Search results
- 1.0605329 - ÚOCHB 2026 RIV FR eng J - Journal Article
Sedláček, Jindřich - Šmahelová, Zuzana - Adámek, Michael - Šubová, Dominika - Svobodová, Lucie - Kadlecová, A. - Majer, Pavel - Machara, Aleš - Grantz Šašková, Klára
Small-molecule activators of NRF1 transcriptional activity prevent protein aggregation.
Biomedicine & Pharmacotherapy. Roč. 183, February (2025), č. článku 117864. ISSN 0753-3322. E-ISSN 1950-6007
R&D Projects: GA ČR(CZ) GA22-16389S; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : proteasome * NRF1 (NFE2L1) * DDI2 * NGLY1 * protein aggregates * small molecules * neurodegenerative diseases
OECD category: Organic chemistry
Impact factor: 6.9, year: 2023 ; AIS: 1.141, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.biopha.2025.117864DOI: https://doi.org/10.1016/j.biopha.2025.117864
Permanent Link: https://hdl.handle.net/11104/0363012File Download Size Commentary Version Access 10.1016j.biopha.2025.117864.pdf 1 6.7 MB Publisher’s postprint open-access - 2.0598945 - ÚOCHB 2025 RIV US eng J - Journal Article
Nedomová, Monika - Haberecht-Müller, S. - Möller, S. - Venz, S. - Procházková, M. - Procházka, J. - Sedlák, František - Chawengsaksophak, Kallayanee - Hammer, E. - Kašpárek, Petr - Adámek, Michael - Sedláček, Radislav - Konvalinka, Jan - Krüger, E. - Grantz Šašková, Klára
DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
iScience. Roč. 27, č. 10 (2024), č. článku 110893. E-ISSN 2589-0042
R&D Projects: GA ČR(CZ) GA22-16389S; GA MŠMT LM2023036; GA MŠMT EF18_046/0015861
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : bZIP transcription factor * TANK-binding kinase-1 * interferon
OECD category: Biochemistry and molecular biology
Impact factor: 4.6, year: 2023 ; AIS: 1.5, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.isci.2024.110893DOI: https://doi.org/10.1016/j.isci.2024.110893
Permanent Link: https://hdl.handle.net/11104/0356512Research data: IMPC - 3.0545469 - ÚOCHB 2022 RIV DE eng J - Journal Article
Hejdánková, Zuzana - Vaněk, Václav - Sedlák, František - Procházka, Jan - Diederichs, Audrey - Kereiche, Sami - Novotná, Barbora - Buděšínský, Miloš - Birkuš, Gabriel - Grantz Šašková, Klára - Cígler, Petr
Lipid Nanoparticles for Broad-Spectrum Nucleic Acid Delivery.
Advanced Functional Materials. Roč. 31, č. 47 (2021), č. článku 2101391. ISSN 1616-301X. E-ISSN 1616-3028
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LM2018126; GA MŠMT EF16_013/0001789; GA MŠMT EF18_046/0015861; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : cyclic dinucleotides * DNA * drug delivery * lipid nanoparticles * RNA
OECD category: Biochemistry and molecular biology
Impact factor: 19.924, year: 2021 ; AIS: 3.643, rok: 2021
Method of publishing: Limited access
Result website:
https://doi.org/10.1002/adfm.202101391DOI: https://doi.org/10.1002/adfm.202101391
Permanent Link: http://hdl.handle.net/11104/0322155 - 4.0524767 - ÚOCHB 2021 RIV CH eng J - Journal Article
Fassmannová, Dominika - Sedlák, František - Sedláček, Jindřich - Špička, I. - Grantz Šašková, Klára
Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma.
Cancers (Basel). Roč. 12, č. 5 (2020), č. článku 1065. ISSN 2072-6694. E-ISSN 2072-6694
Institutional support: RVO:61388963
Keywords : proteasome * TCF11/Nrf1 * DDI2 * nelfinavir * multiple myeloma * proteasome inhibitors * bortezomib * carfilzomib
OECD category: Cell biology
Impact factor: 6.639, year: 2020 ; AIS: 1.323, rok: 2020
Method of publishing: Open access
Result website:
https://www.mdpi.com/2072-6694/12/5/1065DOI: https://doi.org/10.3390/cancers12051065
Permanent Link: http://hdl.handle.net/11104/0309062 - 5.0509273 - ÚOCHB 2020 RIV NL eng J - Journal Article
Svoboda, Michal - Konvalinka, Jan - Trempe, J. F. - Grantz Šašková, Klára
The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response.
Dna Repair. Roč. 80, Aug (2019), s. 45-51. ISSN 1568-7864. E-ISSN 1568-7856
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : yeast * hydroxyurea * protease * DNA replication stress * Ddi1 * Wss1
OECD category: Cell biology
Impact factor: 3.339, year: 2019 ; AIS: 1.468, rok: 2019
Method of publishing: Open access
Result website:
https://www.sciencedirect.com/science/article/pii/S1568786419300874?via%3DihubDOI: https://doi.org/10.1016/j.dnarep.2019.06.008
Permanent Link: http://hdl.handle.net/11104/0300029File Download Size Commentary Version Access 0509273.pdf 3 1.8 MB Publisher’s postprint open-access - 6.0503801 - ÚOCHB 2020 RIV GB eng J - Journal Article
Srb, Pavel - Svoboda, Michal - Benda, L. - Lepšík, Martin - Tarábek, Ján - Šícha, Václav - Grüner, Bohumír - Grantz Šašková, Klára - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, Jan - Veverka, Václav
Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy.
