Search results

  1. 1.
    0604028 - ÚOCHB 2026 RIV NL eng J - Journal Article
    Novotný, Pavel - Humpolíčková, Jana - Nováková, Veronika - Stanchev, Stancho - Stříšovský, Kvido - Zgarbová, Michala - Weber, Jan - Kryštůfek, Robin - Starková, Jana - Hradilek, Martin - Moravcová, Adéla - Günterová, Jana - Bach, Kathrin - Majer, Pavel - Konvalinka, Jan - Majerová, Taťána
    The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
    Journal of Biological Chemistry. Roč. 301, č. 1 (2025), č. článku 108079. ISSN 0021-9258. E-ISSN 1083-351X
    R&D Projects: GA MŠMT(CZ) LX22NPO5103; GA MŠMT(CZ) LUC23180
    Institutional support: RVO:61388963
    Keywords : SARS-CoV-2 * protease * autoprocessing * virus
    OECD category: Biochemistry and molecular biology
    Impact factor: 4, year: 2023 ; AIS: 1.471, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1016/j.jbc.2024.108079DOI: https://doi.org/10.1016/j.jbc.2024.108079
    Permanent Link: https://hdl.handle.net/11104/0361353
     
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    10.1016j.jbc.2024.108079.pdf12.5 MBPublisher’s postprintopen-access
     
  2. 2.
    0603191 - ÚOCHB 2026 RIV NL eng J - Journal Article
    Čermáková, Kateřina - Gregor, Jiří - Král, Michal - Karlukova, Elena - Navrátil, Václav - Reiberger, Róbert - Berenguer Albiñana, Carlos - Bechynský, Vít - Majer, Pavel - Konvalinka, Jan - Machara, Aleš - Kožíšek, Milan
    The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase.
    European Journal of Pharmaceutical Sciences. Roč. 205, February (2025), č. článku 106990. ISSN 0928-0987. E-ISSN 1879-0720
    R&D Projects: GA MŠMT(CZ) LX22NPO5103
    Institutional support: RVO:61388963
    Keywords : influenza A polymerase * pimodivir * DNA-linked inhibitor antibody assay * alphascreen * cap snatching * inhibitor
    OECD category: Biochemical research methods
    Impact factor: 4.3, year: 2023 ; AIS: 0.66, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1016/j.ejps.2024.106990DOI: https://doi.org/10.1016/j.ejps.2024.106990
    Permanent Link: https://hdl.handle.net/11104/0360433
     
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    10.1016j.ejps.2024.106990.pdf24.2 MBPublisher’s postprintopen-access
     
  3. 3.
    0600731 - ÚOCHB 2026 RIV US eng J - Journal Article
    Král, Michal - Kotačka, Tomáš - Reiberger, Róbert - Panýrková, Gabriela - Radilová, Kateřina - Osifová, Zuzana - Flieger, Miroslav - Konvalinka, Jan - Majer, Pavel - Kožíšek, Milan - Machara, Aleš
    3’-Dehydroxypurpurogallin-4-Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure-Activity Relationship Analysis, and Structural Characterization of Protein Complex.
    ChemMedChem. Roč. 20, č. 3 (2025), č. článku e202400577. ISSN 1860-7179. E-ISSN 1860-7187
    R&D Projects: GA MŠMT(CZ) LX22NPO5103
    Institutional support: RVO:61388963 ; RVO:61388971
    Keywords : chemical synthesis * endonuclease * enzymeinhibition * influenza * metalloenzymes * purpurogallin * influenza polymerase * endonuclease
    OECD category: Medicinal chemistry
    Impact factor: 3.6, year: 2023 ; AIS: 0.714, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1002/cmdc.202400577DOI: https://doi.org/10.1002/cmdc.202400577
    Permanent Link: https://hdl.handle.net/11104/0358023
     
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    10.1002cmdc.202400577.pdf01.3 MBPublisher’s postprintopen-access
     
