Search results
- 1.0604028 - ÚOCHB 2026 RIV NL eng J - Journal Article
Novotný, Pavel - Humpolíčková, Jana - Nováková, Veronika - Stanchev, Stancho - Stříšovský, Kvido - Zgarbová, Michala - Weber, Jan - Kryštůfek, Robin - Starková, Jana - Hradilek, Martin - Moravcová, Adéla - Günterová, Jana - Bach, Kathrin - Majer, Pavel - Konvalinka, Jan - Majerová, Taťána
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
Journal of Biological Chemistry. Roč. 301, č. 1 (2025), č. článku 108079. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MŠMT(CZ) LUC23180
Institutional support: RVO:61388963
Keywords : SARS-CoV-2 * protease * autoprocessing * virus
OECD category: Biochemistry and molecular biology
Impact factor: 4, year: 2023 ; AIS: 1.471, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.jbc.2024.108079DOI: https://doi.org/10.1016/j.jbc.2024.108079
Permanent Link: https://hdl.handle.net/11104/0361353File Download Size Commentary Version Access 10.1016j.jbc.2024.108079.pdf 1 2.5 MB Publisher’s postprint open-access - 2.0603191 - ÚOCHB 2026 RIV NL eng J - Journal Article
Čermáková, Kateřina - Gregor, Jiří - Král, Michal - Karlukova, Elena - Navrátil, Václav - Reiberger, Róbert - Berenguer Albiñana, Carlos - Bechynský, Vít - Majer, Pavel - Konvalinka, Jan - Machara, Aleš - Kožíšek, Milan
The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase.
European Journal of Pharmaceutical Sciences. Roč. 205, February (2025), č. článku 106990. ISSN 0928-0987. E-ISSN 1879-0720
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : influenza A polymerase * pimodivir * DNA-linked inhibitor antibody assay * alphascreen * cap snatching * inhibitor
OECD category: Biochemical research methods
Impact factor: 4.3, year: 2023 ; AIS: 0.66, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.ejps.2024.106990DOI: https://doi.org/10.1016/j.ejps.2024.106990
Permanent Link: https://hdl.handle.net/11104/0360433File Download Size Commentary Version Access 10.1016j.ejps.2024.106990.pdf 2 4.2 MB Publisher’s postprint open-access - 3.0600731 - ÚOCHB 2026 RIV US eng J - Journal Article
Král, Michal - Kotačka, Tomáš - Reiberger, Róbert - Panýrková, Gabriela - Radilová, Kateřina - Osifová, Zuzana - Flieger, Miroslav - Konvalinka, Jan - Majer, Pavel - Kožíšek, Milan - Machara, Aleš
3’-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex.
ChemMedChem. Roč. 20, č. 3 (2025), č. článku e202400577. ISSN 1860-7179. E-ISSN 1860-7187
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963 ; RVO:61388971
Keywords : chemical synthesis * endonuclease * enzymeinhibition * influenza * metalloenzymes * purpurogallin * influenza polymerase * endonuclease
OECD category: Medicinal chemistry
Impact factor: 3.6, year: 2023 ; AIS: 0.714, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1002/cmdc.202400577DOI: https://doi.org/10.1002/cmdc.202400577
Permanent Link: https://hdl.handle.net/11104/0358023File Download Size Commentary Version Access 10.1002cmdc.202400577.pdf 0 1.3 MB Publisher’s postprint open-access - 4.0599989 - ÚOCHB 2025 RIV NL eng J - Journal Article
Čermáková, Kateřina - Šimková, Adéla - Wichterle, Filip - Kryštůfek, Robin - Staňurová, Jana - Vaníčková, Z. - Bušek, P. - Konvalinka, Jan - Šácha, Pavel
Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.
