Search results
- 1.0638382 - MBÚ 2026 RIV GB eng J - Journal Article
Kilic, Irfan Baki - Weberová, Petra - VanDyke, D. - Šírová, Milada - Kubešová, Kateřina - Fabilane, C. S. - Mazhara, Vladyslav - Liu, K. - Běhalová, Kateřina - Ptáček, Bohumil - Říhová, Blanka - Spangler, J. B. - Kovář, Marek
Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion.
Journal for ImmunoTherapy of Cancer. Roč. 13, č. 8 (2025), č. článku e010465. ISSN 2051-1426. E-ISSN 2051-1426
R&D Projects: GA ČR(CZ) GA22-20548S; GA MŠMT LX22NPO5102
Institutional support: RVO:61388971
Keywords : in-vivo expansion * selective stimulation * dose interleukin-2 * receptor * complexes * antibody * naive * homeostasis * autoimmune * resistance * Cytokine * Immune Checkpoint Inhibitor * Immunotherapy * T cell * T regulatory cell Treg
OECD category: Immunology
Impact factor: 10.6, year: 2024 ; AIS: 3.789, rok: 2024
Method of publishing: Open access
Result website:
https://jitc.bmj.com/content/13/8/e010465DOI: https://doi.org/10.1136/jitc-2024-010465
Permanent Link: https://hdl.handle.net/11104/0369063File Download Size Commentary Version Access Temporal optimization.pdf 1 8.8 MB Publisher’s postprint open-access - 2.0619166 - MBÚ 2026 RIV GB eng J - Journal Article
Matušková, H. - Mařásek, P. - Mazhara, Vladyslav - Simonova, E. - Kosinová, L. - Daněk, P. - Daňová, K. - Šajnerová, K. - Malátová, I. - Hrabánková, K. - Greco, D. - Martinec, O. - Fabišik, M. - Podzimková, N. - Hladíková, K. - Běhalová, Kateřina - Antošová, Z. - Šírová, Milada - Mikysková, Romana - Reiniš, Milan - Kovář, Marek - Béchard, D. - Moebius, U. - Palová Jelínková, L. - Spíšek, R. - Steegmaier, M. - Adkins, I.
Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v.
Journal for ImmunoTherapy of Cancer. Roč. 13, č. 4 (2025), č. článku 10.1136/jitc-2024-010736. ISSN 2051-1426. E-ISSN 2051-1426
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61388971 ; RVO:68378050
Keywords : Cytokine * Immune Checkpoint Inhibitor * Immunotherapy * T cell * Tumor microenvironment - TME
OECD category: Immunology
Impact factor: 10.6, year: 2024 ; AIS: 3.789, rok: 2024
Method of publishing: Open access
Result website:
https://jitc.bmj.com/content/13/4/e010736DOI: https://doi.org/10.1136/jitc-2024-010736
Permanent Link: https://hdl.handle.net/11104/0365893File Download Size Commentary Version Access Novel PD-1-targeted.pdf 1 3.9 MB Publisher’s postprint open-access - 3.0618471 - MBÚ 2026 RIV NL eng J - Journal Article
Kaňa, Martin - Braunová, Alena - Starenko, Daniil - Frejková, Markéta - Bouček, Jan - Říhová, Blanka - Kovář, Marek - Etrych, Tomáš - Šírová, Milada
Overcoming P-glycoprotein-mediated multidrug resistance in cancer cells through micelle-forming PHPMA-b-PPO diblock copolymers for doxorubicin delivery.
Journal of Controlled Release. Roč. 381, May 10 (2025), č. článku 113645. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA MZd(CZ) NU21-03-00273; GA MŠMT LX22NPO5102
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : Multidrug resistance * P-glycoprotein inhibition * Sensitization to chemotherapy * Intracellular ATP depletion * HPMA copolymer * PPO * Diblock copolymers * Drug delivery system
OECD category: Immunology; Polymer science (UMCH-V)
Impact factor: 11.5, year: 2024 ; AIS: 1.971, rok: 2024
Method of publishing: Open access
Result website:
https://www.sciencedirect.com/science/article/pii/S0168365925002652DOI: https://doi.org/10.1016/j.jconrel.2025.113645
Permanent Link: https://hdl.handle.net/11104/0365334File Download Size Commentary Version Access Kana et al _Corrigendum JCR 2025.pdf 2 249.9 KB Other open-access Kana et al JCR 2025.pdf 1 13.2 MB Publisher’s postprint open-access - 4.0604832 - ÚMCH 2026 RIV US eng J - Journal Article
Pytlíková, Sára - Konefal, Rafal - Pola, Robert - Braunová, Alena - Lobaz, Volodymyr - Šlouf, Miroslav - Beneš, Hynek - Starenko, Daniil - Běhalová, Kateřina - Kovář, Marek - Etrych, Tomáš - Laga, Richard - Pechar, Michal
Dual thermo- and pH-responsive polymer nanoparticle assemblies for potential stimuli-controlled drug delivery.
