Search results
- 1.0383182 - BTÚ 2013 RIV NL eng J - Journal Article
Rodriguez-Enriquez, S. - Hernandez-Esquivel, L. - Marin-Hernandez, A. - Dong, L.-F. - Akporiaye, E. - Neužil, Jiří - Ralph, S.J. - Moreno-Sanchez, R.
Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue.
Biochimica Et Biophysica Acta-Bioenergetics. Roč. 1817, č. 9 (2012), s. 1597-1607. ISSN 0005-2728. E-ISSN 1879-2650
R&D Projects: GA ČR GAP301/10/1937
Institutional research plan: CEZ:AV0Z50520701
Keywords : Mitochondria * respiratory complex II * vitamin E analogs
Subject RIV: CE - Biochemistry
Impact factor: 4.624, year: 2012
Permanent Link: http://hdl.handle.net/11104/0213201 - 2.0369512 - BTÚ 2012 RIV NL eng J - Journal Article
Ito, K. - Scott, S.A. - Cutler, S. - Dong, L.-F. - Neužil, Jiří - Blanchard, H. - Ralph, S.J.
Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress.
Angiogenesis. Roč. 14, č. 3 (2011), s. 293-307. ISSN 0969-6970. E-ISSN 1573-7209
Institutional research plan: CEZ:AV0Z50520701
Keywords : Galectin-1 inhibitor * oxidative stress * angiogenesis
Subject RIV: FD - Oncology ; Hematology
Impact factor: 6.063, year: 2011
Permanent Link: http://hdl.handle.net/11104/0203559 - 3.0369496 - BTÚ 2012 RIV US eng J - Journal Article
Neužil, Jiří - Černý, Jiří - Dyason, J.C. - Dong, L.-F. - Ralph, S.J.
Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells.
Molecular Nutrition & Food Research. Roč. 55, č. 10 (2011), s. 1543-1551. ISSN 1613-4125. E-ISSN 1613-4133
Institutional research plan: CEZ:AV0Z50520701
Keywords : Vitamin E analogues * mitochondrial complex II * modelling
Subject RIV: CE - Biochemistry
Impact factor: 4.301, year: 2011
Permanent Link: http://hdl.handle.net/11104/0203545 - 4.0369494 - BTÚ 2012 RIV US eng J - Journal Article
Ralph, S.J. - Moreno-Sanchez, R. - Neužil, Jiří - Rodriguez-Enriquez, S.
Inhibitors of Succinate: Quinone Reductase/Complex II Regulate Production of Mitochondrial Reactive Oxygen Species and Protect Normal Cells from Ischemic Damage but Induce Specific Cancer Cell Death.
Pharmaceutical Research. Roč. 28, č. 11 (2011), s. 2695-2730. ISSN 0724-8741. E-ISSN 1573-904X
Institutional research plan: CEZ:AV0Z50520701
Keywords : Mitocans * SDH/Complex II * mitochondrial ROS production
Subject RIV: CE - Biochemistry
Impact factor: 4.093, year: 2011
Permanent Link: http://hdl.handle.net/11104/0006745 - 5.0369481 - BTÚ 2012 RIV US eng J - Journal Article
Rohlena, Jakub - Dong, L.-F. - Ralph, S.J. - Neužil, Jiří
Anticancer Drugs Targeting the Mitochondrial Electron Transport Chain.
Antioxidants & Redox Signaling. Roč. 15, č. 12 (2011), s. 2951-2974. ISSN 1523-0864. E-ISSN 1557-7716
R&D Projects: GA AV ČR(CZ) KAN200520703
Institutional research plan: CEZ:AV0Z50520701
Keywords : Targets for anticancer drugs * mitochondrial electron transport chain * mitocans
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 8.456, year: 2011
Permanent Link: http://hdl.handle.net/11104/0203533File Download Size Commentary Version Access Rohlena et al., 2011, ARS 15, 2951.pdf 5 593.5 KB Publisher’s postprint require - 6.0360075 - BTÚ 2012 RIV US eng J - Journal Article
Dong, L.-F. - Jameson, V.J.A. - Tilly, D. - Procházka, L. - Rohlena, Jakub - Vališ, Karel - Truksa, Jaroslav - Zobalová, Renata - Mandavian, E. - Klučková, Katarína - Stantic, M. - Štursa, Jan - Freeman, R. - Witting, P.K. - Norberg, E. - Goodwin, J. - Salvatore, B.A. - Novotná, Jana - Turánek, J. - Ledvina, Miroslav - Hozák, Pavel - Zhivotovsky, B. - Coster, M. - Ralph, S.J. - Smith, R.A.J. - Neužil, Jiří
Mitochondrial targeting of [alpha]-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy.
