Search results
- 1.0474801 - ÚOCHB 2018 RIV NL eng J - Journal Article
Hercík, Kamil - Kozák, Jaroslav - Šála, Michal - Dejmek, Milan - Hřebabecký, Hubert - Zborníková, Eva - Smola, Miroslav - Růžek, Daniel - Nencka, Radim - Bouřa, Evžen
Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase.
Antiviral Research. Roč. 137, Jan (2017), s. 131-133. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA ČR GA15-09310S
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : hepatitis C virus * borne encephalitis virus * crystal structure
OECD category: Organic chemistry
Impact factor: 4.307, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271754 - 2.0474385 - ÚOCHB 2018 RIV US eng J - Journal Article
Mejdrová, Ivana - Chalupská, Dominika - Plačková, Pavla - Müller, C. - Šála, Michal - Klíma, Martin - Bäumlová, Adriana - Hřebabecký, Hubert - Procházková, Eliška - Dejmek, Milan - Strunin, Dmytro - Weber, Jan - Lee, G. - Matoušová, Marika - Mertlíková-Kaiserová, Helena - Ziebuhr, J. - Birkuš, G. - Bouřa, Evžen - Nencka, Radim
Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase III beta (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Journal of Medicinal Chemistry. Roč. 60, č. 1 (2017), s. 100-118. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA15-09310S
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : C virus replication * lipid kinase * crystal structure
OECD category: Organic chemistry
Impact factor: 6.253, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271447
Research data: CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank, CSB Protein Data Bank - 3.0474384 - ÚOCHB 2018 RIV US eng J - Journal Article
Humpolíčková, Jana - Mejdrová, Ivana - Matoušová, Marika - Nencka, Radim - Bouřa, Evžen
Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase III beta (PI4KB).
Journal of Medicinal Chemistry. Roč. 60, č. 1 (2017), s. 119-127. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA15-09310S
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : crystal structure * replication * PI4KIII beta
OECD category: Organic chemistry
Impact factor: 6.253, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271445 - 4.0463529 - ÚOCHB 2017 RIV US eng J - Journal Article
Galeta, Juraj - Šála, Michal - Dračínský, Martin - Vrábel, Milan - Havlas, Zdeněk - Nencka, Radim
Single-Step Formation of Pyrimido[4,5-d]pyridazines by a Pyrimidine-Tetrazine Tandem Reaction.
Organic Letters. Roč. 18, č. 15 (2016), s. 3594-3597. ISSN 1523-7060. E-ISSN 1523-7052
R&D Projects: GA ČR GA15-09310S; GA ČR GA15-11223S; GA ČR GJ15-06020Y; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963
Keywords : heterocycles * organic synthesis * DFT calculations
Subject RIV: CC - Organic Chemistry
Impact factor: 6.579, year: 2016
Permanent Link: http://hdl.handle.net/11104/0262703 - 5.0460249 - ÚOCHB 2017 RIV GB eng J - Journal Article
Šála, Michal - Kögler, Martin - Plačková, Pavla - Mejdrová, Ivana - Hřebabecký, Hubert - Procházková, Eliška - Strunin, Dmytro - Lee, G. - Birkuš, G. - Weber, Jan - Mertlíková-Kaiserová, Helena - Nencka, Radim
Purine analogs as phosphatidylinositol 4-kinase III beta inhibitors.
Bioorganic and Medicinal Chemistry Letters. Roč. 26, č. 11 (2016), s. 2706-2712. ISSN 0960-894X. E-ISSN 1464-3405
R&D Projects: GA ČR GA15-09310S; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : phosphatidylinositol 4-kinase * purine * PI4K III beta * antiviral agent * hepatitis C virus
Subject RIV: CC - Organic Chemistry
Impact factor: 2.454, year: 2016
Permanent Link: http://hdl.handle.net/11104/0260372 - 6.0449209 - ÚOCHB 2016 RIV US eng J - Journal Article
Bouřa, Evžen - Nencka, Radim
Phosphatidylinositol 4-kinases: Function, structure, and inhibition.
Experimental Cell Research. Roč. 337, č. 2 (2015), s. 136-145. ISSN 0014-4827. E-ISSN 1090-2422
R&D Projects: GA ČR GJ15-21030Y; GA MŠMT LO1302; GA ČR GA15-09310S
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : phosphatidylinositol 4-kinase * inhibitor * crystal structure * virus
Subject RIV: CC - Organic Chemistry
Impact factor: 3.378, year: 2015
Permanent Link: http://hdl.handle.net/11104/0250870 - 7.0448379 - ÚOCHB 2016 RIV GB eng J - Journal Article
Hřebabecký, Hubert - Procházková, Eliška - Šála, Michal - Plačková, Pavla - Tloušťová, Eva - Barauskas, O. - Lee, Y. J. - Tian, Y. - Mackman, R. - Nencka, Radim
Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides.
Organic & Biomolecular Chemistry. Roč. 13, č. 35 (2015), s. 9300-9313. ISSN 1477-0520. E-ISSN 1477-0539
R&D Projects: GA ČR GPP207/12/P625; GA ČR GA15-09310S; GA ČR GA13-24880S; GA MV VG20102015046
Institutional support: RVO:61388963
Keywords : nucleic acid analogs * nucleoside triphosphates * sugar ring
Subject RIV: CC - Organic Chemistry
Impact factor: 3.559, year: 2015
http://pubs.rsc.org/en/content/articlepdf/2015/ob/c5ob00987a
Permanent Link: http://hdl.handle.net/11104/0250113 - 8.0446387 - ÚOCHB 2016 RIV DK eng J - Journal Article
Klíma, Martin - Bäumlová, Adriana - Chalupská, Dominika - Hřebabecký, Hubert - Dejmek, Milan - Nencka, Radim - Bouřa, Evžen
The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Acta Crystallographica Section D-Biological Crystallography. Roč. 71, č. 7 (2015), s. 1555-1563. ISSN 1399-0047. E-ISSN 2059-7983
R&D Projects: GA ČR GJ15-21030Y; GA ČR GA15-09310S; GA MŠMT LO1302
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : phosphatidyl inositol * kinase * crystal structure * ATP * inhibitor
Subject RIV: CE - Biochemistry
Impact factor: 2.512, year: 2015
Permanent Link: http://hdl.handle.net/11104/0248456 - 9.0444785 - ÚOCHB 2016 RIV US eng J - Journal Article
Mejdrová, Ivana - Chalupská, Dominika - Kögler, Martin - Šála, Michal - Plačková, Pavla - Bäumlová, Adriana - Hřebabecký, Hubert - Procházková, Eliška - Dejmek, Milan - Guillon, Rémi - Strunin, Dmytro - Weber, Jan - Lee, G. - Birkuš, G. - Mertlíková-Kaiserová, Helena - Bouřa, Evžen - Nencka, Radim
Highly Selective Phosphatidylinositol 4-Kinase III beta Inhibitors and Structural Insight into Their Mode of Action.
Journal of Medicinal Chemistry. Roč. 58, č. 9 (2015), s. 3767-3793. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LO1302; GA ČR GA15-09310S; GA ČR GJ15-21030Y
EU Projects: European Commission(XE) 333916 - STARPI4K
Institutional support: RVO:61388963
Keywords : phosphatidylinositol 4-kinase III beta * broad-spectrum antiviral agents * positive-sense RNA viruses
Subject RIV: CC - Organic Chemistry
Impact factor: 5.589, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247293