Search results
- 1.0468507 - ÚOCHB 2017 US eng A - Abstract
Krečmerová, Marcela - Tichý, Tomáš - Pomeisl, Karel - Andrei, G. - Balzarini, J. - Snoeck, R.
Antiviral acyclic nucleoside phosphonates: New structures and prodrugs.
Madridge Journal of Pharmaceutical Research. Roč. 1, č. 2 (2016), s. 37
[PharmaMed-2016. International Conference on Medicinal and Pharmaceutical Chemistry. 05.12.2016-07.12.2016, Dubai]
R&D Projects: GA ČR(CZ) GA14-00522S
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * prodrugs * antivirals * 5-azacytosine
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0266341 - 2.0436686 - ÚOCHB 2015 PT eng A - Abstract
Tichý, Tomáš - Pomeisl, Karel - Williams, M. - Krylov, I. - McKenna, C. - Krečmerová, Marcela
Tyrosine-based prodrugs of acyclic nucleoside phosphonates.
EFMC-ISMC 2014. 23rd International Symposium on Medicinal Chemistry. Lisbon: -, 2014.
[EFMC-ISMC 2014. International Symposium on Medicinal Chemistry /23./. 07.09.2014-11.09.2014, Lisbon]
R&D Projects: GA ČR(CZ) GA14-00522S
Grant - others:GA AV ČR(CZ) M200551201
Institutional support: RVO:61388963
Keywords : prodrugs * phosphonates * tyrosine
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0240428 - 3.0429755 - ÚOCHB 2015 GB eng A - Abstract
Pomeisl, Karel - Beier, Petr - Pohl, Radek - Krečmerová, Marcela
Synthesis of side-chain gem-difluorinated acyclic nucleoside phosphonates.
15th Tetrahedron Symposium. Challenges in Bioorganic and Organic Medicinal Chemistry. London: Elsevier, 2014. P1.68.
[Tetrahedron Symposium. Challenges in Bioorganic and Organic Medicinal Chemistry /15./. 24.06.2014-27.06.2014, London]
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * difluoromethylation * FPMPA * diethyldifluoromethylphosphonate
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0234823 - 4.0399428 - ÚOCHB 2014 CZ cze A - Abstract
Krečmerová, Marcela - Tichý, Tomáš - Pomeisl, Karel
Nové formy proléčiv biologicky aktivních nukleotidových analogů.
[New prodrug forms of biologically active nucleotide analogues.]
Liblice 2013. 48th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2013. s. 33-33.
[Liblice 2013. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /48./. 01.11.2013-03.11.2013, Špindlerův Mlýn]
R&D Projects: GA MPO FR-TI4/625
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonate * antivirals * cytostatics * prodrug
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0226713 - 5.0384400 - ÚOCHB 2013 US eng A - Abstract
Pomeisl, Karel - Andrei, G. - Snoeck, R. - Pohl, Radek - Krečmerová, Marcela
Synthesis of some thymine acyclic nucleoside phosphonates bearing short phosphonoalkyl chains and evaluation of their antiviral activity.
2nd Antivirals Congress. From Bench to Bedside. Cambridge: Elsevier, 2012.
[Antivirals Congress. From Bench to Bedside /2./. 11.11.2012-13.11.2012, Cambridge]
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * phosphonoalkyl * antiviral activity
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0214070 - 6.0382590 - ÚOCHB 2013 CA eng A - Abstract
Pomeisl, Karel - Votruba, Ivan - Holý, Antonín - Pohl, Radek - Blažek, Jiří - Krečmerová, Marcela
Pyrimidine acyclic nucleoside phosphonates and their phosphorylated analogs as potential multisubstrate inhibitors of thymidine phosphorylase.
Ottawa 2012 International Symposium On Biochemistry and Biophysics. Ottawa: -, 2012. -.
[Ottawa 2012 International Symposium On Biochemistry and Biophysics. 24.10.2012-25.10.2012, Ottawa]
R&D Projects: GA MPO FR-TI4/625
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * thymidine phosphorylase * phosphorylation * pyrimidines
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0212770 - 7.0367761 - ÚOCHB 2012 US eng A - Abstract
Pomeisl, Karel
Syntheses of 1-[2-(phosphonomethoxy)alkyl)thymine monophosphates as potential inhibitors of human thymidine phosphorylase.
43rd Western Regional Meeting. Pasadena: ACS, 2011. RM WRM15-RM WRM15.
[Western Regional Meeting /43./. 10.11.2011-12.11.2011, Pasadena]
R&D Projects: GA MŠMT 1M0508; GA MŠMT(CZ) ME10040
Institutional research plan: CEZ:AV0Z40550506
Keywords : thymidine phosphorylase * phosphorylation * acyclic nucleoside phosphonates * pyrimidines
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0202317 - 8.0367758 - ÚOCHB 2012 US eng A - Abstract
Tichý, Tomáš - Pomeisl, Karel - Krečmerová, Marcela - McKenna, C.
Synthesis of tyrosine side chain-linked prodrugs of PMEG and cpr-PMEDAP.
43rd Western Regional Meeting. Pasadena: ACS, 2011. RM WRM16-RM WRM16.
[Western Regional Meeting /43./. 10.11.2011-12.11.2011, Pasadena]
R&D Projects: GA MŠMT 1M0508; GA MŠMT(CZ) ME10040
Institutional research plan: CEZ:AV0Z40550506
Keywords : prodrugs * tyrosine * acyclic nucleoside phosphonate * antiproliferative effects
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0202314 - 9.0362830 - ÚOCHB 2012 GR eng A - Abstract
Pomeisl, Karel - Holý, Antonín - Krečmerová, Marcela
Syntheses of alpha-branched alkyl and aryl N-9-[2-(phoshonomethoxy)ethyl]-purines.
ESOC 2011. 17th European Symposium on Organic Chemistry. Crete: University of Crete, 2011. P1.163-P1.163.
[ESOC 2011. European Symposium on Organic Chemistry /17./. 10.07.2011-15.07.2011, Crete]
R&D Projects: GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : malaria * acyclic nucleoside phosphonates * dioxolanes * Mitsunobu reaction * hypoxanthine-guanine-xanthine phosphoribosyltransferase
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0199027 - 10.0352079 - ÚOCHB 2011 US eng A - Abstract
Pomeisl, Karel - Fanfrlík, Jindřich - Přenosil, Ondřej - Votruba, Ivan - Horská, Květoslava - Pohl, Radek - Tichý, Tomáš - Krečmerová, Marcela
Docking Study of Pyrimidine Acyclic Nucleoside Phosphonates in Interaction with Human Thymidine Phosphorylase as a Support for Potential Explanation of their Inhibitory Activity.
Frontiers in the Simulation of Macromolecules. A Symposium in Honor of Professor Arieh Warshel on the Event of His 70th Birtday. Los Angeles: University of Southern California, 2010. s. 45-45.
[Frontiers in the Simulation of Macromolecules. A Symposium in Honor of Professor Arieh Warshel on the Event of His 70th Birtday. 12.11.2010-14.11.2010, Los Angeles]
R&D Projects: GA MŠMT(CZ) ME10040
Institutional research plan: CEZ:AV0Z40550506
Keywords : thymidine phosphorylase * phosphates * acyclic nucleoside phosphonates * docking study
Subject RIV: CC - Organic Chemistry
Permanent Link: http://hdl.handle.net/11104/0191670