Search results
- 1.0314715 - FGÚ 2009 CH eng A - Abstract
Michal, Pavel - Doležal, Vladimír - El-Fakahany, E. E.
Membrane cholesterol content influences the affinity for carbachol and internalization of the muscarinic M2 receptors expressed in Chinese hamster ovary cells.
[Obsah membránového cholesterolu ovlivňnuje afinitu pro karbachol a internalizaci muskarinových M2 receptorů exprimovaných v CHO buňkách.]
6th FENS forum. Geneva: Swiss Society for Neuroscience, 2008. s. 122-122. ISBN 92-990014-3-X.
[FENS. Forum of European Neuroscience /6./. 12.07.2008-16.07.2008, Geneva]
R&D Projects: GA AV ČR(CZ) IAA500110703; GA ČR(CZ) GP305/05/P209
Grant - others:NIH(US) NS25743
Institutional research plan: CEZ:AV0Z50110509
Keywords : spo2 * muscarinic receptor * cholesterol
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0165131 - 2.0141193 - FGU-C 950221 CZ eng A - Abstract
Jakubík, Jan - Bačáková, Lucie - El-Fakahany, E. E. - Tuček, Stanislav
Allosteric control of the binding properties of muscarinic receptor subtypes M1-M5 in cho cell lines.
Physiologia Bohemoslovaca. Roč. 44, - (1995), s. 5P. ISSN 0369-9463
Permanent Link: http://hdl.handle.net/11104/0038923 - 3.0092725 - FGÚ 2008 CZ eng A - Abstract
Michal, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Activation of non-preferential Gq/11 and Gs G-proteins by muscarinic M2 receptors is agonist-dependent.
[Aktivace nepreferenčních Gq/11 a Gs G-proteinů muskarinovými M2 receptory je závislá na typu agonisty.]
Physiological Research. Fyziologický ústav AV ČR, v. v. i. Roč. 56, č. 3 (2007), 23P-23P. ISSN 0862-8408. E-ISSN 1802-9973.
[Fyziologické dny /83./. 06.02.2007-08.02.2007, Brno]
R&D Projects: GA ČR(CZ) GA305/05/0452; GA ČR(CZ) GP305/05/P209; GA MŠMT(CZ) LC554
Grant - others:NIH(US) NS25743
Institutional research plan: CEZ:AV0Z50110509
Keywords : cpo1 * muscarinic * G-protein * receptor
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0152971 - 4.0092719 - FGÚ 2008 US eng A - Abstract
Michal, Pavel - Doležal, Vladimír - El-Fakahany, E. E.
Muscarinic M1 and M2 receptors activate Gi/o, Gs or Gq/11 G-proteins.
[Muskarinové M1 a M2 receptory aktivují Gi/o, Gs a Gq/11 G-proteiny.]
Journal of Neurochemistry. Wiley. Roč. 102, Suppl.1 (2007), s. 104-105. ISSN 0022-3042. E-ISSN 1471-4159.
[Biennial meeting of the International Society for Neurochemistry /21./ and Annual meeting of the American Society for Neurochemistry /38./. 19.08.2007-24.08.2007, Cancun]
R&D Projects: GA ČR(CZ) GA305/05/0452; GA ČR(CZ) GP305/05/P209; GA MŠMT(CZ) LC554
Grant - others:NIH(US) NS25743
Institutional research plan: CEZ:AV0Z50110509
Keywords : cpo1 * G-proteins * muscarinic * siRNA
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0152966 - 5.0092710 - FGÚ 2008 CZ eng A - Abstract
Michal, Pavel - El-Fakahany, E. E. - Doležal, Vladimír
Cholesterol differentially influeces G-protein signaling activated by the muscarinic M2 receptor.
[Membránový cholesterol rozdílně ovlivňuje G-proteinový signál aktivovaný muskarinovými M2 receptory.]
Programme and abstracts of the 6th Conference of the Czech Neuroscience Society. Praha: The Czech Neuroscience Society, 2007. s. 89-89.
[Conference of the Czech Neuroscience Society /6./. 19.11.2007-20.11.2007, Praha]
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GP305/05/P209; GA ČR(CZ) GA305/05/0452
Grant - others:NIH(US) NS25743
Institutional research plan: CEZ:AV0Z50110509
Keywords : spo2 * cholesterol * muscarinic * G-protein
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0152958 - 6.0091833 - FGÚ 2008 CZ eng A - Abstract
Machová, Eva - Jakubík, Jan - El-Fakahany, E. E. - Doležal, Vladimír
Delayed effects of xanomeline on evoked ACh release from rat brain slices.
