Search results
- 1.0534782 - ÚMCH 2021 RIV US eng J - Journal Article
Lynn, G. M. - Sedlik, C. - Baharom, F. - Zhu, Y. - Ramirez-Valdez, R. A. - Coble, V. L. - Tobin, K. - Nichols, S. R. - Itzkowitz, Y. - Zaidi, N. - Gammon, J. M. - Blobel, N. J. - Denizeau, J. - de la Rochere, P. - Francica, B. J. - Decker, B. - Maciejewski, M. - Cheung, J. - Yamane, H. - Smelkinson, M. G. - Francica, J. R. - Laga, Richard - Bernstock, J. D. - Seymour, L. W. - Drake, C. G. - Jewell, C. M. - Lantz, O. - Piaggio, E. - Ishizuka, A. S. - Seder, R. A.
Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens.
Nature Biotechnology. Roč. 38, č. 3 (2020), s. 320-332. ISSN 1087-0156. E-ISSN 1546-1696
R&D Projects: GA ČR(CZ) GA19-08176S; GA MŠMT(CZ) LQ1604
Institutional support: RVO:61389013
Keywords : peptide-based vaccines * nanoparticle carriers * toll-like receptor-7/8 agonist
OECD category: Polymer science
Impact factor: 54.908, year: 2020
Method of publishing: Open access
https://www.nature.com/articles/s41587-019-0390-x
Permanent Link: http://hdl.handle.net/11104/0312953 - 2.0501308 - ÚMCH 2020 RIV US eng J - Journal Article
Lynn, G. M. - Chytil, Petr - Francica, J. R. - Lagová, A. - Kueberuwa, G. - Ishizuka, A. S. - Zaidi, N. - Ramirez-Valdez, R. A. - Blobel, N. J. - Baharom, F. - Leal, J. - Wang, A. Q. - Gerner, M. Y. - Etrych, Tomáš - Ulbrich, Karel - Seymour, L. W. - Seder, R. A. - Laga, Richard
Impact of polymer-TLR-7/8 agonist (adjuvant) morphology on the potency and mechanism of CD8 T cell induction.
Biomacromolecules. Roč. 20, č. 2 (2019), s. 854-870. ISSN 1525-7797. E-ISSN 1526-4602
R&D Projects: GA ČR(CZ) GJ16-14957Y; GA MŠMT(CZ) LQ1604
Institutional support: RVO:61389013
Keywords : hydrophilic polymers * toll-like receptor-7/8 agonists * polymer immunostimulants
OECD category: Polymer science
Impact factor: 6.092, year: 2019
Method of publishing: Limited access
https://pubs.acs.org/doi/10.1021/acs.biomac.8b01473
Permanent Link: http://hdl.handle.net/11104/0293622 - 3.0464818 - ÚMCH 2017 RIV US eng J - Journal Article
Francica, J. R. - Lynn, G. M. - Laga, Richard - Joyce, M. G. - Ruckwardt, T. J. - Morabito, K. M. - Chen, M. - Chaudhuri, R. - Zhang, B. - Sastry, M. - Druz, A. - Ko, K. - Choe, M. - Pechar, Michal - Georgiev, I. S. - Kueltzo, L. A. - Seymour, L. W. - Mascola, J. R. - Kwong, P. D. - Graham, B. S. - Seder, R. A.
Thermoresponsive polymer nanoparticles co-deliver RSV F trimers with a TLR-7/8 adjuvant.
Bioconjugate Chemistry. Roč. 27, č. 10 (2016), s. 2372-2385. ISSN 1043-1802. E-ISSN 1520-4812
R&D Projects: GA ČR(CZ) GJ16-14957Y; GA MŠMT(CZ) LQ1604
Institutional support: RVO:61389013
Keywords : thermoresponsive polymers * polymer vaccines * toll-like receptor agonists
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 4.818, year: 2016
Permanent Link: http://hdl.handle.net/11104/0264112 - 4.0450872 - ÚMCH 2016 RIV US eng J - Journal Article
Lynn, G. M. - Laga, Richard - Darrah, P. A. - Ishizuka, A. S. - Balaci, A. J. - Dulcey, A. E. - Pechar, Michal - Pola, Robert - Gerner, M. Y. - Yamamoto, A. - Buechler, C. R. - Quinn, K. M. - Smelkinson, M. G. - Vanek, O. - Cawood, R. - Hills, T. - Vasalatiy, O. - Kastenmüller, K. - Francica, J. R. - Stutts, L. - Tom, J. K. - Ah Ryu, K. - Esser-Kahn, A. P. - Etrych, Tomáš - Fisher, K. D. - Seymour, L. W. - Seder, R. A.
In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity.
