Search results
- 1.0580702 - MBÚ 2025 RIV NL eng J - Journal Article
Kovář, Marek - Šubr, Vladimír - Běhalová, Kateřina - Studenovský, Martin - Starenko, Daniil - Kovářová, Jiřina - Procházková, Petra - Etrych, Tomáš - Kostka, Libor
Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation.
Nanomedicine: Nanotechnology, Biology and Medicine. Roč. 56, February 2024 (2024), s. 102730. ISSN 1549-9634. E-ISSN 1549-9642
R&D Projects: GA MZd(CZ) NU21-03-00273; GA MŠMT LX22NPO5102
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : STAT3 inhibitor * Doxorubicin * HPMA copolymer carrier * pH-sensitive drug * release
OECD category: Pharmacology and pharmacy; Medicinal chemistry (UMCH-V)
Impact factor: 5.4, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S1549963423000813
Permanent Link: https://hdl.handle.net/11104/0349459File Download Size Commentary Version Access 0580702.pdf 1 5 MB CC BY license Publisher’s postprint open-access Kovar et al_Nanomedicine.pdf 0 5 MB Publisher’s postprint open-access - 2.0569557 - ÚMG 2024 RIV GB eng J - Journal Article
Tsyklauri, Oksana - Chadimová, Tereza - Niederlová, Veronika - Kovářová, Jiřina - Michálik, Juraj - Malátová, Iva - Janušová, Šárka - Ivashchenko, Olha - Rossez, H. - Drobek, Aleš - Večeřová, Hana - Galati, V. - Kovář, Marek - Štěpánek, Ondřej
Regulatory T cells suppress the formation of potent KLRK1 and IL- 7R expressing effector CD8 T cells by limiting IL-2.
eLife. Roč. 12, Jan 27 (2023), č. článku e79342. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MŠMT LX22NPO5102; GA ČR GJ19-03435Y; GA ČR(CZ) GA22-20548S; GA ČR GA22-18046S; GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109
EU Projects: European Commission(XE) 802878 - FunDiT
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : IL-2 * T cells * autoimmunity * cytotoxic * immune suppression * immunology * inflammation * mouse * regulatory T cells
OECD category: Immunology; Immunology (MBU-M)
Impact factor: 7.7, year: 2022
Method of publishing: Open access
https://elifesciences.org/articles/79342
Permanent Link: https://hdl.handle.net/11104/0340929File Download Size Commentary Version Access elife-Tsyklauri O.-2023.pdf 0 3.4 MB Publisher’s postprint open-access - 3.0559474 - ÚMCH 2023 RIV US eng J - Journal Article
Kousalová, Jana - Šírová, Milada - Kostka, Libor - Šubr, Vladimír - Kovářová, Jiřina - Běhalová, Kateřina - Studenovský, Martin - Kovář, Marek - Etrych, Tomáš
Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines.
Nanomedicine: Nanotechnology, Biology and Medicine. Roč. 44, August (2022), č. článku 102578. ISSN 1549-9634. E-ISSN 1549-9642
R&D Projects: GA MŠMT(CZ) LTAUSA18083
Grant - others:AV ČR(CZ) JSPS-22-01
Program: Bilaterální spolupráce
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : matrix metalloproteinases * metastases * actinonin
OECD category: Polymer science; Oncology (MBU-M)
Impact factor: 5.4, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1549963422000648?via%3Dihub
Permanent Link: https://hdl.handle.net/11104/0332758 - 4.0558143 - ÚMCH 2023 RIV CH eng J - Journal Article
Studenovský, Martin - Rumlerová, Anna - Kovářová, Jiřina - Dvořáková, Barbora - Sivák, Ladislav - Kostka, Libor - Berdár, Daniel - Etrych, Tomáš - Kovář, Marek
HPMA copolymer mebendazole conjugate allows systemic administration and possesses antitumour activity in vivo.
Pharmaceutics. Roč. 14, č. 6 (2022), č. článku 1201. E-ISSN 1999-4923
R&D Projects: GA ČR(CZ) GA19-05649S; GA MŠMT(CZ) LTAUSA18083
Grant - others:AV ČR(CZ) JSPS-22-01
Program: Bilaterální spolupráce
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : mebendazole * drug delivery * cancer therapy
OECD category: Polymer science; Pharmacology and pharmacy (MBU-M)
Impact factor: 5.4, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1999-4923/14/6/1201
Permanent Link: https://hdl.handle.net/11104/0333076 - 5.0558142 - ÚMCH 2023 RIV US eng J - Journal Article
Kostka, Libor - Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Šírová, Milada - Říhová, Blanka - Sedláček, Radislav - Etrych, Tomáš - Kovář, Marek
Simultaneous delivery of doxorubicin and protease inhibitor derivative to solid tumors via star-shaped polymer nanomedicines overcomes P-gp- and STAT3-mediated chemoresistance.