Free Radical Biology and Medicine. Roč. 50, č. 11 (2011), s. 1546-1555. ISSN 0891-5849. E-ISSN 1873-4596
R&D Projects: GA ČR GA204/08/0811; GA ČR GAP301/10/1937; GA AV ČR IAA500520702; GA AV ČR KAN200520703; GA AV ČR KJB500970904; GA AV ČR KAN200100801
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50520514; CEZ:AV0Z4055905
Keywords : Triphenyl phosphonium * reactive oxygen species * apoptosis
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.423, year: 2011
Permanent Link: http://hdl.handle.net/11104/0197713File Download Size Commentary Version Access Dong et al., 2011, Free Radic Biol Chem.pdf 5 444.4 KB Publisher’s postprint require - 7.0358947 - BTÚ 2011 RIV US eng J - Journal Article
Vališ, Karel - Procházka, L. - Bouřa, Evžen - Chladová, Jaromíra - Obšil, T. - Rohlena, Jakub - Truksa, Jaroslav - Dong, L.F. - Ralph, S.J. - Neužil, Jiří
Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.
Cancer Research. Roč. 71, č. 3 (2011), s. 946-954. ISSN 0008-5472. E-ISSN 1538-7445
R&D Projects: GA AV ČR(CZ) KJB500970904; GA ČR(CZ) GA204/08/0811; GA AV ČR(CZ) IAA500520702; GA ČR GAP301/10/1937
Institutional research plan: CEZ:AV0Z50520701; CEZ:AV0Z50110509
Keywords : Mst1 kinase * FoxO proteins * alpha-tocopheryl succinate
Subject RIV: FD - Oncology ; Hematology
Impact factor: 7.856, year: 2011
Permanent Link: http://hdl.handle.net/11104/0196844 - 8.0349341 - BTÚ 2011 RIV NL eng J - Journal Article
Ralph, S.J. - Rodriguez-Enriquez, S. - Neužil, Jiří - Moreno-Sanchez, R.
Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger.
Molecular Aspects of Medicine. Roč. 31, č. 1 (2010), s. 29-59. ISSN 0098-2997. E-ISSN 1872-9452
Institutional research plan: CEZ:AV0Z50520701
Keywords : Mitocans * reactive oxygen species * anti-cancer drugs
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 10.552, year: 2010
Permanent Link: http://hdl.handle.net/11104/0189607 - 9.0349092 - BTÚ 2011 RIV NL eng J - Journal Article
Ralph, S.J. - Rodruguez-Enriquez, S. - Neužil, Jiří - Saavedra, E. - Moreno-Sanchez, R.
The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy.
Molecular Aspects of Medicine. Roč. 31, č. 2 (2010), s. 145-170. ISSN 0098-2997. E-ISSN 1872-9452
Institutional research plan: CEZ:AV0Z50520701
Keywords : Carcinogenesis * mitocans * hypoxia
Subject RIV: FD - Oncology ; Hematology
Impact factor: 10.552, year: 2010
Permanent Link: http://hdl.handle.net/11104/0189422 - 10.0349091 - BTÚ 2011 RIV NL eng J - Journal Article
Procházka, L. - Dong, L.F. - Vališ, Karel - Freeman, R. - Ralph, S.J. - Turánek, J. - Neužil, Jiří
Alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels.
Apoptosis. Roč. 15, č. 7 (2010), s. 782-794. ISSN 1360-8185. E-ISSN 1573-675X
R&D Projects: GA AV ČR(CZ) KAN200520703; GA AV ČR(CZ) IAA500520702; GA AV ČR(CZ) IAA500520602
Institutional research plan: CEZ:AV0Z50520701
Keywords : Vitamin E succinate * apoptosis * Noxa-Bak
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.397, year: 2010
Permanent Link: http://hdl.handle.net/11104/0189421