Search results
- 1.0509814 - ÚOCHB 2020 RIV GB eng J - Journal Article
Pomeisl, Karel - Krečmerová, Marcela - Pohl, Radek - Snoeck, R. - Andrei, G.
Synthesis of fluorinated acyclic nucleoside phosphonates with 5-azacytosine base moiety.
Tetrahedron. Roč. 75, č. 39 (2019), č. článku 130529. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA MŠMT(CZ) LM2015064; GA MŠMT(CZ) LO1304
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * 5-azacytosine * fluorinated nucleotides * prodrugs * phosphonates
OECD category: Organic chemistry
Impact factor: 2.233, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0040402019308622?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0300433 - 2.0504619 - ÚOCHB 2020 RIV US eng J - Journal Article
Pomeisl, Karel - Pohl, Radek - Snoeck, R. - Andrei, G. - Krečmerová, Marcela
Utilization of 1,3-Dioxolanes in the Synthesis of alpha-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of alpha-branched Substitution for Potential Biological Activity.
Nucleosides Nucleotides & Nucleic Acids. Roč. 38, č. 2 (2019), s. 119-156. ISSN 1525-7770. E-ISSN 1532-2335
R&D Projects: GA ČR(CZ) GA14-00522S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * PMEG * PEEG * 1,3-dioxolanes * dialkyl phosphite * trialkyl phosphite
OECD category: Organic chemistry
Impact factor: 1.556, year: 2019
Method of publishing: Limited access
https://www.tandfonline.com/doi/full/10.1080/15257770.2018.1506884
Permanent Link: http://hdl.handle.net/11104/0296206 - 3.0503710 - ÚOCHB 2020 RIV GB eng J - Journal Article
Pomeisl, Karel - Lamatová, Nikola - Šolínová, Veronika - Pohl, Radek - Brabcová, Jana - Kašička, Václav - Krečmerová, Marcela
Enantioselective resolution of side-chain modified gem-difluorinated alcohols catalysed by Candida antarctica lipase B and monitored by capillary electrophoresis.
Bioorganic & Medicinal Chemistry. Roč. 27, č. 7 (2019), s. 1246-1253. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR(CZ) GA14-00522S; GA ČR(CZ) GA17-10832S; GA ČR(CZ) GA18-02597S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * Candida antarctica lipase * capillary electrophoresis * enantioselective resolution * enzyme catalysis * gem-difluorinated alcohols * isomerisation * transesterification
OECD category: Organic chemistry
Impact factor: 3.073, year: 2019
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0968089618318169?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0296678 - 4.0477657 - ÚOCHB 2018 RIV GB eng J - Journal Article
Krečmerová, Marcela - Dračínský, Martin - Snoeck, R. - Balzarini, J. - Pomeisl, Karel - Andrei, G.
New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
Bioorganic & Medicinal Chemistry. Roč. 25, č. 17 (2017), s. 4637-4648. ISSN 0968-0896. E-ISSN 1464-3391
R&D Projects: GA ČR(CZ) GA14-00522S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * open-ring * PMEO-DAPy * 5-azacytosine * PME-azaC * HPMP-5-azaC
OECD category: Organic chemistry
Impact factor: 2.881, year: 2017
Permanent Link: http://hdl.handle.net/11104/0273937 - 5.0469886 - ÚOCHB 2017 RIV DE eng J - Journal Article
Pomeisl, Karel - Beier, Petr - Pohl, Radek - Krečmerová, Marcela
Novel and Efficient Synthesis of gem-Difluorinated Derivatives of Acyclic Nucleoside Phosphonates (ANPs).
ChemistrySelect. Roč. 1, č. 10 (2016), s. 2102-2106. ISSN 2365-6549. E-ISSN 2365-6549
R&D Projects: GA ČR(CZ) GA14-00522S
Institutional support: RVO:61388963
Keywords : difluoromethylation * difluoromethylphosphonate * acyclic nucleoside phosphonate * phosphonate ester * microwave reaction
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0267657 - 6.0376556 - ÚOCHB 2013 RIV US eng J - Journal Article
Pomeisl, Karel - Horská, Květoslava - Pohl, Radek - Blažek, Jiří - Krečmerová, Marcela
Syntheses of 1-[2-(Phosphonomethoxy)Alkyl]Thymine Monophosphates and an Evaluation of their Inhibitory Activity Toward Human Thymidine Phosphorylase.