  4. 4.
    0599989 - ÚOCHB 2025 RIV NL eng J - Journal Article
    Čermáková, Kateřina - Šimková, Adéla - Wichterle, Filip - Kryštůfek, Robin - Staňurová, Jana - Vaníčková, Z. - Bušek, P. - Konvalinka, Jan - Šácha, Pavel
    Sensitive quantification of fibroblast activation protein and high-throughput screening for inhibition by FDA-approved compounds.
    European Journal of Medicinal Chemistry. Roč. 280, December (2024), č. článku 116948. ISSN 0223-5234. E-ISSN 1768-3254
    R&D Projects: GA MZd(CZ) NU22-03-00318; GA ČR(CZ) GA24-10814S; GA MŠMT LX22NPO5102; GA MŠMT(CZ) LM2023053
    Institutional support: RVO:61388963
    Keywords : DIANA * fibroblast activation protein * high-throughput screening * FAP quantification
    OECD category: Medicinal chemistry
    Impact factor: 6, year: 2023 ; AIS: 0.979, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1016/j.ejmech.2024.116948DOI: https://doi.org/10.1016/j.ejmech.2024.116948
    Permanent Link: https://hdl.handle.net/11104/0357358
     
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    10.1016j.ejmech.2024.116948.pdf23.3 MBPublisher’s postprintopen-access
     
  5. 5.
    0598945 - ÚOCHB 2025 RIV US eng J - Journal Article
    Nedomová, Monika - Haberecht-Müller, S. - Möller, S. - Venz, S. - Procházková, M. - Procházka, J. - Sedlák, František - Chawengsaksophak, Kallayanee - Hammer, E. - Kašpárek, Petr - Adámek, Michael - Sedláček, Radislav - Konvalinka, Jan - Krüger, E. - Grantz Šašková, Klára
    DDI2 protease controls embryonic development and inflammation via TCF11/NRF1.
    iScience. Roč. 27, č. 10 (2024), č. článku 110893. E-ISSN 2589-0042
    R&D Projects: GA ČR(CZ) GA22-16389S; GA MŠMT LM2023036; GA MŠMT EF18_046/0015861
    Institutional support: RVO:61388963 ; RVO:68378050
    Keywords : bZIP transcription factor * TANK-binding kinase-1 * interferon
    OECD category: Biochemistry and molecular biology
    Impact factor: 4.6, year: 2023 ; AIS: 1.5, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1016/j.isci.2024.110893DOI: https://doi.org/10.1016/j.isci.2024.110893
    Permanent Link: https://hdl.handle.net/11104/0356512
     
    Research data: IMPC
  6. 6.
    0587571 - ÚOCHB 2025 RIV US eng J - Journal Article
    Hadzima, Martin - Faucher, F. F. - Blažková, K. - Yim, J. J. - Guerra, M. - Chen, S. - Woods, E. C. - Park, K. W. - Šácha, Pavel - Šubr, Vladimír - Kostka, Libor - Etrych, Tomáš - Majer, Pavel - Konvalinka, Jan - Bogyo, M.
    Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases.
    ACS Sensors. Roč. 9, č. 7 (2024), s. 3720-3729. ISSN 2379-3694. E-ISSN 2379-3694
    R&D Projects: GA MŠMT LX22NPO5102; GA MŠMT(CZ) EF18_053/0016940; GA MZd(CZ) NU21-08-00280; GA ČR(CZ) GA23-05642S
    Institutional support: RVO:61388963 ; RVO:61389013
    Keywords : fluorescence * imaging * protease * cancer * HPMA copolymer * iBody
    OECD category: Polymer science; Polymer science (UMCH-V)
    Impact factor: 8.3, year: 2023 ; AIS: 1.583, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1021/acssensors.4c00912DOI: https://doi.org/10.1021/acssensors.4c00912
    Permanent Link: https://hdl.handle.net/11104/0354701
     
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    10.1021acssensors.4c00912.pdf16.2 MBPublisher’s postprintopen-access
     
  7. 7.
    0586357 - ÚOCHB 2025 RIV NL eng J - Journal Article
    Zamani, Mohammad Reza - Hadzima, Martin - Blažková, Kristýna - Šubr, Vladimír - Ormsby, Tereza - Celis-Gutierrez, J. - Malissen, B. - Kostka, Libor - Etrych, Tomáš - Šácha, Pavel - Konvalinka, Jan
    Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker.
    Journal of Biological Chemistry. Roč. 300, č. 6 (2024), č. článku 107325. ISSN 0021-9258. E-ISSN 1083-351X
    R&D Projects: GA MŠMT LX22NPO5102; GA ČR(CZ) GA23-05642S
    Institutional support: RVO:61388963 ; RVO:61389013
    Keywords : PD-1 * PD-L1 * immune checkpoint * HPMA copolymer * antibody mimetic * T-cell * inhibitor * immunotherapy * immunosuppression * tumor immunology
    OECD category: Biochemistry and molecular biology; Polymer science (UMCH-V)
    Impact factor: 4, year: 2023 ; AIS: 1.471, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1016/j.jbc.2024.107325DOI: https://doi.org/10.1016/j.jbc.2024.107325
    Permanent Link: https://hdl.handle.net/11104/0353904
     
