Search results
- 1.0583095 - ÚOCHB 2025 RIV US eng J - Journal Article
Štěpánová, Sille - Andris, Erik - Gutten, Ondrej - Buděšínský, Miloš - Dejmek, Milan - Břehová, Petra - Rulíšek, Lubomír - Kašička, Václav
Acidity constants and protonation sites of cyclic dinucleotides determined by capillary electrophoresis, quantum chemical calculations, and NMR spectroscopy.
Electrophoresis. Roč. 45, 7/8 (2024), s. 687-705. ISSN 0173-0835. E-ISSN 1522-2683
Institutional support: RVO:61388963
Keywords : acidity constant * capillary electrophoresis * cyclic dinucleotides * DFT calculations * NMR spectroscopy
Impact factor: 2.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/elps.202300232
Permanent Link: https://hdl.handle.net/11104/0351092 - 2.0581779 - ÚOCHB 2025 RIV US eng J - Journal Article
Štěpánová, Sille - Břehová, Petra - Kašička, Václav
The separation of cyclic diadenosine diphosphorothioate and the diastereomers of its difluorinated derivative and the estimation of the binding constants and ionic mobilities of their complexes with 2-hydroxypropyl-β-cyclodextrin by affinity capillary electrophoresis.
Electrophoresis. (2024). ISSN 0173-0835. E-ISSN 1522-2683
R&D Projects: GA ČR(CZ) GA20-03899S
Institutional support: RVO:61388963
Keywords : affinity capillary electrophoresis * binding constant * chiral analysis * cyclic dinucleotides * cyclodextrins
Impact factor: 2.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/elps.202300191
Permanent Link: https://hdl.handle.net/11104/0349913 - 3.0574366 - ÚOCHB 2024 RIV US eng J - Journal Article
Břehová, Petra - Řezníčková, E. - Škach, Kryštof - Jorda, R. - Dejmek, Milan - Vojáčková, V. - Šála, Michal - Kovalová, M. - Dračínský, Martin - Dolníková, A. - Strmeň, Timotej - Kinnertová, M. - Chalupský, Karel - Dvořáková, Alexandra - Gucký, T. - Mertlíková-Kaiserová, Helena - Klener, P. - Nencka, Radim - Kryštof, V.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Journal of Medicinal Chemistry. Roč. 66, č. 16 (2023), s. 11133-11157. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : gene expression * highly potent
OECD category: Oncology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.3c00575
Permanent Link: https://hdl.handle.net/11104/0344703File Download Size Commentary Version Access 10.1021acs.jmedchem.3c00575.pdf 0 7.8 MB Publisher’s postprint open-access - 4.0569689 - ÚOCHB 2024 RIV US eng J - Journal Article
Nuta, G. C. - Gilad, Y. - Goldberg, N. - Meril, S. - Bahlsen, M. - Carvalho, S. - Kozer, N. - Barr, H. - Sirkis, Y. F. - Hercík, Kamil - Břehová, Petra - Nencka, Radim - Bialik, S. - Eisenstein, M. - Kimchi, A.
Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction.
Autophagy. Roč. 19, č. 8 (2023), s. 2372-2385. ISSN 1554-8627. E-ISSN 1554-8635
Institutional support: RVO:61388963
Keywords : autophagy inhibition * cancer * drug screen * LC3B * pancreatic cancer * protein-fragment complementation assay * small molecules
OECD category: Organic chemistry
Impact factor: 13.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1080/15548627.2023.2178159
Permanent Link: https://hdl.handle.net/11104/0341063 - 5.0565954 - ÚOCHB 2024 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Vaneková, Lenka - Břehová, Petra - Dejmek, Milan - Vavřina, Zdeněk - Birkuš, Gabriel - Brázdová, Andrea
Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells.
