Search results
- 1.0618471 - MBÚ 2026 RIV NL eng J - Journal Article
Kaňa, Martin - Braunová, Alena - Starenko, Daniil - Frejková, Markéta - Bouček, Jan - Říhová, Blanka - Kovář, Marek - Etrych, Tomáš - Šírová, Milada
Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery.
Journal of Controlled Release. Roč. 381, May 10 (2025), č. článku 113645. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA MZd(CZ) NU21-03-00273; GA MŠMT LX22NPO5102
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Multidrug resistance * P-glycoprotein inhibition * Sensitization to chemotherapy * Intracellular ATP depletion * HPMA copolymer * PPO * Diblock copolymers * Drug delivery system
OECD category: Immunology; Polymer science (UMCH-V)
Impact factor: 10.5, year: 2023 ; AIS: 1.79, rok: 2023
Method of publishing: Open access
Result website:
https://www.sciencedirect.com/science/article/pii/S0168365925002652DOI: https://doi.org/10.1016/j.jconrel.2025.113645
Permanent Link: https://hdl.handle.net/11104/0365334File Download Size Commentary Version Access Kana et al JCR 2025.pdf 0 13.2 MB Publisher’s postprint open-access - 2.0565337 - ÚMCH 2024 RIV NL eng J - Journal Article
Kostka, Libor - Kotrchová, Lenka - Randárová, Eva - Ferreira, C. A. - Malátová, Iva - Lee, H. J. - Olson, A. P. - Engle, J. W. - Kovář, Marek - Cai, W. - Šírová, Milada - Etrych, Tomáš
Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models.
Journal of Controlled Release. Roč. 353, January (2023), s. 549-562. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA MŠMT LX22NPO5102; GA MŠMT(CZ) LTAUSA18083
Grant - others:AV ČR(CZ) MSM200502104
Program: Program na podporu mezinárodní spolupráce začínajících výzkumných pracovníků
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : drug delivery * cancer * polymeric carriers
OECD category: Polymer science; Pharmacology and pharmacy (MBU-M)
Impact factor: 10.5, year: 2023 ; AIS: 1.79, rok: 2023
Method of publishing: Open access
Result website:
https://www.sciencedirect.com/science/article/pii/S0168365922008148?via%3DihubDOI: https://doi.org/10.1016/j.jconrel.2022.11.060
Permanent Link: https://hdl.handle.net/11104/0336896File Download Size Commentary Version Access 0565337.pdf 1 8 MB Creative Commons Attribution 4.0 International License (CC BY) Publisher’s postprint open-access - 3.0563741 - MBÚ 2023 RIV CH eng J - Journal Article
Antošová, Z. - Podzimkova, N. - Tomala, Jakub - Augustýnková, K. - Sajnerová, K. - Nedvědová, E. - Šírová, Milada - de Martynoff, G. - Bechard, D. - Moebius, U. - Kovář, Marek - Špíšek, R. - Adkins, I.
SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity.
Frontiers in Immunology. Roč. 13, OCT 10 2022 (2022), č. článku 989895. ISSN 1664-3224. E-ISSN 1664-3224
Institutional support: RVO:61388971
Keywords : NK cells * antibody-dependent cytotoxicity * interleukin-15 * immunotherapy * therapeutic antibodies * rli-15
OECD category: Oncology
Impact factor: 7.3, year: 2022 ; AIS: 1.765, rok: 2022
Method of publishing: Open access
Result website:
https://www.frontiersin.org/articles/10.3389/fimmu.2022.989895/fullDOI: https://doi.org/10.3389/fimmu.2022.989895
Permanent Link: https://hdl.handle.net/11104/0335572 - 4.0559474 - ÚMCH 2023 RIV US eng J - Journal Article
Kousalová, Jana - Šírová, Milada - Kostka, Libor - Šubr, Vladimír - Kovářová, Jiřina - Běhalová, Kateřina - Studenovský, Martin - Kovář, Marek - Etrych, Tomáš
Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines.