Nucleosides Nucleotides & Nucleic Acids. Roč. 31, č. 1/3 (2012), s. 159-171. ISSN 1525-7770. E-ISSN 1532-2335
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : thymidine phosphorylase * phosphorylation * acyclic nucleoside phosphonates
Subject RIV: CC - Organic Chemistry
Impact factor: 0.713, year: 2012
Permanent Link: http://hdl.handle.net/11104/0208924 - 7.0350272 - ÚOCHB 2011 RIV US eng J - Journal Article
Krečmerová, Marcela - Holý, Antonín - Andrei, G. - Pomeisl, Karel - Tichý, Tomáš - Břehová, Petra - Masojídková, Milena - Dračínský, Martin - Pohl, Radek - Laflamme, G. - Naesens, L. - Hui, H. - Cihlař, T. - Neyts, J. - De Clercq, E. - Balzarini, J. - Snoeck, R.
Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents.
Journal of Medicinal Chemistry. Roč. 53, č. 19 (2010), s. 6825-6837. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT 1M0508; GA MŠMT(CZ) ME10040
Grant - others:NIH(US) 1UC1 AI062540-01
Institutional research plan: CEZ:AV0Z40550506
Keywords : phosphonates * prodrugs * poxvirus * herpes virus * bioterrorism
Subject RIV: CC - Organic Chemistry
Impact factor: 5.207, year: 2010
Permanent Link: http://hdl.handle.net/11104/0190312 - 8.0330906 - ÚOCHB 2010 RIV GB eng J - Journal Article
Pomeisl, Karel - Holý, Antonín - Pohl, Radek - Horská, Květoslava
Use of Pd-catalyzed Suzuki-Miyaura coupling reaction in the rapid synthesis of 5-aryl-6-(phosphonomethoxy)uracils and evaluation of their inhibitory effect towards human thymidine phosphorylase.
Tetrahedron. Roč. 65, č. 41 (2009), s. 8486-8492. ISSN 0040-4020. E-ISSN 1464-5416
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * Suzuki-Miyaura reaction * thymidine phosphorylase * human thymidine phosphorylase
Subject RIV: CC - Organic Chemistry
Impact factor: 3.219, year: 2009
Permanent Link: http://hdl.handle.net/11104/0176579 - 9.0305693 - ÚOCHB 2008 RIV GB eng J - Journal Article
Pomeisl, Karel - Holý, Antonín - Votruba, Ivan - Pohl, Radek
Syntheses of N3-substituted thymine acyclic nucleoside phosphonates and a comparison of their inhibitory effect towards thymidine phosphorylase.
[Syntézy N3-substituovaných thyminových acyklických nukleosidových fosfonátů a zhodnocení jejich inhibičního účinku vůči thymidinfosforylase.]
Bioorganic and Medicinal Chemistry Letters. Roč. 18, č. 4 (2008), s. 1364-1367. ISSN 0960-894X. E-ISSN 1464-3405
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * thymidine phosphorylase * fluorination * pyrimidine
Subject RIV: CC - Organic Chemistry
Impact factor: 2.531, year: 2008
Permanent Link: http://hdl.handle.net/11104/0158901 - 10.0098779 - ÚOCHB 2008 RIV US eng J - Journal Article
Pomeisl, Karel - Votruba, Ivan - Holý, Antonín - Pohl, Radek
Syntheses of pyrimidine acyclic nucleoside phosphonates as potent inhibitors of thymidine phosphorylase (PD-ECGF) from SD-lymphoma.
[Syntézy pyrimidinových acyklických nukleosidových fosfonátů jako silných inhibitorů tymidin fosforylasy (PD-ECGF) z SD-lymfomu.]
Nucleosides Nucleotides & Nucleic Acids. Roč. 26, 8/9 (2007), s. 1025-1028. ISSN 1525-7770. E-ISSN 1532-2335.
[International Roundtable /17./. Bern, 03.09.2006-07.09.2006]
R&D Projects: GA MŠMT 1M0508
Grant - others:Descartes Prize(XE) HPAW-CT-2002-9001
Institutional research plan: CEZ:AV0Z40550506
Keywords : acyclic nucleoside phosphonates * thymidine phosphorylase * pyrimidines * FPMP derivatives * fluorination
Subject RIV: CC - Organic Chemistry
Impact factor: 0.723, year: 2007
Permanent Link: http://hdl.handle.net/11104/0157598