Search results
- 1.0578510 - ÚOCHB 2024 RIV US eng J - Journal Article
Novotná, Kateřina - Tenora, Lukáš - Prchalová, E. - Paule, J. - Alt, J. - Veeravalli, V. - Lam, J. - Wu, Y. - Šnajdr, Ivan - Gori, S. - Mettu, V. S. - Tsukamoto, T. - Majer, Pavel - Slusher, B. S. - Rais, R.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-L-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
Journal of Medicinal Chemistry. Roč. 66, č. 22 (2023), s. 15493-15510. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LTAUSA18166; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : phase-I * 6-diazo-5-oxo-l-norleucine DON * clinical pharmacology
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01681
Permanent Link: https://hdl.handle.net/11104/0347498File Download Size Commentary Version Access 10.1021acs.jmedchem.3c01681.pdf 0 2.8 MB Publisher’s postprint open-access - 2.0576214 - ÚOCHB 2024 RIV US eng J - Journal Article
Lemberg, K. M. - Ali, E. S. - Krečmerová, Marcela - Aguilar, J. M. H. - Alt, J. - Peters, D. E. - Zhao, L. - Wu, Y. - Nuha, N. - Asara, J. M. - Staedtke, V. - Pratilas, C. A. - Majer, Pavel - Rais, R. - Ben-Sahra, I. - Slusher, B. S.
Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.
Molecular Cancer Therapeutics. Roč. 22, č. 12 (2023), s. 1390-1403. ISSN 1535-7163. E-ISSN 1538-8514
R&D Projects: GA MŠMT(CZ) LM2023053
Institutional support: RVO:61388963
Keywords : loading 6-mercaptopurine therapies * standard dose 6-mercaptopurine * combination 6-mercaptopurine
OECD category: Medicinal chemistry
Impact factor: 5.7, year: 2022
Method of publishing: Open access
https://doi.org/10.1158/1535-7163.MCT-23-0258
Permanent Link: https://hdl.handle.net/11104/0345801 - 3.0574532 - BTÚ 2024 RIV US eng J - Journal Article
Motlová, Lucia - Šnajdr, Ivan - Kutil, Zsofia - Andris, Erik - Ptáček, Jakub - Novotná, Adéla - Nováková, Zora - Havlínová, Barbora - Tueckmantel, W. - Dráberová, Helena - Majer, Pavel - Schutkowski, M. - Kozikowski, A. - Rulíšek, Lubomír - Bařinka, Cyril
Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6).
ACS Chemical Biology. Roč. 18, č. 7 (2023), s. 1594-1610. ISSN 1554-8929. E-ISSN 1554-8937
R&D Projects: GA ČR(CZ) GA21-31806S; GA ČR(CZ) GA23-05940S; GA MŠMT(CZ) LUAUS23247
Research Infrastructure: CIISB III - 90242; EATRIS-CZ IV - 90253
Institutional support: RVO:86652036 ; RVO:61388963
Keywords : BASIS-SETS * COSMO * ENERGY * REFINEMENT
OECD category: Biochemistry and molecular biology
Impact factor: 4, year: 2022
Method of publishing: Open access
https://pubs.acs.org/doi/10.1021/acschembio.3c00212
Permanent Link: https://hdl.handle.net/11104/0347139 - 4.0574388 - ÚOCHB 2024 RIV US eng J - Journal Article
Peters, D. E. - Norris, L. D. - Tenora, Lukáš - Šnajdr, Ivan - Ponti, A. K. - Zhu, X. - Sakamoto, S. - Veeravalli, V. - Pradhan, M. - Alt, J. - Thomas, A. G. - Majer, Pavel - Rais, R. - McDonald, C. - Slusher, B. S.
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Science Translational Medicine. Roč. 15, č. 708 (2023), č. článku eabn7491. ISSN 1946-6234. E-ISSN 1946-6242
R&D Projects: GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : gene expression profiles * dextran sulfate sodium * membrane antigen PSMA
OECD category: Medicinal chemistry
Impact factor: 17.1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1126/scitranslmed.abn7491
Permanent Link: https://hdl.handle.net/11104/0344718 - 5.0571548 - BTÚ 2024 RIV CH eng J - Journal Article
Ptáček, Jakub - Šnajdr, Ivan - Schimer, Jiří - Kutil, Zsofia - Mikesova, Jana - Baranová, Petra - Havlínová, Barbora - Tueckmantel, W. - Majer, Pavel - Kozikowski, A. - Bařinka, Cyril
Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells.
International Journal of Molecular Sciences. Roč. 24, č. 5 (2023), č. článku 4720. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA21-31806S; GA MŠMT LX22NPO5102
Institutional support: RVO:86652036 ; RVO:61388963
Keywords : metallohydrolase * histone deacetylase * inhibitor profiling * tubulin * histone acetylation * nanoBRET
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/1422-0067/24/5/4720
Permanent Link: https://hdl.handle.net/11104/0342903 - 6.0570994 - ÚOCHB 2024 RIV NL eng J - Journal Article
Frejlachová, A. - Lencová, R. - Venhauerová, A. - Skaličková, M. - Uher, O. - Caisova, V. - Majer, Pavel - Tenora, Lukáš - Hansen, P. - Chmelař, J. - Kopecký, J. - Zhuang, Z. - Pacak, K. - Ženka, J.
