Search results
- 1.0556564 - ÚOCHB 2023 RIV AE eng J - Journal Article
Toman, D. - Jorda, R. - Ajani, Haresh - Kryštof, V. - Cankař, P.
Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases.
Medicinal Chemistry. Roč. 18, č. 4 (2022), s. 484-496. ISSN 1573-4064. E-ISSN 1875-6638
Institutional support: RVO:61388963
Keywords : CDK inhibitors * styrylpyrazoles * Suzuki-Miyaura cross-coupling reaction * Vilsmeier-Haack reaction * CAN508 * K562
OECD category: Medicinal chemistry
Impact factor: 2.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.2174/1573406417666210806095710
Permanent Link: http://hdl.handle.net/11104/0330725 - 2.0545107 - ÚOCHB 2022 RIV US eng J - Journal Article
Dayal, N. - Řezníčková, E. - Hernandez, D. E. - Peřina, M. - Torregrosa-Allen, S. - Elzey, B. D. - Škerlová, Jana - Ajani, Haresh - Djukic, Stefan - Vojáčková, V. - Lepšík, Martin - Řezáčová, Pavlína - Kryštof, V. - Jorda, R. - Sintim, H. O.
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Journal of Medicinal Chemistry. Roč. 64, č. 15 (2021), s. 10981-10996. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : discovery * FLT3 * cell proliferation
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c00330
Permanent Link: http://hdl.handle.net/11104/0321867 - 3.0543264 - ÚEB 2022 RIV GB eng J - Journal Article
Kiełczewska, U. - Jorda, Radek - Gonzalez, Gabriel - Morzycki, J.W. - Ajani, Haresh - Svrčková, K. - Štěpánková, Š. - Wojtkielewicz, A.
The synthesis and cholinesterase inhibitory activities of solasodine analogues with seven-membered F ring.
Journal of Steroid Biochemistry and Molecular Biology. Roč. 205, JAN (2021), č. článku 105776. ISSN 0960-0760
R&D Projects: GA ČR GA20-15621S
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Cholinesterase inhibition * Ring expansion * Solasodine * Spiro compounds * Spirostane * Steroidal alkaloids
OECD category: Biochemistry and molecular biology
Impact factor: 5.011, year: 2021
Method of publishing: Open access
http://doi.org/10.1016/j.jsbmb.2020.105776
Permanent Link: http://hdl.handle.net/11104/0320501File Download Size Commentary Version Access 2021_Kielczewska_JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY_105776.pdf 3 3.5 MB Other open-access - 4.0525593 - ÚOCHB 2021 RIV DE eng J - Journal Article
Kalčic, Filip - Kolman, Viktor - Ajani, Haresh - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema.
ChemMedChem. Roč. 15, č. 15 (2020), s. 1398-1407. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : anti-inflammatory * mPGES-1 * prostaglandin E2 * pyrimidines * Suzuki Miyaura reaction
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 3.466, year: 2020
Method of publishing: Limited access
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202000258
Permanent Link: http://hdl.handle.net/11104/0309705 - 5.0523373 - ÚOCHB 2021 RIV GB eng J - Journal Article
Köprülüoglu, Cemal - Dejmek, Milan - Šála, Michal - Ajani, Haresh - Hřebabecký, Hubert - Fanfrlík, Jindřich - Jorda, Radek - Dračínský, Martin - Procházková, Eliška - Šácha, Pavel - Kryštof, Vladimír - Hobza, Pavel - Lepšík, Martin - Nencka, Radim
Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors.
Journal of Molecular Recognition. Roč. 33, č. 8 (2020), č. článku e2842. ISSN 0952-3499. E-ISSN 1099-1352
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61389030
Keywords : ATP-competitive type I inhibitors * cyclin-dependent kinase 2 * protein-ligand binding * quantum mechanical scoring
OECD category: Physical chemistry
Impact factor: 2.137, year: 2020
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmr.2842
Permanent Link: http://hdl.handle.net/11104/0307732 - 6.0512138 - ÚEB 2020 RIV FR eng J - Journal Article
Řezníčková, Eva - Gucký, Tomáš - Kováčová, Veronika - Ajani, Haresh - Jorda, Radek - Kryštof, Vladimír
Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity.