ACS Applied Bio Materials. Roč. 8, č. 1 (2025), s. 271-284. ISSN 2576-6422. E-ISSN 2576-6422
R&D Projects: GA MŠMT(CZ) LUAUS24239; GA MŠMT LX22NPO5102; GA MŠMT(CZ) LM2023053
Institutional support: RVO:61389013 ; RVO:61388971
Keywords : thermoresponsive polymers * pH-sensitive polymers * self-assembling block copolymers
OECD category: Polymer science; Pharmacology and pharmacy (MBU-M)
Impact factor: 4.7, year: 2024 ; AIS: 0.669, rok: 2024
Method of publishing: Open access
Result website:
https://pubs.acs.org/doi/10.1021/acsabm.4c01167DOI: https://doi.org/10.1021/acsabm.4c01167
Permanent Link: https://hdl.handle.net/11104/0362350File Download Size Commentary Version Access 0604832.pdf 1 4 MB License CC-BY 4.0 Publisher’s postprint open-access - 5.0598961 - BTÚ 2025 RIV US eng J - Journal Article
Leonard, E. K. - Tomala, Jakub - Gould, J. R. - Leff, M. I. - Li, J. - Li, P. - Porter, M. J. - Johansen, E. R. - Thompson, L. - Cao, S.D. - Hou, S. - Henclová, Tereza - Huličiak, Maroš - Sargunas, P. R. - Fabilane, Ch. S. - Vaněk, O. - Kovář, Marek - Schneider, Bohdan - Raimondi, G. - Leonard, W. J. - Spangler, J. B.
Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
JCI Insight. Roč. 9, č. 18 (2024), č. článku e173469. E-ISSN 2379-3708
Institutional support: RVO:86652036 ; RVO:61388971
Keywords : receptor-alpha subunit * selective stimulation * high-affinity * nk cells * melanoma
OECD category: Biochemistry and molecular biology; Immunology (MBU-M)
Impact factor: 6.1, year: 2024 ; AIS: 2.712, rok: 2024
Method of publishing: Open access
Result website:
https://insight.jci.org/articles/view/173469/pdf
DOI: https://doi.org/10.1172/jci.insight.173469
Permanent Link: https://hdl.handle.net/11104/0357629 - 6.0598151 - MBÚ 2026 RIV US eng J - Journal Article
Láníčková, T. - Hensler, M. - Kašíková, L. - Vošáhlíková, Š. - Angelidou, A. - Pasulka, J. - Griebler, H. - Drozenová, J. - Mojžíšová, K. - Vankerckhoven, A. - Laco, J. - Ryška, A. - Dundr, P. - Kocián, R. - Cibula, D. - Brtnický, T. - Škapa, P. - Jacob, F. - Kovář, Marek - Práznovec, I. - McNeish, I. A. - Halaška, M. J. - Rob, L. - Coosemans, A. - Orsulic, S. - Galluzzi, L. - Špíšek, R. - Fučíková, J.
Chemotherapy drives tertiary lymphoid structures that correlate with ICI-responsive TCF1+CD8+ T cells in metastatic ovarian cancer.
Clinical Cancer Research. Roč. 31, č. 1 (2025), s. 164-180. ISSN 1078-0432. E-ISSN 1557-3265
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61388971
Keywords : Tertiary Lymphoid Structures * T Cells * Ovarian Cancer
OECD category: Immunology
Impact factor: 10.2, year: 2024 ; AIS: 4.242, rok: 2024
Method of publishing: Open access
Result website:
https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-24-1594/747939/Chemotherapy-Drives-Tertiary-Lymphoid-StructuresDOI: https://doi.org/10.1158/1078-0432.CCR-24-1594
Permanent Link: https://hdl.handle.net/11104/0355883File Download Size Commentary Version Access Chemoterapy drives tertiary lymphoid structures.pdf 5 12.8 MB Publisher’s postprint open-access - 7.0584603 - MBÚ 2025 RIV US eng J - Journal Article
Kašíková, L. - Raková, J. - Hensler, M. - Láníčková, T. - Tománková, J. - Pasulka, J. - Drozenová, J. - Mojžíšová, K. - Fialová, A. - Vošahlíková, Š. - Laco, J. - Ryška, A. - Dundr, P. - Kocián, R. - Brtnický, T. - Skapa, P. - Čapková, L. - Kovář, Marek - Procházka, Jan - Práznovec, I. - Koblížek, V. - Tasková, A. - Tanaka, H. - Lischke, R. - Mendez, F. C. - Vachtenheim, J. J. - Heinzelmann-Schwarz, V. - Jacob, F. - McNeish, I. A. - Halaška, M. J. - Rob, L. - Cibula, D. - Orsulic, S. - Galluzzi, L. - Spíšek, R. - Fučíková, J.
Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer.
