Search results
- 1.0578510 - ÚOCHB 2024 RIV US eng J - Journal Article
Novotná, Kateřina - Tenora, Lukáš - Prchalová, E. - Paule, J. - Alt, J. - Veeravalli, V. - Lam, J. - Wu, Y. - Šnajdr, Ivan - Gori, S. - Mettu, V. S. - Tsukamoto, T. - Majer, Pavel - Slusher, B. S. - Rais, R.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Journal of Medicinal Chemistry. Roč. 66, č. 22 (2023), s. 15493-15510. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18166; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : phase-I * 6-diazo-5-oxo-l-norleucine DON * clinical pharmacology
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01681
Permanent Link: https://hdl.handle.net/11104/0347498File Download Size Commentary Version Access 10.1021acs.jmedchem.3c01681.pdf 0 2.8 MB Publisher’s postprint open-access - 2.0574388 - ÚOCHB 2024 RIV US eng J - Journal Article
Peters, D. E. - Norris, L. D. - Tenora, Lukáš - Šnajdr, Ivan - Ponti, A. K. - Zhu, X. - Sakamoto, S. - Veeravalli, V. - Pradhan, M. - Alt, J. - Thomas, A. G. - Majer, Pavel - Rais, R. - McDonald, C. - Slusher, B. S.
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Science Translational Medicine. Roč. 15, č. 708 (2023), č. článku eabn7491. ISSN 1946-6234. E-ISSN 1946-6242
R&D Projects: GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : gene expression profiles * dextran sulfate sodium * membrane antigen PSMA
OECD category: Medicinal chemistry
Impact factor: 17.1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1126/scitranslmed.abn7491
Permanent Link: https://hdl.handle.net/11104/0344718 - 3.0574332 - ÚOCHB 2024 RIV NL eng J - Journal Article
Novotná, Kateřina - Thomas, A. G. - Štěpánek, O. - Murphy, B. - Hin, N. - Skácel, J. - Mueller, L. - Tenora, Lukáš - Pal, A. - Alt, J. - Wu, Y. - Paule, J. - Rais, R. - Slusher, B. S. - Tsukamoto, T.
Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
European Journal of Medicinal Chemistry. Roč. 259, November (2023), č. článku 115674. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61388963
Keywords : phosphodiesterase * neutral sphingomyelinase 2 * ceramide * sphingomyelin * pyrazolo[1,5-a]pyrimidin-3-amine
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2023.115674
Permanent Link: https://hdl.handle.net/11104/0344672 - 4.0570994 - ÚOCHB 2024 RIV NL eng J - Journal Article
Frejlachová, A. - Lencová, R. - Venhauerová, A. - Skaličková, M. - Uher, O. - Caisova, V. - Majer, Pavel - Tenora, Lukáš - Hansen, P. - Chmelař, J. - Kopecký, J. - Zhuang, Z. - Pacak, K. - Ženka, J.
The combination of immunotherapy and a glutamine metabolism inhibitor represents an effective therapeutic strategy for advanced and metastatic murine pancreatic adenocarcinoma.
International Immunopharmacology. Roč. 118, May (2023), č. článku 110150. ISSN 1567-5769. E-ISSN 1878-1705
Institutional support: RVO:61388963
Keywords : cancer * pancreatic adenocarcinoma * intratumoral * immunotherapy * glutamine antagonist
OECD category: Medicinal chemistry
Impact factor: 5.6, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.intimp.2023.110150
Permanent Link: https://hdl.handle.net/11104/0342323 - 5.0565069 - ÚOCHB 2023 RIV US eng J - Journal Article
Rais, R. - Lemberg, K. M. - Tenora, Lukáš - Arwood, M. L. - Pal, A. - Alt, J. - Wu, Y. - Lam, J. - Aguilar, J. M. H. - Zhao, L. - Peters, D. E. - Tallon, C. - Pandey, R. - Thomas, A. G. - Dash, R. P. - Seiwert, T. - Majer, Pavel - Leone, R. D. - Powell, J. D. - Slusher, B. S.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Science Advances. Roč. 8, č. 46 (2022), č. článku eabq5925. ISSN 2375-2548. E-ISSN 2375-2548
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : 6-diazo-5-oxo-l-norleucine DON * phase II * glutamine metabolism
OECD category: Organic chemistry
Impact factor: 13.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1126/sciadv.abq5925
Permanent Link: https://hdl.handle.net/11104/0336617 - 6.0547369 - ÚOCHB 2022 RIV AE eng J - Journal Article
Alt, J. - Gori, S. S. - Lemberg, K. M. - Pal, A. - Veeravalli, V. - Wu, Y. - Aguilar, J. M. H. - Dash, R. P. - Tenora, Lukáš - Majer, Pavel - Sun, Q. - Slusher, B. S. - Rais, R.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement.