European Journal of Medicinal Chemistry. Roč. 280, December (2024), č. článku 116948. ISSN 0223-5234. E-ISSN 1768-3254
R&D Projects: GA MZd(CZ) NU22-03-00318; GA ČR(CZ) GA24-10814S; GA MŠMT LX22NPO5102; GA MŠMT(CZ) LM2023053
Institutional support: RVO:61388963
Keywords : DIANA * fibroblast activation protein * high-throughput screening * FAP quantification
OECD category: Medicinal chemistry
Impact factor: 6, year: 2023 ; AIS: 0.979, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.ejmech.2024.116948DOI: https://doi.org/10.1016/j.ejmech.2024.116948
Permanent Link: https://hdl.handle.net/11104/0357358File Download Size Commentary Version Access 10.1016j.ejmech.2024.116948.pdf 2 3.3 MB Publisher’s postprint open-access - 5.0598945 - ÚOCHB 2025 RIV US eng J - Journal Article
Nedomová, Monika - Haberecht-Müller, S. - Möller, S. - Venz, S. - Procházková, M. - Procházka, J. - Sedlák, František - Chawengsaksophak, Kallayanee - Hammer, E. - Kašpárek, Petr - Adámek, Michael - Sedláček, Radislav - Konvalinka, Jan - Krüger, E. - Grantz Šašková, Klára
DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
iScience. Roč. 27, č. 10 (2024), č. článku 110893. E-ISSN 2589-0042
R&D Projects: GA ČR(CZ) GA22-16389S; GA MŠMT LM2023036; GA MŠMT EF18_046/0015861
Institutional support: RVO:61388963 ; RVO:68378050
Keywords : bZIP transcription factor * TANK-binding kinase-1 * interferon
OECD category: Biochemistry and molecular biology
Impact factor: 4.6, year: 2023 ; AIS: 1.5, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.isci.2024.110893DOI: https://doi.org/10.1016/j.isci.2024.110893
Permanent Link: https://hdl.handle.net/11104/0356512Research data: IMPC - 6.0587571 - ÚOCHB 2025 RIV US eng J - Journal Article
Hadzima, Martin - Faucher, F. F. - Blažková, K. - Yim, J. J. - Guerra, M. - Chen, S. - Woods, E. C. - Park, K. W. - Šácha, Pavel - Šubr, Vladimír - Kostka, Libor - Etrych, Tomáš - Majer, Pavel - Konvalinka, Jan - Bogyo, M.
Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases.
ACS Sensors. Roč. 9, č. 7 (2024), s. 3720-3729. ISSN 2379-3694. E-ISSN 2379-3694
R&D Projects: GA MŠMT LX22NPO5102; GA MŠMT(CZ) EF18_053/0016940; GA MZd(CZ) NU21-08-00280; GA ČR(CZ) GA23-05642S
Institutional support: RVO:61388963 ; RVO:61389013
Keywords : fluorescence * imaging * protease * cancer * HPMA copolymer * iBody
OECD category: Polymer science; Polymer science (UMCH-V)
Impact factor: 8.3, year: 2023 ; AIS: 1.583, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1021/acssensors.4c00912DOI: https://doi.org/10.1021/acssensors.4c00912
Permanent Link: https://hdl.handle.net/11104/0354701File Download Size Commentary Version Access 10.1021acssensors.4c00912.pdf 1 6.2 MB Publisher’s postprint open-access - 7.0586357 - ÚOCHB 2025 RIV NL eng J - Journal Article
Zamani, Mohammad Reza - Hadzima, Martin - Blažková, Kristýna - Šubr, Vladimír - Ormsby, Tereza - Celis-Gutierrez, J. - Malissen, B. - Kostka, Libor - Etrych, Tomáš - Šácha, Pavel - Konvalinka, Jan
Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker.
