Search results
- 1.0525049 - ÚOCHB 2021 RIV US eng J - Journal Article
Tykvart, Jan - Navrátil, Václav - Kugler, Michael - Šácha, Pavel - Schimer, Jiří - Hlavačková, Anna - Tenora, Lukáš - Zemanová, Jitka - Dejmek, Milan - Král, V. - Potáček, M. - Majer, Pavel - Jahn, Ullrich - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, Jan
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA).
SLAS Discovery. Roč. 25, č. 9 (2020), s. 1026-1037. ISSN 2472-5552. E-ISSN 2472-5560
R&D Projects: GA ČR(CZ) GA19-10280S; GA ČR(CZ) GA17-14510S; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : high-throughput screening * carbonic anhydrase IX * drug discovery * DNA-linked inhibitor antibody assay
OECD category: Biochemistry and molecular biology
Impact factor: 2.918, year: 2020
Method of publishing: Limited access
https://journals.sagepub.com/doi/10.1177/2472555220918836
Permanent Link: http://hdl.handle.net/11104/0309265 - 2.0510216 - ÚOCHB 2020 RIV US eng J - Journal Article
Vorlová, Barbora - Knedlík, Tomáš - Tykvart, Jan - Konvalinka, Jan
GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.
Frontiers in Bioscience. Roč. 24, č. 4 (2019), s. 648-687. ISSN 1093-9946. E-ISSN 1093-4715
R&D Projects: GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : GCPII * GCPIII * PSMA * FOLH1 * NAALAD2 * NAAG * folate * BCG * Review
OECD category: Biochemistry and molecular biology
Impact factor: 2.747, year: 2019
Method of publishing: Limited access
http://www.bioscience.org/2019/v24/af/4742/list.htm
Permanent Link: http://hdl.handle.net/11104/0300749 - 3.0479478 - ÚOCHB 2018 RIV GB eng J - Journal Article
Knedlík, Tomáš - Vorlová, Barbora - Navrátil, Václav - Tykvart, Jan - Sedlák, František - Vaculín, Š. - Franěk, M. - Šácha, Pavel - Konvalinka, Jan
Mouse glutamate carboxypeptidaseII (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII.
FEBS Open Bio. Roč. 7, č. 9 (2017), s. 1362-1378. ISSN 2211-5463. E-ISSN 2211-5463
R&D Projects: GA ČR(CZ) GA16-02938S; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : glutamate carboxypeptidase II * mouse animal model * neuronal disorders * prostate cancer * prostate-specific membrane antigen
OECD category: Biochemistry and molecular biology
Impact factor: 1.782, year: 2017
http://onlinelibrary.wiley.com/doi/10.1002/2211-5463.12276/full
Permanent Link: http://hdl.handle.net/11104/0275468 - 4.0475093 - ÚOCHB 2018 RIV GB eng J - Journal Article
Navrátil, Václav - Schimer, Jiří - Tykvart, Jan - Knedlík, Tomáš - Vik, V. - Majer, Pavel - Konvalinka, Jan - Šácha, Pavel
DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening.
Nucleic Acids Research. Roč. 45, č. 2 (2017), č. článku e10. ISSN 0305-1048. E-ISSN 1362-4962
R&D Projects: GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : quantitative PCR * enzyme detection * inhibitor screening
OECD category: Biochemical research methods
Impact factor: 11.561, year: 2017
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkw853
Permanent Link: http://hdl.handle.net/11104/0271968File Download Size Commentary Version Access 0475093.pdf 4 1.8 MB Publisher’s postprint open-access - 5.0468320 - ÚOCHB 2017 RIV GB eng J - Journal Article
Navrátil, Michal - Tykvart, Jan - Schimer, Jiří - Pachl, Petr - Navrátil, Václav - Rokob, T. A. - Hlouchová, Klára - Rulíšek, Lubomír - Konvalinka, Jan
Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities.
FEBS Journal. Roč. 283, č. 13 (2016), s. 2528-2545. ISSN 1742-464X. E-ISSN 1742-4658
R&D Projects: GA ČR(CZ) GBP208/12/G016; GA ČR(CZ) GA14-31419S; GA MŠMT LO1302; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : arene-binding site * GCPIII * prostate-specific membrane antigen * QM/MM calculations * beta-citryl-L-glutamate
Subject RIV: CE - Biochemistry
Impact factor: 3.902, year: 2016
Permanent Link: http://hdl.handle.net/11104/0266128 - 6.0459191 - ÚOCHB 2017 RIV GB eng J - Journal Article
Klíma, Martin - Tóth, D. J. - Hexnerová, Rozálie - Bäumlová, Adriana - Chalupská, Dominika - Tykvart, Jan - Řežábková, L. - Sengupta, N. - Man, Petr - Dubánková, Anna - Humpolíčková, Jana - Nencka, Radim - Veverka, Václav - Balla, T. - Bouřa, Evžen
Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein.