Current Drug Metabolism. Roč. 22, č. 9 (2021), s. 735-745. ISSN 1389-2002. E-ISSN 1875-5453
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : Glutamine antagonist * purine synthesis * formylglycinamide ribonucleotide * formylglycinamidine ribonucleotide * biomarker * cancer * LC-MS
OECD category: Organic chemistry
Impact factor: 3.408, year: 2021
Method of publishing: Limited access
https://doi.org/10.2174/1389200222666210831125041
Permanent Link: http://hdl.handle.net/11104/0323608 - 7.0531033 - ÚOCHB 2021 RIV US eng J - Journal Article
Oh, M. H. - Sun, I. H. - Zhao, L. - Leone, R. D. - Sun, I. M. - Xu, W. - Collins, S. L. - Tam, A. J. - Blosser, R. L. - Patel, C. H. - Englert, J. M. - Arwood, M. L. - Wen, J. - Chan-Li, Y. - Tenora, Lukáš - Majer, Pavel - Rais, R. - Slusher, B. S. - Horton, M. R. - Powell, J. D.
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
Journal of Clinical Investigation. Roč. 130, č. 7 (2020), s. 3865-3884. ISSN 0021-9738. E-ISSN 1558-8238
Institutional support: RVO:61388963
Keywords : cancer immunotherapy * immunology * innate immunity * oncology
OECD category: Medicinal chemistry
Impact factor: 14.808, year: 2020
Method of publishing: Open access
https://www.jci.org/articles/view/131859
Permanent Link: http://hdl.handle.net/11104/0309795 - 8.0525049 - ÚOCHB 2021 RIV US eng J - Journal Article
Tykvart, Jan - Navrátil, Václav - Kugler, Michael - Šácha, Pavel - Schimer, Jiří - Hlavačková, Anna - Tenora, Lukáš - Zemanová, Jitka - Dejmek, Milan - Král, V. - Potáček, M. - Majer, Pavel - Jahn, Ullrich - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, Jan
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA).
SLAS Discovery. Roč. 25, č. 9 (2020), s. 1026-1037. ISSN 2472-5552. E-ISSN 2472-5560
R&D Projects: GA ČR(CZ) GA19-10280S; GA ČR(CZ) GA17-14510S; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : high-throughput screening * carbonic anhydrase IX * drug discovery * DNA-linked inhibitor antibody assay
OECD category: Biochemistry and molecular biology
Impact factor: 2.918, year: 2020
Method of publishing: Limited access
https://journals.sagepub.com/doi/10.1177/2472555220918836
Permanent Link: http://hdl.handle.net/11104/0309265 - 9.0522291 - ÚOCHB 2021 RIV US eng J - Journal Article
Lemberg, K. M. - Zhao, L. - Wu, Y. - Veeravalli, V. - Alt, J. - Aguilar, J. M. H. - Dash, R. P. - Lam, J. - Tenora, Lukáš - Rodriguez, C. - Nedelcovych, M. T. - Brayton, C. - Majer, Pavel - Blakeley, J. O. - Rais, R. - Slusher, B. S.
The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor.
Molecular Cancer Therapeutics. Roč. 19, č. 2 (2020), s. 397-408. ISSN 1535-7163. E-ISSN 1538-8514
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : 6-diazo-5-oxo-L-norleucine DON * cancer * metabolism
OECD category: Organic chemistry
Impact factor: 6.261, year: 2020
Method of publishing: Limited access
https://mct.aacrjournals.org/content/19/2/397
Permanent Link: http://hdl.handle.net/11104/0306808 - 10.0510193 - ÚOCHB 2020 RIV US eng J - Journal Article
Dash, R. P. - Tichý, Tomáš - Veeravalli, V. - Lam, J. - Alt, J. - Wu, Y. - Tenora, Lukáš - Majer, Pavel - Slusher, B. S. - Rais, R.
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
Molecular Pharmaceutics. Roč. 16, č. 10 (2019), s. 4292-4301. ISSN 1543-8384. E-ISSN 1543-8392
Institutional support: RVO:61388963
Keywords : 2-PMPA * glutamate carboxypeptidase II * oral bioavailability * pharmacokinetics * prodrugs
OECD category: Organic chemistry
Impact factor: 4.321, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00637
Permanent Link: http://hdl.handle.net/11104/0300720