Nature Biotechnology. Roč. 33, č. 11 (2015), s. 1201-1210. ISSN 1087-0156. E-ISSN 1546-1696
R&D Projects: GA MŠMT(CZ) EE2.3.30.0029
Institutional support: RVO:61389013
Keywords : adjuvants * biomedical engineering * drug delivery
Subject RIV: CE - Biochemistry
Impact factor: 43.113, year: 2015
Permanent Link: http://hdl.handle.net/11104/0252994 - 5.0448519 - ÚMCH 2016 RIV CZ eng J - Journal Article
Kostka, Libor - Šubr, Vladimír - Laga, Richard - Chytil, Petr - Ulbrich, Karel - Seymour, L. W. - Etrych, Tomáš
Nanotherapeutics shielded with a pH responsive polymeric layer.
Physiological Research. Roč. 64, Suppl. 1 (2015), S29-S40. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA MŠMT(CZ) EE2.3.30.0029; GA MŠMT(CZ) ED1.1.00/02.0109; GA ČR(CZ) GAP301/12/1254
Institutional support: RVO:61389013
Keywords : nanotherapeutics * coating * pH responsive
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.643, year: 2015
http://www.biomed.cas.cz/physiolres/pdf/64%20Suppl%201/64_S29.pdf
Permanent Link: http://hdl.handle.net/11104/0252995 - 6.0399052 - ÚMCH 2014 RIV US eng J - Journal Article
Carlisle, R. - Choi, J. - Bazan-Peregrino, M. - Laga, R. - Šubr, Vladimír - Kostka, Libor - Ulbrich, Karel - Coussios, C. C. - Seymour, L. W.
Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound.
JNCI-Journal of the National Cancer Institute. Roč. 105, č. 22 (2013), s. 1701-1710. ISSN 0027-8874. E-ISSN 1460-2105
Grant - others:AV ČR(CZ) AP0802
Program: Akademická prémie - Praemium Academiae
Institutional support: RVO:61389013
Keywords : cancer * intravenous * adenovirus
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 15.161, year: 2013
Permanent Link: http://hdl.handle.net/11104/0227733 - 7.0384590 - ÚMCH 2013 RIV GB eng J - Journal Article
Green, N. K. - Hale, A. - Cawood, R. - Illingworth, S. - Herbert, C. - Hermiston, T. - Šubr, Vladimír - Ulbrich, Karel - van Rooijen, N. - Seymour, L. W. - Fisher, K. D.
Tropism ablation and stealthing of oncolytic adenovirus enhances systemic delivery to tumors and improves virotherapy of cancer.
Nanomedicine. Roč. 7, č. 11 (2012), s. 1683-1695. ISSN 1743-5889. E-ISSN 1748-6963
R&D Projects: GA AV ČR IAAX00500803
Institutional research plan: CEZ:AV0Z40500505
Institutional support: RVO:61389013
Keywords : clodronate liposomes * polymer-coated adenovirus * predosing strategy
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.260, year: 2012
Permanent Link: http://hdl.handle.net/11104/0216116 - 8.0378755 - ÚMCH 2013 RIV NL eng J - Journal Article
Laga, Richard - Carlisle, R. - Tangney, M. - Ulbrich, Karel - Seymour, L. W.
Polymer coatings for delivery of nucleic acid therapeutics.
Journal of Controlled Release. Roč. 161, č. 2 (2012), s. 537-553. ISSN 0168-3659. E-ISSN 1873-4995
R&D Projects: GA AV ČR IAAX00500803
Institutional research plan: CEZ:AV0Z40500505
Keywords : gene delivery * polymer coating * viral vectors
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 7.633, year: 2012
Permanent Link: http://hdl.handle.net/11104/0210151 - 9.0368414 - ÚMCH 2012 RIV NL eng J - Journal Article
Seki, T. - Carroll, F. - Illingworth, S. - Green, N. - Cawood, R. - Bachtarzi, H. - Šubr, Vladimír - Fisher, K. D. - Seymour, L. W.
Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway.
Journal of Controlled Release. Roč. 156, č. 3 (2011), s. 381-389. ISSN 0168-3659. E-ISSN 1873-4995
Institutional research plan: CEZ:AV0Z40500505
Keywords : drug delivery * adenovirus * vascular permeability
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 5.732, year: 2011
Permanent Link: http://hdl.handle.net/11104/0202765 - 10.0362894 - ÚMCH 2012 RIV GB eng J - Journal Article
Bachtarzi, H. - Stevenson, M. - Šubr, Vladimír - Seymour, L. W. - Fisher, K. D.
E-selectin is a viable route of infection for polymer-coated adenovirus retargeting in TNF-.alpha.-activated human umbilical vein endothelial cells.
Journal of Drug Targeting. Roč. 19, č. 8 (2011), s. 690-700. ISSN 1061-186X. E-ISSN 1029-2330
Institutional research plan: CEZ:AV0Z40500505
Keywords : polymer-coated virus * vascular targeting * inflammation
Subject RIV: CD - Macromolecular Chemistry
Impact factor: 2.696, year: 2011
Permanent Link: http://hdl.handle.net/11104/0199069