Nanomedicine: Nanotechnology, Biology and Medicine. Roč. 44, August (2022), č. článku 102578. ISSN 1549-9634. E-ISSN 1549-9642
R&D Projects: GA MŠMT(CZ) LTAUSA18083
Grant - others:AV ČR(CZ) JSPS-22-01
Program: Bilaterální spolupráce
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : matrix metalloproteinases * metastases * actinonin
OECD category: Polymer science; Oncology (MBU-M)
Impact factor: 5.4, year: 2022 ; AIS: 0.847, rok: 2022
Method of publishing: Limited access
Result website:
https://www.sciencedirect.com/science/article/pii/S1549963422000648?via%3DihubDOI: https://doi.org/10.1016/j.nano.2022.102578
Permanent Link: https://hdl.handle.net/11104/0332758 - 5.0558142 - ÚMCH 2023 RIV US eng J - Journal Article
Kostka, Libor - Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Šírová, Milada - Říhová, Blanka - Sedláček, Radislav - Etrych, Tomáš - Kovář, Marek
Simultaneous delivery of doxorubicin and protease inhibitor derivative to solid tumors via star-shaped polymer nanomedicines overcomes P-gp- and STAT3-mediated chemoresistance.
Biomacromolecules. Roč. 23, č. 6 (2022), s. 2522-2535. ISSN 1525-7797. E-ISSN 1526-4602
R&D Projects: GA ČR(CZ) GA19-05649S; GA MZd(CZ) NU21-03-00273; GA MŠMT(CZ) LTAUSA18083; GA MŠMT(CZ) LM2018126; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61389013 ; RVO:61388971 ; RVO:68378050
Keywords : HPMA * RAFT * star-like
OECD category: Polymer science; Microbiology (MBU-M); Genetics and heredity (medical genetics to be 3) (UMG-J)
Impact factor: 6.2, year: 2022 ; AIS: 1.076, rok: 2022
Method of publishing: Limited access
Result website:
https://pubs.acs.org/doi/10.1021/acs.biomac.2c00256DOI: https://doi.org/10.1021/acs.biomac.2c00256
Permanent Link: https://hdl.handle.net/11104/0332796File Download Size Commentary Version Access Simultaneous delivery.pdf 0 11 MB Publisher’s postprint require - 6.0556381 - MBÚ 2023 RIV US eng J - Journal Article
Vrbata, David - Filipová, Marcela - Tavares, Marina Rodrigues - Červený, Jakub - Vlachová, Miluše - Šírová, Milada - Pelantová, Helena - Petrásková, Lucie - Bumba, Ladislav - Konefal, Rafal - Etrych, Tomáš - Křen, Vladimír - Chytil, Petr - Bojarová, Pavla
Glycopolymers Decorated with 3-O-Substituted Thiodigalactosides as Potent Multivalent Inhibitors of Galectin-3.
Journal of Medicinal Chemistry. Roč. 65, č. 5 (2022), s. 3866-3878. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LTC19038; GA ČR(CZ) GA22-00262S; GA MZd(CZ) NU21-03-00273
EU Projects: European Commission(XE) CA17140 - COST Action
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : digit nm affinity * high selectivity * click chemistry * copolymers * glycopeptide * recognition * derivatives * apoptosis * fibrosis * arginine
OECD category: Biochemistry and molecular biology; Polymer science (UMCH-V)
Impact factor: 7.3, year: 2022 ; AIS: 1.587, rok: 2022
Method of publishing: Limited access
Result website:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c01625DOI: https://doi.org/10.1021/acs.jmedchem.1c01625
Permanent Link: http://hdl.handle.net/11104/0330739File Download Size Commentary Version Access 2022_Glycopolymers Decorated with 3‑O-Substituted Thiodigalactosides.pdf 0 6.1 MB Publisher’s postprint require - 7.0542896 - MBÚ 2022 RIV NL eng J - Journal Article
Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Dvořáková, Barbora - Šírová, Milada - Říhová, Blanka - Randárová, Eva - Kraus, Michal - Tomala, Jakub - Studenovský, Martin - Vondráčková, Michaela - Sedláček, Radislav - Makovický, Peter - Fučíková, J. - Vošahlíková, Š. - Spíšek, R. - Kostka, Libor - Etrych, Tomáš - Kovář, Marek
Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.