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    10.1016j.jbc.2024.107325.pdf41.6 MBPublisher’s postprintopen-access
     
  8. 8.
    0583976 - ÚOCHB 2025 RIV US eng J - Journal Article
    Sedlák, František - Kvasnička, A. - Marešová, Barbora - Brumarová, R. - Dobešová, D. - Dostálová, K. - Šrámková, Karolína - Pehr, Martin - Šácha, Pavel - Friedecký, D. - Konvalinka, Jan
    Parallel Metabolomics and Lipidomics of a PSMA/GCPII Deficient Mouse Model Reveal Alteration of NAAG Levels and Brain Lipid Composition.
    ACS Chemical Neuroscience. Roč. 15, č. 7 (2024), s. 1342-1355. ISSN 1948-7193. E-ISSN 1948-7193
    R&D Projects: GA ČR(CZ) GA21-04166S; GA MŠMT LX22NPO5102
    Institutional support: RVO:61388963
    Keywords : lipidomics * metabolomics * N-acetyl-aspartyl-glutamate * glutamate carboxypeptidase II * FOLH1 * folyl-poly-γ-glutamyl hydrolase I
    OECD category: Biochemistry and molecular biology
    Impact factor: 4.2, year: 2023 ; AIS: 0.982, rok: 2023
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1021/acschemneuro.3c00494DOI: https://doi.org/10.1021/acschemneuro.3c00494
    Permanent Link: https://hdl.handle.net/11104/0351973
     
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    10.1021acschemneuro.3c00494.pdf04.8 MBPublisher’s postprintopen-access
     
  9. 9.
    0565334 - ÚOCHB 2023 RIV NL eng J - Journal Article
    Majerová, Taťána - Konvalinka, Jan
    Viral proteases as therapeutic targets.
    Molecular Aspects of Medicine. Roč. 88, December (2022), č. článku 101159. ISSN 0098-2997. E-ISSN 1872-9452
    R&D Projects: GA MŠMT(CZ) LX22NPO5103
    Institutional support: RVO:61388963
    Keywords : hepatitis C virus * human immunodeficiency virus * orally bioavailable inhibitor
    OECD category: Virology
    Impact factor: 10.6, year: 2022 ; AIS: 2.725, rok: 2022
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1016/j.mam.2022.101159DOI: https://doi.org/10.1016/j.mam.2022.101159
    Permanent Link: https://hdl.handle.net/11104/0336883
     
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    10.1016j.mam.2022.101159.pdf48.1 MBPublisher’s postprintopen-access
     
  10. 10.
    0563164 - ÚOCHB 2023 RIV NL eng J - Journal Article
    Radilová, Kateřina - Zima, Václav - Král, Michal - Machara, Aleš - Majer, Pavel - Hodek, Jan - Weber, Jan - Brynda, Jiří - Strmeň, Timotej - Konvalinka, Jan - Kožíšek, Milan
    Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction.
    Antiviral Research. Roč. 208, December (2022), č. článku 105449. ISSN 0166-3542. E-ISSN 1872-9096
    R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA MŠMT(CZ) LX22NPO5103
    Institutional support: RVO:61388963
    Keywords : antiviral peptides * influenza A polymerase * protein-protein interaction * AlphaScreen * isothermal titration calorimetry
    OECD category: Biochemistry and molecular biology
    Impact factor: 7.6, year: 2022 ; AIS: 1.345, rok: 2022
    Method of publishing: Open access
    Result website:
    https://doi.org/10.1016/j.antiviral.2022.105449DOI: https://doi.org/10.1016/j.antiviral.2022.105449
    Permanent Link: https://hdl.handle.net/11104/0335206
     
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    10.1016j.antiviral.2022.105449.pdf56.4 MBPublisher’s postprintopen-access
     

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