Search results
- 1.0583244 - FGÚ 2025 RIV CH eng J - Journal Article
Kysilov, Bohdan - Kuchtiak, Viktor - Hrčka Krausová, Barbora - Balík, Aleš - Kořínek, Miloslav - Fili, Klevinda - Dobrovolski, Mark - Abramová, Vera - Chodounská, Hana - Kudová, Eva - Božíková, Paulina - Černý, Jiří - Smejkalová, Tereza - Vyklický ml., Ladislav
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids.
Cellular and Molecular Life Sciences. Roč. 81, č. 1 (2024), č. článku 36. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR(CZ) GA23-04922S; GA TA ČR(CZ) TN02000109; GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:67985823 ; RVO:61388963 ; RVO:86652036
Keywords : glutamate receptors * channelopathy * endogenous neuroactive steroid * GRIN2 genes * surface expression * rescue pharmacology
OECD category: Neurosciences (including psychophysiology
Impact factor: 8, year: 2022
Method of publishing: Open access
https://doi.org/10.1007/s00018-023-05062-6
Permanent Link: https://hdl.handle.net/11104/0351253 - 2.0572804 - FGÚ 2024 RIV US eng J - Journal Article
Abramová, Vera - Leal Alvarado, Vanessa - Hill, M. - Smejkalová, Tereza - Malý, Michal - Valeš, Karel - Dittert, Ivan - Božíková, Paulina - Kysilov, Bohdan - Hrčka Krausová, Barbora - Vyklický, Vojtěch - Balík, Aleš - Fili, Klevinda - Kořínek, Miloslav - Chodounská, Hana - Kudová, Eva - Číž, D. - Martinovič, J. - Černý, Jiří - Bartůněk, Petr - Vyklický ml., Ladislav
Effects of Pregnanolone Glutamate and Its Metabolites on GABAA and NMDA Receptors and Zebrafish Behavior.
ACS Chemical Neuroscience. Roč. 14, č. 10 (2023), s. 1870-1883. ISSN 1948-7193. E-ISSN 1948-7193
R&D Projects: GA MZd(CZ) EF16_025/0007444; GA MŠMT LM2023052; GA ČR(CZ) GA23-04922S; GA TA ČR(CZ) TN02000109
Research Infrastructure: CZ-OPENSCREEN IV - 90252
Institutional support: RVO:67985823 ; RVO:86652036 ; RVO:61388963 ; RVO:68378050
Keywords : negative allosteric modulator * thigmotaxis * steroid * glutamate * zebrafish
OECD category: Neurosciences (including psychophysiology; Neurosciences (including psychophysiology (UOCHB-X); Biochemistry and molecular biology (UMG-J); Biochemistry and molecular biology (BTO-N)
Impact factor: 5, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acschemneuro.3c00131
Permanent Link: https://hdl.handle.net/11104/0343402 - 3.0558978 - FGÚ 2023 RIV GB eng J - Journal Article
Kysilov, Bohdan - Hrčka Krausová, Barbora - Vyklický, Vojtěch - Smejkalová, Tereza - Kořínek, Miloslav - Horák, Martin - Chodounská, Hana - Kudová, Eva - Černý, Jiří - Vyklický ml., Ladislav
Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations.
British Journal of Pharmacology. Roč. 179, č. 15 (2022), s. 3970-3990. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA20-17945S; GA MZd(CZ) EF16_025/0007444; GA TA ČR(CZ) TN01000013
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : GRIN channelopathy * NMDA receptor * positive allosteric modulator * steroids * transmembrane domain
OECD category: Neurosciences (including psychophysiology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1111/bph.15841
Permanent Link: https://hdl.handle.net/11104/0332640 - 4.0555872 - FGÚ 2023 RIV GB eng J - Journal Article
Štefková-Mazochová, K. - Danda, H. - Dehaen, W. - Jurásek, B. - Šíchová, K. - Pinterová-Leca, N. - Mazoch, V. - Hrčka Krausová, Barbora - Kysilov, Bohdan - Smejkalová, Tereza - Vyklický ml., Ladislav - Kohout, M. - Hájková, K. - Svozil, Daniel - Horsley, R. R. - Kuchař, M. - Páleníček, T.
Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats.
British Journal of Pharmacology. Roč. 179, č. 1 (2022), s. 65-83. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA20-17945S; GA MZd(CZ) EF16_025/0007444; GA MŠMT(CZ) LM2018130
Research Infrastructure: CZ-OPENSCREEN III - 90130
Institutional support: RVO:67985823 ; RVO:68378050
Keywords : deschloroketamine * enantiomers * locomotion * NMDA receptor * pharmacokinetics * pharmacokinetics
OECD category: Pharmacology and pharmacy
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1111/bph.15680
Permanent Link: http://hdl.handle.net/11104/0330327 - 5.0552392 - FGÚ 2022 RIV CH eng J - Journal Article
Hirschfeldová, Kateřina - Černý, Jiří - Božíková, P. - Kuchtiak, Viktor - Rausch, T. - Beneš, V. - Španiel, F. - Greguš, D. - Horáček, J. - Vyklický ml., Ladislav - Balík, Aleš
Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia.
