Search results
- 1.0560992 - ÚOCHB 2023 RIV US eng J - Journal Article
Santos, L. H. - Kronenberger, T. - Almeida, R. G. - Silva, E. B. - Rocha, R. E. O. - Oliveira, J. C. - Barreto, L. V. - Skinner, D. - Fajtová, Pavla - Giardini, M. A. - Woodworth, B. - Bardine, C. - Lourenço, A. L. - Craik, C. S. - Poso, A. - Podust, L. M. - McKerrow, J. H. - Siqueira-Neto, J. L. - O'Donoghue, A. J. - Da Silva Júnior, E. N. - Ferreira, R. S.
Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2.
Journal of Chemical Information and Modeling. Roč. 62, č. 24 (2022), s. 6553-6573. ISSN 1549-9596. E-ISSN 1549-960X
Institutional support: RVO:61388963
Keywords : nor-β-lapachone * Trypanosoma cruzi activity * potent antitumor activity
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jcim.2c00693
Permanent Link: https://hdl.handle.net/11104/0333755 - 2.0558333 - ÚOCHB 2023 RIV US eng J - Journal Article
Ashhurst, A. S. - Tang, A. H. - Fajtová, Pavla - Yoon, M. C. - Aggarwal, A. - Bedding, M. J. - Stoye, A. - Beretta, L. - Pwee, D. - Drelich, A. - Skinner, D. - Li, L. - Meek, T. D. - McKerrow, J. H. - Hook, V. - Tseng, C. T. - Larance, M. - Turville, S. - Gerwick, W. H. - O'Donoghue, A. J. - Payne, R. J.
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Journal of Medicinal Chemistry. Roč. 65, č. 4 (2022), s. 2956-2970. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:61388963
Keywords : acute respiratory syndrome * cell entry * selective inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.1c01494
Permanent Link: http://hdl.handle.net/11104/0332059
Research data: PRIDE - 3.0542400 - ÚOCHB 2022 RIV US eng J - Journal Article
Mellott, D. M. - Tseng, C. T. - Drelich, A. - Fajtová, Pavla - Chenna, B. C. - Kostomiris, D. H. - Hsu, J. - Zhu, J. - Taylor, Z. W. - Kocurek, K. I. - Tat, V. - Katzfuss, A. - Li, L. - Giardini, M. A. - Skinner, D. - Hirata, K. - Yoon, M. C. - Beck, S. - Carlin, A. F. - Clark, A. E. - Beretta, L. - Maneval, D. - Hook, V. - Frueh, F. - Hurst, B. L. - Wang, H. - Raushel, F. M. - O'Donoghue, A. J. - De Siqueira-Neto, J. L. - Meek, T. D. - McKerrow, J. H.
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells.
ACS Chemical Biology. Roč. 16, č. 4 (2021), s. 642-650. ISSN 1554-8929. E-ISSN 1554-8937
Institutional support: RVO:61388963
Keywords : respiratory syndrome coronavirus * spike protein * entry
OECD category: Biochemistry and molecular biology
Impact factor: 4.634, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acschembio.0c00875
Permanent Link: http://hdl.handle.net/11104/0319818 - 4.0446340 - ÚOCHB 2016 RIV US eng J - Journal Article
Fajtová, Pavla - Štefanic, S. - Hradilek, Martin - Dvořák, Jan - Vondrášek, Jiří - Jílková, Adéla - Ulrychová, Lenka - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael - Horn, Martin
Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.
PLoS Neglected Tropical Diseases. Roč. 9, č. 6 (2015), e0003827/1-e0003827/24. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA ČR(CZ) GAP302/11/1481; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : Schistosoma mansoni * schistosomiasis * prolyl oligopeptidase * blood fluke
Subject RIV: CE - Biochemistry; EB - Genetics ; Molecular Biology (UMG-J)
Impact factor: 3.948, year: 2015
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003827
Permanent Link: http://hdl.handle.net/11104/0248346File Download Size Commentary Version Access 0446340.PDF 3 5.8 MB Publisher’s postprint open-access - 5.0438380 - ÚOCHB 2015 RIV GB eng J - Journal Article
Jílková, Adéla - Horn, Martin - Řezáčová, Pavlína - Marešová, Lucie - Fajtová, Pavla - Brynda, Jiří - Vondrášek, Jiří - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael
Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch.
Structure. Roč. 22, č. 12 (2014), s. 1786-1798. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA ČR GA203/09/1585; GA MŠMT LH12023; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : human procathepsin B * slow binding inhibition * asparaginyl endopeptidase
Subject RIV: CE - Biochemistry
Impact factor: 5.618, year: 2014
Permanent Link: http://hdl.handle.net/11104/0241842 - 6.0429904 - ÚOCHB 2015 RIV US eng J - Journal Article
Horn, Martin - Fajtová, Pavla - Arreola, L. R. - Ulrychová, Lenka - Bartošová-Sojková, Pavla - Franta, Zdeněk - Protasio, A. V. - Opavský, David - Vondrášek, Jiří - McKerrow, J. H. - Mareš, Michael - Caffrey, C. R. - Dvořák, Jan
Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni - 'The Undiscovered Country'.
