Search results
- 1.0546864 - FGÚ 2022 RIV US eng J - Journal Article
Dolejší, Eva - Chetverikov, Nikolai - Szánti-Pintér, Eszter - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - El-Fakahany, E. E. - Kudová, Eva - Jakubík, Jan
Neuroactive steroids, WIN-compounds and cholesterol share a common binding site on muscarinic acetylcholine receptors.
Biochemical Pharmacology. Roč. 192, Oct (2021), č. článku 114699. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 6.100, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.bcp.2021.114699
Permanent Link: http://hdl.handle.net/11104/0323241 - 2.0546861 - FGÚ 2022 RIV NL eng J - Journal Article
Dolejší, Eva - Szánti-Pintér, Eszter - Chetverikov, Nikolai - Nelic, Dominik - Randáková, Alena - Doležal, Vladimír - Kudová, Eva - Jakubík, Jan
Neurosteroids and steroid hormones are allosteric modulators of muscarinic receptor.
Neuropharmacology. Roč. 199, Nov 1 (2021), č. článku 108798. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA19-05318S
Grant - others:AV ČR(CZ) StrategieAV21/10
Program: StrategieAV
Institutional support: RVO:67985823 ; RVO:61388963
Keywords : neurosteroid * steroid hormone * allosteric modulation * muscarinic receptor
OECD category: Physiology (including cytology); Physiology (including cytology) (UOCHB-X)
Impact factor: 5.273, year: 2021
Method of publishing: Open access
https://doi.org/10.1016/j.neuropharm.2021.108798
Permanent Link: http://hdl.handle.net/11104/0323238 - 3.0538466 - FGÚ 2021 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Chetverikov, Nikolai - El-Fakahany, E. E. - Doležal, Vladimír
The operational model of allosteric modulation of pharmacological agonism.
Scientific Reports. Roč. 10, č. 1 (2020), č. článku 14421. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : receptor theory * operational model * allosteric modulation
OECD category: Pharmacology and pharmacy
Impact factor: 4.380, year: 2020
Method of publishing: Open access
https://www.nature.com/articles/s41598-020-71228-y
Permanent Link: http://hdl.handle.net/11104/0316262 - 4.0524902 - FGÚ 2021 RIV US eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Doležal, Vladimír - El-Fakahany, E. E. - Boulos, J. - Jakubík, Jan
Agonist-Specific Conformations of the M-2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics.
Journal of Chemical Information and Modeling. Roč. 60, č. 4 (2020), s. 2325-2338. ISSN 1549-9596. E-ISSN 1549-960X
R&D Projects: GA ČR(CZ) GA17-16182S; GA ČR(CZ) GJ19-06106Y
Research Infrastructure: CESNET II - 90042
Institutional support: RVO:67985823
Keywords : muscarinic receptors * agonist-specific conformations * signalling bias * accelerated molecular dynamics
OECD category: Pharmacology and pharmacy
Impact factor: 4.956, year: 2020
Method of publishing: Limited access
https://doi.org/10.1021/acs.jcim.0c00041
Permanent Link: http://hdl.handle.net/11104/0309133 - 5.0524282 - FGÚ 2021 RIV GB eng J - Journal Article
Randáková, Alena - Nelic, Dominik - Ungerová, Dana - Nwokoye, P. - Su, Q. - Doležal, Vladimír - El-Fakahany, E. E. - Boulos, J. - Jakubík, Jan
Novel M-2-selective, G(i)-biased agonists of muscarinic acetylcholine receptors.
British Journal of Pharmacology. Roč. 177, č. 9 (2020), s. 2073-2089. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA17-16182S
Research Infrastructure: CESNET II - 90042
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * functionally selective agonists * signalling bias
OECD category: Physiology (including cytology)
Impact factor: 8.740, year: 2020
Method of publishing: Limited access
https://doi.org/10.1111/bph.14970
Permanent Link: http://hdl.handle.net/11104/0308655 - 6.0504453 - FGÚ 2020 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Rudajev, Vladimír - Zimčík, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Applications and limitations of fitting of the operational model to determine relative efficacies of agonists.
Scientific Reports. Roč. 9, Mar 15 (2019), č. článku 4637. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : operational model of agonism * affinity * efficacy
OECD category: Physiology (including cytology)
Impact factor: 3.998, year: 2019
Method of publishing: Open access
https://doi.org/10.1038/s41598-019-40993-w
Permanent Link: http://hdl.handle.net/11104/0296081 - 7.0504451 - FGÚ 2020 RIV US eng J - Journal Article
Jakubík, Jan - Randáková, Alena - El-Fakahany, E. E. - Doležal, Vladimír
Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators.
PLoS ONE. Roč. 14, č. 3 (2019), č. článku e0214255. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GBP304/12/G069; GA ČR(CZ) GA19-05318S
Institutional support: RVO:67985823
Keywords : binding experiments * equlibrium * allosteric modulation
OECD category: Physiology (including cytology)
Impact factor: 2.740, year: 2019
Method of publishing: Open access
https://doi.org/10.1371/journal.pone.0214255
Permanent Link: http://hdl.handle.net/11104/0296079 - 8.0490235 - FGÚ 2019 RIV GB eng J - Journal Article
Randáková, Alena - Rudajev, Vladimír - Doležal, Vladimír - Boulos, J. - Jakubík, Jan
Novel long‐acting antagonists of muscarinic ACh receptors.
British Journal of Pharmacology. Roč. 175, č. 10 (2018), s. 1731-1743. ISSN 0007-1188. E-ISSN 1476-5381
R&D Projects: GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * long-acting antagonists * tetrahydropyridinium slats
OECD category: Physiology (including cytology)
Impact factor: 6.583, year: 2018
Permanent Link: http://hdl.handle.net/11104/0284504 - 9.0489273 - FGÚ 2019 RIV NL eng J - Journal Article
Randáková, Alena - Dolejší, Eva - Rudajev, Vladimír - Zimčík, Pavel - Doležal, Vladimír - El-Fakahany, E. E. - Jakubík, Jan
Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline.
Neuropharmacology. Roč. 133, May 1 (2018), s. 129-144. ISSN 0028-3908. E-ISSN 1873-7064
R&D Projects: GA ČR(CZ) GA14-05696S; GA ČR(CZ) GA17-16182S
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * membrane cholesterol * xanomeline * receptor activation * molecular dynamics
OECD category: Physiology (including cytology)
Impact factor: 4.367, year: 2018
Permanent Link: http://hdl.handle.net/11104/0283716 - 10.0474008 - FGÚ 2018 RIV GB eng J - Journal Article
Jakubík, Jan - Randáková, Alena - Zimčík, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors.
Scientific Reports. Roč. 7, Jan 16 (2017), č. článku 40381. ISSN 2045-2322. E-ISSN 2045-2322
R&D Projects: GA ČR(CZ) GBP304/12/G069
Institutional support: RVO:67985823
Keywords : muscarinic acetylcholine receptors * N-methylscopolamine * ligand binding * molecular dynamics
OECD category: Physiology (including cytology)
Impact factor: 4.122, year: 2017
Permanent Link: http://hdl.handle.net/11104/0271108