Search results

  1. 1.
    0524504 - BTÚ 2021 RIV US eng J - Journal Article
    Ustinova, Kseniya - Nováková, Zora - Saito, M. - Meleshin, M. - Mikesova, Jana - Kutil, Zsofia - Baranová, Petra - Havlínová, Barbora - Schutkowski, M. - Matthias, P. - Bařinka, Cyril
    The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation.
    Journal of Biological Chemistry. Roč. 295, č. 9 (2020), s. 2614-2628. ISSN 0021-9258
    R&D Projects: GA MŠk(CZ) LM2015062; GA ČR GA15-19640S; GA MŠk(CZ) LM2015043; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : structure-function * protein-protein interaction * substrate specificity
    Subject RIV: EB - Genetics ; Molecular Biology
    OBOR OECD: Biochemistry and molecular biology
    Impact factor: 4.106, year: 2018
    https://www.jbc.org/content/295/9/2614.full#ack-1
    Permanent Link: http://hdl.handle.net/11104/0308861
     
  2. 2.
    0520948 - BTÚ 2020 RIV US eng J - Journal Article
    Kozikowski, A. P. - Shen, S. - Pardo, M. - Tayares, M. T. - Szarics, D. - Benoy, V. - Zimprich, Ch. A. - Kutil, Zsofia - Zhang, G. - Bařinka, Cyril - Robers, M. B. - Van den Bosch, L. - Eubanks, J. H. - Jope, R. S.
    Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome.
    ACS Chemical Neuroscience. Roč. 10, č. 3 (2019), s. 1679-1695. ISSN 1948-7193
    R&D Projects: GA ČR GA15-19640S; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : fmr1 knockout mice * mental-retardation protein * tubulin acetylation * metabotropic glutamate * negative regulator
    Subject RIV: EB - Genetics ; Molecular Biology
    OBOR OECD: Biochemistry and molecular biology
    Impact factor: 3.861, year: 2018
    https://pubs.acs.org/doi/10.1021/acschemneuro.8b00600
    Permanent Link: http://hdl.handle.net/11104/0305622
     
  3. 3.
    0519605 - BTÚ 2020 RIV US eng J - Journal Article
    Kutil, Zsofia - Mikesova, Jana - Zessin, M. - Meleshin, M. - Nováková, Zora - Alquicer, Glenda - Kozikowski, A. - Sippl, W. - Bařinka, Cyril - Schutkowski, M.
    Continuous Activity Assay for HDAC11 Enabling Reevaluation of HDAC Inhibitors.
    ACS Omega. Roč. 4, č. 22 (2019), s. 19895-19904. ISSN 2470-1343
    R&D Projects: GA ČR GA15-19640S; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : histone deacetylase inhibitors * sir2 family * POSTTRANSLATIONAL MODIFICATIONS
    Subject RIV: EB - Genetics ; Molecular Biology
    OBOR OECD: Biochemistry and molecular biology
    Impact factor: 2.584, year: 2018
    https://pubs.acs.org/doi/10.1021/acsomega.9b02808
    Permanent Link: http://hdl.handle.net/11104/0305194
     
  4. 4.
    0519596 - BTÚ 2020 RIV US eng J - Journal Article
    Zessin, M. - Kutil, Zsofia - Meleshin, M. - Nováková, Zora - Ghazy, E. - Kalbas, D. - Marek, M. - Romier, Ch. - Sippl, W. - Bařinka, Cyril - Schutkowski, M.
    One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity.
    Biochemistry. Roč. 58, č. 48 (2019), s. 4777-4789. ISSN 0006-2960
    R&D Projects: GA ČR GA15-19640S; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : fluorescence quenching probes * epsilon-thioacetyl-lysine * deacetylase assay * sir2 family
    Subject RIV: EB - Genetics ; Molecular Biology
    OBOR OECD: Biochemistry and molecular biology
    Impact factor: 2.952, year: 2018
    https://pubs.acs.org/doi/10.1021/acs.biochem.9b00786
    Permanent Link: http://hdl.handle.net/11104/0304590
     
  5. 5.
    0510836 - BTÚ 2020 RIV US eng J - Journal Article
    Banerjee, S. R. - Kumar, V. - Lisok, A. - Plyku, D. - Nováková, Zora - Brummet, M. - Wharram, B. - Bařinka, Cyril - Hobbs, R. - Pomper, M.G.
    Evaluation of In-111-DOTA-5D3, a Surrogate SPECT Imaging Agent for Radioimmunotherapy of Prostate-Specific Membrane Antigen.
    Journal of Nuclear Medicine. Roč. 60, č. 3 (2019), s. 400-406. ISSN 0161-5505
    Institutional support: RVO:86652036
    Keywords : SPECT/CT * immunoimaging * PSMA * monoclonal antibody
    Subject RIV: FP - Other Medical Disciplines
    OBOR OECD: Radiology, nuclear medicine and medical imaging
    Impact factor: 7.308, year: 2018
    http://jnm.snmjournals.org/content/60/3/400
    Permanent Link: http://hdl.handle.net/11104/0301229
     
