Search results
- 1.0548073 - ÚOCHB 2022 RIV CH eng J - Journal Article
Harmatha, Juraj - Buděšínský, Miloš - Zídek, Zdeněk - Kmoníčková, Eva
Spirostanol Saponins from Flowers of Allium Porrum and Related Compounds Indicating Cytotoxic Activity and Affecting Nitric Oxide Production Inhibitory Effect in Peritoneal Macrophages.
Molecules. Roč. 26, č. 21 (2021), č. článku 6533. E-ISSN 1420-3049
R&D Projects: GA ČR GA305/07/0061
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : Allium porrum * NO production * aginoside * alliporin * cytotoxicity * leek flowers * steroid saponins
OECD category: Organic chemistry; Toxicology (UEM-P)
Impact factor: 4.927, year: 2021
Method of publishing: Open access
https://doi.org/10.3390/molecules26216533
Permanent Link: http://hdl.handle.net/11104/0324192 - 2.0543665 - ÚOCHB 2022 RIV DE eng J - Journal Article
Kalčic, Filip - Kolman, Viktor - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted Pyrimidines as Potent Inhibitors of Prostaglandin E2 Production: Increasing Aqueous Solubility.
ChemMedChem. Roč. 16, č. 18 (2021), s. 2802-2806. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : anti-inflammatory * prostaglandin E2 * pyrimidines * solubility * synthesis
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 3.540, year: 2021
Method of publishing: Limited access
https://doi.org/10.1002/cmdc.202100263
Permanent Link: http://hdl.handle.net/11104/0320847 - 3.0525593 - ÚOCHB 2021 RIV DE eng J - Journal Article
Kalčic, Filip - Kolman, Viktor - Ajani, Haresh - Zídek, Zdeněk - Janeba, Zlatko
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema.
ChemMedChem. Roč. 15, č. 15 (2020), s. 1398-1407. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : anti-inflammatory * mPGES-1 * prostaglandin E2 * pyrimidines * Suzuki Miyaura reaction
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 3.466, year: 2020
Method of publishing: Limited access
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cmdc.202000258
Permanent Link: http://hdl.handle.net/11104/0309705 - 4.0505590 - ÚOCHB 2020 RIV IT eng J - Journal Article
Harmatha, Juraj - Buděšínský, Miloš - Jurášek, M. - Zimmermann, T. - Drašar, P. - Zídek, Zdeněk - Kmoníčková, Eva - Vejvodová, L.
Structural modification of trilobolide for upgrading its immunobiological properties and reducing its cytotoxic action.
Fitoterapia. Roč. 134, Apr (2019), s. 88-95. ISSN 0367-326X. E-ISSN 1873-6971
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : sesquiterpene lactones * trilobolide derivatives * cytotoxicity * nitric oxide production * immunomodulatory activity
OECD category: Organic chemistry; Pharmacology and pharmacy (UEM-P)
Impact factor: 2.527, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0367326X18320987?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0297060 - 5.0493581 - ÚOCHB 2019 RIV FR eng J - Journal Article
Kolman, Viktor - Kalčic, Filip - Jansa, Petr - Zídek, Zdeněk - Janeba, Zlatko
Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production.
European Journal of Medicinal Chemistry. Roč. 156, Aug 5 (2018), s. 295-301. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidines * Suzuki-Miyaura reaction * prostaglandin E2 * inhibitor
OECD category: Organic chemistry; Medicinal chemistry (UEM-P)
Impact factor: 4.833, year: 2018
Permanent Link: http://hdl.handle.net/11104/0286924 - 6.0476117 - ÚOCHB 2018 RIV NL eng J - Journal Article
Kolman, Viktor - Jansa, Petr - Kalčic, Filip - Janeba, Zlatko - Zídek, Zdeněk
Polysubstituted 4,6-bis(hetero)arylpyrimidines as dual inhibitors of nitric oxide and prostaglandin E-2 production.
