Search results
- 1.0583190 - ÚOCHB 2025 RIV US eng J - Journal Article
Klíma, Martin - Dejmek, Milan - Duchoslav, Vojtěch - Eisenreichová, Andrea - Šála, Michal - Chalupský, Karel - Chalupská, Dominika - Novotná, Barbora - Birkuš, Gabriel - Nencka, Radim - Bouřa, Evžen
Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Structure. Roč. 32, č. 4 (2024), s. 433-439. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Impact factor: 5.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.str.2024.01.008
Permanent Link: https://hdl.handle.net/11104/0351191File Download Size Commentary Version Access 10.1016j.str.2024.01.008.pdf 0 3.1 MB Publisher’s postprint open-access - 2.0583095 - ÚOCHB 2025 RIV US eng J - Journal Article
Štěpánová, Sille - Andris, Erik - Gutten, Ondrej - Buděšínský, Miloš - Dejmek, Milan - Břehová, Petra - Rulíšek, Lubomír - Kašička, Václav
Acidity constants and protonation sites of cyclic dinucleotides determined by capillary electrophoresis, quantum chemical calculations, and NMR spectroscopy.
Electrophoresis. (2024). ISSN 0173-0835. E-ISSN 1522-2683
Institutional support: RVO:61388963
Keywords : acidity constant * capillary electrophoresis * cyclic dinucleotides * DFT calculations * NMR spectroscopy
Impact factor: 2.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/elps.202300232
Permanent Link: https://hdl.handle.net/11104/0351092 - 3.0580756 - ÚOCHB 2025 RIV US eng J - Journal Article
Cermakova, K. - Tao, L. - Dejmek, Milan - Šála, Michal - Montierth, M D. - Chan, Y. S. - Patel, I. - Chambers, C. - Loeza Cabrera, M. - Hoffman, D. - Parchem, R. J. - Wang, W. - Nencka, Radim - Barbieri, E. - Hodges, H. C.
Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF.
Nucleic Acids Research. Roč. 52, č. 1 (2024), s. 4-21. ISSN 0305-1048. E-ISSN 1362-4962
Institutional support: RVO:61388963
Keywords : neuroblastoma * differentiation * transcription
Impact factor: 14.9, year: 2022
Method of publishing: Open access
https://doi.org/10.1093/nar/gkad1081
Permanent Link: https://hdl.handle.net/11104/0349518
Research data: ZENODO - 4.0574898 - ÚOCHB 2024 RIV NL eng J - Journal Article
Misehe, Mbilo - Matoušová, Marika - Dvořáková, Alexandra - Hercík, Kamil - Škach, Kryštof - Chalupská, Dominika - Dejmek, Milan - Šála, Michal - Hájek, Miroslav - Bouřa, Evžen - Mertlíková-Kaiserová, Helena - Nencka, Radim
Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases.
European Journal of Medicinal Chemistry. Roč. 260, November (2023), č. článku 115717. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Institutional support: RVO:61388963
Keywords : kinase inhibitor * quinazoline derivatives * RIPK2 * NOD * inflammation * RIPK3
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115717
Permanent Link: https://hdl.handle.net/11104/0344824File Download Size Commentary Version Access 10.1016j.ejmech.2023.115717.pdf 0 4.4 MB Publisher’s postprint open-access - 5.0574383 - ÚOCHB 2024 RIV NL eng J - Journal Article
Dejmek, Milan - Brázdová, Andrea - Otava, Tomáš - Pimková Polidarová, Markéta - Klíma, Martin - Smola, Miroslav - Vavřina, Zdeněk - Buděšínský, Miloš - Dračínský, Martin - Liboska, Radek - Bouřa, Evžen - Birkuš, Gabriel - Nencka, Radim
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
European Journal of Medicinal Chemistry. Roč. 259, November (2023), č. článku 115685. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MZd(CZ) NU20-05-00472
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61388963
Keywords : cyclic dinucleotides * STING * cancer * intratumoral administration * immunotherapy
OECD category: Medicinal chemistry
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.ejmech.2023.115685
Permanent Link: https://hdl.handle.net/11104/0344716File Download Size Commentary Version Access 10.1016j.ejmech.2023.115685.pdf 0 5.2 MB Publisher’s postprint open-access
Research data: PDB - 6.0574366 - ÚOCHB 2024 RIV US eng J - Journal Article
