Search results
- 1.0512138 - ÚEB 2020 RIV FR eng J - Journal Article
Řezníčková, Eva - Gucký, Tomáš - Kováčová, Veronika - Ajani, Haresh - Jorda, Radek - Kryštof, Vladimír
Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity.
European Journal of Medicinal Chemistry. Roč. 182, Nov 15 (2019), č. článku 111663. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Acute myeloid leukaemia * Eosinophilic leukaemia * Kinase inhibitor * PDGFRα
OECD category: Hematology
Impact factor: 5.573, year: 2019
Method of publishing: Limited access
http://dx.doi.org/10.1016/j.ejmech.2019.111663
Permanent Link: http://hdl.handle.net/11104/0302348File Download Size Commentary Version Access 2019_Reznickova_European Journal of Medicinal Chemistry_111663.pdf 3 2.9 MB Other require - 2.0509260 - ÚEB 2020 RIV FR eng J - Journal Article
Jorda, Radek - Řezníčková, Eva - Kiełczewska, U. - Maj, J. - Morzycki, J.W. - Siergiejczyk, L. - Bazgier, Václav - Berka, K. - Rárová, Lucie - Wojtkielewicz, A.
Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines.
European Journal of Medicinal Chemistry. Roč. 179, OCT 1 (2019), s. 483-492. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA ČR(CZ) GA19-01383S; GA MŠMT(CZ) LM2015047
Institutional support: RVO:61389030
Keywords : Galeterone * Prostate * Steroid
OECD category: Organic chemistry
Impact factor: 5.573, year: 2019
Method of publishing: Open access
http://dx.doi.org/10.1016/j.ejmech.2019.06.040
Permanent Link: http://hdl.handle.net/11104/0300005File Download Size Commentary Version Access 2019_Jorda_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_483.pdf 1 2.2 MB Other open-access - 3.0507951 - ÚEB 2020 RIV FR eng J - Journal Article
Jorda, Radek - Lopes, S. M.M. - Řezníčková, Eva - Ajani, H. - Pereira, A. V. - Gomes, C. S.B. - Pinho e Melo, T. M.V.D.
Tetrahydropyrazolo[1,5-a]pyridine-fused steroids and their in vitro biological evaluation in prostate cancer.
European Journal of Medicinal Chemistry. Roč. 178, SEP 15 (2019), s. 168-176. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61389030
Keywords : Androgen * Galeterone * Prostate * pyrazolo[1,5-a]pyridine * Steroid
OECD category: Oncology
Impact factor: 5.573, year: 2019
Method of publishing: Open access
http://dx.doi.org/10.1016/j.ejmech.2019.05.064
Permanent Link: http://hdl.handle.net/11104/0298976File Download Size Commentary Version Access 2019_Jorda_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_168.pdf 0 1.8 MB Other open-access - 4.0496501 - ÚEB 2019 RIV US eng J - Journal Article
Jorda, Radek - Hendrychová, Denisa - Voller, Jiří - Řezníčková, Eva - Gucký, Tomáš - Kryštof, Vladimír
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
Journal of Medicinal Chemistry. Roč. 61, č. 20 (2018), s. 9105-9120. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LO1204; GA ČR GA17-14007S
Institutional support: RVO:61389030
Keywords : small-molecule inhibitors * metastatic breast-cancer * 1st global approval * thermal shift assay * dna-damage response * in-vitro * androgen receptor * cdk inhibitors * highly potent * 2,6,9-trisubstituted purines
OECD category: Oncology
Impact factor: 6.054, year: 2018
Permanent Link: http://hdl.handle.net/11104/0289264File Download Size Commentary Version Access 2018_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_9105.pdf 5 7.3 MB Other open-access - 5.0490059 - ÚEB 2019 RIV US eng J - Journal Article
Gucký, T. - Řezníčková, Eva - Radošová Muchová, T. - Jorda, Radek - Klejová, Z. - Malínková, V. - Berka, K. - Bazgier, V. - Ajani, Haresh - Lepšík, Martin - Divoký, V. - Kryštof, Vladimír
Discovery of N-2-(4-Amino-cyclohexyl)-9-cyclopentyl-N-6-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.
Journal of Medicinal Chemistry. Roč. 61, č. 9 (2018), s. 3855-3869. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LO1204; GA MŠMT(CZ) LM2015047; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : INTERNAL TANDEM DUPLICATION * AMG 925 * QUIZARTINIB
OECD category: Hematology; Medicinal chemistry (UOCHB-X)
Impact factor: 6.054, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284356File Download Size Commentary Version Access 2018_Gucky_JOURNAL OF MEDICINAL CHEMISTRY_3855.pdf 1 5.1 MB Other open-access - 6.0489492 - ÚEB 2019 RIV FR eng J - Journal Article
Milišiunaitė, V. - Arbačiauskienė, E. - Řezníčková, Eva - Jorda, Radek - Malínková, V. - Žukauskaitė, Asta - Holzer, W. - Šačkus, A. - Kryštof, Vladimír
Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.