European Journal of Medicinal Chemistry. Roč. 182, Nov 15 (2019), č. článku 111663. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Acute myeloid leukaemia * Eosinophilic leukaemia * Kinase inhibitor * PDGFRα
OECD category: Hematology
Impact factor: 5.573, year: 2019
Method of publishing: Limited access
http://dx.doi.org/10.1016/j.ejmech.2019.111663
Permanent Link: http://hdl.handle.net/11104/0302348File Download Size Commentary Version Access 2019_Reznickova_European Journal of Medicinal Chemistry_111663.pdf 3 2.9 MB Other require - 7.0492387 - ÚOCHB 2019 RIV GB eng J - Journal Article
Ajani, Haresh - Jansa, J. - Köprülüoglu, Cemal - Hobza, Pavel - Kryštof, Vladimír - Lyčka, A. - Lepšík, Martin
Imidazo[1,2-c]pyrimidin-5(6H)-one as a novel core of cyclin-dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring.
Journal of Molecular Recognition. Roč. 31, č. 9 (2018), č. článku e2720. ISSN 0952-3499. E-ISSN 1099-1352
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61389030
Keywords : binding mode * physics-based scoring * protein-ligand binding
OECD category: Biophysics
Impact factor: 1.919, year: 2018
Permanent Link: http://hdl.handle.net/11104/0285946 - 8.0490059 - ÚEB 2019 RIV US eng J - Journal Article
Gucký, T. - Řezníčková, Eva - Radošová Muchová, T. - Jorda, Radek - Klejová, Z. - Malínková, V. - Berka, K. - Bazgier, V. - Ajani, Haresh - Lepšík, Martin - Divoký, V. - Kryštof, Vladimír
Discovery of N-2-(4-Amino-cyclohexyl)-9-cyclopentyl-N-6-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.
Journal of Medicinal Chemistry. Roč. 61, č. 9 (2018), s. 3855-3869. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LO1204; GA MŠMT(CZ) LM2015047; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : INTERNAL TANDEM DUPLICATION * AMG 925 * QUIZARTINIB
OECD category: Hematology; Medicinal chemistry (UOCHB-X)
Impact factor: 6.054, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284356File Download Size Commentary Version Access 2018_Gucky_JOURNAL OF MEDICINAL CHEMISTRY_3855.pdf 1 5.1 MB Other open-access - 9.0487122 - ÚOCHB 2018 RIV US eng J - Journal Article
Ajani, Haresh - Pecina, Adam - Eyrilmez, Saltuk M. - Fanfrlík, Jindřich - Haldar, Susanta - Řezáč, Jan - Hobza, Pavel - Lepšík, Martin
Superior Performance of the SQM/COSMO Scoring Functions in Native Pose Recognition of Diverse Protein-Ligand Complexes in Cognate Docking.
ACS Omega. Roč. 2, č. 7 (2017), s. 4022-4029. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GJ16-11321Y
Institutional support: RVO:61388963
Keywords : aldose reductase inhibition * biological applications * mechanical calculations
OECD category: Physical chemistry
https://pubs.acs.org/doi/full/10.1021/acsomega.7b00503
Permanent Link: http://hdl.handle.net/11104/0281802 - 10.0475922 - ÚOCHB 2018 RIV FR eng J - Journal Article
Hylsová, M. - Carbain, B. - Fanfrlík, Jindřich - Musilová, L. - Haldar, Susanta - Köprülüoglu, Cemal - Ajani, Haresh - Brahmkshatriya, Pathik - Jorda, Radek - Kryštof, Vladimír - Hobza, Pavel - Echalier, A. - Paruch, K. - Lepšík, Martin
Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.
European Journal of Medicinal Chemistry. Roč. 126, Jan 27 (2017), s. 1118-1128. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA15-15264S; GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963 ; RVO:61389030
Keywords : cyclin-dependent kinase 2 * ATP-competitive type I inhibitors * pyrazolo[1,5-a]pyrimidine * quantum mechanical scoring * protein-ligand binding * molecular dynamics
OECD category: Organic chemistry
Impact factor: 4.816, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272505File Download Size Commentary Version Access 2017_Hylsova_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_1118.pdf 1 1.7 MB Other open-access