Search results
- 1.0545764 - ÚEB 2022 RIV FR eng J - Journal Article
Krajčovičová, S. - Jorda, Radek - Vanda, D. - Soural, M. - Kryštof, Vladimír
1,4,6-Trisubstituted imidazo[4,5-c]pyridines as inhibitors of Bruton's tyrosine kinase.
European Journal of Medicinal Chemistry. Roč. 211, FEB 5 (2021), č. článku 113094. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61389030
Keywords : Bruton's tyrosine kinase * imidazo[4,5-c]pyridine * Inhibitor * Protein kinase
OECD category: Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions (pharmacogenomics, gene-based therapeutics)
Impact factor: 7.088, year: 2021
Method of publishing: Open access
http://doi.org/10.1016/j.ejmech.2020.113094
Permanent Link: http://hdl.handle.net/11104/0322426File Download Size Commentary Version Access 2021_Krajcovicova_European Journal Of Medicinal Chemistry_113094.pdf 1 1.5 MB Other open-access - 2.0541026 - ÚEB 2022 RIV CZ eng J - Journal Article
Spicakova, A. - Kraus, Petr - Gucký, Tomáš - Kryštof, Vladimír - Strnad, Miroslav - Bazgier, V. - Otyepka, M. - Kubickova, V. - Poruba, M. - Rácová, Z. - Zapletalová, I. - Anzenbacher, P.
in vitro and in silico Studies of Interaction of Synthetic 2,6,9-Trisubstituted Purine Kinase Inhibitors BPA-302, BP-21 and BP-117 With Liver Drug-Metabolizing Cytochromes P450.
Physiological Research. Roč. 69, SEP (2020), s. 627-636. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MZd(CZ) NV17-28231A
Institutional support: RVO:61389030
Keywords : r-roscovitine * cell-cycle * cancer * series * Cytochrome P450 inhibition * High performance liquid chromatography * Cyclin-dependent kinase inhibitor * FLT3-ITD inhibitor * Drug metabolism
OECD category: Organic chemistry
Impact factor: 1.881, year: 2020
Method of publishing: Open access
https://www.biomed.cas.cz/physiolres/pdf/2020/69_S627.pdf
Permanent Link: http://hdl.handle.net/11104/0318600File Download Size Commentary Version Access 2020_Spicakova_Physiological Research_S627.pdf 1 2.5 MB Other open-access - 3.0535283 - ÚEB 2021 RIV FR eng J - Journal Article
Jorda, Radek - Krajčovičová, S. - Králová, P. - Soural, M. - Kryštof, Vladimír
Scaffold hopping of the SYK inhibitor entospletinib leads to broader targeting of the BCR signalosome.
European Journal of Medicinal Chemistry. Roč. 204, OCT 15 (2020), č. článku 112636. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61389030
Keywords : Bruton's tyrosine kinase * Protein kinase * Scaffold hopping * Selectivity * Spleen tyrosine kinase
OECD category: Hematology
Impact factor: 6.514, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.ejmech.2020.112636
Permanent Link: http://hdl.handle.net/11104/0313353File Download Size Commentary Version Access 2020_Jorda_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_112636.pdf 1 1.5 MB Other open-access - 4.0533489 - ÚEB 2021 RIV GB eng J - Journal Article
Štětková, M. - Growková, K. - Fojtík, P. - Valčíková, B. - Palušová, V. - Verlande, A. - Jorda, Radek - Kryštof, Vladimír - Hejret, V. - Alexiou, P. - Rotrekl, V. - Uldrijan, S.
CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells.
Cell Death & Disease. Roč. 11, č. 9 (2020), č. článku 754. ISSN 2041-4889. E-ISSN 2041-4889
Institutional support: RVO:61389030
Keywords : DEPENDENT KINASE INHIBITOR * RNA-POLYMERASE-II * NUCLEAR ACCUMULATION
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 8.469, year: 2020
Method of publishing: Open access
http://doi.org/10.1038/s41419-020-02971-3
Permanent Link: http://hdl.handle.net/11104/0311866File Download Size Commentary Version Access 2020_Stetkova_CELL DEATH & DISEASE_754.pdf 1 2.3 MB Other open-access - 5.0532929 - ÚEB 2022 RIV GB eng J - Journal Article
Varvuolytė, G. - Malina, L. - Bieliauskas, A. - Hošíková, B. - Simerská, Helena - Kolářová, H. - Kleizienė, N. - Kryštof, Vladimír - Šačkus, A. - Žukauskaitė, Asta
Synthesis and photodynamic properties of pyrazole-indole hybrids in the human skin melanoma cell line G361.
Dyes and Pigments. Roč. 183, DEC (2020), č. článku 108666. ISSN 0143-7208. E-ISSN 1873-3743
Institutional support: RVO:61389030
Keywords : Conjugated system * Cytotoxicity * Fluorescence * Indole * Photodynamic effect * Pyrazole
OECD category: Cell biology
Impact factor: 4.889, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.dyepig.2020.108666
Permanent Link: http://hdl.handle.net/11104/0311308File Download Size Commentary Version Access 2020_Varvuolyte_DYES AND PIGMENTS_108666.pdf 1 5.1 MB Other open-access - 6.0524325 - ÚEB 2021 RIV FR eng J - Journal Article
Said, M. A. - Eldehna, W. M. - Nocentini, A. - Fahim, S. H. - Bonardi, A. - Elgazar, A. A. - Kryštof, Vladimír - Soliman, D. H. - Abdel-Aziz, F.A. - Gratteri, P. - Abou-Seri, S. M. - Supuran, C.T.
Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation.
European Journal of Medicinal Chemistry. Roč. 189, MAR 1 (2020), č. článku 112019. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61389030
Keywords : can508 * carbonic anhydrase inhibitors * CDK inhibitors * Imidazopyrazoles * Molecular docking * Pyrazolopyrimidines
OECD category: Oncology
Impact factor: 6.514, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.ejmech.2019.112019
Permanent Link: http://hdl.handle.net/11104/0308686File Download Size Commentary Version Access 2020_Said_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_112019.pdf 1 1.6 MB Other open-access - 7.0523953 - ÚEB 2021 RIV CH eng J - Journal Article
Salas, C. O. - Zarate, A. M. - Kryštof, Vladimír - Mella, J. - Faundez, M. - Brea, J. - Loza, M. I. - Brito, I. - Hendrychová, Denisa - Jorda, Radek - Cabrera, A. R. - Tapia, R. A. - Espinosa-Bustos, C.
Promising 2,6,9-trisubstituted purine derivatives for anticancer compounds: Synthesis, 3D-QSAR, and preliminary biological assays.
International Journal of Molecular Sciences. Roč. 21, č. 1 (2020), č. článku 161. E-ISSN 1422-0067
Institutional support: RVO:61389030
Keywords : 3d-qsar * Apoptosis * Cancer * Cell cycle * Cytotoxicity * Purine derivatives
OECD category: Oncology
Impact factor: 5.924, year: 2020
Method of publishing: Open access
http://doi.org/10.3390/ijms21010161
Permanent Link: http://hdl.handle.net/11104/0308263File Download Size Commentary Version Access 2020_Salas_INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES_161.pdf 1 5.1 MB Other open-access - 8.0523649 - ÚEB 2020 RIV FR eng J - Journal Article
Jorda, Radek - Magar, P. P. - Hendrychová, Denisa - Pauk, K. - Dibus, M. - Pilařová, E. - Imramovský, A. - Kryštof, Vladimír
Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells.
European Journal of Medicinal Chemistry. Roč. 188, FEB 15 (2020), č. článku 112036. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:61389030
Keywords : Adhesion * Apoptosis * cytotoxicity * Detachment * Dipeptide
OECD category: Medicinal chemistry
Impact factor: 6.514, year: 2020
Method of publishing: Open access
http://doi.org/10.1016/j.ejmech.2020.112036
Permanent Link: http://hdl.handle.net/11104/0307967File Download Size Commentary Version Access 2020_Jorda_EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY_112036.pdf 3 1.3 MB Other open-access - 9.0523373 - ÚOCHB 2021 RIV GB eng J - Journal Article
Köprülüoglu, Cemal - Dejmek, Milan - Šála, Michal - Ajani, Haresh - Hřebabecký, Hubert - Fanfrlík, Jindřich - Jorda, Radek - Dračínský, Martin - Procházková, Eliška - Šácha, Pavel - Kryštof, Vladimír - Hobza, Pavel - Lepšík, Martin - Nencka, Radim
Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors.
Journal of Molecular Recognition. Roč. 33, č. 8 (2020), č. článku e2842. ISSN 0952-3499. E-ISSN 1099-1352
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963 ; RVO:61389030
Keywords : ATP-competitive type I inhibitors * cyclin-dependent kinase 2 * protein-ligand binding * quantum mechanical scoring
OECD category: Physical chemistry
Impact factor: 2.137, year: 2020
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmr.2842
Permanent Link: http://hdl.handle.net/11104/0307732 - 10.0521912 - ÚEB 2020 RIV US eng J - Journal Article
Bertrand, J. - Dostálová, Hana - Kryštof, Vladimír - Jorda, Radek - Castro, A. - Mella, J. - Espinosa-Bustos, C. - María Zarate, A. - Salas, C. O.
New 2,6,9-trisubstituted purine derivatives as Bcr-Abl and Btk inhibitors and as promising agents against leukemia.
Bioorganic Chemistry. Roč. 94, JAN (2020), č. článku 103361. ISSN 0045-2068. E-ISSN 1090-2120
Institutional support: RVO:61389030
Keywords : Bcr-Abl inhibitors * Btk inhibitors * Docking * Leukemia * Purine derivatives * qsar
OECD category: Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions (pharmacogenomics, gene-based therapeutics)
Impact factor: 5.275, year: 2020
Method of publishing: Open access
http://dx.doi.org/10.1016/j.bioorg.2019.103361
Permanent Link: http://hdl.handle.net/11104/0306457File Download Size Commentary Version Access 2020_Bertrand_Bioorganic Chemistry_103361.pdf 2 3 MB Other open-access