Journal of Controlled Release. Roč. 332, APR 10 2021 (2021), s. 563-580. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR(CZ) GA19-05649S; GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: CCP - 90040
Institutional support: RVO:61388971 ; RVO:61389013 ; RVO:68378050
Keywords : Ritonavir derivate * Polymer carrier * pH-controlled release * Antitumor activity * Proteasome inhibition * STAT3 signaling inhibition
OECD category: Microbiology; Polymer science (UMCH-V)
Impact factor: 11.467, year: 2021 ; AIS: 1.655, rok: 2021
Method of publishing: Limited access
Result website:
https://www.sciencedirect.com/science/article/pii/S0168365921001267DOI: https://doi.org/10.1016/j.jconrel.2021.03.015
Permanent Link: http://hdl.handle.net/11104/0320232File Download Size Commentary Version Access Polymer-ritonavir derivate nanomedicine.pdf 0 11.3 MB Publisher’s postprint require - 8.0539979 - ÚMCH 2022 RIV CH eng J - Journal Article
Tavares, Marina Rodrigues - Hrabánková, Klára - Konefal, Rafal - Kaňa, Martin - Říhová, Blanka - Etrych, Tomáš - Šírová, Milada - Chytil, Petr
HPMA-based copolymers carrying STAT3 inhibitor cucurbitacin-D as stimulus-sensitive nanomedicines for oncotherapy.
Pharmaceutics. Roč. 13, č. 2 (2021), č. článku 179. ISSN 1999-4923. E-ISSN 1999-4923
R&D Projects: GA ČR(CZ) GA17-08084S; GA MŠMT(CZ) LTAUSA18083
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : cucurbitacin-D * immuno-oncotherapy * N-(2-hydroxypropyl) methacrylamide (HPMA)
OECD category: Polymer science; Microbiology (MBU-M)
Impact factor: 6.525, year: 2021 ; AIS: 0.879, rok: 2021
Method of publishing: Open access
Result website:
https://www.mdpi.com/1999-4923/13/2/179DOI: https://doi.org/10.3390/pharmaceutics13020179
Permanent Link: http://hdl.handle.net/11104/0317666 - 9.0522842 - ÚMCH 2021 RIV NL eng J - Journal Article
Braunová, Alena - Chytil, Petr - Laga, Richard - Šírová, Milada - Machová, Daniela - Parnica, Jozef - Říhová, Blanka - Janoušková, Olga - Etrych, Tomáš
Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties.
Journal of Controlled Release. Roč. 321, 10 May (2020), s. 718-733. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA MZd(CZ) NV16-28600A; GA ČR(CZ) GA17-13283S; GA ČR(CZ) GA17-08084S; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) LTAUSA18083; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA19-01417S
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : polymer micelles * drug delivery * EPR effect
OECD category: Polymer science; Microbiology (MBU-M)
Impact factor: 9.776, year: 2020 ; AIS: 1.785, rok: 2020
Method of publishing: Limited access
Result website:
https://www.sciencedirect.com/science/article/pii/S0168365920301413?via%3DihubDOI: https://doi.org/10.1016/j.jconrel.2020.03.002
Permanent Link: http://hdl.handle.net/11104/0308163 - 10.0521948 - ÚMCH 2021 RIV GB eng J - Journal Article
Kostka, Libor - Kotrchová, Lenka - Šubr, Vladimír - Libánská, Alena - Ferreira, C. A. - Malátová, Iva - Lee, H. J. - Barnhart, T. E. - Engle, J. W. - Cai, W. - Šírová, Milada - Etrych, Tomáš
HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours.
Biomaterials. Roč. 235, March (2020), s. 1-14, č. článku 119728. ISSN 0142-9612. E-ISSN 1878-5905
R&D Projects: GA MŠMT(CZ) LTAUSA18083; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA17-13283S; GA ČR(CZ) GA19-05649S; GA MZd(CZ) NV16-28600A
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : HPMA * star-like polymers * drug delivery
OECD category: Polymer science; Microbiology (MBU-M)
Impact factor: 12.479, year: 2020 ; AIS: 2.195, rok: 2020
Method of publishing: Limited access
Result website:
https://www.sciencedirect.com/science/article/pii/S0142961219308464?via%3DihubDOI: https://doi.org/10.1016/j.biomaterials.2019.119728
Permanent Link: http://hdl.handle.net/11104/0306712