Břehová, Petra - Řezníčková, E. - Škach, Kryštof - Jorda, R. - Dejmek, Milan - Vojáčková, V. - Šála, Michal - Kovalová, M. - Dračínský, Martin - Dolníková, A. - Strmeň, Timotej - Kinnertová, M. - Chalupský, Karel - Dvořáková, Alexandra - Gucký, T. - Mertlíková-Kaiserová, Helena - Klener, P. - Nencka, Radim - Kryštof, V.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Journal of Medicinal Chemistry. Roč. 66, č. 16 (2023), s. 11133-11157. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : gene expression * highly potent
OECD category: Oncology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.3c00575
Permanent Link: https://hdl.handle.net/11104/0344703File Download Size Commentary Version Access 10.1021acs.jmedchem.3c00575.pdf 0 7.8 MB Publisher’s postprint open-access - 7.0574244 - ÚOCHB 2024 RIV US eng J - Journal Article
Štefek, Milan - Chalupská, Dominika - Chalupský, Karel - Zgarbová, Michala - Dvořáková, Alexandra - Krafčíková, Petra - Li, A. S. M. - Šála, Michal - Dejmek, Milan - Otava, Tomáš - Chaloupecká, Ema - Kozák, Jaroslav - Kozic, Ján - Vedadi, M. - Weber, Jan - Mertlíková-Kaiserová, Helena - Nencka, Radim
Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors.
ACS Omega. Roč. 8, č. 30 (2023), s. 27410-27418. ISSN 2470-1343. E-ISSN 2470-1343
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : SARS-CoV-2 * genetics * inhibitors
OECD category: Virology
Impact factor: 4.1, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsomega.3c02815
Permanent Link: https://hdl.handle.net/11104/0344580File Download Size Commentary Version Access acsomega.3c02815 (2).pdf 0 5.1 MB Publisher’s postprint open-access - 8.0571238 - ÚOCHB 2024 RIV US eng J - Journal Article
Chambers, C. - Cermakova, K. - Chan, Y. S. - Kurtz, K. - Wohlan, K. - Lewis, A. H. - Wang, C. - Pham, A. - Dejmek, Milan - Šála, Michal - Loeza Cabrera, M. - Aguilar, R. - Nencka, Radim - Lacorazza, H. D. - Rau, R. E. - Hodges, H. C.
SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia.
Cancer Research. Roč. 83, č. 7 (2023), s. 983-996. ISSN 0008-5472. E-ISSN 1538-7445
Institutional support: RVO:61388963
Keywords : chromatin-remodeling complexes * pioneer transcription factors * ATPase subunit
OECD category: Organic chemistry
Impact factor: 11.2, year: 2022
Method of publishing: Open access
https://doi.org/10.1158/0008-5472.CAN-22-2129
Permanent Link: https://hdl.handle.net/11104/0342509 - 9.0565954 - ÚOCHB 2024 RIV US eng J - Journal Article
Pimková Polidarová, Markéta - Vaneková, Lenka - Břehová, Petra - Dejmek, Milan - Vavřina, Zdeněk - Birkuš, Gabriel - Brázdová, Andrea
Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells.
ACS Infectious Diseases. Roč. 9, č. 1 (2023), s. 23-32. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : chronic hepatitis B * STING * nonparenchymal liver cells * antiviral immunity * cytokine * HBV-persistent mouse model
OECD category: Biochemistry and molecular biology
Impact factor: 5.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acsinfecdis.2c00424
Permanent Link: https://hdl.handle.net/11104/0337421 - 10.0563157 - ÚOCHB 2023 RIV US eng J - Journal Article
Vavřina, Zdeněk - Perlíková, Pavla - Milisavljevič, Nemanja - Chevrier, Florian - Smola, Miroslav - Smith, Joshua - Dejmek, Milan - Havlíček, Vojtěch - Buděšínský, Miloš - Liboska, Radek - Vaneková, Lenka - Brynda, Jiří - Bouřa, Evžen - Řezáčová, Pavlína - Hocek, Michal - Birkuš, Gabriel
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Journal of Medicinal Chemistry. Roč. 65, č. 20 (2022), s. 14082-14103. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LX22NPO5102; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : GMP-AMP synthase * interferon genes * adapter protein
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c01305
Permanent Link: https://hdl.handle.net/11104/0335201File Download Size Commentary Version Access 10.1021acs.jmedchem.2c01305.pdf 2 6.9 MB Publisher’s postprint open-access