PLoS Neglected Tropical Diseases. Roč. 8, č. 3 (2014), e2766/1-e2766/13. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA ČR(CZ) GAP302/11/1481; GA MŠMT(CZ) ME10011
EU Projects: European Commission(XE) 248642 - SCHISTOSOMA PROTEASE
Institutional support: RVO:61388963 ; RVO:68378050 ; RVO:60077344
Keywords : schistosomiasis * blood fluke * serine protease
Subject RIV: CE - Biochemistry; EB - Genetics ; Molecular Biology (UMG-J); FN - Epidemiology, Contagious Diseases ; Clinical Immunology (BC-A)
Impact factor: 4.446, year: 2014
http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002766
Permanent Link: http://hdl.handle.net/11104/0234956 - 7.0377766 - BC 2013 RIV US eng J - Journal Article
Sojka, Daniel - Franta, Zdeněk - Frantová, Helena - Bartošová, Pavla - Horn, Martin - Váchová, Jana - O’Donoghue, A. J. - Eroy-Reveles, A. A. - Craik, C. S. - Knudsen, G. M. - Caffrey, C. R. - McKerrow, J. H. - Mareš, Michael - Kopáček, Petr
Characterization of Gut-associated Cathepsin D Hemoglobinase from Tick Ixodes ricinus (IrCD1).
Journal of Biological Chemistry. Roč. 287, č. 25 (2012), s. 21152-21163. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA AV ČR IAA600960910; GA MŠMT(CZ) LC06009; GA AV ČR KJB600960911; GA ČR GPP502/11/P682; GA AV ČR IAA400550705; GA ČR(CZ) GAP207/10/2183
Institutional research plan: CEZ:AV0Z60220518
Institutional support: RVO:61388963
Keywords : RHIPICEPHALUS BOOPHILUS MICROPLUS * HARD TICK * ORNITHODOROS-MOUBATA * ASPARTIC PROTEINASE * RECOGNITION DOMAIN * MOLECULAR-CLONING * ACTIVE-SITE * EXPRESSION * INHIBITOR * PROTEASE
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 4.651, year: 2012
Permanent Link: http://hdl.handle.net/11104/0209839 - 8.0367385 - BC 2012 RIV AU eng J - Journal Article
Franta, Zdeněk - Sojka, Daniel - Frantová, Helena - Dvořák, Jan - Horn, Martin - Srba, Jindřich - Talacko, Pavel - Mareš, Michael - Schneider, E. - Craik, C. S. - McKerrow, J. H. - Caffrey, C. R. - Kopáček, Petr
IrCL1-The haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.
International Journal for Parasitology. Roč. 41, č. 12 (2011), 1253-1262. ISSN 0020-7519. E-ISSN 1879-0135
R&D Projects: GA AV ČR IAA600960910; GA ČR(CZ) GAP207/10/2183; GA ČR GPP502/11/P682; GA MŠMT(CZ) LC06009
Institutional research plan: CEZ:AV0Z60220518; CEZ:AV0Z40550506
Keywords : tick gut * hemoglobin digestion * cathepsin L
Subject RIV: EC - Immunology
Impact factor: 3.393, year: 2011
Permanent Link: http://hdl.handle.net/11104/0202091 - 9.0365166 - ÚOCHB 2012 RIV US eng J - Journal Article
Jílková, Adéla - Řezáčová, Pavlína - Lepšík, Martin - Horn, Martin - Váchová, Jana - Fanfrlík, Jindřich - Brynda, Jiří - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael
Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.
Journal of Biological Chemistry. Roč. 286, č. 41 (2011), s. 35770-35881. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA ČR GA203/09/1585; GA ČR GAP208/11/0295; GA MŠMT OC09007
Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50520514
Keywords : cathepsin B * schistosoma * crystal structure
Subject RIV: CC - Organic Chemistry
Impact factor: 4.773, year: 2011
Permanent Link: http://hdl.handle.net/11104/0200472 - 10.0352015 - BC 2011 RIV NL eng J - Journal Article
Dvořák, Jan - Beckmann, S. - Lim, K.-C. - Engel, J. C. - Grevelding, C. G. - McKerrow, J. H. - Caffrey, C. R.
Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes.
Molecular and Biochemical Parasitology. Roč. 170, č. 1 (2010), s. 37-40. ISSN 0166-6851. E-ISSN 1872-9428
Institutional research plan: CEZ:AV0Z60220518
Keywords : Schistosoma * Protease * Transgene * Gene promoter * Biolistics * Electroporation
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.875, year: 2010
Permanent Link: http://hdl.handle.net/11104/0191626