Search results
- 1.0586002 - ÚOCHB 2025 RIV US eng J - Journal Article
Spiwoková, Petra - Horn, Martin - Fanfrlík, Jindřich - Jílková, Adéla - Fajtová, Pavla - Leontovyč, Adrian - Houštecká, Radka - Bieliková, Lucia - Brynda, Jiří - Chanová, M. - Mertlíková-Kaiserová, Helena - Diaz-Caro, E. J. E. - Almaliti, J. - El Sakkary, N. - Gerwick, W. H. - Caffrey, C. R. - Mareš, Michael
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
ACS Infectious Diseases. (2024). ISSN 2373-8227
R&D Projects: GA MŠMT(CZ) LTAUSA19109; GA MŠMT(CZ) LUAUS23050; GA MZd(CZ) NV18-05-00345
Institutional support: RVO:61388963
Keywords : cathepsin B * cysteine proteas * drug targe * parasit * schistosoma manson * acrylamide inhibitor
Impact factor: 5.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acsinfecdis.3c00589
Permanent Link: https://hdl.handle.net/11104/0353623 - 2.0582851 - ÚOCHB 2025 RIV CH eng J - Journal Article
Matoušková, Zuzana - Orsághová, Katarína - Srb, Pavel - Pytelková, Jana - Kukačka, Zdeněk - Buša, Michal - Hajdušek, Ondřej - Šíma, Radek - Fábry, Milan - Novák, Petr - Horn, Martin - Kopáček, Petr - Mareš, Michael
An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans.
International Journal of Molecular Sciences. Roč. 25, č. 4 (2024), č. článku 2240. ISSN 1661-6596
R&D Projects: GA ČR(CZ) GA21-08826S; GA ČR(CZ) GA22-27695S; GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GA22-30920S; GA MŠMT(CZ) LUC23037
Institutional support: RVO:61388963 ; RVO:61388971 ; RVO:60077344
Keywords : cathepsin * cysteine protease * tick * parasite * saliva * thyropin * protease inhibitor * protein structure
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms25042240
Permanent Link: https://hdl.handle.net/11104/0350903 - 3.0580493 - BC 2024 RIV CH eng J - Journal Article
Martins, Larissa Almeida - Buša, Michal - Chlastáková, A. - Kotál, Jan - Beránková, Z. - Stergiou, N. - Jmel, Mohamed Amine - Schmitt, E. - Chmelař, J. - Mareš, Michael - Kotsyfakis, Michalis
Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host.
Cellular and Molecular Life Sciences. Roč. 80, č. 11 (2023), č. článku 339. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LTAUSA19109
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : ray crystal-structure * sialostatin-l * functional expression * cysteine cathepsins * mammalian legumain * ixodes-scapularis * inhibitors * stefin * generation * peptidase * Ixodes ricinus * Tick saliva * Cystatins * Protease inhibition * Protein structure * Host-parasite interactions
OECD category: Biochemistry and molecular biology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 8, year: 2022
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s00018-023-04993-4
Permanent Link: https://hdl.handle.net/11104/0349268 - 4.0570585 - ÚOCHB 2024 RIV US eng J - Journal Article
Buša, Michal - Matoušková, Zuzana - Bartošová-Sojková, Pavla - Pachl, Petr - Řezáčová, Pavlína - Eichenberger, R. M. - Deplazes, P. - Horn, Martin - Štefanić, S. - Mareš, Michael
An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.
Journal of Biological Chemistry. Roč. 299, č. 3 (2023), č. článku 102970. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA19-17269S; GA ČR(CZ) GA21-16565S; GA MŠMT(CZ) LTAUSA19109
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : cystatin * stefin * protease inhibitor * cysteine cathepsin * protein structure * protein evolution * helminth parasite
OECD category: Biochemistry and molecular biology
Impact factor: 4.8, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.jbc.2023.102970
Permanent Link: https://hdl.handle.net/11104/0341888
Research data: RCSB PDB - 5.0561246 - ÚOCHB 2023 RIV DE eng J - Journal Article
Lemke, C. - Jílková, Adéla - Ferber, D. - Braune, A. - On, A. - Johe, P. - Zíková, Alena - Schirmeister, T. - Mareš, Michael - Horn, Martin - Gütschow, M.
Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain.
