Search results
- 1.0556294 - ÚMG 2022 RIV CH eng J - Journal Article
Reiberger, R. - Radilova, K. - Král, M. - Zima, V. - Majer, P. - Brynda, Jiří - Dračínský, M. - Konvalinka, J. - Kožíšek, M. - Machara, A.
Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors.
International Journal of Molecular Sciences. Roč. 22, č. 14 (2021), č. článku 7735. E-ISSN 1422-0067
Institutional support: RVO:68378050
Keywords : bio-isosterism * cross-coupling * endonuclease inhibitor * flavonoids * influenza * Mannich reaction * RNA polymerase
OECD category: Biochemistry and molecular biology
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/14/7735
Permanent Link: http://hdl.handle.net/11104/0330581 - 2.0548554 - ÚMG 2022 RIV DE eng J - Journal Article
Kugler, Michael - Nekvinda, J. - Holub, J. - El Anwar, S. - Das, V. - Šícha, V. - Pospíšilová, K. - Fábry, Milan - Král, Vlastimil - Brynda, Jiří - Kašička, V. - Hajduch, M. - Řezáčová, Pavlína - Grüner, B.
Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds.
Chembiochem. Roč. 22, č. 18 (2021), s. 2741-2761. ISSN 1439-4227. E-ISSN 1439-7633
Institutional support: RVO:68378050
Keywords : carbonic anhydrase * carborane * cobalt bis(dicarbollide) * crystallography * enzyme inhibition * SAR studies
OECD category: Biochemistry and molecular biology
Impact factor: 3.468, year: 2021
Method of publishing: Limited access
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202100121
Permanent Link: http://hdl.handle.net/11104/0324600 - 3.0548549 - ÚMG 2022 RIV GB eng J - Journal Article
Šoltysová, M. - Sieglová, Irena - Fábry, Milan - Brynda, Jiří - Škerlová, Jana - Řezáčová, Pavlína
Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family.
Acta Crystallographica Section D-Structural Biology. Roč. 77, č. 11 (2021), s. 1411-1424. ISSN 2059-7983. E-ISSN 2059-7983
Institutional support: RVO:68378050
Keywords : SorC/DeoR family * protein-DNA complexes * transcription repressors * Bacillus subtilis * deoxyribonucleoside regulator bsDeoR * gene regulator bsCggR * carbohydrate catabolism
OECD category: Biochemistry and molecular biology
Impact factor: 5.699, year: 2021
Method of publishing: Limited access
https://scripts.iucr.org/cgi-bin/paper?S2059798321009633
Permanent Link: http://hdl.handle.net/11104/0324596 - 4.0544834 - ÚMG 2022 RIV US eng J - Journal Article
Kryštůfek, R. - Šácha, P. - Starková, J. - Brynda, Jiří - Hradilek, M. - Tloušťová, E. - Grzymska, J. - Rut, W. - Boucher, M. J. - Drag, M. - Majer, P. - Hájek, M. - Řezáčová, Pavlína - Madhani, H. D. - Craik, C. S. - Konvalinka, J.
Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
Journal of Medicinal Chemistry. Roč. 64, č. 10 (2021), s. 6706-6719. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : immunodeficiency-virus hiv * in-vitro * virulence factors * type-1 protease * inhibitors * pepsin * specificity * meningitis * expression * strategies
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c02177
Permanent Link: http://hdl.handle.net/11104/0321646 - 5.0540277 - ÚMG 2021 RIV US eng J - Journal Article
Tykvart, J. - Navrátil, V. - Kugler, Michael - Šácha, P. - Schimer, J. - Hlaváčková, A. - Tenora, L. - Zemanová, J. - Dejmek, M. - Král, Vlastimil - Potáček, M. - Majer, P. - Jahn, U. - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, J.
Identification of Novel Carbonic Anhydrase IX Inhibitors Using High-Throughput Screening of Pooled Compound Libraries by DNA-Linked Inhibitor Antibody Assay (DIANA).
SLAS Discovery. Roč. 25, č. 9 (2020), s. 1026-1037. ISSN 2472-5552. E-ISSN 2472-5560
Institutional support: RVO:68378050
Keywords : high-throughput screening * carbonic anhydrase IX * drug discovery * DNA-linked inhibitor antibody assay
OECD category: Biochemistry and molecular biology
Impact factor: 2.918, year: 2020
Method of publishing: Limited access
https://journals.sagepub.com/doi/10.1177/2472555220918836
Permanent Link: http://hdl.handle.net/11104/0317971 - 6.0540276 - ÚMG 2021 RIV GB eng J - Journal Article
Pachl, P. - Kapešová, J. - Brynda, Jiří - Biedermannova, L. - Pelantová, H. - Bojarová, P. - Křen, V. - Řezáčová, Pavlína - Kotik, M.