Nitric Oxide-Biology and Chemistry. Roč. 67, Jul 1 (2017), s. 53-57. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA TA ČR(CZ) TE01020028
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidine derivatives * nitric oxide * prostaglandin E-2 * dual inhibitors * anti-inflammatory properties
OECD category: Biochemistry and molecular biology; Organic chemistry (UEM-P)
Impact factor: 4.367, year: 2017
Permanent Link: http://hdl.handle.net/11104/0272652 - 7.0459500 - ÚEM 2017 RIV NL eng J - Journal Article
Zídek, Zdeněk - Kverka, Miloslav - Dusilová, Adéla - Kmoníčková, Eva - Jansa, Petr
Dual inhibition of nitric oxide and prostaglandin E2 production by polysubstituted 2-aminopyrimidines.
Nitric Oxide-Biology and Chemistry. Roč. 57, jul (2016), s. 48-56. ISSN 1089-8603. E-ISSN 1089-8611
R&D Projects: GA ČR(CZ) GAP303/12/0172
Institutional support: RVO:68378041 ; RVO:61388963
Keywords : pyrimidines * nitric oxide * prostaglandin E-2
Subject RIV: FR - Pharmacology ; Medidal Chemistry; CC - Organic Chemistry (UOCHB-X)
Impact factor: 4.181, year: 2016
Permanent Link: http://hdl.handle.net/11104/0259692 - 8.0455314 - ÚOCHB 2016 RIV IT eng J - Journal Article
Harmatha, Juraj - Vokáč, Karel - Buděšínský, Miloš - Zídek, Zdeněk - Kmoníčková, Eva
Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide.
Fitoterapia. Roč. 107, Dec (2015), s. 90-99. ISSN 0367-326X. E-ISSN 1873-6971
R&D Projects: GA ČR GA305/07/0061
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : sesquiterpene lactones * guaianolides * trilobolide derivatives * nitric oxide * cytokines * immunoactivity
Subject RIV: CC - Organic Chemistry
Impact factor: 2.408, year: 2015
Permanent Link: http://hdl.handle.net/11104/0255933 - 9.0451787 - ÚEM 2016 RIV US eng J - Journal Article
Li, Y.J. - Guo, Y. - Yang, Q. - Weng, X. G. - Yang, L. - Wang, Y.J. - Chen, Y. - Zhang, D. - Li, Q. - Liu, X.C. - Kan, X.X. - Chen, X. - Zhu, X.X. - Kmoníčková, E. - Zídek, Zdeněk
Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo.
Toxicology and Applied Pharmacology. Roč. 286, č. 3 (2015), s. 151-158. ISSN 0041-008X. E-ISSN 1096-0333
Institutional support: RVO:68378041
Keywords : Artemisia annua L. * Flavonoids * Casticin * Chrysosplenol D * Inflammation
Subject RIV: EC - Immunology
Impact factor: 3.847, year: 2015
Permanent Link: http://hdl.handle.net/11104/0253408 - 10.0444646 - ÚOCHB 2016 RIV US eng J - Journal Article
Jansa, Petr - Holý, Antonín - Dračínský, Martin - Kolman, Viktor - Janeba, Zlatko - Kmoníčková, Eva - Zídek, Zdeněk
Synthesis and structure-activity relationship studies of polysubstituted pyrimidines as inhibitors of immune-activated nitric oxide production.
Medicinal Chemistry Research. Roč. 24, č. 5 (2015), s. 2154-2166. ISSN 1054-2523. E-ISSN 1554-8120
R&D Projects: GA ČR(CZ) GAP303/12/0172; GA MV VG20102015046
Institutional support: RVO:61388963 ; RVO:68378041
Keywords : pyrimidine * nitric oxide * NO * anti-inflammatory
Subject RIV: CC - Organic Chemistry
Impact factor: 1.436, year: 2015
Permanent Link: http://hdl.handle.net/11104/0247170