Search results
- 1.0360075 - BTÚ 2012 RIV US eng J - Journal Article
Dong, L.-F. - Jameson, V.J.A. - Tilly, D. - Procházka, L. - Rohlena, Jakub - Vališ, Karel - Truksa, Jaroslav - Zobalová, Renata - Mandavian, E. - Klučková, Katarína - Stantic, M. - Štursa, Jan - Freeman, R. - Witting, P.K. - Norberg, E. - Goodwin, J. - Salvatore, B.A. - Novotná, Jana - Turánek, J. - Ledvina, Miroslav - Hozák, Pavel - Zhivotovsky, B. - Coster, M. - Ralph, S.J. - Smith, R.A.J. - Neužil, Jiří
Mitochondrial targeting of [alpha]-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy.
Free Radical Biology and Medicine. Roč. 50, č. 11 (2011), s. 1546-1555. ISSN 0891-5849. E-ISSN 1873-4596
R&D Projects: GA ČR GA204/08/0811; GA ČR GAP301/10/1937; GA AV ČR IAA500520702; GA AV ČR KAN200520703; GA AV ČR KJB500970904; GA AV ČR KAN200100801
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50520514; CEZ:AV0Z4055905
Keywords : Triphenyl phosphonium * reactive oxygen species * apoptosis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.423, year: 2011
Permanent Link: http://hdl.handle.net/11104/0197713File Download Size Commentary Version Access Dong et al., 2011, Free Radic Biol Chem.pdf 5 444.4 KB Publisher’s postprint require - 2.0349091 - BTÚ 2011 RIV NL eng J - Journal Article
Procházka, L. - Dong, L.F. - Vališ, Karel - Freeman, R. - Ralph, S.J. - Turánek, J. - Neužil, Jiří
Alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels.
Apoptosis. Roč. 15, č. 7 (2010), s. 782-794. ISSN 1360-8185. E-ISSN 1573-675X
R&D Projects: GA AV ČR(CZ) KAN200520703; GA AV ČR(CZ) IAA500520702; GA AV ČR(CZ) IAA500520602
Institutional research plan: CEZ:AV0Z50520701
Keywords : Vitamin E succinate * apoptosis * Noxa-Bak
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.397, year: 2010
Permanent Link: http://hdl.handle.net/11104/0189421 - 3.0324996 - BTÚ 2009 RIV US eng J - Journal Article
Dong, L.F. - Freeman, R. - Liu, J. - Zobalová, Renata - Marin-Hernandez, A. - Stantic, M. - Rohlena, Jakub - Vališ, Karel - Rodriguez-Enriquez, S. - Butcher, B. - Goodwin, J. - Brunk, U.T. - Witting, P. K. - Moreno-Sanchez, R. - Scheffler, I.E. - Ralph, S.J. - Neužil, Jiří
Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II.
[Potlačení nádorového růstu in vivo mitokanem alfa-tokoferylsukcinátem vyžaduje respirační komplex II.]
Clinical Cancer Research. Roč. 15, č. 5 (2009), s. 1593-1600. ISSN 1078-0432. E-ISSN 1557-3265
R&D Projects: GA ČR(CZ) GA204/08/0811; GA AV ČR(CZ) IAA500520702
Institutional research plan: CEZ:AV0Z50520701
Keywords : SDHC-mutants * mitocans * mitochondrial complex II
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 6.747, year: 2009
Permanent Link: http://hdl.handle.net/11104/0172563 - 4.0313507 - BTÚ 2009 RIV GB eng J - Journal Article
Dong, L.F. - Low, P. - Dyason, J.C. - Wang, X.-F. - Prochazka, L. - Witting, P.-K. - Freeman, R. - Swettenham, E. - Vališ, Karel - Liu, J. - Zobalová, Renata - Turanek, J. - Spitz, D.R. - Domann, F.E. - Scheffler, I.E. - Ralph, S.J. - Neužil, Jiří
alpha-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding.
[alfa-Tokoferylsukcinát indukuje apoptózu zasažením míst vázajících ubichinon v mitochondriálním respiračním komplexu II.]
Oncogene. Roč. 27, č. 31 (2008), s. 4324-4335. ISSN 0950-9232. E-ISSN 1476-5594
R&D Projects: GA AV ČR IAA500520702; GA AV ČR KAN200520703
Grant - others:GA MZe(CZ) MZE-0002716201
Institutional research plan: CEZ:AV0Z50520701
Keywords : Reactive oxygen species * apoptosis * anti-cancer drug target
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 7.216, year: 2008
Permanent Link: http://hdl.handle.net/11104/0164309 - 5.0096337 - ÚMG 2008 RIV US eng J - Journal Article
Neužil, Jiří - Dyason, J.C. - Freeman, R. - Dong, L.F. - Procházka, L. - Wang, X. F. - Scheffler, I. - Ralph, S.J.
Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II.
[Mitokany jako protirakovinné látky zasahující mitochondrie: studie s analogy vitaminu E, inhibitory komplexu II.]
Journal of Bioenergetics and Biomembranes. Roč. 39, č. 1 (2007), s. 65-72. ISSN 0145-479X. E-ISSN 1573-6881
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50520514
Keywords : mitocans * mitochondria * complex II
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.634, year: 2007
Permanent Link: http://hdl.handle.net/11104/0155728 - 6.0096295 - ÚMG 2008 RIV NL eng J - Journal Article
Neužil, Jiří - Dong, L.F. - Ramanathapuram, L. - Hahn, T. - Chladová, Miroslava - Wang, X. F. - Zobalová, Renata - Procházka, L. - Gold, M. - Freeman, R. - Turánek, J. - Akporiaye, E.T. - Dyason, J.C. - Ralph, S.J.
Vitamin E analogues as a novel group of mitocans: Anti-cancer agents that act by targeting mitochondria.
[Analogy vitaminu E jako nová skupina mitokanů: protirakovinné látky, které účinkují zasažením mitochondrií.]
Molecular Aspects of Medicine. Roč. 28, 5-6 (2007), s. 607-645. ISSN 0098-2997. E-ISSN 1872-9452
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50520514
Keywords : tocopherol analogues * apoptosis * reactive oxygen species
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 7.386, year: 2007
Permanent Link: http://hdl.handle.net/11104/0155699