Scientific Reports. Roč. 6, Mar 24 (2016), č. článku 23641. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR GJ15-21030Y; GA MŠMT LO1302; GA MŠMT(CZ) LK11205; GA MŠMT(CZ) LO1304; GA MŠMT LO1509
Institutional support: RVO:61388963 ; RVO:61388971
Keywords : 4-kinase III beta * phosphatidylinositol 4-kinases * endoplasmic reticulum
Subject RIV: CE - Biochemistry; EE - Microbiology, Virology (MBU-M)
Impact factor: 4.259, year: 2016
http://www.nature.com/articles/srep23641
Permanent Link: http://hdl.handle.net/11104/0259422File Download Size Commentary Version Access 0459191.pdf 5 5.4 MB Publisher’s postprint open-access - 7.0458826 - ÚOCHB 2017 RIV DE eng J - Journal Article
Šácha, Pavel - Knedlík, Tomáš - Schimer, Jiří - Tykvart, Jan - Parolek, Jan - Navrátil, Václav - Dvořáková, Petra - Sedlák, František - Ulbrich, Karel - Strohalm, Jiří - Majer, Pavel - Šubr, Vladimír - Konvalinka, Jan
iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties.
Angewandte Chemie - International Edition. Roč. 55, č. 7 (2016), s. 2356-2360. ISSN 1433-7851. E-ISSN 1521-3773
R&D Projects: GA ČR GBP208/12/G016; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:61389013
Keywords : antibody mimetics * HPMA * molecular recognition * polymer conjugates * protein targeting
Subject RIV: CE - Biochemistry; CD - Macromolecular Chemistry (UMCH-V)
Impact factor: 11.994, year: 2016
http://onlinelibrary.wiley.com/doi/10.1002/anie.201508642/full
Permanent Link: http://hdl.handle.net/11104/0259057 - 8.0445391 - ÚOCHB 2016 RIV US eng J - Journal Article
Tykvart, Jan - Schimer, Jiří - Jančařík, Andrej - Bařinková, Jitka - Navrátil, Václav - Starková, Jana - Šrámková, Karolína - Konvalinka, Jan - Majer, Pavel - Šácha, Pavel
Design of Highly Potent Urea-Based, Exosite-Binding Inhibitors Selective for Glutamate Carboxypeptidase II.
Journal of Medicinal Chemistry. Roč. 58, č. 10 (2015), s. 4357-4363. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GBP208/12/G016; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : GCPII selective inhibitors * GCPIII * GCPII
Subject RIV: CE - Biochemistry
Impact factor: 5.589, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247685 - 9.0444448 - ÚOCHB 2016 RIV US eng J - Journal Article
Tykvart, Jan - Bařinka, Cyril - Svoboda, Michal - Navrátil, Václav - Souček, Radko - Hubálek, Martin - Hradilek, Martin - Šácha, Pavel - Lubkowski, J. - Konvalinka, Jan
Structural and Biochemical Characterization of a Novel Aminopeptidase from Human Intestine.
Journal of Biological Chemistry. Roč. 290, č. 18 (2015), s. 11321-11336. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA ČR GAP304/12/0847; GA MŠMT LO1302; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388963 ; RVO:86652036
Keywords : glutamate carboxypeptidase II * reaction mechanism * expression
Subject RIV: CE - Biochemistry
Impact factor: 4.258, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247123 - 10.0436943 - ÚOCHB 2015 RIV US eng J - Journal Article
Tykvart, Jan - Navrátil, Václav - Sedlák, František - Corey, E. - Colombatti, M. - Fracasso, G. - Koukolík, F. - Bařinka, Cyril - Šácha, Pavel - Konvalinka, Jan
Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA).
Prostate. Roč. 74, č. 16 (2014), s. 1674-1690. ISSN 0270-4137. E-ISSN 1097-0045
R&D Projects: GA ČR GAP304/12/0847; GA MŠMT LO1302; GA ČR GAP301/12/1513; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388963 ; RVO:86652036
Keywords : glutamate carboxypeptidase II * prostate-specific membrane antigen * folate hydrolase * NAALADase * Western blot * immunohistochemistry * ELISA * flow cytometry * surface plasmon resonance
Subject RIV: CE - Biochemistry
Impact factor: 3.565, year: 2014
Permanent Link: http://hdl.handle.net/11104/0240877