Nature Communications. Roč. 15, č. 1 (2024), s. 2528. ISSN 2041-1723. E-ISSN 2041-1723
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61388971 ; RVO:68378050
Keywords : lymphoid structures * B cells * T cell * ovarian cancer
OECD category: Immunology
Impact factor: 15.7, year: 2024 ; AIS: 5.611, rok: 2024
Method of publishing: Open access
Result website:
https://www.nature.com/articles/s41467-024-46873-wDOI: https://doi.org/10.1038/s41467-024-46873-w
Permanent Link: https://hdl.handle.net/11104/0352493File Download Size Commentary Version Access Tertiary lymphoid structures.pdf 4 13.1 MB Publisher’s postprint open-access - 8.0580702 - MBÚ 2025 RIV NL eng J - Journal Article
Kovář, Marek - Šubr, Vladimír - Běhalová, Kateřina - Studenovský, Martin - Starenko, Daniil - Kovářová, Jiřina - Procházková, Petra - Etrych, Tomáš - Kostka, Libor
Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation.
Nanomedicine: Nanotechnology, Biology and Medicine. Roč. 56, February 2024 (2024), s. 102730. ISSN 1549-9634. E-ISSN 1549-9642
R&D Projects: GA MZd(CZ) NU21-03-00273; GA MŠMT LX22NPO5102
Institutional support: RVO:61388971 ; RVO:61389013
Keywords : STAT3 inhibitor * Doxorubicin * HPMA copolymer carrier * pH-sensitive drug * release
OECD category: Pharmacology and pharmacy; Medicinal chemistry (UMCH-V)
Impact factor: 4.6, year: 2024 ; AIS: 0.775, rok: 2024
Method of publishing: Open access
Result website:
https://www.sciencedirect.com/science/article/pii/S1549963423000813DOI: https://doi.org/10.1016/j.nano.2023.102730
Permanent Link: https://hdl.handle.net/11104/0349459File Download Size Commentary Version Access 0580702.pdf 10 5 MB CC BY license Publisher’s postprint open-access Kovar et al_Nanomedicine.pdf 0 5 MB Publisher’s postprint open-access - 9.0578373 - ÚMG 2024 RIV GB eng J - Journal Article
Niederlová, Veronika - Tsyklauri, Oksana - Kovář, Marek - Štěpánek, Ondřej
IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy.
Trends in Immunology. Roč. 44, č. 11 (2023), s. 890-901. ISSN 1471-4906. E-ISSN 1471-4981
R&D Projects: GA ČR GA22-21356S; GA ČR(CZ) GA22-20548S; GA MŠMT(CZ) LX22NPO5103; GA MŠMT LX22NPO5102
EU Projects: European Commission(XE) 802878 - FunDiT
Research Infrastructure: e-INFRA CZ II - 90254
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : cancer * cytotoxic T cells * il-2 * immunotherapy * pd-1 * regulatory T cell
OECD category: Immunology; Immunology (MBU-M)
Impact factor: 13.1, year: 2023 ; AIS: 5.517, rok: 2023
Method of publishing: Open access
Result website:
https://www.sciencedirect.com/science/article/pii/S1471490623001953?via%3DihubDOI: https://doi.org/10.1016/j.it.2023.09.003
Permanent Link: https://hdl.handle.net/11104/0347367File Download Size Commentary Version Access IL-2-driven CD8+ T cell.pdf 1 2 MB Publisher’s postprint open-access Niederlova et al_Trends in Immunology.pdf 0 2 MB Publisher’s postprint open-access - 10.0571076 - MBÚ 2024 RIV DE eng J - Journal Article
Holíček, P. - Truxová, I. - Raková, J. - Šálek, C. - Hensler, M. - Kovář, Marek - Reiniš, Milan - Mikyšková, Romana - Pasulka, J. - Vošahlíková, Š. - Remešová, H. - Valentová, I. - Lysák, D. - Holubová, M. - Kašpar, Petr - Procházka, Jan - Kašíková, L. - Špíšek, R. - Galluzzi, L. - Fučiková, J.
Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients.
Cell Death & Disease. Roč. 14, č. 3 (2023), č. článku 209. ISSN 2041-4889. E-ISSN 2041-4889
R&D Projects: GA MŠMT LM2023036; GA MŠMT LX22NPO5102
Institutional support: RVO:61388971 ; RVO:68378050
Keywords : acute myeloid-leukemia * alpha * cells * metastasis * signature * radiation * rna
OECD category: Immunology; Cell biology (UMG-J)
Impact factor: 8.1, year: 2023 ; AIS: 1.997, rok: 2023
Method of publishing: Open access
Result website:
https://www.nature.com/articles/s41419-023-05728-wDOI: https://doi.org/10.1038/s41419-023-05728-w
Permanent Link: https://hdl.handle.net/11104/0342383File Download Size Commentary Version Access Type I interferon signaling.pdf 0 1.4 MB Publisher’s postprint open-access