Search results
- 1.0579058 - FGÚ 2024 RIV US eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Jakubík, Jan
A critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy.
Scientific Reports. Roč. 13, č. 1 (2023), č. článku 17587. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA23-04670S; GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:67985823
Keywords : protein-coupled receptors * autoinhibition * selectivity * mechanisms * bias
OECD category: Pharmacology and pharmacy
Impact factor: 4.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1038/s41598-023-45004-7
Permanent Link: https://hdl.handle.net/11104/0347935File Download Size Commentary Version Access 23_0099_0579058.pdf 0 3.8 MB Publisher’s postprint open-access - 2.0567543 - ÚOCHB 2024 RIV CH eng J - Journal Article
Szczurowska, Ewa - Szánti-Pintér, Eszter - Chetverikov, Nikolai - Randáková, Alena - Kudová, Eva - Jakubík, Jan
Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids.
International Journal of Molecular Sciences. Roč. 24, č. 1 (2023), č. článku 507. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * Alzheimer's disease * Parkinson's disease * schizophrenia * substance abuse * depression
OECD category: Neurosciences (including psychophysiology; Physiology (including cytology) (FGU-C)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms24010507
Permanent Link: https://hdl.handle.net/11104/0338789File Download Size Commentary Version Access 23_0567543.pdf 1 3.4 MB Publisher’s postprint open-access - 3.0566162 - FGÚ 2023 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena
Insights into the operational model of agonism of receptor dimers.
Expert Opinion on Drug Discovery. Roč. 17, č. 11 (2022), s. 1181-1191. ISSN 1746-0441. E-ISSN 1746-045X
R&D Projects: GA ČR(CZ) GJ19-06106Y
Institutional support: RVO:67985823
Keywords : operational model of agonism * operational efficacy * allosteric modulation * receptor dimers * GPCRs * receptor channels
OECD category: Pharmacology and pharmacy
Impact factor: 6.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1080/17460441.2023.2147502
Permanent Link: https://hdl.handle.net/11104/0337590 - 4.0564844 - ÚOCHB 2023 RIV CH eng J - Journal Article
Szczurowska, Ewa - Szánti-Pintér, Eszter - Randáková, Alena - Jakubík, Jan - Kudová, Eva
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids.
International Journal of Molecular Sciences. Roč. 23, č. 21 (2022), č. článku 13075. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5104
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Biochemistry and molecular biology; Physiology (including cytology) (FGU-C)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms232113075
Permanent Link: https://hdl.handle.net/11104/0336401File Download Size Commentary Version Access 10.3390ijms232113075.pdf 3 4.3 MB Publisher’s postprint open-access - 5.0546864 - FGÚ 2022 RIV US eng J - Journal Article
Dolejší, Eva - Chetverikov, Nikolai - Szánti-Pintér, Eszter - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - El-Fakahany, E. E. - Kudová, Eva - Jakubík, Jan
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors.
Biochemical Pharmacology. Roč. 192, Oct (2021), č. článku 114699. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 6.100, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.bcp.2021.114699
Permanent Link: http://hdl.handle.net/11104/0323241 - 6.0546861 - FGÚ 2022 RIV NL eng J - Journal Article
Dolejší, Eva - Szánti-Pintér, Eszter - Chetverikov, Nikolai - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - Kudová, Eva - Jakubík, Jan
Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptor.
Neuropharmacology. Roč. 199, Nov 1 (2021), č. článku 108798. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neurosteroid * steroid hormone * allosteric modulation * muscarinic receptor
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 5.273, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.neuropharm.2021.108798
Permanent Link: http://hdl.handle.net/11104/0323238 - 7.0546460 - FGÚ 2022 RIV CH eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Hochmalová, Martina - Zimčík, Pavel - Mulenga, Mutale Jane - Boulos, J. - Jakubík, Jan
Fusion with Promiscuous G alpha(16) Subunit Reveals Signaling Bias at Muscarinic Receptors.
International Journal of Molecular Sciences. Roč. 22, č. 18 (2021), č. článku 10089. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GJ19-06106Y
Institutional support: RVO:67985823
Keywords : muscarinic receptors * signaling bias * fusion proteins * non-canonical signaling
OECD category: Pharmacology and pharmacy
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/18/10089
Permanent Link: http://hdl.handle.net/11104/0322964 - 8.0544565 - FGÚ 2022 RIV US eng J - Journal Article
Staszewski, M. - Nelic, Dominik - Jończyk, J. - Dubiel, M. - Frank, A. - Stark, H. - Bajda, M. - Jakubík, Jan - Walczyński, K.
Guanidine Derivatives: How Simple Structural Modification of Histamine H3R Antagonists Has Led to the Discovery of Potent Muscarinic M2R/M4R Antagonists.
ACS Chemical Neuroscience. Roč. 12, č. 13 (2021), s. 2503-2519. ISSN 1948-7193. E-ISSN 1948-7193
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : antagonists * histamine H3 receptor * muscarinic M2 receptor * muscarinic M4 receptor * structure−activity relationships * guanidine
OECD category: Physiology (including cytology)
Impact factor: 5.780, year: 2021
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acschemneuro.1c00237
Permanent Link: http://hdl.handle.net/11104/0321411 - 9.0542922 - FGÚ 2022 RIV GB eng J - Journal Article
Randáková, Alena - Jakubík, Jan
Functionally selective and biased agonists of muscarinic receptors.
Pharmacological Research. Roč. 169, July (2021), č. článku 105641. ISSN 1043-6618. E-ISSN 1096-1186
R&D Projects: GA ČR(CZ) GJ19-06106Y
Institutional support: RVO:67985823
Keywords : muscarinic receptors * signalling bias * functional selectivity * G-proteins * beta-arrestins
OECD category: Pharmacology and pharmacy
Impact factor: 10.334, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.phrs.2021.105641
Permanent Link: http://hdl.handle.net/11104/0320252 - 10.0541423 - FGÚ 2022 RIV CH eng J - Journal Article
Jakubík, Jan - El-Fakahany, E. E.
Allosteric Modulation of GPCRs of Class A by Cholesterol.
International Journal of Molecular Sciences. Roč. 22, č. 4 (2021), č. článku 1953. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : GPCRs * cholesterol * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/4/1953
Permanent Link: http://hdl.handle.net/11104/0318982