Search results
- 1.0584811 - BTÚ 2025 RIV GB eng J - Journal Article
Malarikova, D. - Jorda, R. - Kupcová, K. - Senavova, J. - Dolníková, A. - Pokorná, E. - Kazantsev, D. - Nozickova, K. - Sovilj, Dana - Bellanger, C. - Chiron, D. - Anděra, Ladislav - Kryštof, V. - Strnad, Miroslav - Helman, K. - Klánová, M. - Trněný, M. - Havranek, O. - Klener, P.
Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without iRB1/i deletion.
EXP HEMATOL ONCOL. Roč. 13, č. 1 (2024), č. článku 34. E-ISSN 2162-3619
Institutional support: RVO:86652036 ; RVO:61389030
Keywords : cdk4/6 * Cyclin-dependent kinase (CDK) inhibitors * Palbociclib * bcl2 * Venetoclax * rb1 * Mantle cell lymphoma (MCL)
OECD category: Oncology
Impact factor: 10.9, year: 2022
Method of publishing: Open access
https://ehoonline.biomedcentral.com/articles/10.1186/s40164-024-00499-2
Permanent Link: https://hdl.handle.net/11104/0353392 - 2.0579081 - ÚMG 2024 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Peřina, M. - Vojáčková, V. - Pospíšil, T. - Djukic, S. - Škerlová, Jana - Grúz, J. - Renešová, N. - Klener, P. - Řezáčová, P. - Strnad, M. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-id/i]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry. Roč. 65, č. 13 (2022), s. 8881-8896. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : roscovitine * expression * cell line
OECD category: Biochemistry and molecular biology
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c02184
Permanent Link: https://hdl.handle.net/11104/0347953 - 3.0574366 - ÚOCHB 2024 RIV US eng J - Journal Article
Břehová, Petra - Řezníčková, E. - Škach, Kryštof - Jorda, R. - Dejmek, Milan - Vojáčková, V. - Šála, Michal - Kovalová, M. - Dračínský, Martin - Dolníková, A. - Strmeň, Timotej - Kinnertová, M. - Chalupský, Karel - Dvořáková, Alexandra - Gucký, T. - Mertlíková-Kaiserová, Helena - Klener, P. - Nencka, Radim - Kryštof, V.
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping.
Journal of Medicinal Chemistry. Roč. 66, č. 16 (2023), s. 11133-11157. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MZd(CZ) NU20-05-00472; GA MŠMT LX22NPO5102
Institutional support: RVO:61388963
Keywords : gene expression * highly potent
OECD category: Oncology
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://doi.org/10.1021/acs.jmedchem.3c00575
Permanent Link: https://hdl.handle.net/11104/0344703File Download Size Commentary Version Access 10.1021acs.jmedchem.3c00575.pdf 0 7.8 MB Publisher’s postprint open-access - 4.0571975 - ÚEB 2024 RIV NL eng J - Journal Article
Kovalová, M. - Havlíček, Libor - Djukic, Stefan - Škerlová, Jana - Peřina, M. - Pospíšil, T. - Řezníčková, E. - Řezáčová, Pavlína - Jorda, R. - Kryštof, V.
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7.
Biomedicine & Pharmacotherapy. Roč. 161, MAY (2023), č. článku 114492. ISSN 0753-3322. E-ISSN 1950-6007
R&D Projects: GA MŠMT LX22NPO5102
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Cyclin-dependent kinase 7 * Inhibitor * pyrazolo[4,3-d]pyrimidine * Selectivity
OECD category: Medicinal chemistry
Impact factor: 7.5, year: 2022
Method of publishing: Open access
https://doi.org/10.1016/j.biopha.2023.114492
Permanent Link: https://hdl.handle.net/11104/0342824File Download Size Commentary Version Access 2023_Kovalova_BIOMEDICINE & PHARMACOTHERAPY_114492.pdf 2 3.3 MB Other open-access - 5.0562052 - ÚEB 2023 RIV US eng J - Journal Article
Jorda, R. - Havlíček, Libor - Peřina, M. - Vojáčková, V. - Pospíšil, T. - Djukic, Stefan - Škerlová, Jana - Grúz, J. - Renešová, N. - Klener, P. - Řezáčová, Pavlína - Strnad, Miroslav - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3- d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Journal of Medicinal Chemistry. Roč. 65, č. 13 (2022), s. 8881-8896. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729; GA ČR(CZ) GA20-25308S
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : Antineoplastic Agents * Cell Line * Cyclin-Dependent Kinases
OECD category: Organic chemistry
Impact factor: 7.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c02184
Permanent Link: https://hdl.handle.net/11104/0334472File Download Size Commentary Version Access 2022_Jorda_JOURNAL OF MEDICINAL CHEMISTRY_8881.pdf 3 9 MB Other require - 6.0556564 - ÚOCHB 2023 RIV AE eng J - Journal Article
Toman, D. - Jorda, R. - Ajani, Haresh - Kryštof, V. - Cankař, P.
Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases.
Medicinal Chemistry. Roč. 18, č. 4 (2022), s. 484-496. ISSN 1573-4064. E-ISSN 1875-6638
Institutional support: RVO:61388963
Keywords : CDK inhibitors * styrylpyrazoles * Suzuki-Miyaura cross-coupling reaction * Vilsmeier-Haack reaction * CAN508 * K562
OECD category: Medicinal chemistry
Impact factor: 2.3, year: 2022
Method of publishing: Limited access
https://doi.org/10.2174/1573406417666210806095710
Permanent Link: http://hdl.handle.net/11104/0330725 - 7.0548632 - ÚIACH 2022 RIV CH eng J - Journal Article
Rouchal, M. - Rudolfová, J. - Kryštof, V. - Vojáčková, V. - Čmelík, Richard - Vícha, R.
Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity.
International Journal of Molecular Sciences. Roč. 22, č. 23 (2021), č. článku 12675. E-ISSN 1422-0067
Institutional support: RVO:68081715
Keywords : adamantane * 2,6,9-trisubstituted purine * molecular docking
OECD category: Analytical chemistry
Impact factor: 6.208, year: 2021
Method of publishing: Limited access
Permanent Link: http://hdl.handle.net/11104/0324667File Download Size Commentary Version Access 0548632.pdf 1 1.2 MB Publisher’s postprint require - 8.0545107 - ÚOCHB 2022 RIV US eng J - Journal Article
Dayal, N. - Řezníčková, E. - Hernandez, D. E. - Peřina, M. - Torregrosa-Allen, S. - Elzey, B. D. - Škerlová, Jana - Ajani, Haresh - Djukic, Stefan - Vojáčková, V. - Lepšík, Martin - Řezáčová, Pavlína - Kryštof, V. - Jorda, R. - Sintim, H. O.
3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.
Journal of Medicinal Chemistry. Roč. 64, č. 15 (2021), s. 10981-10996. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) EF16_019/0000729
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61388963
Keywords : discovery * FLT3 * cell proliferation
OECD category: Medicinal chemistry
Impact factor: 8.039, year: 2021
Method of publishing: Limited access
https://doi.org/10.1021/acs.jmedchem.1c00330
Permanent Link: http://hdl.handle.net/11104/0321867 - 9.0544833 - ÚMG 2022 RIV FR eng J - Journal Article
Jansa, J. - Jorda, R. - Škerlová, J. - Pachl, P. - Peřina, M. - Řezníčková, E. - Heger, T. - Gucký, T. - Řezáčová, Pavlína - Lyčka, A. - Kryštof, V.
Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure.
European Journal of Medicinal Chemistry. Roč. 216, April (2021), č. článku 113309. ISSN 0223-5234. E-ISSN 1768-3254
Institutional support: RVO:68378050
Keywords : Kinase inhibitor * Cyclin-dependent kinase 2 * imidazo[1,2-c]pyrimidin-5(6H)-one * X-ray crystallography * Co-crystal * Activity assay * itc
OECD category: Biochemistry and molecular biology
Impact factor: 7.088, year: 2021
Method of publishing: Limited access
https://www-sciencedirect-com.d360prx.biomed.cas.cz/science/article/pii/S0223523421001586?via%3Dihub
Permanent Link: http://hdl.handle.net/11104/0321645 - 10.0541528 - ÚMG 2021 RIV US eng J - Journal Article
Jorda, R. - Havlíček, L. - Šturc, A. - Tušková, D. - Daumová, L. - Alam, M. - Škerlová, Jana - Nekardová, M. - Peřina, M. - Pospíšil, T. - Šiiroká, J. - Urbánek, L. - Pachl, P. - Řezáčová, Pavlína - Strnad, M. - Klener, P. - Kryštof, V.
3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.
Journal of Medicinal Chemistry. Roč. 62, č. 9 (2019), s. 4606-4623. ISSN 0022-2623. E-ISSN 1520-4804
Institutional support: RVO:68378050
Keywords : biological evaluation * cell-cycle * roscovitine * potent * apoptosis * subgroups * purines * abt-199
OECD category: Biochemistry and molecular biology
Impact factor: 6.205, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00189
Permanent Link: http://hdl.handle.net/11104/0319083