Physical Chemistry Chemical Physics. Roč. 21, č. 10 (2019), s. 5661-5673. ISSN 1463-9076. E-ISSN 1463-9084
R&D Projects: GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LK11205; GA ČR(CZ) GA15-05677S; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61388980
Keywords : HIV-1 protease * pseudocontact shifts * proteins
OECD category: Biochemistry and molecular biology; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 3.430, year: 2019 ; AIS: 0.854, rok: 2019
Method of publishing: Limited access
Result website:
https://pubs.rsc.org/en/content/articlelanding/2019/CP/C9CP00416E#!divAbstractDOI: https://doi.org/10.1039/c9cp00416e
Permanent Link: http://hdl.handle.net/11104/0296717 - 7.0491050 - ÚOCHB 2019 RIV GB eng J - Journal Article
Ramirez, J. - Lectez, B. - Osinalde, N. - Sivá, Monika - Elu, N. - Aloria, K. - Procházková, Michaela - Perez, C. - Martínez-Hernández, J. - Barrio, R. - Grantz Šašková, Klára - Arizmendi, J. M. - Mayor, U.
Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.
Human Molecular Genetics. Roč. 27, č. 11 (2018), s. 1955-1971. ISSN 0964-6906. E-ISSN 1460-2083
R&D Projects: GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT ED2.1.00/19.0395
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : Angelman syndrome * ubiquitin * Ddi1
OECD category: Biochemistry and molecular biology
Impact factor: 4.544, year: 2018 ; AIS: 2.078, rok: 2018
DOI: https://doi.org/10.1093/hmg/ddy103
Permanent Link: http://hdl.handle.net/11104/0285297 - 8.0464345 - ÚOCHB 2017 RIV GB eng J - Journal Article
Trempe, J. F. - Grantz Šašková, Klára - Sivá, Monika - Ratcliffe, C. D. H. - Veverka, Václav - Hoegl, A. - Ménade, M. - Feng, X. - Shenker, S. - Svoboda, Michal - Kožíšek, Milan - Konvalinka, Jan - Gehring, K.
Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family.
Scientific Reports. Roč. 6, Sep 20 (2016), č. článku 33671. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA MŠMT(CZ) LK11205; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : ubiquitin-associated domains * ray solution scattering * torsion angle dynamics
Subject RIV: CE - Biochemistry
Impact factor: 4.259, year: 2016 ; AIS: 1.484, rok: 2016
Result website:
http://www.nature.com/articles/srep33671DOI: https://doi.org/10.1038/srep33671
Permanent Link: http://hdl.handle.net/11104/0263262File Download Size Commentary Version Access 0464345.pdf 4 5.3 MB Publisher’s postprint open-access - 9.0463511 - ÚOCHB 2017 RIV GB eng J - Journal Article
Sivá, Monika - Svoboda, Michal - Veverka, Václav - Trempe, J. F. - Hofmann, K. - Kožíšek, Milan - Hexnerová, Rozálie - Sedlák, František - Belza, Jan - Brynda, Jiří - Šácha, Pavel - Hubálek, Martin - Starková, Jana - Flaisigová, Iva - Konvalinka, Jan - Grantz Šašková, Klára
Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.
Scientific Reports. Roč. 6, Jul 27 (2016), č. článku 30443. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GBP208/12/G016
Institutional support: RVO:61388963
Keywords : human DNA-damage-inducible 2 protein * proteasome * ubiquitin * retroviral protease-like domain
Subject RIV: CE - Biochemistry
Impact factor: 4.259, year: 2016 ; AIS: 1.484, rok: 2016
Result website:
http://www.nature.com/articles/srep30443DOI: https://doi.org/10.1038/srep30443
Permanent Link: http://hdl.handle.net/11104/0262688File Download Size Commentary Version Access 0463511.pdf 4 7.5 MB Publisher’s postprint open-access - 10.0458499 - ÚOCHB 2017 RIV US eng J - Journal Article
Machara, A. - Lux, V. - Kožíšek, Milan - Grantz Šašková, Klára - Štěpánek, O. - Kotora, M. - Parkan, Kamil - Pávová, Marcela - Glass, B. - Sehr, P. - Lewis, J. - Müller, B. - Kräusslich, H. G. - Konvalinka, Jan
Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds.
Journal of Medicinal Chemistry. Roč. 59, č. 2 (2016), s. 545-558. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA ČR GA13-19561S
EU Projects: European Commission(XE) 201095 - HIV ACE
Institutional support: RVO:61388963
Keywords : HIV-1 assembly * capsid * high-throughput screening * AlphaScreen assay
Subject RIV: CE - Biochemistry
Impact factor: 6.259, year: 2016 ; AIS: 1.517, rok: 2016
DOI: https://doi.org/10.1021/acs.jmedchem.5b01089
Permanent Link: http://hdl.handle.net/11104/0258765