Search results
- 1.0540888 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Rubešová, Petra - Fanfrlík, Jindřich - Fajtová, Pavla - Řezáčová, Pavlína - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Emal, C. D. - Renslo, A. R. - Roush, W. R. - Horn, Martin - Caffrey, C. R. - Mareš, Michael
Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
ACS Infectious Diseases. Roč. 7, č. 5 (2021), s. 1077-1088. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LH15040; GA MŠMT LO1302; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine peptidase * drug target * parasite * Schistosoma mansoni * vinyl sulfone inhibitor
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00501
Permanent Link: http://hdl.handle.net/11104/0318491 - 2.0538821 - ÚOCHB 2022 RIV US eng J - Journal Article
Jílková, Adéla - Horn, Martin - Fanfrlík, Jindřich - Küppers, J. - Pachl, Petr - Řezáčová, Pavlína - Lepšík, Martin - Fajtová, Pavla - Rubešová, Petra - Chanová, M. - Caffrey, C. R. - Gütschow, M. - Mareš, Michael
Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity.
ACS Infectious Diseases. Roč. 7, č. 1 (2021), s. 189-201. ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MZd(CZ) NV18-05-00345; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : azapeptide inhibitors * cysteine proteases * protein structures * structure-activity relationships * schistosomiasis
OECD category: Biochemistry and molecular biology
Impact factor: 5.578, year: 2021
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.0c00644
Permanent Link: http://hdl.handle.net/11104/0316970 - 3.0491001 - ÚOCHB 2019 RIV US eng J - Journal Article
Leontovyč, Adrian - Ulrychová, Lenka - O'Donoghue, A.J. - Vondrášek, Jiří - Marešová, Lucie - Hubálek, Martin - Fajtová, Pavla - Chanová, M. - Jiang, Z. - Craik, C. S. - Caffrey, C. R. - Mareš, Michael - Dvořák, Jan - Horn, Martin
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.
PLoS Neglected Tropical Diseases. Roč. 12, č. 4 (2018), č. článku e0006446. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA MŠMT LD15101; GA MŠMT(CZ) LH15040; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : Echinococcus granulosus * cathepsin B * molecular characterization
OECD category: Biochemistry and molecular biology
Impact factor: 4.487, year: 2018
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006446
Permanent Link: http://hdl.handle.net/11104/0285096File Download Size Commentary Version Access 0491001.pdf 2 17.8 MB Publisher’s postprint open-access - 4.0471827 - ÚMG 2017 RIV FR eng J - Journal Article
Dvořák, Jan - Fajtová, P. - Ulrychová, Lenka - Leontovyc, A. - Rojo-Arreola, L. - Suzuki, B.M. - Horn, M. - Mareš, M. - Craik, C. S. - Caffrey, C. R. - O'Donoghue, A.J.
Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.
Biochimie. Roč. 122, jaro (2016), s. 99-109. ISSN 0300-9084. E-ISSN 1638-6183
R&D Projects: GA ČR(CZ) GAP302/11/1481; GA MŠMT LO1302
Institutional support: RVO:68378050
Keywords : Parasite * Fluke * Secretion * Excretion * Protease * Inhibitor
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.112, year: 2016
Permanent Link: http://hdl.handle.net/11104/0269152File Download Size Commentary Version Access Biochimie_J_Dvorak_2016.pdf 4 2.1 MB Publisher’s postprint require - 5.0471793 - ÚOCHB 2017 RIV FR eng J - Journal Article
Dvořák, Jan - Fajtová, Pavla - Ulrychová, L. - Leontovyč, Adrian - Rojo-Arreola, L. - Suzuki, B.M. - Horn, Martin - Mareš, Michael - Craik, C. S. - Caffrey, C. R. - O'Donoghue, A.J.
Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.
Biochimie. Roč. 122, Mar (2016), s. 99-109. ISSN 0300-9084. E-ISSN 1638-6183
R&D Projects: GA ČR(CZ) GAP302/11/1481; GA MŠMT LO1302
Institutional support: RVO:61388963
Keywords : parasite * fluke * secretion * excretion * protease * inhibitor
Subject RIV: CE - Biochemistry
Impact factor: 3.112, year: 2016
Permanent Link: http://hdl.handle.net/11104/0269112 - 6.0469034 - BC 2017 RIV FR eng J - Journal Article
Dvořák, Jan - Fajtová, P. - Ulrychová, L. - Leontovyc, A. - Rojo-Arreola, L. - Suzuki, B.M. - Horn, M. - Mareš, M. - Craik, C. S. - Caffrey, C. R. - O'Donoghue, A.J.
Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.
Biochimie. Roč. 122, MAR (2016), s. 99-109. ISSN 0300-9084. E-ISSN 1638-6183
Institutional support: RVO:60077344
Keywords : parasite * fluke * secretion * excretion * protease * inhibitor
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.112, year: 2016
Permanent Link: http://hdl.handle.net/11104/0266930 - 7.0446340 - ÚOCHB 2016 RIV US eng J - Journal Article
Fajtová, Pavla - Štefanic, S. - Hradilek, Martin - Dvořák, Jan - Vondrášek, Jiří - Jílková, Adéla - Ulrychová, Lenka - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael - Horn, Martin
Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.
PLoS Neglected Tropical Diseases. Roč. 9, č. 6 (2015), e0003827/1-e0003827/24. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA ČR(CZ) GAP302/11/1481; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : Schistosoma mansoni * schistosomiasis * prolyl oligopeptidase * blood fluke
Subject RIV: CE - Biochemistry; EB - Genetics ; Molecular Biology (UMG-J)
Impact factor: 3.948, year: 2015
http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003827
Permanent Link: http://hdl.handle.net/11104/0248346File Download Size Commentary Version Access 0446340.PDF 3 5.8 MB Publisher’s postprint open-access - 8.0438380 - ÚOCHB 2015 RIV GB eng J - Journal Article
Jílková, Adéla - Horn, Martin - Řezáčová, Pavlína - Marešová, Lucie - Fajtová, Pavla - Brynda, Jiří - Vondrášek, Jiří - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael
Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch.
Structure. Roč. 22, č. 12 (2014), s. 1786-1798. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA ČR GA203/09/1585; GA MŠMT LH12023; GA MŠMT LO1302
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : human procathepsin B * slow binding inhibition * asparaginyl endopeptidase
Subject RIV: CE - Biochemistry
Impact factor: 5.618, year: 2014
Permanent Link: http://hdl.handle.net/11104/0241842 - 9.0429904 - ÚOCHB 2015 RIV US eng J - Journal Article
Horn, Martin - Fajtová, Pavla - Arreola, L. R. - Ulrychová, Lenka - Bartošová-Sojková, Pavla - Franta, Zdeněk - Protasio, A. V. - Opavský, David - Vondrášek, Jiří - McKerrow, J. H. - Mareš, Michael - Caffrey, C. R. - Dvořák, Jan
Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni - 'The Undiscovered Country'.
PLoS Neglected Tropical Diseases. Roč. 8, č. 3 (2014), e2766/1-e2766/13. ISSN 1935-2735. E-ISSN 1935-2735
R&D Projects: GA ČR(CZ) GAP302/11/1481; GA MŠMT(CZ) ME10011
EU Projects: European Commission(XE) 248642 - SCHISTOSOMA PROTEASE
Institutional support: RVO:61388963 ; RVO:68378050 ; RVO:60077344
Keywords : schistosomiasis * blood fluke * serine protease
Subject RIV: CE - Biochemistry; EB - Genetics ; Molecular Biology (UMG-J); FN - Epidemiology, Contagious Diseases ; Clinical Immunology (BC-A)
Impact factor: 4.446, year: 2014
http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002766
Permanent Link: http://hdl.handle.net/11104/0234956 - 10.0397478 - BC 2014 RIV GB eng J - Journal Article
Sojka, Daniel - Franta, Zdeněk - Horn, Martin - Caffrey, C. R. - Mareš, Michael - Kopáček, Petr
New insights into the machinery of blood digestion by ticks.
Trends in Parasitology. Roč. 29, č. 6 (2013), s. 276-285. ISSN 1471-4922. E-ISSN 1471-5007
R&D Projects: GA ČR GA13-11043S; GA ČR(CZ) GAP207/10/2183; GA ČR GPP502/11/P682; GA AV ČR IAA600960910
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : tick * Ixodes * hemoglobin * digestion * peptidase * cathepsin
Subject RIV: EC - Immunology
Impact factor: 6.217, year: 2013
Permanent Link: http://hdl.handle.net/11104/0225104