Journal of Biological Chemistry. Roč. 300, č. 6 (2024), č. článku 107325. ISSN 0021-9258. E-ISSN 1083-351X
R&D Projects: GA MŠMT LX22NPO5102; GA ČR(CZ) GA23-05642S
Institutional support: RVO:61388963 ; RVO:61389013
Keywords : PD-1 * PD-L1 * immune checkpoint * HPMA copolymer * antibody mimetic * T-cell * inhibitor * immunotherapy * immunosuppression * tumor immunology
OECD category: Biochemistry and molecular biology; Polymer science (UMCH-V)
Impact factor: 4, year: 2023 ; AIS: 1.471, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.jbc.2024.107325DOI: https://doi.org/10.1016/j.jbc.2024.107325
Permanent Link: https://hdl.handle.net/11104/0353904File Download Size Commentary Version Access 10.1016j.jbc.2024.107325.pdf 4 1.6 MB Publisher’s postprint open-access - 8.0583976 - ÚOCHB 2025 RIV US eng J - Journal Article
Sedlák, František - Kvasnička, A. - Marešová, Barbora - Brumarová, R. - Dobešová, D. - Dostálová, K. - Šrámková, Karolína - Pehr, Martin - Šácha, Pavel - Friedecký, D. - Konvalinka, Jan
Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition.
ACS Chemical Neuroscience. Roč. 15, č. 7 (2024), s. 1342-1355. ISSN 1948-7193. E-ISSN 1948-7193
R&D Projects: GA ČR(CZ) GA21-04166S; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : lipidomics * metabolomics * N-acetyl-aspartyl-glutamate * glutamate carboxypeptidase II * FOLH1 * folyl-poly-γ-glutamyl hydrolase I
OECD category: Biochemistry and molecular biology
Impact factor: 4.2, year: 2023 ; AIS: 0.982, rok: 2023
Method of publishing: Open access
Result website:
https://doi.org/10.1021/acschemneuro.3c00494DOI: https://doi.org/10.1021/acschemneuro.3c00494
Permanent Link: https://hdl.handle.net/11104/0351973File Download Size Commentary Version Access 10.1021acschemneuro.3c00494.pdf 0 4.8 MB Publisher’s postprint open-access - 9.0565334 - ÚOCHB 2023 RIV NL eng J - Journal Article
Majerová, Taťána - Konvalinka, Jan
Viral proteases as therapeutic targets.
Molecular Aspects of Medicine. Roč. 88, December (2022), č. článku 101159. ISSN 0098-2997. E-ISSN 1872-9452
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : hepatitis C virus * human immunodeficiency virus * orally bioavailable inhibitor
OECD category: Virology
Impact factor: 10.6, year: 2022 ; AIS: 2.725, rok: 2022
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.mam.2022.101159DOI: https://doi.org/10.1016/j.mam.2022.101159
Permanent Link: https://hdl.handle.net/11104/0336883File Download Size Commentary Version Access 10.1016j.mam.2022.101159.pdf 4 8.1 MB Publisher’s postprint open-access - 10.0563164 - ÚOCHB 2023 RIV NL eng J - Journal Article
Radilová, Kateřina - Zima, Václav - Král, Michal - Machara, Aleš - Majer, Pavel - Hodek, Jan - Weber, Jan - Brynda, Jiří - Strmeň, Timotej - Konvalinka, Jan - Kožíšek, Milan
Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.
Antiviral Research. Roč. 208, December (2022), č. článku 105449. ISSN 0166-3542. E-ISSN 1872-9096
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:61388963
Keywords : antiviral peptides * influenza A polymerase * protein-protein interaction * AlphaScreen * isothermal titration calorimetry
OECD category: Biochemistry and molecular biology
Impact factor: 7.6, year: 2022 ; AIS: 1.345, rok: 2022
Method of publishing: Open access
Result website:
https://doi.org/10.1016/j.antiviral.2022.105449DOI: https://doi.org/10.1016/j.antiviral.2022.105449
Permanent Link: https://hdl.handle.net/11104/0335206File Download Size Commentary Version Access 10.1016j.antiviral.2022.105449.pdf 5 6.4 MB Publisher’s postprint open-access