Rutinosidase from Aspergillus niger: crystal structure and insight into the enzymatic activity.
FEBS Journal. Roč. 287, č. 15 (2020), s. 3315-3327. ISSN 1742-464X. E-ISSN 1742-4658
Institutional support: RVO:68378050
Keywords : catalytic mechanism * diglycosidase * rutin * siras * X-ray crystallography
OECD category: Biochemistry and molecular biology
Impact factor: 5.542, year: 2020
Method of publishing: Limited access
https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/febs.15208
Permanent Link: http://hdl.handle.net/11104/0317970 - 7.0539592 - ÚOCHB 2022 RIV DE eng J - Journal Article
Šolínová, Veronika - Brynda, Jiří - Šícha, Václav - Holub, Josef - Grüner, Bohumír - Kašička, Václav
Determination of acidity constants, ionic mobilities, and hydrodynamic radii of carborane-based inhibitors of carbonic anhydrases by capillary electrophoresis.
Electrophoresis. Roč. 42, 7/8 (2021), s. 910-919. ISSN 0173-0835. E-ISSN 1522-2683
R&D Projects: GA ČR(CZ) GA20-03899S
Institutional support: RVO:61388963 ; RVO:68378050 ; RVO:61388980
Keywords : acid dissociation constant * capillary electrophoresis * carboranes * limiting ionic mobilities * stokes hydrodynamic radii
OECD category: Analytical chemistry; Inorganic and nuclear chemistry (UACH-T)
Impact factor: 3.595, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/elps.202000298
Permanent Link: http://hdl.handle.net/11104/0318117 - 8.0539172 - ÚMG 2021 RIV GB eng J - Journal Article
Lux, V. - Brouns, T. - Cermakova, K. - Srb, P. - Fábry, Milan - Mádlíková, M. - Hořejší, Magdalena - Kukačka, Z. - Novák, P. - Kugler, M. - Brynda, Jiří - DeRijck, J. - Christ, F. - Debyser, Z. - Veverka, V.
Molecular Mechanism of LEDGF/p75 Dimerization.
Structure. Roč. 28, č. 12 (2020), s. 1288-1299. ISSN 0969-2126. E-ISSN 1878-4186
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:68378050
Keywords : PSIP1 * domain swapping * eletrostatic stapling * epigenetics * mixed-lineage leukemia * paramagnetic NMR * protein-protein interaction * transcription
OECD category: Biochemistry and molecular biology
Impact factor: 5.006, year: 2020
Method of publishing: Limited access
https://www.cell.com/structure/fulltext/S0969-2126(20)30325-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0969212620303257%3Fshowall%3Dtrue
Permanent Link: http://hdl.handle.net/11104/0316873 - 9.0539170 - ÚMG 2021 RIV GB eng J - Journal Article
Kugler, Michael - Holub, J. - Brynda, Jiří - Pospíšilová, K. - El Anwar, S. - Bavol, D. - Havránek, M. - Král, Vlastimil - Fábry, Milan - Gruner, B. - Řezáčová, Pavlína
The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 35, č. 1 (2020), s. 1800-1810. ISSN 1475-6366. E-ISSN 1475-6374
Institutional support: RVO:68378050
Keywords : tumor hypoxia * medicinal chemistry * drug discovery * binding-sites * inhibition * boron * pharmacophores * opportunities * conjugation * metastasis * Carbonic anhydrase IX * carborane * enzyme inhibitors * structure-activity relationship
OECD category: Biochemistry and molecular biology
Impact factor: 5.051, year: 2020
Method of publishing: Open access
https://www.tandfonline.com/doi/full/10.1080/14756366.2020.1816996
Permanent Link: http://hdl.handle.net/11104/0316870 - 10.0539161 - ÚMG 2021 RIV FR eng J - Journal Article
Zima, V. - Radilova, K. - Kožíšek, M. - Albinana, C. B. - Karlukova, E. - Brynda, Jiří - Fanfrlik, J. - Flieger, M. - Hodek, J. - Weber, J. - Majer, P. - Konvalinka, J. - Machara, A.
Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
European Journal of Medicinal Chemistry. Roč. 208, December (2020), č. článku 112754. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:68378050
Keywords : Influenza * Neuraminidase * Polyphenols * PA(N) endonuclease Inhibitors * RNA polymerase
OECD category: Biochemistry and molecular biology
Impact factor: 6.514, year: 2020
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0223523420307261?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0316866