European Journal of Medicinal Chemistry. Roč. 150, APR 25 (2018), s. 908-919. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : Apoptosis * G2/M cell cycle arrest * Pyrazole * Structure-activity relationships
OECD category: Biochemistry and molecular biology
Impact factor: 4.833, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283900File Download Size Commentary Version Access 2018_Milisiunaite_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_908.pdf 3 1.8 MB Other open-access - 7.0488706 - ÚEB 2019 RIV NL eng J - Journal Article
Jorda, Radek - Bučková, Zuzana - Řezníčková, Eva - Bouchal, J. - Kryštof, Vladimír
Selective inhibition reveals cyclin-dependent kinase 2 as another kinase that phosphorylates the androgen receptor at serine 81.
Biochimica Et Biophysica Acta-Molecular Cell Research. Roč. 1865, č. 2 (2018), s. 354-363. ISSN 0167-4889. E-ISSN 1879-2596
R&D Projects: GA MŠMT(CZ) LO1204; GA MŠMT(CZ) LO1304
Institutional support: RVO:61389030
Keywords : Androgen receptor * Cyclin-dependent kinase * Inhibitor * Phosphorylation * Serine 81
OECD category: Biochemistry and molecular biology
Impact factor: 4.739, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283248File Download Size Commentary Version Access 2018_Jorda_BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH_354.pdf 2 2.4 MB Other open-access - 8.0482957 - ÚEB 2018 RIV GB eng J - Journal Article
Malínková, Veronika - Řezníčková, Eva - Jorda, Radek - Gucký, T. - Kryštof, Vladimír
Trisubstituted purine inhibitors of PDGFR alpha and their antileukemic activity in the human eosinophilic cell line EOL-1.
Bioorganic & Medicinal Chemistry. Roč. 25, č. 24 (2017), s. 6523-6535. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : dependent kinase inhibitors * src tyrosine kinase * 2,6,9-trisubstituted purines * therapeutic target * potent inhibitor * imatinib * leukemia * mutations * mutant * domain
OECD category: Hematology
Impact factor: 2.881, year: 2017
Permanent Link: http://hdl.handle.net/11104/0278331File Download Size Commentary Version Access 2017_Malinkova_Bioorganic & medicinal chemistry_6523.pdf 1 1.1 MB Other open-access - 9.0481497 - ÚEB 2018 RIV JP eng J - Journal Article
Cavallaro, V. - Řezníčková, Eva - Jorda, Radek - Alza, N.P. - Murray, A.P. - Kryštof, Vladimír
Semisynthetic Esters of 17-Hydroxycativic Acid with in Vitro Cytotoxic Activity against Leukemia Cell Lines.
Biological & Pharmaceutical Bulletin. Roč. 40, č. 11 (2017), s. 1923-1928. ISSN 0918-6158
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : biological evaluation * derivatives * andrographolide * apoptosis * cancer * agents * diterpenes * inhibition * activation * chemistry * diterpenoid * 17-hydroxycativic acid * cytotoxic activity * human cancer cell * apoptosis
OECD category: Hematology
Impact factor: 1.694, year: 2017
Permanent Link: http://hdl.handle.net/11104/0277043File Download Size Commentary Version Access 2017_Cavallaro_BIOLOGICAL & PHARMACEUTICAL BULLETIN_1923.pdf 2 957.7 KB Other open-access - 10.0479189 - ÚEB 2018 RIV US eng J - Journal Article
Xavier, N.M. - Goncalves-Pereira, R. - Jorda, Radek - Řezníčková, Eva - Kryštof, Vladimír - Oliveira, M.C.
Synthesis and antiproliferative evaluation of novel azido nucleosides and their phosphoramidate derivatives.
Pure and Applied Chemistry. Roč. 89, č. 9 (2017), s. 1267-1281. ISSN 0033-4545. E-ISSN 1365-3075
R&D Projects: GA MŠMT(CZ) LO1204
Institutional support: RVO:61389030
Keywords : anticancer activity * azido nucleosides * bioactive molecules * ics-28 * N-glycosylation * nucleoside phosphoramidates * nucleoside/nucleotide analogs * Staudinger-phosphite reaction
OECD category: Organic chemistry
Impact factor: 5.294, year: 2017
Permanent Link: http://hdl.handle.net/11104/0275188File Download Size Commentary Version Access 2017_Xavier_PURE AND APPLIED CHEMISTRY_1267.pdf 0 603.4 KB Other open-access