Search results

  1. 1.
    0558142 - ÚMCH 2023 RIV US eng J - Journal Article
    Kostka, Libor - Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Šírová, Milada - Říhová, Blanka - Sedláček, Radislav - Etrych, Tomáš - Kovář, Marek
    Simultaneous delivery of doxorubicin and protease inhibitor derivative to solid tumors via star-shaped polymer nanomedicines overcomes P-gp- and STAT3-mediated chemoresistance.
    Biomacromolecules. Roč. 23, č. 6 (2022), s. 2522-2535. ISSN 1525-7797. E-ISSN 1526-4602
    R&D Projects: GA ČR(CZ) GA19-05649S; GA MZd(CZ) NU21-03-00273; GA MŠk(CZ) LTAUSA18083; GA MŠk(CZ) LM2018126; GA MŠk(CZ) ED1.1.00/02.0109
    Research Infrastructure: CCP II - 90126
    Institutional support: RVO:61389013 ; RVO:61388971 ; RVO:68378050
    Keywords : HPMA * RAFT * star-like
    OECD category: Polymer science; Microbiology (MBU-M); Genetics and heredity (medical genetics to be 3) (UMG-J)
    Impact factor: 6.2, year: 2022
    Method of publishing: Limited access
    https://pubs.acs.org/doi/10.1021/acs.biomac.2c00256
    Permanent Link: https://hdl.handle.net/11104/0332796
     
     
  2. 2.
    0542896 - MBÚ 2022 RIV NL eng J - Journal Article
    Sivák, Ladislav - Šubr, Vladimír - Kovářová, Jiřina - Dvořáková, Barbora - Šírová, Milada - Říhová, Blanka - Randárová, Eva - Kraus, Michal - Tomala, Jakub - Studenovský, Martin - Vondráčková, Michaela - Sedláček, Radislav - Makovický, Peter - Fučíková, J. - Vošahlíková, Š. - Spíšek, R. - Kostka, Libor - Etrych, Tomáš - Kovář, Marek
    Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.
    Journal of Controlled Release. Roč. 332, APR 10 2021 (2021), s. 563-580. ISSN 0168-3659. E-ISSN 1873-4995
    R&D Projects: GA ČR(CZ) GA19-05649S; GA MŠk(CZ) LM2015040; GA MŠk(CZ) ED1.1.00/02.0109
    Research Infrastructure: CCP - 90040
    Institutional support: RVO:61388971 ; RVO:61389013 ; RVO:68378050
    Keywords : Ritonavir derivate * Polymer carrier * pH-controlled release * Antitumor activity * Proteasome inhibition * STAT3 signaling inhibition
    OECD category: Microbiology; Polymer science (UMCH-V)
    Impact factor: 11.467, year: 2021
    Method of publishing: Limited access
    https://www.sciencedirect.com/science/article/pii/S0168365921001267
    Permanent Link: http://hdl.handle.net/11104/0320232
     
     
  3. 3.
    0539979 - ÚMCH 2022 RIV CH eng J - Journal Article
    Tavares, Marina Rodrigues - Hrabánková, Klára - Konefal, Rafal - Kaňa, Martin - Říhová, Blanka - Etrych, Tomáš - Šírová, Milada - Chytil, Petr
    HPMA-based copolymers carrying STAT3 inhibitor cucurbitacin-D as stimulus-sensitive nanomedicines for oncotherapy.
    Pharmaceutics. Roč. 13, č. 2 (2021), č. článku 179. E-ISSN 1999-4923
    R&D Projects: GA ČR(CZ) GA17-08084S; GA MŠk(CZ) LTAUSA18083
    Institutional support: RVO:61389013 ; RVO:61388971
    Keywords : cucurbitacin-D * immuno-oncotherapy * N-(2-hydroxypropyl) methacrylamide (HPMA)
    OECD category: Polymer science; Microbiology (MBU-M)
    Impact factor: 6.525, year: 2021
    Method of publishing: Open access
    https://www.mdpi.com/1999-4923/13/2/179
    Permanent Link: http://hdl.handle.net/11104/0317666
     
     
  4. 4.
    0522842 - ÚMCH 2021 RIV NL eng J - Journal Article
    Braunová, Alena - Chytil, Petr - Laga, Richard - Šírová, Milada - Machová, Daniela - Parnica, Jozef - Říhová, Blanka - Janoušková, Olga - Etrych, Tomáš
    Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties.
    Journal of Controlled Release. Roč. 321, 10 May (2020), s. 718-733. ISSN 0168-3659. E-ISSN 1873-4995
    R&D Projects: GA MZd(CZ) NV16-28600A; GA ČR(CZ) GA17-13283S; GA ČR(CZ) GA17-08084S; GA MŠk(CZ) LQ1604; GA MŠk(CZ) LTAUSA18083; GA MŠk(CZ) ED1.1.00/02.0109; GA ČR(CZ) GA19-01417S
    Institutional support: RVO:61389013 ; RVO:61388971
    Keywords : polymer micelles * drug delivery * EPR effect
    OECD category: Polymer science; Microbiology (MBU-M)
    Impact factor: 9.776, year: 2020
    Method of publishing: Limited access
    https://www.sciencedirect.com/science/article/pii/S0168365920301413?via%3Dihub
    Permanent Link: http://hdl.handle.net/11104/0308163
     
