Search results
- 1.0558142 - ÚMCH 2023 RIV US eng J - Journal Article
Kostka, Libor - Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Šírová, Milada - Říhová, Blanka - Sedláček, Radislav - Etrych, Tomáš - Kovář, Marek
Simultaneous delivery of doxorubicin and protease inhibitor derivative to solid tumors via star-shaped polymer nanomedicines overcomes P-gp- and STAT3-mediated chemoresistance.
Biomacromolecules. Roč. 23, č. 6 (2022), s. 2522-2535. ISSN 1525-7797. E-ISSN 1526-4602
R&D Projects: GA ČR(CZ) GA19-05649S; GA MZd(CZ) NU21-03-00273; GA MŠMT(CZ) LTAUSA18083; GA MŠMT(CZ) LM2018126; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: CCP II - 90126
Institutional support: RVO:61389013 ; RVO:61388971 ; RVO:68378050
Keywords : HPMA * RAFT * star-like
OECD category: Polymer science; Microbiology (MBU-M); Genetics and heredity (medical genetics to be 3) (UMG-J)
Impact factor: 6.2, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.biomac.2c00256
Permanent Link: https://hdl.handle.net/11104/0332796 - 2.0542896 - MBÚ 2022 RIV NL eng J - Journal Article
Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Dvořáková, Barbora - Šírová, Milada - Říhová, Blanka - Randárová, Eva - Kraus, Michal - Tomala, Jakub - Studenovský, Martin - Vondráčková, Michaela - Sedláček, Radislav - Makovický, Peter - Fučíková, J. - Vošahlíková, Š. - Spíšek, R. - Kostka, Libor - Etrych, Tomáš - Kovář, Marek
Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.
Journal of Controlled Release. Roč. 332, APR 10 2021 (2021), s. 563-580. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR(CZ) GA19-05649S; GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: CCP - 90040
Institutional support: RVO:61388971 ; RVO:61389013 ; RVO:68378050
Keywords : Ritonavir derivate * Polymer carrier * pH-controlled release * Antitumor activity * Proteasome inhibition * STAT3 signaling inhibition
OECD category: Microbiology; Polymer science (UMCH-V)
Impact factor: 11.467, year: 2021
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0168365921001267
Permanent Link: http://hdl.handle.net/11104/0320232 - 3.0539979 - ÚMCH 2022 RIV CH eng J - Journal Article
Tavares, Marina Rodrigues - Hrabánková, Klára - Konefal, Rafal - Kaňa, Martin - Říhová, Blanka - Etrych, Tomáš - Šírová, Milada - Chytil, Petr
HPMA-based copolymers carrying STAT3 inhibitor cucurbitacin-D as stimulus-sensitive nanomedicines for oncotherapy.
Pharmaceutics. Roč. 13, č. 2 (2021), č. článku 179. E-ISSN 1999-4923
R&D Projects: GA ČR(CZ) GA17-08084S; GA MŠMT(CZ) LTAUSA18083
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : cucurbitacin-D * immuno-oncotherapy * N-(2-hydroxypropyl) methacrylamide (HPMA)
OECD category: Polymer science; Microbiology (MBU-M)
Impact factor: 6.525, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1999-4923/13/2/179
Permanent Link: http://hdl.handle.net/11104/0317666 - 4.0522842 - ÚMCH 2021 RIV NL eng J - Journal Article
Braunová, Alena - Chytil, Petr - Laga, Richard - Šírová, Milada - Machová, Daniela - Parnica, Jozef - Říhová, Blanka - Janoušková, Olga - Etrych, Tomáš
Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties.
Journal of Controlled Release. Roč. 321, 10 May (2020), s. 718-733. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA MZd(CZ) NV16-28600A; GA ČR(CZ) GA17-13283S; GA ČR(CZ) GA17-08084S; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) LTAUSA18083; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA19-01417S
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : polymer micelles * drug delivery * EPR effect
OECD category: Polymer science; Microbiology (MBU-M)
Impact factor: 9.776, year: 2020
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0168365920301413?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0308163 - 5.0492820 - ÚMCH 2019 RIV US eng J - Journal Article
Chytil, Petr - Šírová, Milada - Kudláčová, Júlia - Říhová, Blanka - Ulbrich, Karel - Etrych, Tomáš
Bloodstream stability predetermines the antitumor efficacy of micellar polymer-doxorubicin drug conjugates with pH-triggered drug release.