  6. 6.
    0510823 - BTÚ 2020 RIV GB eng J - Journal Article
    Knox, T. - Sahakian, E. - Banik, D. - Hadley, M. - Palmer, E. - Noonepalle, S. - Kim, J. - Powers, J. - Gracia-Hernandez, M. - Oliveira, V. - Cheng, F. - Chen, J. - Bařinka, Cyril - Pinilla-Ibarz, J. - Lee, N. H. - Kozikowski, A. - Villagra, A.
    Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells.
    Scientific Reports. Roč. 9, APR 16 2019 (2019), č. článku 6136. ISSN 2045-2322
    Institutional support: RVO:86652036
    Keywords : HISTONE DEACETYLASE 6 * LIGAND 1 EXPRESSION * INFILTRATING LYMPHOCYTES
    Subject RIV: EB - Genetics ; Molecular Biology
    OBOR OECD: Biochemistry and molecular biology
    Impact factor: 4.011, year: 2018
    https://www.nature.com/articles/s41598-019-42237-3
    Permanent Link: http://hdl.handle.net/11104/0301209
     
  7. 7.
    0510407 - BTÚ 2020 RIV US eng J - Journal Article
    Wu, H. - Yang, K. - Zhang, Z. - Leisten, E.D. - Li, Z. - Xie, H. - Liu, J. - Smith, K. A. - Nováková, Zora - Bařinka, Cyril - Tang, W.
    Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity.
    Journal of Medicinal Chemistry. Roč. 62, č. 15 (2019), s. 7042-7057. ISSN 0022-2623
    R&D Projects: GA ČR GA15-19640S; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : INDUCED PROTEIN-DEGRADATION * E3 UBIQUITIN LIGASE * MULTIPLE-MYELOMA
    Subject RIV: FR - Pharmacology ; Medidal Chemistry
    OBOR OECD: Pharmacology and pharmacy
    Impact factor: 6.054, year: 2018
    https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00516
    Permanent Link: http://hdl.handle.net/11104/0300924
     
  8. 8.
    0510398 - BTÚ 2020 RIV US eng J - Journal Article
    Shen, S. - Hadley, M. - Ustinova, Kseniya - Pavlíček, Jiří - Knox, T. - Noonepalle, S. - Tavares, M. T. - Zimprich, Ch. A. - Zhang, A. - Robers, M. B. - Bařinka, Cyril - Kozikowski, A. P. - Villagra, A.
    Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models.
    Journal of Medicinal Chemistry. Roč. 62, č. 18 (2019), s. 8557-8577. ISSN 0022-2623
    R&D Projects: GA ČR GA15-19640S; GA MŠk(CZ) LM2015043; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036
    Keywords : HDAC6-SELECTIVE INHIBITORS * ACQUIRED-RESISTANCE * HDAC6 INHIBITOR
    Subject RIV: FR - Pharmacology ; Medidal Chemistry
    OBOR OECD: Pharmacology and pharmacy
    Impact factor: 6.054, year: 2018
    https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00946
    Permanent Link: http://hdl.handle.net/11104/0300905
     
  9. 9.
    0505012 - BTÚ 2020 RIV US eng J - Journal Article
    Kutil, Zsofia - Škultétyová, Ĺubica - Rauh, D. - Meleshin, M. - Šnajdr, Ivan - Nováková, Zora - Mikesova, Jana - Pavlíček, Jiří - Hadzima, Martin - Baranová, Petra - Havlínová, Barbora - Majer, Pavel - Schutkowski, M. - Bařinka, Cyril
    The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries.
    FASEB Journal. Roč. 33, č. 3 (2019), s. 4035-4045. ISSN 0892-6638
    R&D Projects: GA ČR GA15-19640S; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:86652036 ; RVO:61388963
    Keywords : human acetylome * deacylation * deformylation
    Subject RIV: EB - Genetics ; Molecular Biology; EB - Genetics ; Molecular Biology (UOCHB-X)
    OBOR OECD: Biochemistry and molecular biology; Biochemistry and molecular biology (UOCHB-X)
    Impact factor: 5.391, year: 2018
    https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201801680R
    Permanent Link: http://hdl.handle.net/11104/0296540
     
  10. 10.
    0501629 - BTÚ 2019 RIV GB eng J - Journal Article
    Bařinka, Cyril - Nováková, Zora - Hin, N. - Bím, Daniel - Ferraris, D. V. - Duvall, B. - Kabarriti, G. - Tsukamoto, R. - Buděšínský, Miloš - Motlová, Lucia - Rojas, C. - Slusher, B. S. - Rokob, T. A. - Rulíšek, Lubomír - Tsukamoto, T.
    Structural and computational basis for potent inhibition of glutamate carboxypeptidase II by carbamate-based inhibitors.
    Bioorganic & Medicinal Chemistry. Roč. 27, č. 2 (2019), s. 255-264. ISSN 0968-0896
    R&D Projects: GA MŠk(CZ) LM2015043; GA MŠk(CZ) EF16_013/0001776; GA MŠk(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA17-24155S
    Grant - others:Ga MŠk(CZ) LM2015070
    Institutional support: RVO:86652036 ; RVO:61388963
    Keywords : Glutamate carboxypeptidase II * Prostate-specific membrane antigen * Crystal structure
    Subject RIV: EB - Genetics ; Molecular Biology; CF - Physical ; Theoretical Chemistry (UOCHB-X)
    OBOR OECD: Biochemistry and molecular biology; Physical chemistry (UOCHB-X)
    Impact factor: 2.802, year: 2018
    Permanent Link: http://hdl.handle.net/11104/0293626