milan - Vojáčková, V. - Šála, Michal - Kovalová, M. - Dračínský, Martin - Dolníková, A. - Strmeň, Timotej - Kinnertová, M. - Chalupský, Karel - Dvořáková, Alexandra - Gucký, T. - Mertlíková-Kaiserová, Helena - Klener, P. - Nencka, Radim - Kryštof, V.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Journal of Medicinal Chemistry. Roč. 66, č. 16 (2023), s. 11133-11157. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : gene expression * highly potent
OECD category: Oncology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.3c00575
Permanent Link: https://hdl.handle.net/11104/0344703File Download Size Commentary Version Access 10.1021acs.jmedchem.3c00575.pdf 0 7.8 MB Publisher’s postprint open-access - 2.0571975 - ÚEB 2024 RIV NL eng J - Journal Article
Kovalová, M. - Havlíček, Libor - Djukic, Stefan - Škerlová, Jana - Peřina, M. - Pospíšil, T. - Řezníčková, E. - Řezáčová, Pavlína - Jorda, R. - Kryštof, V.
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7.
Biomedicine & Pharmacotherapy. Roč. 161, MAY (2023), č. článku 114492. ISSN 0753-3322. E-ISSN 1950-6007
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Cyclin-dependent kinase 7 * Inhibitor * pyrazolo[4,3-d]pyrimidine * Selectivity
OECD category: Medicinal chemistry
Impact factor: 7.5, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.biopha.2023.114492
Permanent Link: https://hdl.handle.net/11104/0342824File Download Size Commentary Version Access 2023_Kovalova_BIOMEDICINE & PHARMACOTHERAPY_114492.pdf 2 3.3 MB Other open-access - 3.0556295 - ÚMG 2022 RIV US eng J - Journal Article
Dayal, N. - Řezníčková, E. - Hernandez, D. - Peřina, M. - Torregrosa-Allen, S. - Elzey, B. D. - Škerlová, Jana - Ajani, H. - Djukic, S. - Vojáčková, V. - Lepšík, M. - Řezáčová, Pavlína - Krystof, V. - Jorda, R. - Sintim, H. O.
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Journal of Medicinal Chemistry. Roč. 64, č. 15 (2021), s. 10981-10996. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : discovery * flt3
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00330
Permanent Link: http://hdl.handle.net/11104/0330582 - 4.0545107 - ÚOCHB 2022 RIV US eng J - Journal Article
Dayal, N. - Řezníčková, E. - Hernandez, D. E. - Peřina, M. - Torregrosa-Allen, S. - Elzey, B. D. - Škerlová, Jana - Ajani, Haresh - Djukic, Stefan - Vojáčková, V. - Lepšík, Martin - Řezáčová, Pavlína - Kryštof, V. - Jorda, R. - Sintim, H. O.
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Journal of Medicinal Chemistry. Roč. 64, č. 15 (2021), s. 10981-10996. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : discovery * FLT3 * cell proliferation
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c00330
Permanent Link: http://hdl.handle.net/11104/0321867 - 5.0544833 - ÚMG 2022 RIV FR eng J - Journal Article
Jansa, J. - Jorda, R. - Škerlová, J. - Pachl, P. - Peřina, M. - Řezníčková, E. - Heger, T. - Gucký, T. - Řezáčová, Pavlína - Lyčka, A. - Kryštof, V.
Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure.
European Journal of Medicinal Chemistry. Roč. 216, April (2021), č. článku 113309. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:68378050
Keywords : Kinase inhibitor * Cyclin-dependent kinase 2 * imidazo[1,2-c]pyrimidin-5(6H)-one * X-ray crystallography * Co-crystal * Activity assay * itc
OECD category: Biochemistry and molecular biology
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://www-sciencedirect-com.d360prx.biomed.cas.cz/science/article/pii/S0223523421001586?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0321645 - 6.0541414 - ÚOCHB 2022 RIV FR eng J - Journal Article
Jansa, J. - Jorda, R. - Škerlová, Jana - Pachl, Petr - Peřina, M. - Řezníčková, E. - Heger, T. - Gucký, T. - Řezáčová, Pavlína - Lyčka, A. - Kryštof, V.
Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure.
European Journal of Medicinal Chemistry. Roč. 216, Apr 15 (2021), č. článku 113309. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : activity assay * Co-crystal * cyclin-dependent kinase 2 * imidazo[1,2-c]pyrimidin-5(6H)-one * ITC * kinase inhibitor * X-ray crystallography
OECD category: Biochemistry and molecular biology
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113309
Permanent Link: http://hdl.handle.net/11104/0318978