Biomacromolecules. Roč. 23, č. 6 (2022), s. 2522-2535. ISSN 1525-7797. E-ISSN 1526-4602
R&D Projects: GA ČR(CZ) GA19-05649S; GA MZd(CZ) NU21-03-00273; GA MŠMT(CZ) LTAUSA18083; GA MŠMT(CZ) LM2018126; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61389013 ; RVO:61388971 ; RVO:68378050
Keywords : HPMA * RAFT * star-like
OECD category: Polymer science; Microbiology (MBU-M); Genetics and heredity (medical genetics to be 3) (UMG-J)
Impact factor: 6.2, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.biomac.2c00256
Permanent Link: https://hdl.handle.net/11104/0332796 - 6.0550778 - MBÚ 2022 RIV GB eng J - Journal Article
Tomala, Jakub - Weberová, Petra - Tomalová, Barbora - Zákostelská, Zuzana - Sivák, Ladislav - Kovářová, Jiřina - Kovář, Marek
IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-gamma production by CD25(+)Foxp3(-) T cells.
eLife. Roč. 10, DEC 21 2021 (2021), č. článku e62432. ISSN 2050-084X. E-ISSN 2050-084X
R&D Projects: GA ČR GA13-12885S; GA ČR(CZ) GA18-12973S; GA MZd(CZ) NV19-03-00179
Institutional support: RVO:61388971
Keywords : il-2 * tolerance * responses * suppression * il-2 * anti-il-2 mab complexes * cd25 * T cells * IFN-gamma * lps * hyperreactivity * Mouse
OECD category: Immunology
Impact factor: 8.713, year: 2021
Method of publishing: Open access
https://elifesciences.org/articles/62432
Permanent Link: http://hdl.handle.net/11104/0326088 - 7.0542896 - MBÚ 2022 RIV NL eng J - Journal Article
Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Dvořáková, Barbora - Šírová, Milada - Říhová, Blanka - Randárová, Eva - Kraus, Michal - Tomala, Jakub - Studenovský, Martin - Vondráčková, Michaela - Sedláček, Radislav - Makovický, Peter - Fučíková, J. - Vošahlíková, Š. - Spíšek, R. - Kostka, Libor - Etrych, Tomáš - Kovář, Marek
Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.
Journal of Controlled Release. Roč. 332, APR 10 2021 (2021), s. 563-580. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR(CZ) GA19-05649S; GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: CCP - 90040
Institutional support: RVO:61388971 ; RVO:61389013 ; RVO:68378050
Keywords : Ritonavir derivate * Polymer carrier * pH-controlled release * Antitumor activity * Proteasome inhibition * STAT3 signaling inhibition
OECD category: Microbiology; Polymer science (UMCH-V)
Impact factor: 11.467, year: 2021
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0168365921001267
Permanent Link: http://hdl.handle.net/11104/0320232 - 8.0399622 - MBÚ 2014 RIV US eng J - Journal Article
Tomala, Jakub - Kovářová, Jiřina - Kabešová, Martina - Votavová, Petra - Chmelová, Helena - Dvořáková, Barbora - Říhová, Blanka - Kovář, Marek
Chimera of IL-2 Linked to Light Chain of anti-IL-2 mAb Mimics IL-2/anti-IL-2 mAb Complexes Both Structurally and Functionally.
ACS Chemical Biology. Roč. 8, č. 5 (2013), s. 871-876. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR GAP301/11/0325
Institutional support: RVO:61388971
Keywords : IN-VIVO EXPANSION * IL-2 * ANTIBODY
Subject RIV: CE - Biochemistry
Impact factor: 5.356, year: 2013
Permanent Link: http://hdl.handle.net/11104/0227039 - 9.0154815 - MBU-M 20030184 RIV US eng J - Journal Article
El-Azami-El-Idrisi, M. - Bauche, C. - Loucká, Jiřina - Osička, Radim - Šebo, Peter - Ladant, D. - Leclerc, C.
Internation of Bordetella pertussis Adenylate Cyclase with CD11b/CD18.
Journal of Biological Chemistry. Roč. 278, č. 40 (2003), s. 38514-38521. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA AV ČR IPP1050128; GA ČR GA310/01/0934; GA AV ČR IAA5020907
Grant - others:GA by National Institutes of Health Grant(XX) 55000334; GA QLK2-CT-1999(XX) 00556
Institutional research plan: CEZ:AV0Z5020903
Keywords : cyaa * rtx * cd11b
Subject RIV: EE - Microbiology, Virology
Impact factor: 6.482, year: 2003
Permanent Link: http://hdl.handle.net/11104/0052299 - 10.0154375 - MBU-M 20020005 RIV US eng J - Journal Article
Loucká, Jiřina - Schlecht, G. - Vojtová, Jana - Leclerc, C. - Šebo, Peter
Delivery of a MalE CD4+-T-Cell Epitope into the Major Histocompatibility Complex Class II Antigen Presentation Pathway by Bordetella pertussis Adenylate Cyclase ral NPKSupply.
Infection and Immunity. Roč. 70, č. 2 (2002), s. 1002-1005. ISSN 0019-9567. E-ISSN 1098-5522
R&D Projects: GA ČR GA310/01/0934; GA AV ČR IAA5020907; GA MŠMT ME 167
Grant - others:QLK2-CT(US) 00556
Institutional research plan: CEZ:AV0Z5020903
Keywords : delivery * epitope * complex
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.039, year: 2002
Permanent Link: http://hdl.handle.net/11104/0051865