The combination of immunotherapy and a glutamine metabolism inhibitor represents an effective therapeutic strategy for advanced and metastatic murine pancreatic adenocarcinoma.
International Immunopharmacology. Roč. 118, May (2023), č. článku 110150. ISSN 1567-5769. E-ISSN 1878-1705
Institutional support: RVO:61388963
Keywords : cancer * pancreatic adenocarcinoma * intratumoral * immunotherapy * glutamine antagonist
OECD category: Medicinal chemistry
Impact factor: 5.6, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.intimp.2023.110150
Permanent Link: https://hdl.handle.net/11104/0342323 - 7.0568134 - ÚOCHB 2024 RIV GB eng J - Journal Article
Tsai, J. - Gori, S. - Alt, J. - Tiwari, S. - Iyer, J. - Talwar, R. - Hinsu, D. - Ahirwar, K. - Mohanty, S. - Khunt, C. - Sutariya, B. - Jani, K. - Venkatasubbaiah, V. - Patel, A. - Meghapara, J. - Joshi, K. - Sahu, R. - Rana, V. - Nigade, P. - Talluri, R. S. - Murty, K. V. S. N. - Joshi, K. - Ramanathan, V. - Li, A. - Islam, N. - Šnajdr, Ivan - Majer, Pavel - Rais, R. - Slusher, B. S. - Garza, L. A.
Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata.
PNAS Nexus. Roč. 2, č. 1 (2023), č. článku pgac297. E-ISSN 2752-6542
Institutional support: RVO:61388963
Keywords : alopecia areata * hair growth * topical * itaconate * prodrug * inflammation * immunosuppression * cytokine * interleukin * interferon * double-stranded RNA * polyinosinic–polycytidylic acid * hair cycle * anagen * telogen * keratinocyte * stability * pharmacokinetics * cytotoxicity
OECD category: Medicinal chemistry
Method of publishing: Open access
https://doi.org/10.1093/pnasnexus/pgac297
Permanent Link: https://hdl.handle.net/11104/0339488
Research data: Mendeley Data - 8.0566618 - ÚOCHB 2024 RIV US eng J - Journal Article
Poláchová, Edita - Bach, Kathrin - Heuten, E. - Stanchev, Stancho - Tichá, Anežka - Lampe, P. - Majer, Pavel - Langer, T. - Lemberg, M. K. - Stříšovský, Kvido
Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy.
Journal of Medicinal Chemistry. Roč. 66, č. 1 (2023), s. 251-265. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT LO1302; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : lipid bilayer nanodiscs * membrane proteins * PINK1
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.2c01092
Permanent Link: https://hdl.handle.net/11104/0338165 - 9.0565749 - ÚOCHB 2024 RIV GB eng J - Journal Article
Kugler, Michael - Hadzima, Martin - Dzijak, Rastislav - Rampmaier, Robert - Srb, Pavel - Vrzal, Lukáš - Voburka, Zdeněk - Majer, Pavel - Řezáčová, Pavlína - Vrábel, Milan
Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study.
RSC MEDICINAL CHEMISTRY. Roč. 14, č. 1 (2023), s. 144-153. E-ISSN 2632-8682
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
EU Projects: European Commission(XE) 677465 - SWEETOOLS
Institutional support: RVO:61388963
Keywords : fragment-based discovery * combinatorial libraries * generation
OECD category: Biochemical research methods
Impact factor: 4.1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1039/D2MD00330A
Permanent Link: https://hdl.handle.net/11104/0337258File Download Size Commentary Version Access 10.1039D2MD00330A.pdf 0 6.5 MB Publisher’s postprint require
Research data: Worldwide PBD, Worldwide PBD, Worldwide PBD, Worldwide PBD, Worldwide PBD, Worldwide PBD - 10.0565069 - ÚOCHB 2023 RIV US eng J - Journal Article
Rais, R. - Lemberg, K. M. - Tenora, Lukáš - Arwood, M. L. - Pal, A. - Alt, J. - Wu, Y. - Lam, J. - Aguilar, J. M. H. - Zhao, L. - Peters, D. E. - Tallon, C. - Pandey, R. - Thomas, A. G. - Dash, R. P. - Seiwert, T. - Majer, Pavel - Leone, R. D. - Powell, J. D. - Slusher, B. S.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Science Advances. Roč. 8, č. 46 (2022), č. článku eabq5925. ISSN 2375-2548. E-ISSN 2375-2548
R&D Projects: GA MŠMT LTAUSA18166
Institutional support: RVO:61388963
Keywords : 6-diazo-5-oxo-l-norleucine DON * phase II * glutamine metabolism
OECD category: Organic chemistry
Impact factor: 13.6, year: 2022
Method of publishing: Open access
https://doi.org/10.1126/sciadv.abq5925
Permanent Link: https://hdl.handle.net/11104/0336617