     
  5. 5.
    0492820 - ÚMCH 2019 RIV US eng J - Journal Article
    Chytil, Petr - Šírová, Milada - Kudláčová, Júlia - Říhová, Blanka - Ulbrich, Karel - Etrych, Tomáš
    Bloodstream stability predetermines the antitumor efficacy of micellar polymer-doxorubicin drug conjugates with pH-triggered drug release.
    Molecular Pharmaceutics. Roč. 15, č. 9 (2018), s. 3654-3663. ISSN 1543-8384. E-ISSN 1543-8392
    R&D Projects: GA ČR(CZ) GA17-08084S; GA ČR(CZ) GA17-13283S; GA MŠk(CZ) LO1507
    Institutional support: RVO:61389013 ; RVO:61388971
    Keywords : degradation * HPMA copolymer * pH-controlled release
    OECD category: Polymer science; Microbiology (MBU-M)
    Impact factor: 4.396, year: 2018
    Permanent Link: http://hdl.handle.net/11104/0286873
     
     
  6. 6.
    0482796 - MBÚ 2018 RIV GB eng J - Journal Article
    Šírová, Milada - Horková, Veronika - Etrych, Tomáš - Chytil, Petr - Říhová, Blanka - Studenovský, Martin
    Polymer donors of nitric oxide improve the treatment of experimental solid tumours with nanosized polymer therapeutics.
    Journal of Drug Targeting. Roč. 25, 9-10 (2017), s. 796-808. ISSN 1061-186X. E-ISSN 1029-2330
    R&D Projects: GA ČR(CZ) GA14-12742S; GA MZd(CZ) NV16-28600A
    Institutional support: RVO:61388971 ; RVO:61389013
    Keywords : Drug delivery * HPMA copolymers * enhanced EPR effect
    OECD category: Microbiology; Polymer science (UMCH-V)
    Impact factor: 3.408, year: 2017
    Permanent Link: http://hdl.handle.net/11104/0278186
     
     
  7. 7.
    0481666 - ÚMCH 2019 RIV NL eng J - Journal Article
    Studenovský, Martin - Sivák, Ladislav - Sedláček, Ondřej - Konefal, Rafal - Horková, Veronika - Etrych, Tomáš - Kovář, Marek - Říhová, Blanka - Šírová, Milada
    Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue.
    Journal of Controlled Release. Roč. 269, 10 January (2018), s. 214-224. ISSN 0168-3659. E-ISSN 1873-4995
    R&D Projects: GA ČR(CZ) GA14-12742S; GA MZd(CZ) NV16-28600A; GA MŠk(CZ) LQ1604; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:61389013 ; RVO:61388971
    Keywords : enhanced permeability and retention effect * nitric oxide donor * polymer-based cytotoxic drugs
    OECD category: Polymer science; Microbiology (MBU-M)
    Impact factor: 7.901, year: 2018
    Permanent Link: http://hdl.handle.net/11104/0278289
     
     
  8. 8.
    0473875 - MBÚ 2018 RIV NL eng J - Journal Article
    Šírová, Milada - Strohalm, Jiří - Chytil, Petr - Lidický, Ondřej - Tomala, Jakub - Říhová, Blanka - Etrych, Tomáš
    The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel.
    Journal of Controlled Release. Roč. 246, JAN 28 (2017), s. 1-11. ISSN 0168-3659. E-ISSN 1873-4995
    R&D Projects: GA ČR(CZ) GA14-12742S; GA ČR(CZ) GA15-02986S; GA MŠk(CZ) LQ1604; GA MŠk(CZ) ED1.1.00/02.0109; GA MZd(CZ) NV16-28600A; GA ČR(CZ) GAP301/12/1254
    Institutional support: RVO:61388971 ; RVO:61389013
    Keywords : Drug delivery * HPMA * Doxorubicin
    OECD category: Immunology; Polymer science (UMCH-V)
    Impact factor: 7.877, year: 2017
    Permanent Link: http://hdl.handle.net/11104/0270992
     
     
  9. 9.
    0473557 - MBÚ 2018 RIV GB eng J - Journal Article
    Sivák, Ladislav - Šubr, Vladimír - Tomala, Jakub - Říhová, Blanka - Strohalm, Jiří - Etrych, Tomáš - Kovář, Marek
    Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate.
    Biomaterials. Roč. 115, JAN 2017 (2017), s. 65-80. ISSN 0142-9612. E-ISSN 1878-5905
    R&D Projects: GA ČR(CZ) GAP301/12/1254; GA MŠk(CZ) LQ1604; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:61388971 ; RVO:61389013
    Keywords : Multidrug resistance * P-glycoprotein * Doxorubicin
    OECD category: Microbiology; Polymer science (UMCH-V)
    Impact factor: 8.806, year: 2017
    Permanent Link: http://hdl.handle.net/11104/0270692
     
     
  10. 10.
    0463915 - MBÚ 2017 RIV NL eng J - Journal Article
    Tomalová, Barbora - Šírová, Milada - Rossmann, Pavel - Pola, Robert - Strohalm, Jiří - Chytil, Petr - Černý, Viktor - Tomala, Jakub - Kabešová, Martina - Říhová, Blanka - Ulbrich, Karel - Etrych, Tomáš - Kovář, Marek
    The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.
    Journal of Controlled Release. Roč. 223, 10 February (2016), s. 1-10. ISSN 0168-3659. E-ISSN 1873-4995
    R&D Projects: GA ČR(CZ) GAP301/11/0325; GA MŠk(CZ) ED1.1.00/02.0109
    Institutional support: RVO:61388971 ; RVO:61389013
    Keywords : HPMA * Doxorubicin * Structure
    Subject RIV: EE - Microbiology, Virology; CD - Macromolecular Chemistry (UMCH-V)
    Impact factor: 7.786, year: 2016
    Permanent Link: http://hdl.handle.net/11104/0263061
     
     

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