Chemistry - A European Journal. Roč. 28, č. 62 (2022), č. článku e202201636. ISSN 0947-6539. E-ISSN 1521-3765
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:61388963 ; RVO:60077344
Keywords : activity-based probes * affinity chromatography * cysteine proteases * imaging agents * peptidomimetics * rhodesain * size exclusion chromatography
OECD category: Biochemistry and molecular biology; Microbiology (BC-A)
Impact factor: 4.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1002/chem.202201636
Permanent Link: https://hdl.handle.net/11104/0333931 - 6.0553871 - ÚOCHB 2023 RIV GB eng J - Journal Article
Benýšek, Jakub - Buša, Michal - Rubešová, Petra - Fanfrlík, Jindřich - Lepšík, Martin - Brynda, Jiří - Matoušková, Zuzana - Bartz, U. - Horn, Martin - Gütschow, M. - Mareš, Michael
Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.
Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 37, č. 1 (2022), s. 515-526. ISSN 1475-6366. E-ISSN 1475-6374
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : Cathepsin K * protease inhibitor * cyanohydrazide warhead * azadipeptide nitrile * crystal structure
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1080/14756366.2021.2024527
Permanent Link: http://hdl.handle.net/11104/0328551 - 7.0550906 - BC 2022 RIV CH eng J - Journal Article
Kotál, Jan - Buša, Michal - Urbanová, Veronika - Řezáčová, Pavlína - Chmelař, J. - Langhansová, H. - Sojka, Daniel - Mareš, Michael - Kotsyfakis, Michalis
Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion.
International Journal of Molecular Sciences. Roč. 22, č. 10 (2021), č. článku 5371. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA19-07247S; GA ČR(CZ) GA21-08826S; GA MŠMT(CZ) EF16_019/0000759; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:60077344 ; RVO:61388963
Keywords : rhipicephalus boophilus microplus * hard tick * functional-characterization * ornithodoros-moubata * protease inhibitors * proteolytic-enzymes * salivary cystatin * egg-white * expression * gut * cathepsin * crystal structure * cysteine protease * digestion * Ixodes ricinus * midgut * parasite
OECD category: Microbiology; Biochemistry and molecular biology (UOCHB-X)
Impact factor: 6.208, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1422-0067/22/10/5371
Permanent Link: http://hdl.handle.net/11104/0326208 - 8.0545805 - ÚOCHB 2022 RIV US eng J - Journal Article
Lemke, C. - Benýšek, Jakub - Brajtenbach, D. - Breuer, C. - Jílková, Adéla - Horn, Martin - Buša, Michal - Ulrychová, Lenka - Illies, A. - Kubatzky, K. F. - Bartz, U. - Mareš, Michael - Gütschow, M.
An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.
Journal of Medicinal Chemistry. Roč. 64, č. 18 (2021), s. 13793-13806. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : highly potent * vinyl sulfone * inhibitors
OECD category: Biochemistry and molecular biology
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c01178
Permanent Link: http://hdl.handle.net/11104/0322454 - 9.0544813 - ÚOCHB 2022 RIV GB eng J - Journal Article
Li, M. - Srp, Jaroslav - Mareš, Michael - Wlodawer, A. - Gustchina, A.
Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI.
Acta Crystallographica Section D-Structural Biology. Roč. 77, č. 8 (2021), s. 1084-1098. ISSN 2059-7983. E-ISSN 2059-7983
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : proteases * kallikreins * trypsin * chymotrypsin * plant Kunitz inhibitors * protein–protein interactions * Bauhinia bauhinioides * BbKI * human kallikrein 4
OECD category: Biochemistry and molecular biology
Impact factor: 5.699, year: 2021
Method of publishing: Limited access
https://doi.org/10.1107/S2059798321006483
Permanent Link: http://hdl.handle.net/11104/0321620 - 10.0543094 - ÚOCHB 2022 RIV GB eng J - Journal Article
Ulrychová, Lenka - Ostašov, P. - Chanová, M. - Mareš, Michael - Horn, Martin - Dvořák, J.
Spatial expression pattern of serine proteases in the blood fluke Schistosoma mansoni determined by fluorescence RNA in situ hybridization.
Parasites & Vectors. Roč. 14, č. 1 (2021), č. článku 274. ISSN 1756-3305. E-ISSN 1756-3305
R&D Projects: GA MZd(CZ) NV18-05-00345; GA ČR(CZ) GA19-17269S; GA MŠMT(CZ) 8J19AT036
Institutional support: RVO:61388963
Keywords : blood fluke * fluorescence RNA in situ hybridization * mRNA detection * platyhelminthes * Schistosoma mansoni * serine proteases * transcript
OECD category: Biochemistry and molecular biology
Impact factor: 4.052, year: 2021
Method of publishing: Open access
https://doi.org/10.1186/s13071-021-04773-8
Permanent Link: http://hdl.handle.net/11104/0320382