Journal of Personalized Medicine. Roč. 11, č. 12 (2021), č. článku 1250. E-ISSN 2075-4426
R&D Projects: GA MŠMT(CZ) LTAUSA19122; GA ČR(CZ) GA20-17945S; GA TA ČR(CZ) TN01000013; GA MZd(CZ) EF16_025/0007444; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: e-INFRA CZ - 90140; ELIXIR-CZ II - 90131
Institutional support: RVO:67985823
Keywords : schizophrenia * ionotropic glutamate receptor * intron * genetic variations * SNP * haplotypes * scoring model * BrainAGE
OECD category: Neurosciences (including psychophysiology
Impact factor: 3.508, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2075-4426/11/12/1250
Permanent Link: http://hdl.handle.net/11104/0327533 - 6.0546480 - FGÚ 2022 RIV GB eng J - Journal Article
Smejkalová, Tereza - Kořínek, Miloslav - Krůšek, Jan - Hrčka Krausová, Barbora - Candelas Serra, Miriam - Hajduković, Dragana - Kudová, Eva - Chodounská, Hana - Vyklický ml., Ladislav
Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms.
British Journal of Pharmacology. Roč. 178, č. 19 (2021), s. 3888-3904. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA MZd(CZ) EF16_025/0007444; GA ČR(CZ) GJ16-03913Y; GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) LQ1604
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : glutamate * Munc13-1 * neurosteroid * phorbol ester * pregnanolone * presynaptic
OECD category: Neurosciences (including psychophysiology; Organic chemistry (UOCHB-X)
Impact factor: 9.473, year: 2021
Method of publishing: Open access
https://doi.org/10.1111/bph.15529
Permanent Link: http://hdl.handle.net/11104/0322979 - 7.0544687 - FGÚ 2022 RIV CH eng J - Journal Article
Holubová, K. - Chvojková, M. - Hrčka Krausová, Barbora - Vyklický, Vojtěch - Kudová, Eva - Chodounská, Hana - Vyklický ml., Ladislav - Valeš, Karel
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia.
Biomolecules. Roč. 11, č. 7 (2021), č. článku 1026. E-ISSN 2218-273X
R&D Projects: GA MZd(CZ) EF16_025/0007444; GA ČR(CZ) GA20-17945S; GA ČR(CZ) GA18-09296S; GA MZd(CZ) NU20-04-00389
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neurosteroids * schizophrenia * MK-801 * cognition * anxiety * stress
OECD category: Neurosciences (including psychophysiology; Organic chemistry (UOCHB-X)
Impact factor: 6.064, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2218-273X/11/7/1026
Permanent Link: http://hdl.handle.net/11104/0321516 - 8.0541892 - FGÚ 2022 RIV US eng J - Journal Article
Hubálková, Pavla - Ladislav, Marek - Vyklický, Vojtěch - Smejkalová, Tereza - Hrčka Krausová, Barbora - Kysilov, Bohdan - Krůšek, Jan - Naimová, Žaneta - Kořínek, Miloslav - Chodounská, Hana - Kudová, Eva - Černý, Jiří - Vyklický ml., Ladislav
Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity.
Journal of Neuroscience. Roč. 41, č. 10 (2021), s. 2119-2134. ISSN 0270-6474. E-ISSN 1529-2401
R&D Projects: GA ČR(CZ) GA20-17945S; GA ČR(CZ) GJ16-03913Y; GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) LQ1604; GA MZd(CZ) EF16_025/0007444
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : carboxy-terminal domain * molecular dynamics simulation * neurosteroid * NMDAR * palmitoylation * single-channel recording
OECD category: Neurosciences (including psychophysiology
Impact factor: 6.709, year: 2021
Method of publishing: Open access with time embargo
https://doi.org/10.1523/JNEUROSCI.2654-20.2021
Permanent Link: http://hdl.handle.net/11104/0319387 - 9.0531944 - FGÚ 2021 RIV US eng J - Journal Article
Hrčka Krausová, Barbora - Kysilov, Bohdan - Černý, Jiří - Vyklický, Vojtěch - Smejkalová, Tereza - Ladislav, Marek - Balík, Aleš - Kořínek, Miloslav - Chodounská, Hana - Kudová, Eva - Vyklický ml., Ladislav
Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor.
Journal of Neuroscience. Roč. 40, č. 31 (2020), s. 5922-5936. ISSN 0270-6474. E-ISSN 1529-2401
R&D Projects: GA ČR(CZ) GA17-02300S; GA ČR(CZ) GJ16-03913Y; GA TA ČR(CZ) TN01000013; GA ČR(CZ) GA20-17945S; GA MŠMT(CZ) LQ1604
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : glutamate receptors * neurosteroids * patch clamp * structure
OECD category: Neurosciences (including psychophysiology
Impact factor: 6.167, year: 2020
Method of publishing: Open access with time embargo
https://doi.org/10.1523/JNEUROSCI.3010-19.2020
Permanent Link: http://hdl.handle.net/11104/0310574 - 10.0531929 - FGÚ 2021 RIV GB eng J - Journal Article
Kořínek, Miloslav - González-González, I. M. - Smejkalová, Tereza - Hajduković, Dragana - Skřenková, Kristýna - Krůšek, Jan - Horák, Martin - Vyklický ml., Ladislav
Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission.
Scientific Reports. Roč. 10, č. 1 (2020), č. článku 12651. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA17-02300S; GA ČR(CZ) GJ16-03913Y; GA TA ČR(CZ) TN01000013; GA MŠMT(CZ) LQ1604
Institutional support: RVO:67985823
Keywords : synaptic transmission * cholesterol * NMDA receptor * NMDA receptor * neuroprotection * synapse * membrane
OECD category: Neurosciences (including psychophysiology
Impact factor: 4.380, year: 2020
Method of publishing: Open access
https://www.nature.com/articles/s41598-020-69454-5
Permanent Link: http://hdl.handle.net/11104/0310562