Molecular Pharmaceutics. Roč. 15, č. 9 (2018), s. 3654-3663. ISSN 1543-8384. E-ISSN 1543-8392
R&D Projects: GA ČR(CZ) GA17-08084S; GA ČR(CZ) GA17-13283S; GA MŠMT(CZ) LO1507
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : degradation * HPMA copolymer * pH-controlled release
OECD category: Polymer science; Microbiology (MBU-M)
Impact factor: 4.396, year: 2018
Permanent Link: http://hdl.handle.net/11104/0286873 - 6.0482796 - MBÚ 2018 RIV GB eng J - Journal Article
Šírová, Milada - Horková, Veronika - Etrych, Tomáš - Chytil, Petr - Říhová, Blanka - Studenovský, Martin
Polymer donors of nitric oxide improve the treatment of experimental solid tumours with nanosized polymer therapeutics.
Journal of Drug Targeting. Roč. 25, 9-10 (2017), s. 796-808. ISSN 1061-186X. E-ISSN 1029-2330
R&D Projects: GA ČR(CZ) GA14-12742S; GA MZd(CZ) NV16-28600A
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Drug delivery * HPMA copolymers * enhanced EPR effect
OECD category: Microbiology; Polymer science (UMCH-V)
Impact factor: 3.408, year: 2017
Permanent Link: http://hdl.handle.net/11104/0278186 - 7.0481666 - ÚMCH 2019 RIV NL eng J - Journal Article
Studenovský, Martin - Sivák, Ladislav - Sedláček, Ondřej - Konefal, Rafal - Horková, Veronika - Etrych, Tomáš - Kovář, Marek - Říhová, Blanka - Šírová, Milada
Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue.
Journal of Controlled Release. Roč. 269, 10 January (2018), s. 214-224. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR(CZ) GA14-12742S; GA MZd(CZ) NV16-28600A; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : enhanced permeability and retention effect * nitric oxide donor * polymer-based cytotoxic drugs
OECD category: Polymer science; Microbiology (MBU-M)
Impact factor: 7.901, year: 2018
Permanent Link: http://hdl.handle.net/11104/0278289 - 8.0473875 - MBÚ 2018 RIV NL eng J - Journal Article
Šírová, Milada - Strohalm, Jiří - Chytil, Petr - Lidický, Ondřej - Tomala, Jakub - Říhová, Blanka - Etrych, Tomáš
The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel.
Journal of Controlled Release. Roč. 246, JAN 28 (2017), s. 1-11. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR(CZ) GA14-12742S; GA ČR(CZ) GA15-02986S; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109; GA MZd(CZ) NV16-28600A; GA ČR(CZ) GAP301/12/1254
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Drug delivery * HPMA * Doxorubicin
OECD category: Immunology; Polymer science (UMCH-V)
Impact factor: 7.877, year: 2017
Permanent Link: http://hdl.handle.net/11104/0270992 - 9.0473557 - MBÚ 2018 RIV GB eng J - Journal Article
Sivák, Ladislav - Šubr, Vladimír - Tomala, Jakub - Říhová, Blanka - Strohalm, Jiří - Etrych, Tomáš - Kovář, Marek
Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate.
Biomaterials. Roč. 115, JAN 2017 (2017), s. 65-80. ISSN 0142-9612. E-ISSN 1878-5905
R&D Projects: GA ČR(CZ) GAP301/12/1254; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Multidrug resistance * P-glycoprotein * Doxorubicin
OECD category: Microbiology; Polymer science (UMCH-V)
Impact factor: 8.806, year: 2017
Permanent Link: http://hdl.handle.net/11104/0270692 - 10.0463915 - MBÚ 2017 RIV NL eng J - Journal Article
Tomalová, Barbora - Šírová, Milada - Rossmann, Pavel - Pola, Robert - Strohalm, Jiří - Chytil, Petr - Černý, Viktor - Tomala, Jakub - Kabešová, Martina - Říhová, Blanka - Ulbrich, Karel - Etrych, Tomáš - Kovář, Marek
The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.
Journal of Controlled Release. Roč. 223, 10 February (2016), s. 1-10. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA ČR(CZ) GAP301/11/0325; GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : HPMA * Doxorubicin * Structure
Subject RIV: EE - Microbiology, Virology; CD - Macromolecular Chemistry (UMCH-V)
Impact factor: 7.786, year: 2016
Permanent Link: http://hdl.handle.net/11104/0263061