ACS Infectious Diseases. Roč. 9, č. 1 (2023), s. 23-32. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : chronic hepatitis B * STING * nonparenchymal liver cells * antiviral immunity * cytokine * HBV-persistent mouse model
OECD category: Biochemistry and molecular biology
Impact factor: 5.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acsinfecdis.2c00424
Permanent Link: https://hdl.handle.net/11104/0337421 - 6.0559980 - ÚOCHB 2023 RIV GB eng J - Journal Article
Dejmek, Milan - Šála, Michal - Brázdová, Andrea - Vaneková, Lenka - Smola, Miroslav - Klíma, Martin - Břehová, Petra - Buděšínský, Miloš - Dračínský, Martin - Procházková, Eliška - Zavřel, Martin - Šimák, Ondřej - Páv, Ondřej - Bouřa, Evžen - Birkuš, Gabriel - Nencka, Radim
Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Structure. Roč. 30, č. 8 (2022), s. 1146-1156. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : cyclic dinucleotides * prodrugs * STING agonists * isonucleosides * cytokines * cancer
OECD category: Organic chemistry
Impact factor: 5.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.str.2022.05.012
Permanent Link: https://hdl.handle.net/11104/0333087 - 7.0556396 - ÚOCHB 2023 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Břehová, Petra - Dejmek, Milan - Birkuš, Gabriel - Brázdová, Andrea
STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis.
ACS Infectious Diseases. Roč. 8, č. 3 (2022), s. 463-471. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : STING * cGAS-STING pathway * apoptosis * monocytes * proinflammatory cytokines * interferons
OECD category: Biochemistry and molecular biology
Impact factor: 5.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acsinfecdis.1c00554
Permanent Link: http://hdl.handle.net/11104/0330938 - 8.0543611 - ÚOCHB 2022 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Břehová, Petra - Kaiser, Martin Maxmilian - Smola, Miroslav - Dračínský, Martin - Smith, Joshua - Marek, Aleš - Dejmek, Milan - Šála, Michal - Gutten, Ondrej - Rulíšek, Lubomír - Novotná, Barbora - Brázdová, Andrea - Janeba, Zlatko - Nencka, Radim - Bouřa, Evžen - Páv, Ondřej - Birkuš, Gabriel
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3′,3′-c-Di(2′F,2′dAMP).
Journal of Medicinal Chemistry. Roč. 64, č. 11 (2021), s. 7596-7616. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-08772S
Institutional support: RVO:61388963
Keywords : DNA sensor * interferon genes * cyclic GMP-AMP
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c00301
Permanent Link: http://hdl.handle.net/11104/0320799 - 9.0543267 - ÚOCHB 2022 RIV FR eng J - Journal Article
Břehová, Petra - Chaloupecká, Ema - Česnek, Michal - Skácel, Jan - Dračínský, Martin - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Soto-Velasquez, M. P. - Watts, V. J. - Janeba, Zlatko
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
European Journal of Medicinal Chemistry. Roč. 222, Oct 15 (2021), č. článku 113581. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT LTAUSA18086
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * adefovir * adenylate cyclase * Bacillus anthracis * Bordetella pertussis * inhibitors * prodrugs
OECD category: Organic chemistry
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://doi.org/10.1016/j.ejmech.2021.113581
Permanent Link: http://hdl.handle.net/11104/0320504 - 10.0500199 - ÚOCHB 2019 RIV GB eng J - Journal Article
Baszczyňski, Ondřej - Kaiser, Martin Maxmilian - Česnek, Michal - Břehová, Petra - Jansa, Petr - Procházková, Eliška - Dračínský, Martin - Snoeck, R. - Andrei, G. - Janeba, Zlatko
Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus.
Antiviral Chemistry and Chemotherapy. Roč. 26, Nov 29 (2018), s. 1-13. ISSN 0956-3202
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * xanthine * PMEX * antiviral * HCMV * VZV
OECD category: Organic chemistry
https://journals.sagepub.com/doi/10.1177/2040206618813050
Permanent Link: http://hdl.handle.net/11104/0292843