[Opožděný účinek xanomelinu na evokované uvolňování acetylcholinu z mozkových řezů.]
Programme and abstracts of the 6th Conference of the Czech Neuroscience Society. Praha: The Czech Neuroscience Society, 2007. s. 52-52.
[Conference of the Czech Neuroscience Society /6./. 19.11.2007-20.11.2007, Praha]
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GA305/05/0452
Institutional research plan: CEZ:AV0Z50110509
Keywords : spr2 * effects of xanomeline * ACh release
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0152335 - 7.0091824 - FGÚ 2008 CZ eng A - Abstract
Machová, Eva - Jakubík, Jan - El-Fakahany, E. E. - Doležal, Vladimír
Wash-resistantly bound xanomeline inhibits acetylcholine release by persistent activation of presynaptic M2 and M4 muscarinic receptors.
[Xanomelin neodmyvatelně navázaný na M2 a M4 muskarinové receptory snižuje evokované uvolňování acetylcholinu.]
Vědecká konference 2007 - věda, sport a rock´ n´roll. Praha: 2.Lékařská fakulta UK, 2007. s. 55-55.
[Vědecká konference 2007 - věda, sport a rock´n´roll. 25.04.2007-26.04.2007, Praha]
R&D Projects: GA ČR(CZ) GA305/05/0452; GA MŠMT(CZ) LC554
Grant - others:NIH(US) NS25732
Institutional research plan: CEZ:AV0Z50110509
Keywords : spo2 * xanomeline * acetylcholine * presynaptic muscarinic receptors
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0152327 - 8.0091809 - FGÚ 2008 US eng A - Abstract
Jakubík, Jan - El-Fakahany, E. E. - Doležal, Vladimír
Differences in kinetics of xanomeline wash-resistant binding may constitute basis for its functional selectivity.
[Rozdíly v kinetice neodmyvatelné vazby xanomelinu mohou být podstatou jeho funkční selektivity.]
Journal of Neurochemistry. Wiley. Roč. 102, Suppl.1 (2007), s. 262-262. ISSN 0022-3042. E-ISSN 1471-4159.
[Biennial meeting of the International Society for Neurochemistry /21./ and Annual meeting of the American Society for Neurochemistry /38./. 19.08.2007-24.08.2007, Cancun]
R&D Projects: GA ČR(CZ) GA305/05/0452; GA MŠMT(CZ) LC554
Grant - others:NIH(US) NS25743
Institutional research plan: CEZ:AV0Z50110509
Keywords : cpo1 * muscarinic receptors * xanomeline * functional selectivity
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0152316 - 9.0091771 - FGÚ 2008 CZ eng A - Abstract
Jakubík, Jan - El-Fakahany, E. E. - Doležal, Vladimír
Basis of xanomeline functional selectivity towards M1 versus M2 musacrinic receptors.
[Základy funkční selektivity xanomelinu k M1 versus M2 muskarinovému receptoru.]
Physiological Research. Fyziologický ústav AV ČR, v. v. i. Roč. 56, č. 3 (2007), 14P-14P. ISSN 0862-8408. E-ISSN 1802-9973.
[Fyziologické dny /83./. 06.02.2007-08.02.2007, Brno]
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GA305/05/0452
Institutional research plan: CEZ:AV0Z50110509
Keywords : cpo1 * muscarinic * selectivity * xanomeline
Subject RIV: ED - Physiology
Permanent Link: http://hdl.handle.net/11104/0152289 - 10.0090827 - FGÚ 2008 US eng A - Abstract
Machová, Eva - Jakubík, Jan - El-Fakahany, E. E. - Doležal, Vladimír
Xanomeline wash-resistantly bound to presynaptic M2 and M4 muscarinic receptors decreases the evoked release of acetylcholine.
[Xanomelin neodmyvatelně navázaný na presynaptické muskarinové M2 a M4 receptory snižuje evokované uvolňování acetylcholinu.]
Journal of Neurochemistry. Wiley. Roč. 101, Suppl.1 (2007), s. 52-53. ISSN 0022-3042. E-ISSN 1471-4159.
[ESN - meeting /17./ - Conference on Advances in Molecular Mechanims and Disorders /3./. 19.05.2007-22.05.2007, Salamanca]
R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GA305/05/0452
Grant - others:NIH(US) NS25732
Institutional research plan: CEZ:AV0Z50110509
Keywords : cpo1 * xanomeline * muscarinic receptor
Subject RIV: FH - Neurology
Permanent Link: http://hdl.handle.net/11104/0151589